-
3
-
-
33749017409
-
The human obesity gene map: The 2005 update
-
RANKINEN T., ZUBERI A., CHAGNON Y.C., WEISNAGEL S.J., ARGYROPOULOS G., WALTS B., ET AL. The human obesity gene map: the 2005 update. Obesity 2006; 14: 529-644.
-
(2006)
Obesity
, vol.14
, pp. 529-644
-
-
Rankinen, T.1
Zuberi, A.2
Chagnon, Y.C.3
Weisnagel, S.J.4
Argyropoulos, G.5
Walts, B.6
-
4
-
-
61449105725
-
Leptin: A pivotal regulator of human energy homeostasis
-
FAROOQI I.S., O'RAHILLY S. Leptin: a pivotal regulator of human energy homeostasis. Am J Clin Nutr 2009 (Suppl); 89: 980S-984S.
-
(2009)
Am J Clin Nutr
, vol.89
, Issue.SUPPL.
-
-
Farooqi, I.S.1
O'rahilly, S.2
-
5
-
-
17844401704
-
Anatomy and regulation of the central melanocortin system
-
CONE R.D. Anatomy and regulation of the central melanocortin system. Nat Neurosci 2005; 8: 571-8.
-
(2005)
Nat Neurosci
, vol.8
, pp. 571-8
-
-
Cone, R.D.1
-
6
-
-
3142731898
-
The critical role of the melanocortin system in the control of energy intake
-
SEELEY R.J., DRAZEN D.L., CLEGG D.J. The critical role of the melanocortin system in the control of energy intake. Annu Rev Nutr 2004; 24: 133-49.
-
(2004)
Annu Rev Nutr
, vol.24
, pp. 133-49
-
-
Seeley, R.J.1
Drazen, D.L.2
Clegg, D.J.3
-
8
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
ZHANG Y., PROENCA R., MAFFEI M., BARONE M., LEOPOLD L., FRIEDMAN J.M. ET AL. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425-32.
-
(1994)
Nature
, vol.372
, pp. 425-32
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
Barone, M.4
Leopold, L.5
Friedman, J.M.6
-
9
-
-
0029073613
-
Weight reducing effects of the plasma protein encoded by the obese gene
-
HALAAS J.L., GAJIWALA K.S., MAFFEI M., COHEN S.L., CHAIT B.T., RABINOWITZ D. ET AL. Weight reducing effects of the plasma protein encoded by the obese gene. Science 1995; 269: 543-6.
-
(1995)
Science
, vol.269
, pp. 543-6
-
-
Halaas, J.L.1
Gajiwala, K.S.2
Maffei, M.3
Cohen, S.L.4
Chait, B.T.5
Rabinowitz, D.6
-
10
-
-
1842529267
-
Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin
-
PINTO S., ROSEBERRY A.G., LIU H., DIANO S., SHANABROUGH M., CAI X. ET AL. Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin. Science 2004; 304: 110-5.
-
(2004)
Science
, vol.304
, pp. 110-5
-
-
Pinto, S.1
Roseberry, A.G.2
Liu, H.3
Diano, S.4
Shanabrough, M.5
Cai, X.6
-
11
-
-
0030028959
-
Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (Leptin) receptor
-
CHUA, S.C., CHUNG W.K., WU-PENG X.S. ET AL. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (Leptin) receptor. Science 1996; 271: 994-6.
-
(1996)
Science
, vol.271
, pp. 994-6
-
-
Chua, S.C.1
Chung, W.K.2
Wu-Peng, X.S.3
-
12
-
-
0030878110
-
Congenital leptin deficiency is associated with severe early-onset obesity in humans
-
MONTAGUE C.T., FAROOQI I.S., WHITEHEAD J.P., SOOS M.A., RAU H., WAREHAM N.J. ET AL. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997; 387: 903-8.
-
(1997)
Nature
, vol.387
, pp. 903-8
-
-
Montague, C.T.1
Farooqi, I.S.2
Whitehead, J.P.3
Soos, M.A.4
Rau, H.5
Wareham, N.J.6
-
13
-
-
0032014836
-
A leptin missense mutation associated with hypogo-nadism and morbid obesity
-
STROBEL A., ISSAD T., CAMOIN L., OZATA M., STROSBERG A.D. A leptin missense mutation associated with hypogo-nadism and morbid obesity. Nat Genet 1998; 18: 213-5.
-
(1998)
Nat Genet
, vol.18
, pp. 213-5
-
-
Strobel, A.1
Issad, T.2
Camoin, L.3
Ozata, M.4
Strosberg, A.D.5
-
14
-
-
0033575993
-
Effects of recombinant leptin therapy in a child with congenital leptin deficiency
-
FAROOQI I.S., JEBB S.A., LANGMACK G., LAWRENCE E., CHEETHAM C.H., PRENTICE A.M. ET AL. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 1999; 341: 879-84.
-
(1999)
N Engl J Med
, vol.341
, pp. 879-84
-
-
Farooqi, I.S.1
Jebb, S.A.2
Langmack, G.3
Lawrence, E.4
Cheetham, C.H.5
Prentice, A.M.6
-
15
-
-
34548675339
-
Leptin regulates striatal regions and human eating behavior
-
FAROOQI I.S., BULLMORE E., KEOGH J., GILLARD J., O'RAHIELLY S., FLETCHER P.C. ET AL. Leptin regulates striatal regions and human eating behavior. Science 2007; 317: 1355.
-
(2007)
Science
, vol.317
, pp. 1355
-
-
Farooqi, I.S.1
Bullmore, E.2
Keogh, J.3
Gillard, J.4
O'rahielly, S.5
Fletcher, P.C.6
-
16
-
-
0344450708
-
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
-
CLÉMENT K., VAISSE C., LAHLOU N., CABROL S., PELLOUX V., CASSUTO D. ET AL. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998; 392: 398-401.
-
(1998)
Nature
, vol.392
, pp. 398-401
-
-
Clément, K.1
Vaisse, C.2
Lahlou, N.3
Cabrol, S.4
Pelloux, V.5
Cassuto, D.6
-
17
-
-
33846409122
-
Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor
-
FAROOQI I.S., WANGENSTEEN T., COLLINS S., KIMBER W., MATARESE G., KEOGH J.M. ET AL. Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. N Engl J Med 2007; 356: 237-47.
-
(2007)
N Engl J Med
, vol.356
, pp. 237-47
-
-
Farooqi, I.S.1
Wangensteen, T.2
Collins, S.3
Kimber, W.4
Matarese, G.5
Keogh, J.M.6
-
18
-
-
0030039272
-
Abnormal splicing of the leptin receptor in diabetic mice
-
LEE G.H., PROENCA R., MONTEZ J.M., CARROLL K.M., DARVISHZADEH J.G., LEE J.I. ET AL. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996; 379: 632-5.
-
(1996)
Nature
, vol.379
, pp. 632-5
-
-
Lee, G.H.1
Proenca, R.2
Montez, J.M.3
Carroll, K.M.4
Darvishzadeh, J.G.5
Lee, J.I.6
-
19
-
-
0037456304
-
STAT3 signalling is required for leptin regulation of energy balance but not reproduction
-
BATES S.H., STEARNS W.H., DUNDON T.A., SCHUBERT M., TSO A.W., WANG Y. ET AL. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 2003; 421: 856-9.
-
(2003)
Nature
, vol.421
, pp. 856-9
-
-
Bates, S.H.1
Stearns, W.H.2
Dundon, T.A.3
Schubert, M.4
Tso, A.W.5
Wang, Y.6
-
20
-
-
1842584949
-
Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation
-
GAO Q., WOLFGANG M.J., NESCHEN S., MORINO K., HORVATH T.L., SHULMAN G.I. ET AL. Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc Natl Acad Sci USA 2004; 101: 4661-6.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 4661-6
-
-
Gao, Q.1
Wolfgang, M.J.2
Neschen, S.3
Morino, K.4
Horvath, T.L.5
Shulman, G.I.6
-
21
-
-
34250612718
-
The leptin melanocortin pathway and the control of body weight: Lessons from human and murine genetics
-
OSWAL A., YEO G.S.H. The leptin melanocortin pathway and the control of body weight: lessons from human and murine genetics. Obes Rev 2007; 8: 293-306.
-
(2007)
Obes Rev
, vol.8
, pp. 293-306
-
-
Oswal, A.1
Yeo, G.S.H.2
-
22
-
-
0035950093
-
Intracellular signalling. Key enzyme in leptin-induced anorexia
-
NISWENDER K.D., MORTON G.J., STEARNS W.H., RHODES C.J., MYERS M.G. JR, SCHWARTZ M.W. ET AL. Intracellular signalling. Key enzyme in leptin-induced anorexia. Nature 2001; 413: 794-5.
-
(2001)
Nature
, vol.413
, pp. 794-5
-
-
Niswender, K.D.1
Morton, G.J.2
Stearns, W.H.3
Rhodes, C.J.4
Myers Jr, M.G.5
Schwartz, M.W.6
-
23
-
-
0032567937
-
Disruption of IRS-2 causes type 2 diabetes in mice
-
WITHERS D.J., GUTIERREZ J.S., TOWERY H., BURKS D.J., REN J.M., PREVIS S. ET AL. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 1998; 391: 900-4
-
(1998)
Nature
, vol.391
, pp. 900-4
-
-
Withers, D.J.1
Gutierrez, J.S.2
Towery, H.3
Burks, D.J.4
Ren, J.M.5
Previs, S.6
-
24
-
-
6344243617
-
SH2-B promotes insulin receptor substrate (IRS)1- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin
-
DUAN C., LI M., RUI L. SH2-B promotes insulin receptor substrate (IRS)1- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin. J Biol Chem 2004; 279: 43684-91.
-
(2004)
J Biol Chem
, vol.279
, pp. 43684-91
-
-
Duan, C.1
Li, M.2
Rui, L.3
-
25
-
-
25144523930
-
Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice
-
REN D., LI M., DUAN C., RUI L. Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice. Cell Metab 2005; 2: 95-104.
-
(2005)
Cell Metab
, vol.2
, pp. 95-104
-
-
Ren, D.1
Li, M.2
Duan, C.3
Rui, L.4
-
26
-
-
16844369740
-
PI3K integrates the action of insulin and leptin on hypothalamic neurons
-
XU A.W., KAELIN C.B., TAKEDA K., AKIRA S., SCHWARTZ M.W., BARSH G.S. ET AL. PI3K integrates the action of insulin and leptin on hypothalamic neurons. J Clin Invest 2005; 115: 951-8.
-
(2005)
J Clin Invest
, vol.115
, pp. 951-8
-
-
Xu, A.W.1
Kaelin, C.B.2
Takeda, K.3
Akira, S.4
Schwartz, M.W.5
Barsh, G.S.6
-
28
-
-
0030889192
-
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
-
HUSZAR D., LYNCH C.A., FAIRCHILD-HUNTRESS V., DUNMORE J.H., FANG Q., BERKEMEIER L.R. ET AL. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997; 88: 131-41.
-
(1997)
Cell
, vol.88
, pp. 131-41
-
-
Huszar, D.1
Lynch, C.A.2
Fairchild-Huntress, V.3
Dunmore, J.H.4
Fang, Q.5
Berkemeier, L.R.6
-
29
-
-
52449123919
-
Mutations in ligands and receptor of the leptin-melanocortin pathway that lead to obesity
-
FAROOQI I.S., ÓRAHILLY S. Mutations in ligands and receptor of the leptin-melanocortin pathway that lead to obesity. Nat Clin Pract 2008; 4: 569-77.
-
(2008)
Nat Clin Pract
, vol.4
, pp. 569-77
-
-
Farooqi, I.S.1
Órahilly, S.2
-
30
-
-
59849121365
-
Obesity and eating behaviour in a three- generation Chilean family with carriers of the Thr150Ile mutation in the melanocortin-4 receptor gene
-
SANTOS J.L., AMADOR P., VALLADARES M., ALBALA C., MARTINEZ J.A., MARTI A. Obesity and eating behaviour in a three- generation Chilean family with carriers of the Thr150Ile mutation in the melanocortin-4 receptor gene. J Physiol Biochem 2008; 64: 205-10.
-
(2008)
J Physiol Biochem
, vol.64
, pp. 205-10
-
-
Santos, J.L.1
Amador, P.2
Valladares, M.3
Albala, C.4
Martinez, J.A.5
Marti, A.6
-
31
-
-
6344260502
-
Large quantitative effect of melanocortin-4 receptor gene mutations on body mass index
-
DEMPFLE A., HINNEY A., HEINZEL-GUTENBRUNNER M., RAAB M., GELLER F., GUDERMANN T. ET AL. Large quantitative effect of melanocortin-4 receptor gene mutations on body mass index. J Med Genet 2004; 41: 795-800.
-
(2004)
J Med Genet
, vol.41
, pp. 795-800
-
-
Dempfle, A.1
Hinney, A.2
Heinzel-Gutenbrunner, M.3
Raab, M.4
Geller, F.5
Gudermann, T.6
-
32
-
-
0033818103
-
Inactivation of the mouse melanocor-tin-3 receptor results in increased fat mass and reduced lean body mass
-
CHEN A.S., MARSH D.J., TRUMBAUER M.E., FRAZIER E.G., GUAN X.M., YU H. ET AL. Inactivation of the mouse melanocor-tin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet 2000; 26: 97-102.
-
(2000)
Nat Genet
, vol.26
, pp. 97-102
-
-
Chen, A.S.1
Marsh, D.J.2
Trumbauer, M.E.3
Frazier, E.G.4
Guan, X.M.5
Yu, H.6
-
33
-
-
31544465224
-
The melanocortin system and energy balance
-
BUTLER A. The melanocortin system and energy balance. Peptides 2006; 27: 281-90.
-
(2006)
Peptides
, vol.27
, pp. 281-90
-
-
Butler, A.1
-
34
-
-
42649092119
-
Sporadic mutations in melanocortin receptor 3 in morbid obese individuals
-
MENCARELLI M., WALKER G.E., MAESTRINI S., ALBERTI L., VERTI B., BRUNANI A. ET AL. Sporadic mutations in melanocortin receptor 3 in morbid obese individuals. Eur J Hum Genet 2008; 16: 581-6.
-
(2008)
Eur J Hum Genet
, vol.16
, pp. 581-6
-
-
Mencarelli, M.1
Walker, G.E.2
Maestrini, S.3
Alberti, L.4
Verti, B.5
Brunani, A.6
-
35
-
-
0032863468
-
Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
-
YASWEN L., DIEHL N., BRENNAN M.B., HOCHGESCHWENDER U. Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nat Med 1999; 5: 1066-70.
-
(1999)
Nat Med
, vol.5
, pp. 1066-70
-
-
Yaswen, L.1
Diehl, N.2
Brennan, M.B.3
Hochgeschwender, U.4
-
36
-
-
2942631413
-
O'RAHILLY S. Proopiomelanocortin and energy balance: Insights from human and murine genetics
-
COLL A.P., FAROOQI I.S., CHALLIS B.G., YEO G.S., O'RAHILLY S. Proopiomelanocortin and energy balance: insights from human and murine genetics. J Clin Endocrinol Metab 2004; 89: 2557-62.
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 2557-62
-
-
Coll, A.P.1
Farooqi, I.S.2
Challis, B.G.3
Yeo, G.S.4
-
37
-
-
0242320429
-
Obesity due to proopiomelanocortin deficiency: Three new cases and treatment trials with thyroid hormone and ACTH4-10
-
KRUDE H., BIEBERMANN H., SCHNABEL D., TANSEK M.Z., THEUNISSEN P., MULLIS P.E. ET AL. Obesity due to proopiomelanocortin deficiency: three new cases and treatment trials with thyroid hormone and ACTH4-10. J Clin Endocrinol Metab 2003; 88: 4633-40.
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 4633-40
-
-
Krude, H.1
Biebermann, H.2
Schnabel, D.3
Tansek, M.Z.4
Theunissen, P.5
Mullis, P.E.6
-
38
-
-
33645048441
-
A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance
-
LEE Y.S., CHALLIS B.G., THOMPSON D.A., YEO G.S., KEOGH J.M., MADONNA M.E. ET AL. A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance. Cell Metab 2006; 3: 135-40.
-
(2006)
Cell Metab
, vol.3
, pp. 135-40
-
-
Lee, Y.S.1
Challis, B.G.2
Thompson, D.A.3
Yeo, G.S.4
Keogh, J.M.5
Madonna, M.E.6
-
39
-
-
35348848018
-
The role of proopiomelanocortin (POMC) neurones in feeding behaviour
-
MILLINGTON G.W.M. The role of proopiomelanocortin (POMC) neurones in feeding behaviour. Nutr Metab 2007; 4: 18.
-
(2007)
Nutr Metab
, vol.4
, pp. 18
-
-
Millington, G.W.M.1
-
40
-
-
0346096721
-
Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency
-
JACKSON R.S., CREEMERS J.W., FAROOQI I.S., RAFFIN-SANSON M.L., VARRO A., DOCKRAY G.J. ET AL. Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. J Clin Invest 2003; 112: 1550-60.
-
(2003)
J Clin Invest
, vol.112
, pp. 1550-60
-
-
Jackson, R.S.1
Creemers, J.W.2
Farooqi, I.S.3
Raffin-Sanson, M.L.4
Varro, A.5
Dockray, G.J.6
-
41
-
-
0036679173
-
Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine pep-tide processing defects
-
ZHU X., ZHOU A., DEY A., NORRBOM C., CARROLL R., ZHANG C. ET AL. Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine pep-tide processing defects. Proc Natl Acad Sci USA 2002; 99: 10293-8.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 10293-8
-
-
Zhu, X.1
Zhou, A.2
Dey, A.3
Norrbom, C.4
Carroll, R.5
Zhang, C.6
-
42
-
-
0029040210
-
Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase
-
NAGGERT J.K., FRICKER L.D., VARLAMOV O., NISHINA P.M., ROUILLE Y., STEINER D.F. ET AL. Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Nat Genet 1995; 10: 135-42.
-
(1995)
E mutation which reduces enzyme activity. Nat Genet
, vol.10
, pp. 135-42
-
-
Naggert, J.K.1
Fricker, L.D.2
Varlamov, O.3
Nishina, P.M.4
Rouille, Y.5
Steiner, D.F.6
-
43
-
-
0032857322
-
From Agouti to Pomc-100 years of fat blonde mice
-
BARSH G. From Agouti to Pomc-100 years of fat blonde mice. Nat Med 1999; 5: 984-5.
-
(1999)
Nat Med
, vol.5
, pp. 984-5
-
-
Barsh, G.1
-
45
-
-
33947310031
-
Environmental epigenomics and disease susceptibility
-
JIRTLE R.L., SKINNER M.K. Environmental epigenomics and disease susceptibility. Nat Rev Genet 2007; 8: 253-62.
-
(2007)
Nat Rev Genet
, vol.8
, pp. 253-62
-
-
Jirtle, R.L.1
Skinner, M.K.2
-
46
-
-
25144441651
-
The Agoutirelated protein and its role in energy homeostasis
-
STUTZ A., MORRISON C., ARGYROPOULOS G. The Agoutirelated protein and its role in energy homeostasis. Peptides 2005; 26: 1771-81.
-
(2005)
Peptides
, vol.26
, pp. 1771-81
-
-
Stutz, A.1
Morrison, C.2
Argyropoulos, G.3
-
47
-
-
27344431720
-
NPY/ AGRP neurons are essential for feeding in adult mice but can be ablated in neonates
-
LUQUET S., PÉREZ F.A., HNASKO T.S., PALMITER R.D. NPY/ AGRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 2005; 310: 683-5.
-
(2005)
Science
, vol.310
, pp. 683-5
-
-
Luquet, S.1
Pérez, F.A.2
Hnasko, T.S.3
Palmiter, R.D.4
-
48
-
-
0035942777
-
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
-
COWLEY M.A., SMART J.L., RUBINSTEIN M., CERDÁN M.G., DIANO S., HORVATH T.L. ET AL. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 2001; 411: 480-4.
-
(2001)
Nature
, vol.411
, pp. 480-4
-
-
Cowley, M.A.1
Smart, J.L.2
Rubinstein, M.3
Cerdán, M.G.4
Diano, S.5
Horvath, T.L.6
-
49
-
-
2942733252
-
Leptin receptor signalling in POMC neurons is required for normal body weight homeostasis
-
BALTHASAR N., COPPARI R., MCMINN J., LIU S.M., LEE C.E., TANG V. ET AL. Leptin receptor signalling in POMC neurons is required for normal body weight homeostasis. Neuron 2004; 42: 983-91.
-
(2004)
Neuron
, vol.42
, pp. 983-91
-
-
Balthasar, N.1
Coppari, R.2
McMinn, J.3
Liu, S.M.4
Lee, C.E.5
Tang, V.6
-
50
-
-
23844542825
-
Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through extracellular signal-regulated kinase signaling in rat solitary nucleus
-
SUTTON G.M., DUOS B., PATTERSON L.M., BERTHOUD H.R. Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through extracellular signal-regulated kinase signaling in rat solitary nucleus. Endocrinology 2005; 146: 3739-47.
-
(2005)
Endocrinology
, vol.146
, pp. 3739-47
-
-
Sutton, G.M.1
Duos, B.2
Patterson, L.M.3
Berthoud, H.R.4
-
51
-
-
33745978779
-
Serotonin reciprocally regulates melanocortin neurons to modulate food intake
-
HEISLER L.K., JOBST E.E., SUTTON G.M., ZHOU L., BOROK E., THORNTON-JONES Z. ET AL. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron 2006; 51: 239-49.
-
(2006)
Neuron
, vol.51
, pp. 239-49
-
-
Heisler, L.K.1
Jobst, E.E.2
Sutton, G.M.3
Zhou, L.4
Borok, E.5
Thornton-Jones, Z.6
-
52
-
-
33750712047
-
Keeping the fat off with nesfatin
-
MYERS M.G. Keeping the fat off with nesfatin. Nat Med 2006; 12: 1248-9.
-
(2006)
Nat Med
, vol.12
, pp. 1248-9
-
-
Myers, M.G.1
-
53
-
-
0038392755
-
Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
-
XU B., GOULDING E.H., ZANG K., CEPOI D., CONE R.D., JONES K.R. ET AL. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci 2003; 6: 736-42.
-
(2003)
Nat Neurosci
, vol.6
, pp. 736-42
-
-
Xu, B.1
Goulding, E.H.2
Zang, K.3
Cepoi, D.4
Cone, R.D.5
Jones, K.R.6
-
54
-
-
37549055474
-
SENA-ESTEVES M., RIOS M. Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity
-
UNGER T.J., CALDERON G.A., BRADLEY L.C., SENA-ESTEVES M., RIOS M. Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity. J Neurosci 2007; 27: 14265-74.
-
(2007)
J Neurosci
, vol.27
, pp. 14265-74
-
-
Unger, T.J.1
Calderon, G.A.2
Bradley, L.C.3
-
55
-
-
33845530762
-
Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene
-
GRAY J., YEO G.S., COX J.J., MORTON J., ADLAM A.L., KEOGH J.M. ET AL. Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene. Diabetes 2006; 55: 3366-71.
-
(2006)
Diabetes
, vol.55
, pp. 3366-71
-
-
Gray, J.1
Yeo, G.S.2
Cox, J.J.3
Morton, J.4
Adlam, A.L.5
Keogh, J.M.6
-
56
-
-
50449091665
-
Brain-derived neurotrophic factor in the WAGR syndrome
-
HAN J.C., LIU Q.R., JONES M., LEVINN R.L., MENZIE C.M., JEFFERSON-GEORGE K.S. ET AL. Brain-derived neurotrophic factor in the WAGR syndrome. N Engl J Med 2008; 359: 918-27.
-
(2008)
N Engl J Med
, vol.359
, pp. 918-27
-
-
Han, J.C.1
Liu, Q.R.2
Jones, M.3
Levinn, R.L.4
Menzie, C.M.5
Jefferson-George, K.S.6
-
57
-
-
7044262828
-
A de novo mutation affecting human TrkB associated with severe obesity and developmental delay
-
YEO G.S., CONNIE HUNG C.C., ROCHFORD J., KEOGH J., GRAY J., SIVARAMAKRISHNAN S. ET AL. A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. Nat Neurosci 2004; 7: 1187-9.
-
(2004)
Nat Neurosci
, vol.7
, pp. 1187-9
-
-
Yeo, G.S.1
Connie Hung, C.C.2
Rochford, J.3
Keogh, J.4
Gray, J.5
Sivaramakrishnan, S.6
-
58
-
-
13344295079
-
Serum immunoreactiveleptin concentrations in normal-weight and obese humans
-
CONSIDINE R.V., SINHA M.K., HEIMAN M.L., KRIAUCIUNAS A., STEPHENS T.W., NYCE M.R. ET AL. Serum immunoreactiveleptin concentrations in normal-weight and obese humans. N Engl J Med 1996; 334: 292-5.
-
(1996)
N Engl J Med
, vol.334
, pp. 292-5
-
-
Considine, R.V.1
Sinha, M.K.2
Heiman, M.L.3
Kriauciunas, A.4
Stephens, T.W.5
Nyce, M.R.6
-
59
-
-
0034801977
-
Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors
-
MAAMRA M., BIDLINGMAIER M., POSTEL-VINAY M.C., WU Z., STRASBURGER C.J., ROSS R.J. ET AL. Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors. Endocrinology 2001; 142: 4389-93.
-
(2001)
Endocrinology
, vol.142
, pp. 4389-93
-
-
Maamra, M.1
Bidlingmaier, M.2
Postel-Vinay, M.C.3
Wu, Z.4
Strasburger, C.J.5
Ross, R.J.6
-
60
-
-
0042221558
-
Ultradian oscillations of leptin secretion in humans
-
SINHA M.K., STURIS J., OHANNESIAN J., MAGOSIN S., STEPHENS T., HEIMAN M.L. ET AL. Ultradian oscillations of leptin secretion in humans. Biochem Biophys Res Commun 1996; 228: 733-8.
-
(1996)
Biochem Biophys Res Commun
, vol.228
, pp. 733-8
-
-
Sinha, M.K.1
Sturis, J.2
Ohannesian, J.3
Magosin, S.4
Stephens, T.5
Heiman, M.L.6
-
62
-
-
0036168190
-
Characterization of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity
-
HILEMAN S.M., PIERROZ D.D., MASUZAKI H., BJØRBAEK C., EL-HASCHIMI K., BANKS WA H. ET AL. Characterization of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. Endocrinology 2002; 143: 775-83.
-
(2002)
Endocrinology
, vol.143
, pp. 775-83
-
-
Hileman, S.M.1
Pierroz, D.D.2
Masuzaki, H.3
Bjørbaek, C.4
El-Haschimi, K.5
Banks Wu, H.6
-
63
-
-
0030594830
-
Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
-
CARO J.F., KOLACZYNSKI J.W., NYCE M.R., OHANNESIAN J.P., OPENTANOVA I., GOLDMAN W.H. ET AL. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 1996; 348: 159-61.
-
(1996)
Lancet
, vol.348
, pp. 159-61
-
-
Caro, J.F.1
Kolaczynski, J.W.2
Nyce, M.R.3
Ohannesian, J.P.4
Opentanova, I.5
Goldman, W.H.6
-
64
-
-
84969213492
-
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
THE WELLCOME TRUST CASE CONTROL CONSORTIUM
-
THE WELLCOME TRUST CASE CONTROL CONSORTIUM. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007: 447: 661-78.
-
(2007)
Nature
, vol.447
, pp. 661-78
-
-
-
65
-
-
58149163142
-
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
-
WILLER C.J., SPELIOTES E.K., LOOS R.J., LI S., LINDGREN C.M., HEID I.M. ET AL. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009; 41: 25-34.
-
(2009)
Nat Genet
, vol.41
, pp. 25-34
-
-
Willer, C.J.1
Speliotes, E.K.2
Loos, R.J.3
Li, S.4
Lindgren, C.M.5
Heid, I.M.6
-
66
-
-
58149163141
-
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
-
THORLEIFSSON G., WALTERS G.B., GUDBJARTSSON D.F., STEINTHORSDOTTIR V., SULEM P., HELGADOTTIR A. ET AL. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 2009; 41: 18-24.
-
(2009)
Nat Genet
, vol.41
, pp. 18-24
-
-
Thorleifsson, G.1
Walters, G.B.2
Gudbjartsson, D.F.3
Steinthorsdottir, V.4
Sulem, P.5
Helgadottir, A.6
-
67
-
-
44349142294
-
Common variants near MC4R are associated with fat mass, weight and risk of obesity
-
LOOS R.J., LINDGREN C.M., LI S., WHEELER E., ZHAO J.H., PROKOPENKO I. ET AL. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008; 40: 768-75.
-
(2008)
Nat Genet
, vol.40
, pp. 768-75
-
-
Loos, R.J.1
Lindgren, C.M.2
Li, S.3
Wheeler, E.4
Zhao, J.H.5
Prokopenko, I.6
-
68
-
-
62349114521
-
Anti-melanocortin-4 receptor autoantibodies in obesity
-
PETER J.C., BEKEL A., LECOURT A.C., ZIPFEL G., EFTEKHARI P., NESSLINGER M. ET AL. Anti-melanocortin-4 receptor autoantibodies in obesity. J Clin Endocrinol Metab 2009; 94: 793-800.
-
(2009)
J Clin Endocrinol Metab
, vol.94
, pp. 793-800
-
-
Peter, J.C.1
Bekel, A.2
Lecourt, A.C.3
Zipfel, G.4
Eftekhari, P.5
Nesslinger, M.6
-
69
-
-
0032747280
-
Recombinant leptin for weight loss in obese and lean adults: A randomized, controlled, dose-escalation trial
-
HEYMSFIELD S.B., GREENBERG A.S., FUJIOKA K., DIXON R.M., KUSHNER R., HUNT T.K. ET AL. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 1999; 282: 1568-75.
-
(1999)
JAMA
, vol.282
, pp. 1568-75
-
-
Heymsfield, S.B.1
Greenberg, A.S.2
Fujioka, K.3
Dixon, R.M.4
Kushner, R.5
Hunt, T.K.6
-
70
-
-
69749086148
-
Enhanced weight loss with pramlintide/metreleptin: An integrated neurohormonal approach to obesity pharmacotherapy
-
[Epub ahead of print]
-
RAVUSSIN E., SMITH S.R., MITCHELL J.A., SHRINGARPURE R., SHAN K., MAIER H. ET AL. Enhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy. Obesity 2009 [Epub ahead of print].
-
(2009)
Obesity
-
-
Ravussin, E.1
Smith, S.R.2
Mitchell, J.A.3
Shringarpure, R.4
Shan, K.5
Maier, H.6
-
71
-
-
0037687348
-
Recombinant variant of ciliary neurotrophic factor for weight loss in obese adults: A randomized, dose-ranging study
-
ETTINGER M.P., LITTLEJOHN T.W., SCHWARTZ S.L., WEISS S.R., MCILWAIN H.H., HEYMSFIELD S.B. ET AL. Recombinant variant of ciliary neurotrophic factor for weight loss in obese adults: a randomized, dose-ranging study. JAMA 2003; 289: 1826-32.
-
(2003)
JAMA
, vol.289
, pp. 1826-32
-
-
Ettinger, M.P.1
Littlejohn, T.W.2
Schwartz, S.L.3
Weiss, S.R.4
McIlwain, H.H.5
Heymsfield, S.B.6
-
72
-
-
57849115277
-
Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance
-
OZCAN L., ERGIN A.S., LU A., CHUNG J., SARKAR S., NIE D. ET AL. Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance. Cell Metabolism 2009; 9: 35-51.
-
(2009)
Cell Metabolism
, vol.9
, pp. 35-51
-
-
Ozcan, L.1
Ergin, A.S.2
Lu, A.3
Chung, J.4
Sarkar, S.5
Nie, D.6
-
73
-
-
58849133283
-
Lifestyle intervention in obese children with variations in the melanocortin 4 receptor gene
-
REINEHR T., HEBEBRAND J., FRIEDEL S., TOSCHKE A.M., BRUMM H., BIEBERMANN H., HINNEY A. Lifestyle intervention in obese children with variations in the melanocortin 4 receptor gene. Obesity 2009; 17: 382-9.
-
(2009)
Obesity
, vol.17
, pp. 382-9
-
-
Reinehr, T.1
Hebebrand, J.2
Friedel, S.3
Toschke, A.M.4
Brumm, H.5
Biebermann, H.6
Hinney, A.7
|