-
1
-
-
8844237615
-
Polyubiquitin chains: polymeric protein signals
-
Pickart C.M., and Fushman D. Polyubiquitin chains: polymeric protein signals. Curr Opin Chem Biol 8 (2004) 610-616
-
(2004)
Curr Opin Chem Biol
, vol.8
, pp. 610-616
-
-
Pickart, C.M.1
Fushman, D.2
-
3
-
-
0033016291
-
The ubiquitin-proteasome pathway and pathogenesis of human diseases
-
Schwartz A.L., and Ciechanover A. The ubiquitin-proteasome pathway and pathogenesis of human diseases. Annu Rev Med 50 (1999) 57-74
-
(1999)
Annu Rev Med
, vol.50
, pp. 57-74
-
-
Schwartz, A.L.1
Ciechanover, A.2
-
4
-
-
0035292759
-
Themes and variations on ubiquitylation
-
Weissman A.M. Themes and variations on ubiquitylation. Nat Rev Mol Cell Biol 2 (2001) 169-178
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, pp. 169-178
-
-
Weissman, A.M.1
-
5
-
-
4444318673
-
The SCF ubiquitin ligase: insights into a molecular machine
-
Cardozo T., and Pagano M. The SCF ubiquitin ligase: insights into a molecular machine. Nat Rev Mol Cell Biol 5 (2004) 739-751
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 739-751
-
-
Cardozo, T.1
Pagano, M.2
-
6
-
-
33646345376
-
Ubiquitin ligases: cell-cycle control and cancer
-
Nakayama K.I., and Nakayama K. Ubiquitin ligases: cell-cycle control and cancer. Nat Rev Cancer 6 (2006) 369-381
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 369-381
-
-
Nakayama, K.I.1
Nakayama, K.2
-
7
-
-
11244351579
-
Function and regulation of cullin-RING ubiquitin ligases
-
Petroski M.D., and Deshaies R.J. Function and regulation of cullin-RING ubiquitin ligases. Nat Rev Mol Cell Biol 6 (2005) 9-20
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 9-20
-
-
Petroski, M.D.1
Deshaies, R.J.2
-
8
-
-
33947244472
-
PARC and CUL7 form atypical cullin RING ligase complexes
-
Skaar J.R., Florens L., Tsutsumi T., Arai T., Tron A., Swanson S.K., Washburn M.P., and DeCaprio J.A. PARC and CUL7 form atypical cullin RING ligase complexes. Cancer Res 67 (2007) 2006-2014
-
(2007)
Cancer Res
, vol.67
, pp. 2006-2014
-
-
Skaar, J.R.1
Florens, L.2
Tsutsumi, T.3
Arai, T.4
Tron, A.5
Swanson, S.K.6
Washburn, M.P.7
DeCaprio, J.A.8
-
9
-
-
33746072624
-
The anaphase-promoting complex/cyclosome: APC/C
-
Acquaviva C., and Pines J. The anaphase-promoting complex/cyclosome: APC/C. J Cell Sci 119 (2006) 2401-2404
-
(2006)
J Cell Sci
, vol.119
, pp. 2401-2404
-
-
Acquaviva, C.1
Pines, J.2
-
10
-
-
33747589184
-
The anaphase promoting complex/cyclosome: a machine designed to destroy
-
Peters J.M. The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat Rev Mol Cell Biol 7 (2006) 644-656
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 644-656
-
-
Peters, J.M.1
-
11
-
-
7544234937
-
Systematic analysis and nomenclature of mammalian F-box proteins
-
Jin J., Cardozo T., Lovering R.C., Elledge S.J., Pagano M., and Harper J.W. Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev 18 (2004) 2573-2580
-
(2004)
Genes Dev
, vol.18
, pp. 2573-2580
-
-
Jin, J.1
Cardozo, T.2
Lovering, R.C.3
Elledge, S.J.4
Pagano, M.5
Harper, J.W.6
-
12
-
-
19344375385
-
Interwoven ubiquitination oscillators and control of cell cycle transitions
-
Ang X.L., and Harper J.W. Interwoven ubiquitination oscillators and control of cell cycle transitions. Sci STKE 2004 (2004) pe31
-
(2004)
Sci STKE
, vol.2004
-
-
Ang, X.L.1
Harper, J.W.2
-
13
-
-
1842591241
-
Nedd8 on cullin: building an expressway to protein destruction
-
Pan Z.Q., Kentsis A., Dias D.C., Yamoah K., and Wu K. Nedd8 on cullin: building an expressway to protein destruction. Oncogene 23 (2004) 1985-1997
-
(2004)
Oncogene
, vol.23
, pp. 1985-1997
-
-
Pan, Z.Q.1
Kentsis, A.2
Dias, D.C.3
Yamoah, K.4
Wu, K.5
-
14
-
-
53249154203
-
Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review series
-
Rabut G., and Peter M. Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep 9 (2008) 969-976
-
(2008)
EMBO Rep
, vol.9
, pp. 969-976
-
-
Rabut, G.1
Peter, M.2
-
15
-
-
56449094567
-
The COP9 signalosome: more than a protease
-
This review provides an excellent introduction to the COP9 signalosome, an important regulator of cullin neddylation that was not addressed by this review owing to space constraints.
-
Wei N., Serino G., and Deng X.W. The COP9 signalosome: more than a protease. Trends Biochem Sci 33 (2008) 592-600. This review provides an excellent introduction to the COP9 signalosome, an important regulator of cullin neddylation that was not addressed by this review owing to space constraints.
-
(2008)
Trends Biochem Sci
, vol.33
, pp. 592-600
-
-
Wei, N.1
Serino, G.2
Deng, X.W.3
-
16
-
-
64749098830
-
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
-
This report not only illustrates the role of CRLs in growth control but also suggests that NEDD8 inhibitors are clinically viable chemotherapeutics.
-
Soucy T.A., Smith P.G., Milhollen M.A., Berger A.J., Gavin J.M., Adhikari S., Brownell J.E., Burke K.E., Cardin D.P., Critchley S., et al. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature 458 (2009) 732-736. This report not only illustrates the role of CRLs in growth control but also suggests that NEDD8 inhibitors are clinically viable chemotherapeutics.
-
(2009)
Nature
, vol.458
, pp. 732-736
-
-
Soucy, T.A.1
Smith, P.G.2
Milhollen, M.A.3
Berger, A.J.4
Gavin, J.M.5
Adhikari, S.6
Brownell, J.E.7
Burke, K.E.8
Cardin, D.P.9
Critchley, S.10
-
17
-
-
8344251662
-
Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases
-
Goldenberg S.J., Cascio T.C., Shumway S.D., Garbutt K.C., Liu J., Xiong Y., and Zheng N. Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases. Cell 119 (2004) 517-528
-
(2004)
Cell
, vol.119
, pp. 517-528
-
-
Goldenberg, S.J.1
Cascio, T.C.2
Shumway, S.D.3
Garbutt, K.C.4
Liu, J.5
Xiong, Y.6
Zheng, N.7
-
18
-
-
0036929129
-
NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases
-
Liu J., Furukawa M., Matsumoto T., and Xiong Y. NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases. Mol Cell 10 (2002) 1511-1518
-
(2002)
Mol Cell
, vol.10
, pp. 1511-1518
-
-
Liu, J.1
Furukawa, M.2
Matsumoto, T.3
Xiong, Y.4
-
19
-
-
0036924046
-
CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex
-
Zheng J., Yang X., Harrell J.M., Ryzhikov S., Shim E.H., Lykke-Andersen K., Wei N., Sun H., Kobayashi R., and Zhang H. CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex. Mol Cell 10 (2002) 1519-1526
-
(2002)
Mol Cell
, vol.10
, pp. 1519-1526
-
-
Zheng, J.1
Yang, X.2
Harrell, J.M.3
Ryzhikov, S.4
Shim, E.H.5
Lykke-Andersen, K.6
Wei, N.7
Sun, H.8
Kobayashi, R.9
Zhang, H.10
-
20
-
-
0037453306
-
Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1
-
Oshikawa K., Matsumoto M., Yada M., Kamura T., Hatakeyama S., and Nakayama K.I. Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1. Biochem Biophys Res Commun 303 (2003) 1209-1216
-
(2003)
Biochem Biophys Res Commun
, vol.303
, pp. 1209-1216
-
-
Oshikawa, K.1
Matsumoto, M.2
Yada, M.3
Kamura, T.4
Hatakeyama, S.5
Nakayama, K.I.6
-
21
-
-
3142702185
-
Arabidopsis ETA2, an apparent ortholog of the human cullin-interacting protein CAND1, is required for auxin responses mediated by the SCF(TIR1) ubiquitin ligase
-
Chuang H.W., Zhang W., and Gray W.M. Arabidopsis ETA2, an apparent ortholog of the human cullin-interacting protein CAND1, is required for auxin responses mediated by the SCF(TIR1) ubiquitin ligase. Plant Cell 16 (2004) 1883-1897
-
(2004)
Plant Cell
, vol.16
, pp. 1883-1897
-
-
Chuang, H.W.1
Zhang, W.2
Gray, W.M.3
-
22
-
-
0033781272
-
The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1
-
Furukawa M., Zhang Y., McCarville J., Ohta T., and Xiong Y. The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1. Mol Cell Biol 20 (2000) 8185-8197
-
(2000)
Mol Cell Biol
, vol.20
, pp. 8185-8197
-
-
Furukawa, M.1
Zhang, Y.2
McCarville, J.3
Ohta, T.4
Xiong, Y.5
-
23
-
-
0034712842
-
A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination
-
Podust V.N., Brownell J.E., Gladysheva T.B., Luo R.S., Wang C., Coggins M.B., Pierce J.W., Lightcap E.S., and Chau V. A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination. Proc Natl Acad Sci U S A 97 (2000) 4579-4584
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 4579-4584
-
-
Podust, V.N.1
Brownell, J.E.2
Gladysheva, T.B.3
Luo, R.S.4
Wang, C.5
Coggins, M.B.6
Pierce, J.W.7
Lightcap, E.S.8
Chau, V.9
-
24
-
-
0034117282
-
Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha
-
Read M.A., Brownell J.E., Gladysheva T.B., Hottelet M., Parent L.A., Coggins M.B., Pierce J.W., Podust V.N., Luo R.S., Chau V., et al. Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha. Mol Cell Biol 20 (2000) 2326-2333
-
(2000)
Mol Cell Biol
, vol.20
, pp. 2326-2333
-
-
Read, M.A.1
Brownell, J.E.2
Gladysheva, T.B.3
Hottelet, M.4
Parent, L.A.5
Coggins, M.B.6
Pierce, J.W.7
Podust, V.N.8
Luo, R.S.9
Chau, V.10
-
25
-
-
0034644650
-
Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization
-
Wu K., Chen A., and Pan Z.Q. Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization. J Biol Chem 275 (2000) 32317-32324
-
(2000)
J Biol Chem
, vol.275
, pp. 32317-32324
-
-
Wu, K.1
Chen, A.2
Pan, Z.Q.3
-
26
-
-
0034696819
-
Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF(skp2) toward p27(kip1)
-
Morimoto M., Nishida T., Honda R., and Yasuda H. Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF(skp2) toward p27(kip1). Biochem Biophys Res Commun 270 (2000) 1093-1096
-
(2000)
Biochem Biophys Res Commun
, vol.270
, pp. 1093-1096
-
-
Morimoto, M.1
Nishida, T.2
Honda, R.3
Yasuda, H.4
-
27
-
-
18344391432
-
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex
-
The crystal structure presented in this study is a landmark in the study of the SCF complex. Although the structure is now understood to represent an inactive, closed form, it is still the most complete SCF structure, giving valuable architectural information. Additionally, it introduces key questions about SCF complex-mediated ubiquitination that led to the more recent structural studies of NEDD8-conjugated cullins.
-
Zheng N., Schulman B.A., Song L., Miller J.J., Jeffrey P.D., Wang P., Chu C., Koepp D.M., Elledge S.J., Pagano M., et al. Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature 416 (2002) 703-709. The crystal structure presented in this study is a landmark in the study of the SCF complex. Although the structure is now understood to represent an inactive, closed form, it is still the most complete SCF structure, giving valuable architectural information. Additionally, it introduces key questions about SCF complex-mediated ubiquitination that led to the more recent structural studies of NEDD8-conjugated cullins.
-
(2002)
Nature
, vol.416
, pp. 703-709
-
-
Zheng, N.1
Schulman, B.A.2
Song, L.3
Miller, J.J.4
Jeffrey, P.D.5
Wang, P.6
Chu, C.7
Koepp, D.M.8
Elledge, S.J.9
Pagano, M.10
-
28
-
-
53349121021
-
Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation
-
This study offers an extremely detailed biochemical dissection of SCF complex-mediated ubiquitination.
-
Saha A., and Deshaies R.J. Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation. Mol Cell 32 (2008) 21-31. This study offers an extremely detailed biochemical dissection of SCF complex-mediated ubiquitination.
-
(2008)
Mol Cell
, vol.32
, pp. 21-31
-
-
Saha, A.1
Deshaies, R.J.2
-
29
-
-
17844411190
-
NEDD8 recruits E2-ubiquitin to SCF E3 ligase
-
Kawakami T., Chiba T., Suzuki T., Iwai K., Yamanaka K., Minato N., Suzuki H., Shimbara N., Hidaka Y., Osaka F., et al. NEDD8 recruits E2-ubiquitin to SCF E3 ligase. EMBO J 20 (2001) 4003-4012
-
(2001)
EMBO J
, vol.20
, pp. 4003-4012
-
-
Kawakami, T.1
Chiba, T.2
Suzuki, T.3
Iwai, K.4
Yamanaka, K.5
Minato, N.6
Suzuki, H.7
Shimbara, N.8
Hidaka, Y.9
Osaka, F.10
-
30
-
-
50449108516
-
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation
-
This important study reveals the structural nature of NEDD8 conjugation's stimulation of CRL function, which also solves several mechanistic questions posed by the original SCF complex structure.
-
Duda D.M., Borg L.A., Scott D.C., Hunt H.W., Hammel M., and Schulman B.A. Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation. Cell 134 (2008) 995-1006. This important study reveals the structural nature of NEDD8 conjugation's stimulation of CRL function, which also solves several mechanistic questions posed by the original SCF complex structure.
-
(2008)
Cell
, vol.134
, pp. 995-1006
-
-
Duda, D.M.1
Borg, L.A.2
Scott, D.C.3
Hunt, H.W.4
Hammel, M.5
Schulman, B.A.6
-
31
-
-
10644276385
-
VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases
-
Kamura T., Maenaka K., Kotoshiba S., Matsumoto M., Kohda D., Conaway R.C., Conaway J.W., and Nakayama K.I. VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. Genes Dev 18 (2004) 3055-3065
-
(2004)
Genes Dev
, vol.18
, pp. 3055-3065
-
-
Kamura, T.1
Maenaka, K.2
Kotoshiba, S.3
Matsumoto, M.4
Kohda, D.5
Conaway, R.C.6
Conaway, J.W.7
Nakayama, K.I.8
-
32
-
-
60549091914
-
E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
-
Huang D.T., Ayrault O., Hunt H.W., Taherbhoy A.M., Duda D.M., Scott D.C., Borg L.A., Neale G., Murray P.J., Roussel M.F., et al. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Mol Cell 33 (2009) 483-495
-
(2009)
Mol Cell
, vol.33
, pp. 483-495
-
-
Huang, D.T.1
Ayrault, O.2
Hunt, H.W.3
Taherbhoy, A.M.4
Duda, D.M.5
Scott, D.C.6
Borg, L.A.7
Neale, G.8
Murray, P.J.9
Roussel, M.F.10
-
33
-
-
34250799719
-
Cdc20: a WD40 activator for a cell cycle degradation machine
-
Yu H. Cdc20: a WD40 activator for a cell cycle degradation machine. Mol Cell 27 (2007) 3-16
-
(2007)
Mol Cell
, vol.27
, pp. 3-16
-
-
Yu, H.1
-
34
-
-
70549088824
-
The function of APC/CCdh1 in cell cycle and beyond
-
Li M., and Zhang P. The function of APC/CCdh1 in cell cycle and beyond. Cell Div 4 (2009) 2
-
(2009)
Cell Div
, vol.4
, pp. 2
-
-
Li, M.1
Zhang, P.2
-
35
-
-
34247333444
-
The spindle-assembly checkpoint in space and time
-
Musacchio A., and Salmon E.D. The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol 8 (2007) 379-393
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 379-393
-
-
Musacchio, A.1
Salmon, E.D.2
-
36
-
-
57049097535
-
The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction
-
This report demonstrates that APC/C is both a target and an effector of the spindle assembly checkpoint.
-
Nilsson J., Yekezare M., Minshull J., and Pines J. The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction. Nat Cell Biol 10 (2008) 1411-1420. This report demonstrates that APC/C is both a target and an effector of the spindle assembly checkpoint.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 1411-1420
-
-
Nilsson, J.1
Yekezare, M.2
Minshull, J.3
Pines, J.4
-
37
-
-
60749129493
-
APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation
-
Ge S., Skaar J.R., and Pagano M. APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation. Cell Cycle 8 (2009) 167-171
-
(2009)
Cell Cycle
, vol.8
, pp. 167-171
-
-
Ge, S.1
Skaar, J.R.2
Pagano, M.3
-
38
-
-
2942690009
-
Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae
-
Pan J., and Chen R.H. Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae. Genes Dev 18 (2004) 1439-1451
-
(2004)
Genes Dev
, vol.18
, pp. 1439-1451
-
-
Pan, J.1
Chen, R.H.2
-
39
-
-
46449095540
-
Genomic stability and tumour suppression by the APC/C cofactor Cdh1
-
In addition to demonstrating a role for Cdh1 in maintaining genome stability, this study also provides evidence that Cdh1 probably functions as a tumor suppressor. Somewhat surprisingly, Cdh1 function is not essential for mouse development.
-
Garcia-Higuera I., Manchado E., Dubus P., Canamero M., Mendez J., Moreno S., and Malumbres M. Genomic stability and tumour suppression by the APC/C cofactor Cdh1. Nat Cell Biol 10 (2008) 802-811. In addition to demonstrating a role for Cdh1 in maintaining genome stability, this study also provides evidence that Cdh1 probably functions as a tumor suppressor. Somewhat surprisingly, Cdh1 function is not essential for mouse development.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 802-811
-
-
Garcia-Higuera, I.1
Manchado, E.2
Dubus, P.3
Canamero, M.4
Mendez, J.5
Moreno, S.6
Malumbres, M.7
-
40
-
-
51049088378
-
The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory
-
Li M., Shin Y.H., Hou L., Huang X., Wei Z., Klann E., and Zhang P. The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory. Nat Cell Biol 10 (2008) 802-811
-
(2008)
Nat Cell Biol
, vol.10
, pp. 802-811
-
-
Li, M.1
Shin, Y.H.2
Hou, L.3
Huang, X.4
Wei, Z.5
Klann, E.6
Zhang, P.7
-
41
-
-
0035890165
-
Activation of Cdh1-dependent APC is required for G1 cell cycle arrest and DNA damage-induced G2 checkpoint in vertebrate cells
-
Sudo T., Ota Y., Kotani S., Nakao M., Takami Y., Takeda S., and Saya H. Activation of Cdh1-dependent APC is required for G1 cell cycle arrest and DNA damage-induced G2 checkpoint in vertebrate cells. EMBO J 20 (2001) 6499-6508
-
(2001)
EMBO J
, vol.20
, pp. 6499-6508
-
-
Sudo, T.1
Ota, Y.2
Kotani, S.3
Nakao, M.4
Takami, Y.5
Takeda, S.6
Saya, H.7
-
42
-
-
47549098471
-
The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint
-
Bassermann F., Frescas D., Guardavaccaro D., Busino L., Peschiaroli A., and Pagano M. The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. Cell 134 (2008) 256-267
-
(2008)
Cell
, vol.134
, pp. 256-267
-
-
Bassermann, F.1
Frescas, D.2
Guardavaccaro, D.3
Busino, L.4
Peschiaroli, A.5
Pagano, M.6
-
43
-
-
1842428734
-
M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFβ-TRCP
-
Watanabe N., Arai H., Nishihara Y., Taniguchi M., Hunter T., and Osada H. M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFβ-TRCP. Proc Natl Acad Sci U S A 101 (2004) 4419-4424
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 4419-4424
-
-
Watanabe, N.1
Arai, H.2
Nishihara, Y.3
Taniguchi, M.4
Hunter, T.5
Osada, H.6
-
44
-
-
33746413746
-
SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response
-
Peschiaroli A., Dorrello N.V., Guardavaccaro D., Venere M., Halazonetis T., Sherman N.E., and Pagano M. SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Mol Cell 23 (2006) 319-329
-
(2006)
Mol Cell
, vol.23
, pp. 319-329
-
-
Peschiaroli, A.1
Dorrello, N.V.2
Guardavaccaro, D.3
Venere, M.4
Halazonetis, T.5
Sherman, N.E.6
Pagano, M.7
-
45
-
-
33746429958
-
Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress
-
Mailand N., Bekker-Jensen S., Bartek J., and Lukas J. Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol Cell 23 (2006) 307-318
-
(2006)
Mol Cell
, vol.23
, pp. 307-318
-
-
Mailand, N.1
Bekker-Jensen, S.2
Bartek, J.3
Lukas, J.4
-
46
-
-
33749246225
-
Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery
-
Mamely I., van Vugt M.A., Smits V.A., Semple J.I., Lemmens B., Perrakis A., Medema R.H., and Freire R. Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery. Curr Biol 16 (2006) 1950-1955
-
(2006)
Curr Biol
, vol.16
, pp. 1950-1955
-
-
Mamely, I.1
van Vugt, M.A.2
Smits, V.A.3
Semple, J.I.4
Lemmens, B.5
Perrakis, A.6
Medema, R.H.7
Freire, R.8
-
47
-
-
43049162227
-
Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex
-
Jin L., Williamson A., Banerjee S., Philipp I., and Rape M. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. Cell 133 (2008) 653-665
-
(2008)
Cell
, vol.133
, pp. 653-665
-
-
Jin, L.1
Williamson, A.2
Banerjee, S.3
Philipp, I.4
Rape, M.5
-
48
-
-
33745742269
-
Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology
-
Kirkpatrick D.S., Hathaway N.A., Hanna J., Elsasser S., Rush J., Finley D., King R.W., and Gygi S.P. Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology. Nat Cell Biol 8 (2006) 700-710
-
(2006)
Nat Cell Biol
, vol.8
, pp. 700-710
-
-
Kirkpatrick, D.S.1
Hathaway, N.A.2
Hanna, J.3
Elsasser, S.4
Rush, J.5
Finley, D.6
King, R.W.7
Gygi, S.P.8
-
49
-
-
44349122993
-
Deregulated proteolysis by the F-box proteins SKP2 and β-TRCP: tipping the scales of cancer
-
Frescas D., and Pagano M. Deregulated proteolysis by the F-box proteins SKP2 and β-TRCP: tipping the scales of cancer. Nat Rev Cancer 8 (2008) 438-449
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 438-449
-
-
Frescas, D.1
Pagano, M.2
-
50
-
-
38549086019
-
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
-
Welcker M., and Clurman B.E. FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat Rev Cancer 8 (2008) 83-93
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 83-93
-
-
Welcker, M.1
Clurman, B.E.2
-
51
-
-
35148842479
-
FBXW7/hCDC4 is a general tumor suppressor in human cancer
-
Akhoondi S., Sun D., von der Lehr N., Apostolidou S., Klotz K., Maljukova A., Cepeda D., Fiegl H., Dafou D., Marth C., et al. FBXW7/hCDC4 is a general tumor suppressor in human cancer. Cancer Res 67 (2007) 9006-9012
-
(2007)
Cancer Res
, vol.67
, pp. 9006-9012
-
-
Akhoondi, S.1
Sun, D.2
von der Lehr, N.3
Apostolidou, S.4
Klotz, K.5
Maljukova, A.6
Cepeda, D.7
Fiegl, H.8
Dafou, D.9
Marth, C.10
-
52
-
-
1542364470
-
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development
-
Tsunematsu R., Nakayama K., Oike Y., Nishiyama M., Ishida N., Hatakeyama S., Bessho Y., Kageyama R., Suda T., and Nakayama K.I. Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem 279 (2004) 9417-9423
-
(2004)
J Biol Chem
, vol.279
, pp. 9417-9423
-
-
Tsunematsu, R.1
Nakayama, K.2
Oike, Y.3
Nishiyama, M.4
Ishida, N.5
Hatakeyama, S.6
Bessho, Y.7
Kageyama, R.8
Suda, T.9
Nakayama, K.I.10
-
53
-
-
45149123052
-
Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7
-
This report (and the subsequent reference) details the control of hematopoietic stems by Fbxw7.
-
Thompson B.J., Jankovic V., Gao J., Buonamici S., Vest A., Lee J.M., Zavadil J., Nimer S.D., and Aifantis I. Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7. J Exp Med 205 (2008) 1395-1408. This report (and the subsequent reference) details the control of hematopoietic stems by Fbxw7.
-
(2008)
J Exp Med
, vol.205
, pp. 1395-1408
-
-
Thompson, B.J.1
Jankovic, V.2
Gao, J.3
Buonamici, S.4
Vest, A.5
Lee, J.M.6
Zavadil, J.7
Nimer, S.D.8
Aifantis, I.9
-
54
-
-
42149132696
-
Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL
-
This report (and the previous reference) details the control of hematopoietic stems by Fbxw7.
-
Matsuoka S., Oike Y., Onoyama I., Iwama A., Arai F., Takubo K., Mashimo Y., Oguro H., Nitta E., Ito K., et al. Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Genes Dev 22 (2008) 986-991. This report (and the previous reference) details the control of hematopoietic stems by Fbxw7.
-
(2008)
Genes Dev
, vol.22
, pp. 986-991
-
-
Matsuoka, S.1
Oike, Y.2
Onoyama, I.3
Iwama, A.4
Arai, F.5
Takubo, K.6
Mashimo, Y.7
Oguro, H.8
Nitta, E.9
Ito, K.10
-
55
-
-
1542409037
-
Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein
-
Tetzlaff M.T., Yu W., Li M., Zhang P., Finegold M., Mahon K., Harper J.W., Schwartz R.J., and Elledge S.J. Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc Natl Acad Sci U S A 101 (2004) 3338-3345
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 3338-3345
-
-
Tetzlaff, M.T.1
Yu, W.2
Li, M.3
Zhang, P.4
Finegold, M.5
Mahon, K.6
Harper, J.W.7
Schwartz, R.J.8
Elledge, S.J.9
-
56
-
-
36549071481
-
Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis
-
Onoyama I., Tsunematsu R., Matsumoto A., Kimura T., de Alboran I.M., Nakayama K., and Nakayama K.I. Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis. J Exp Med 204 (2007) 2875-2888
-
(2007)
J Exp Med
, vol.204
, pp. 2875-2888
-
-
Onoyama, I.1
Tsunematsu, R.2
Matsumoto, A.3
Kimura, T.4
de Alboran, I.M.5
Nakayama, K.6
Nakayama, K.I.7
-
57
-
-
42049096542
-
Plk1- and β-TRCP-dependent degradation of Bora controls mitotic progression
-
Seki A., Coppinger J.A., Du H., Jang C.Y., Yates III J.R., and Fang G. Plk1- and β-TRCP-dependent degradation of Bora controls mitotic progression. J Cell Biol 181 (2008) 65-78
-
(2008)
J Cell Biol
, vol.181
, pp. 65-78
-
-
Seki, A.1
Coppinger, J.A.2
Du, H.3
Jang, C.Y.4
Yates III, J.R.5
Fang, G.6
-
58
-
-
51349144633
-
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery
-
Macurek L., Lindqvist A., Lim D., Lampson M.A., Klompmaker R., Freire R., Clouin C., Taylor S.S., Yaffe M.B., and Medema R.H. Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. Nature 455 (2008) 119-123
-
(2008)
Nature
, vol.455
, pp. 119-123
-
-
Macurek, L.1
Lindqvist, A.2
Lim, D.3
Lampson, M.A.4
Klompmaker, R.5
Freire, R.6
Clouin, C.7
Taylor, S.S.8
Yaffe, M.B.9
Medema, R.H.10
-
59
-
-
46249084662
-
Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry
-
Seki A., Coppinger J.A., Jang C.Y., Yates J.R., and Fang G. Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry. Science 320 (2008) 1655-1658
-
(2008)
Science
, vol.320
, pp. 1655-1658
-
-
Seki, A.1
Coppinger, J.A.2
Jang, C.Y.3
Yates, J.R.4
Fang, G.5
-
60
-
-
33750325725
-
S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth
-
Dorrello N.V., Peschiaroli A., Guardavaccaro D., Colburn N.H., Sherman N.E., and Pagano M. S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science 314 (2006) 467-471
-
(2006)
Science
, vol.314
, pp. 467-471
-
-
Dorrello, N.V.1
Peschiaroli, A.2
Guardavaccaro, D.3
Colburn, N.H.4
Sherman, N.E.5
Pagano, M.6
-
61
-
-
58149312710
-
betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis
-
Dehan E., Bassermann F., Guardavaccaro D., Vasiliver-Shamis G., Cohen M., Lowes K.N., Dustin M., Huang D.C., Taunton J., and Pagano M. betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis. Mol Cell 33 (2009) 109-116
-
(2009)
Mol Cell
, vol.33
, pp. 109-116
-
-
Dehan, E.1
Bassermann, F.2
Guardavaccaro, D.3
Vasiliver-Shamis, G.4
Cohen, M.5
Lowes, K.N.6
Dustin, M.7
Huang, D.C.8
Taunton, J.9
Pagano, M.10
-
62
-
-
0038243172
-
Control of meiotic and mitotic progression by the F box protein β-TRCP1 in vivo
-
Guardavaccaro D., Kudo Y., Boulaire J., Barchi M., Busino L., Donzelli M., Margottin-Goguet F., Jackson P.K., Yamasaki L., and Pagano M. Control of meiotic and mitotic progression by the F box protein β-TRCP1 in vivo. Dev Cell 4 (2003) 799-812
-
(2003)
Dev Cell
, vol.4
, pp. 799-812
-
-
Guardavaccaro, D.1
Kudo, Y.2
Boulaire, J.3
Barchi, M.4
Busino, L.5
Donzelli, M.6
Margottin-Goguet, F.7
Jackson, P.K.8
Yamasaki, L.9
Pagano, M.10
-
63
-
-
0037534899
-
Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase
-
Margottin-Goguet F., Hsu J.Y., Loktev A., Hsieh H.M., Reimann J.D., and Jackson P.K. Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase. Dev Cell 4 (2003) 813-826
-
(2003)
Dev Cell
, vol.4
, pp. 813-826
-
-
Margottin-Goguet, F.1
Hsu, J.Y.2
Loktev, A.3
Hsieh, H.M.4
Reimann, J.D.5
Jackson, P.K.6
-
64
-
-
41149130221
-
Control of chromosome stability by the β-TRCP-REST-Mad2 axis
-
Guardavaccaro D., Frescas D., Dorrello N.V., Peschiaroli A., Multani A.S., Cardozo T., Lasorella A., Iavarone A., Chang S., Hernando E., et al. Control of chromosome stability by the β-TRCP-REST-Mad2 axis. Nature 452 (2008) 365-369
-
(2008)
Nature
, vol.452
, pp. 365-369
-
-
Guardavaccaro, D.1
Frescas, D.2
Dorrello, N.V.3
Peschiaroli, A.4
Multani, A.S.5
Cardozo, T.6
Lasorella, A.7
Iavarone, A.8
Chang, S.9
Hernando, E.10
-
65
-
-
0242497228
-
Degradation of Cdc25A by β-TRCP during S phase and in response to DNA damage
-
Busino L., Donzelli M., Chiesa M., Guardavaccaro D., Ganoth D., Dorrello N.V., Hershko A., Pagano M., and Draetta G.F. Degradation of Cdc25A by β-TRCP during S phase and in response to DNA damage. Nature 426 (2003) 87-91
-
(2003)
Nature
, vol.426
, pp. 87-91
-
-
Busino, L.1
Donzelli, M.2
Chiesa, M.3
Guardavaccaro, D.4
Ganoth, D.5
Dorrello, N.V.6
Hershko, A.7
Pagano, M.8
Draetta, G.F.9
-
66
-
-
0347361537
-
SCFβ-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase
-
Jin J., Shirogane T., Xu L., Nalepa G., Qin J., Elledge S.J., and Harper J.W. SCFβ-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev 17 (2003) 3062-3074
-
(2003)
Genes Dev
, vol.17
, pp. 3062-3074
-
-
Jin, J.1
Shirogane, T.2
Xu, L.3
Nalepa, G.4
Qin, J.5
Elledge, S.J.6
Harper, J.W.7
-
67
-
-
55849133733
-
Identification of SCF ubiquitin ligase substrates by global protein stability profiling
-
Yen H.C., and Elledge S.J. Identification of SCF ubiquitin ligase substrates by global protein stability profiling. Science 322 (2008) 923-929
-
(2008)
Science
, vol.322
, pp. 923-929
-
-
Yen, H.C.1
Elledge, S.J.2
-
68
-
-
55849136903
-
Global protein stability profiling in mammalian cells
-
This study introduces a method for measuring the stability of proteins on a global scale. The use of such methods in new screens for substrates of SCF complexes (see reference [67]) or other ubiquitin ligases may faciliate the future identification of substrates. Notably, GPS will probably not help in the identification of substrates for non-degradation types of ubiquitin modification.
-
Yen H.C., Xu Q., Chou D.M., Zhao Z., and Elledge S.J. Global protein stability profiling in mammalian cells. Science 322 (2008) 918-923. This study introduces a method for measuring the stability of proteins on a global scale. The use of such methods in new screens for substrates of SCF complexes (see reference [67]) or other ubiquitin ligases may faciliate the future identification of substrates. Notably, GPS will probably not help in the identification of substrates for non-degradation types of ubiquitin modification.
-
(2008)
Science
, vol.322
, pp. 918-923
-
-
Yen, H.C.1
Xu, Q.2
Chou, D.M.3
Zhao, Z.4
Elledge, S.J.5
-
69
-
-
33750460897
-
Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex
-
Lin D.I., Barbash O., Kumar K.G., Weber J.D., Harper J.W., Klein-Szanto A.J., Rustgi A., Fuchs S.Y., and Diehl J.A. Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex. Mol Cell 24 (2006) 355-366
-
(2006)
Mol Cell
, vol.24
, pp. 355-366
-
-
Lin, D.I.1
Barbash, O.2
Kumar, K.G.3
Weber, J.D.4
Harper, J.W.5
Klein-Szanto, A.J.6
Rustgi, A.7
Fuchs, S.Y.8
Diehl, J.A.9
-
70
-
-
66649117243
-
F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage
-
Santra M.K., Wajapeyee N., and Green M.R. F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage. Nature 459 (2009) 722-725
-
(2009)
Nature
, vol.459
, pp. 722-725
-
-
Santra, M.K.1
Wajapeyee, N.2
Green, M.R.3
-
71
-
-
55549109429
-
A novel mechanism by which thiazolidinediones facilitate the proteasomal degradation of cyclin D1 in cancer cells
-
Wei S., Yang H.C., Chuang H.C., Yang J., Kulp S.K., Lu P.J., Lai M.D., and Chen C.S. A novel mechanism by which thiazolidinediones facilitate the proteasomal degradation of cyclin D1 in cancer cells. J Biol Chem 283 (2008) 26759-26770
-
(2008)
J Biol Chem
, vol.283
, pp. 26759-26770
-
-
Wei, S.1
Yang, H.C.2
Chuang, H.C.3
Yang, J.4
Kulp, S.K.5
Lu, P.J.6
Lai, M.D.7
Chen, C.S.8
-
72
-
-
34047189884
-
A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation
-
Okabe H., Lee S.H., Phuchareon J., Albertson D.G., McCormick F., and Tetsu O. A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation. PLoS ONE 1 (2006) e128
-
(2006)
PLoS ONE
, vol.1
-
-
Okabe, H.1
Lee, S.H.2
Phuchareon, J.3
Albertson, D.G.4
McCormick, F.5
Tetsu, O.6
-
73
-
-
0032530151
-
Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins
-
Yu Z.K., Gervais J.L., and Zhang H. Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins. Proc Natl Acad Sci U S A 95 (1998) 11324-11329
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 11324-11329
-
-
Yu, Z.K.1
Gervais, J.L.2
Zhang, H.3
|