Genetic instability in the human lymphocyte exposed to hypoxia

Cancer Genetics and Cytogenetics

Volumn 196, Issue 1, 2010, Pages 83-88

  Lee, Jae Ho ^a   Choi, In Jang ^a   Song, Dae Kyu ^a   Kim, Dae Kwang ^a  

^a Keimyung University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA;

ADULT; ARTICLE; CELL ISOLATION; CHROMATID EXCHANGE; CONTROLLED STUDY; CYTOGENETICS; DNA REPAIR; GENETIC DAMAGE; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HYPOXIA; LYMPHOCYTE CULTURE; MALE; MICROSATELLITE INSTABILITY; MUTAGENESIS; NORMAL HUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL;

BASE SEQUENCE; CELL HYPOXIA; DNA DAMAGE; DNA PRIMERS; DNA REPAIR; GENOMIC INSTABILITY; HUMANS; LYMPHOCYTES; MICROSATELLITE REPEATS; SISTER CHROMATID EXCHANGE;

EID: 70949095189     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2009.09.002     Document Type: Article

References (41)

1. Harris A.L. Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer 2 (2002) 38-47
2. Hockel M., and Vaupel P. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 93 (2001) 266-276
3. Reynolds T.Y., Rockwell S., and Glazer P.M. Genetic instability induced by the tumor microenvironment. Cancer Res 56 (1996) 5754-5757
4. Huang L.E., Bindra R.S., Glazer P.M., and Harris A.L. Hypoxia-induced genetic instability-a calculated mechanism underlying tumor progression. J Mol Med 85 (2007) 139-148
5. Yuan J., and Glazer P.M. Mutagenesis induced by the tumor microenvironment. Mutat Res 400 (1998) 439-446
6. Papp-Szabo E., Josephy P.D., and Coomber B.L. Microenvironmental influences on mutagenesis in mammary epithelial cells. Int J Cancer 116 (2005) 679-685
7. Bindra R.S., and Glazer P.M. Genetic instability and the tumor microenvironment: towards the concept of microenvironment induced mutagenesis. Mutat Res 569 (2005) 75-85
8. Yuan J., Narayanan L., Rockwell S., and Glazer P.M. Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH. Cancer Res 60 (2000) 4372-4376
9. Carrano A.V., Thompson L.H., Lindl P.A., and Minkler J.L. Sister chromatid exchanges as an indicator of mutagenesis. Nature 271 (1978) 551-553
10. Loukola A., Eklin K., Laiho P., Salovaara R., Kristo P., Järvinen H., Mecklin J.P., Launonen V., and Aaltonen L.A. Microsatellite marker analysis in screening for hereditary nonpolyposis colorectal cancer. Cancer Res 61 (2001) 4545-4549
11. Muc R., and Naidoo R. Microsatellite instability in diagnostic pathology. Curr Diagn Pathol 8 (2002) 318-327
12. Loeb L.A. Microsatellite instability: marker of a mutator phenotype in cancer. Cancer Res 54 (1994) 5059-5063
13. Boland C.R., Thibodeau S.N., Hamilton S.R., Sidransky D., Eshleman J.R., Burt R.W., Meltzer S.J., Rodriguez-Bigas M.A., Fodde R., Ranzani G.N., and Srivastava S. A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 58 (1998) 5248-5257
14. Perucho M. Correspondence re: C.R. Boland et al., A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 1999;59:249-256
15. Benatti P., Gafà R., Barana D., Marino M., Scarselli A., Pedroni M., Maestri I., Guerzoni L., Roncucci L., Menigatti M., Roncari B., Maffei S., Rossi G., Ponti G., Santini A., Losi L., Di Gregorio C., Oliani C., Ponz de Leon M., and Lanza G. Microsatellite instability and colorectal cancer prognosis. Clin Cancer Res 11 (2005) 8332-8340
16. Bianchi M.S., Bianchi N.O., and Bailliet G. Mitochondrial DNA mutations in normal and tumor tissues from breast cancer patients. Cytogenet Cell Genet 71 (1995) 99-103
17. Heerdt B.G., Chen J., Stewart L.R., and Augenlicht L.H. Polymorphisms, but lack of mutations or instability, in the promoter region of mitochondrial genome in human colonic tumors. Cancer Res 54 (1994) 3912-3915
18. Polyak K., Li Y., Zhu H., Lengauer C., Willson J.K., Markowitz S.D., Trush M.A., Kinzler K.W., and Vogelstein B. Somatic mutations of the mitochondrial genome in human colorectal tumours. Nat Genet 20 (1998) 291-293
19. Perry P., and Wolff S. New Giemsa method for the differential staining of sister chromatids. Nature 251 (1974) 156-158
20. Richard S.M., Bailliet G., Páez G.L., Bianchi M.S., Peltomäki P., and Bianchi N.O. Nuclear and mitochondrial genome instability in human breast cancer. Cancer Res 60 (2000) 4231-4237
21. Wilson III D.M., and Thompson L.H. Molecular mechanisms of sister-chromatid exchange. Mutat Res 616 (2007) 11-23
22. Pluquet O., and Hainaut P. Genotoxic and non-genotoxic pathways of p53 induction. Cancer Lett 174 (2001) 1-15
23. Amellem O., and Pettersen E. Cell inactivation and cell cycle inhibition as induced by extreme hypoxia: the possible role of cell cycle arrest as a protection against hypoxia-induced lethal damage. Cell Prolif 24 (1991) 127-141
24. Gardner L.B., Li Q., Park M.S., Flanagan W.M., Semenza G.L., and Dang C.V. Hypoxia inhibits G1/S transition through regulation of p27 expression. J Biol Chem 276 (2001) 7919-7926
25. Goda N., Ryan H.E., Khadivi B., McNulty W., Rickert R.C., and Johnson R.S. Hypoxia-inducible factor 1 alpha is essential for cell cycle arrest during hypoxia. Mol Cell Biol 23 (2003) 359-369
26. Greijer A.E., and van der Wall E. The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. J Clin Pathol 57 (2004) 1009-1014
27. Heacock C.S., and Sutherland R.M. Enhanced synthesis of stress proteins caused by hypoxia and relation to altered cell growth and metabolism. Br J Cancer 62 (1990) 217-225
28. Mihaylova V.T., Bindra R.S., Yuan J., Campisi D., Narayanan L., Jensen R., Giordano F., Johnson R.S., Rockwell S., and Glazer P.M. Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. Mol Cell Biol 23 (2003) 3265-3273
29. An W.G., Kanekal M., Simon M.C., Maltepe E., Blagosklonny M.V., and Neckers L.M. Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha. Nature 392 (1998) 405-408
30. Hansson L.O., Friedler A., Freund S., Rudiger S., and Fersht A.R. Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53. Proc Natl Acad Sci USA 99 (2002) 10305-10309
31. Chen D., Li M., Luo J., and Gu W. Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem 278 (2003) 13595-13598
32. Schmid T., Zhou J., and Brüne B. HIF-1 and p53: communication of transcription factors under hypoxia. J Cell Mol Med 8 (2004) 423-431
33. Boyer M.J., and Tannock I.F. Regulation of intracellular pH in tumor cell lines: influence of microenvironmental conditions. Cancer Res 52 (1992) 4441-4447
34. Rotin D., Robinson B., and Tannock I.F. Influence of hypoxia and an acidic environment on the metabolism and viability of cultured cells: potential implications for cell death in tumors. Cancer Res 46 (1986) 2821-2826
35. Gorringe K.L., Chin S.F., Pharoah P., Staines J.M., Oliveira C., Edwards P.A., and Caldas C. Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer. Carcinogenesis 26 (2005) 923-930
36. Bianchi N.O., Bianchi M.S., and Richard S.M. Mitochondrial genome instability in human cancers. Mutat Res 488 (2001) 9-23
37. Wang Y., Liu V.W., Ngan H.Y., and Nagley P. Frequent occurrence of mitochondrial microsatellite instability in the D-loop region of human cancers. Ann NY Acad Sci 1042 (2005) 123-129
38. Wang Y., Liu V.W., Tsang P.C., Chiu P.M., Cheung A.N., Khoo U.S., Nagley P., and Ngan H.Y. Microsatellite instability in mitochondrial genome of common female cancers. Int J Gynecol Cancer 16 (2006) 259-266
39. Park C.S., and Kim D.K. Sister chromatid exchange frequencies in stomach cancer patients. Korean J Anat 32 (1999) 615-617
40. Cefle K., Ucur A., Guney N., Ozturk S., Palanduz S., Tas F., Asoglu O., Bayrak A., Muslumanoglu M., and Aydiner A. Increased sister chromatid exchange frequency in young women with breast cancer and in their first-degree relatives. Cancer Genet Cytogenet 171 (2006) 65-67
41. Karaman A., Binici D.N., Kabalar M.E., Dursun H., and Kurt A. Alteration of sister chromatid exchange frequencies in gastric cancer and chronic atrophic gastritis patients with and without H. pylori infection. World J Gastroenterol 14 (2008) 2534-2539