Microsatellite marker analysis in screening for hereditary nonpolyposis colorectal cancer (HNPCC)

Cancer Research

Volumn 61, Issue 11, 2001, Pages 4545-4549

  Loukola, A ^a   Eklin, K ^a   Laiho, P ^a   Salovaara, R ^a   Kristo, P ^a   Jarvinen H ^a   Mecklin, J P ^a   Launonen, V ^a   Aaltonen, L A ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

MICROSATELLITE DNA; TUMOR MARKER;

ADULT; AGED; ARTICLE; AUTOSOMAL DOMINANT DISORDER; CANCER SUSCEPTIBILITY; COLONOSCOPY; COLORECTAL CANCER; GENE MUTATION; GERM LINE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MICROSATELLITE INSTABILITY; PHENOTYPE; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; CARRIER PROTEINS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA-BINDING PROTEINS; GENETIC SCREENING; GERM-LINE MUTATION; HUMANS; MICROSATELLITE REPEATS; MIDDLE AGED; MUTS HOMOLOG 2 PROTEIN; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS;

EID: 0035361301     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Extracolonic cancer in hereditary nonpolyposis colorectal cancer
2. New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC
3. Screening reduces colorectal cancer rate in families with hereditary nonpolyposis colorectal cancer
4. Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer
5. Lessons from hereditary colorectal cancer
6. Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer
7. Clues to the pathogenesis of familial colorectal cancer
8. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
9. Microsatellite instability in cancer of the proximal colon
10. Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study
11. Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients
12. Microsatellite instability and mutation analysis of hMSH2 and hMLH1 in patients with sporadic, familial and hereditary colorectal cancer
13. A National Cancer Institute Workshop on microsatellite instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer
14. Genomic instability in colorectal cancer: Relationship to clinicopathological variables and family history
15. Morphology of sporadic colorectal cancer with DNA replication errors
16. Characterization of a subtype of colorectal cancer combining features of the suppressor and mild mutator pathways
17. Molecular nature of colon tumors in hereditary nonpolyposis colorectal cancer, familial polyposis, and sporadic colon cancer
18. Expression of Bcl-2 protein is decreased in colorectal adenocarcinomas with microsatellite instability
19. DNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyposis: A mild mutator pathway for colorectal cancer?
20. Diagnostic microsatellite instability: Definition and correlation with mismatch repair protein expression
21. Microsatellite instability analysis: A multicenter study for reliability and quality control
22. Microsatellite instability in colorectal cancer: Different mutator phenotypes and the principle involvement of. hMLH1
23. BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines
24. Incidence of hereditary nonpolyposis colorectal cancer, and molecular screening for the disease
25. Molecular screening of potential HNPCC patients using a multiplex microsatellite PCR system
26. BAT-26 and BAT-40 instability in colorectal adenomas and carcinomas and germline polymorphisms
27. Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites
28. Polymorphic variation at the BAT-25 and BAT-26 loci in individuals of African origin
29. Population-based molecular detection of hereditary nonpolyposis colorectal cancer
30. Semiautomated assessment of loss of heterozygosity and replication error in tumors
31. Diagnostic use of microsatellite instability in hereditary non-polyposis colorectal cancer
32. Microsatellite instability as a predictor of a mutation in a DNA mismatch repair gene in familial colorectal cancer
33. Microsatellite instability: A useful diagnostic tool to select patients at high risk for hereditary non-polyposis colorectal cancer: A study in different groups of patients with colorectal cancer
34. Association of hereditary nonpolyposis colorectal cancer-related tumors displaying low microsatellite instability with MSH6 germline mutations
35. Correlation between immunohistochemistry for MLH1/MSH2 and microsatellite instability in tumour tissue of HNPCC patients with known germline mutations
36. Genetic predisposition and somatic diversification in tumor development and progression