메뉴 건너뛰기




Volumn 137, Issue 9, 2009, Pages 1225-1234

Leptin-melanocortin system, body weight regulation and obesity;Sistema leptina-melanocortinas en la regulación de la ingesta y el peso corporal

Author keywords

Leptin; Melanocortins; Obesity

Indexed keywords

LEPTIN; MELANOCORTIN;

EID: 70450183813     PISSN: 00349887     EISSN: 07176163     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (12)

References (73)
  • 2
    • 14544272858 scopus 로고    scopus 로고
    • Monogenic obesity in humans
    • Farooqi I.S., O'Rahilly S. Monogenic obesity in humans. Annu Rev Med 2005; 56: 443-58.
    • (2005) Annu Rev Med , vol.56 , pp. 443-58
    • Farooqi, I.S.1    O'rahilly, S.2
  • 4
    • 61449105725 scopus 로고    scopus 로고
    • Leptin: A pivotal regulator of human energy homeostasis
    • FAROOQI I.S., O'RAHILLY S. Leptin: a pivotal regulator of human energy homeostasis. Am J Clin Nutr 2009 (Suppl); 89: 980S-984S.
    • (2009) Am J Clin Nutr , vol.89 , Issue.SUPPL.
    • Farooqi, I.S.1    O'rahilly, S.2
  • 5
    • 17844401704 scopus 로고    scopus 로고
    • Anatomy and regulation of the central melanocortin system
    • CONE R.D. Anatomy and regulation of the central melanocortin system. Nat Neurosci 2005; 8: 571-8.
    • (2005) Nat Neurosci , vol.8 , pp. 571-8
    • Cone, R.D.1
  • 6
    • 3142731898 scopus 로고    scopus 로고
    • The critical role of the melanocortin system in the control of energy intake
    • SEELEY R.J., DRAZEN D.L., CLEGG D.J. The critical role of the melanocortin system in the control of energy intake. Annu Rev Nutr 2004; 24: 133-49.
    • (2004) Annu Rev Nutr , vol.24 , pp. 133-49
    • Seeley, R.J.1    Drazen, D.L.2    Clegg, D.J.3
  • 8
  • 11
    • 0030028959 scopus 로고    scopus 로고
    • Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (Leptin) receptor
    • CHUA, S.C., CHUNG W.K., WU-PENG X.S. ET AL. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (Leptin) receptor. Science 1996; 271: 994-6.
    • (1996) Science , vol.271 , pp. 994-6
    • Chua, S.C.1    Chung, W.K.2    Wu-Peng, X.S.3
  • 12
    • 0030878110 scopus 로고    scopus 로고
    • Congenital leptin deficiency is associated with severe early-onset obesity in humans
    • MONTAGUE C.T., FAROOQI I.S., WHITEHEAD J.P., SOOS M.A., RAU H., WAREHAM N.J. ET AL. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997; 387: 903-8.
    • (1997) Nature , vol.387 , pp. 903-8
    • Montague, C.T.1    Farooqi, I.S.2    Whitehead, J.P.3    Soos, M.A.4    Rau, H.5    Wareham, N.J.6
  • 13
    • 0032014836 scopus 로고    scopus 로고
    • A leptin missense mutation associated with hypogo-nadism and morbid obesity
    • STROBEL A., ISSAD T., CAMOIN L., OZATA M., STROSBERG A.D. A leptin missense mutation associated with hypogo-nadism and morbid obesity. Nat Genet 1998; 18: 213-5.
    • (1998) Nat Genet , vol.18 , pp. 213-5
    • Strobel, A.1    Issad, T.2    Camoin, L.3    Ozata, M.4    Strosberg, A.D.5
  • 16
    • 0344450708 scopus 로고    scopus 로고
    • A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
    • CLÉMENT K., VAISSE C., LAHLOU N., CABROL S., PELLOUX V., CASSUTO D. ET AL. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998; 392: 398-401.
    • (1998) Nature , vol.392 , pp. 398-401
    • Clément, K.1    Vaisse, C.2    Lahlou, N.3    Cabrol, S.4    Pelloux, V.5    Cassuto, D.6
  • 17
    • 33846409122 scopus 로고    scopus 로고
    • Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor
    • FAROOQI I.S., WANGENSTEEN T., COLLINS S., KIMBER W., MATARESE G., KEOGH J.M. ET AL. Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. N Engl J Med 2007; 356: 237-47.
    • (2007) N Engl J Med , vol.356 , pp. 237-47
    • Farooqi, I.S.1    Wangensteen, T.2    Collins, S.3    Kimber, W.4    Matarese, G.5    Keogh, J.M.6
  • 19
    • 0037456304 scopus 로고    scopus 로고
    • STAT3 signalling is required for leptin regulation of energy balance but not reproduction
    • BATES S.H., STEARNS W.H., DUNDON T.A., SCHUBERT M., TSO A.W., WANG Y. ET AL. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 2003; 421: 856-9.
    • (2003) Nature , vol.421 , pp. 856-9
    • Bates, S.H.1    Stearns, W.H.2    Dundon, T.A.3    Schubert, M.4    Tso, A.W.5    Wang, Y.6
  • 20
    • 1842584949 scopus 로고    scopus 로고
    • Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation
    • GAO Q., WOLFGANG M.J., NESCHEN S., MORINO K., HORVATH T.L., SHULMAN G.I. ET AL. Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc Natl Acad Sci USA 2004; 101: 4661-6.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 4661-6
    • Gao, Q.1    Wolfgang, M.J.2    Neschen, S.3    Morino, K.4    Horvath, T.L.5    Shulman, G.I.6
  • 21
    • 34250612718 scopus 로고    scopus 로고
    • The leptin melanocortin pathway and the control of body weight: Lessons from human and murine genetics
    • OSWAL A., YEO G.S.H. The leptin melanocortin pathway and the control of body weight: lessons from human and murine genetics. Obes Rev 2007; 8: 293-306.
    • (2007) Obes Rev , vol.8 , pp. 293-306
    • Oswal, A.1    Yeo, G.S.H.2
  • 24
    • 6344243617 scopus 로고    scopus 로고
    • SH2-B promotes insulin receptor substrate (IRS)1- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin
    • DUAN C., LI M., RUI L. SH2-B promotes insulin receptor substrate (IRS)1- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin. J Biol Chem 2004; 279: 43684-91.
    • (2004) J Biol Chem , vol.279 , pp. 43684-91
    • Duan, C.1    Li, M.2    Rui, L.3
  • 25
    • 25144523930 scopus 로고    scopus 로고
    • Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice
    • REN D., LI M., DUAN C., RUI L. Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice. Cell Metab 2005; 2: 95-104.
    • (2005) Cell Metab , vol.2 , pp. 95-104
    • Ren, D.1    Li, M.2    Duan, C.3    Rui, L.4
  • 29
    • 52449123919 scopus 로고    scopus 로고
    • Mutations in ligands and receptor of the leptin-melanocortin pathway that lead to obesity
    • FAROOQI I.S., ÓRAHILLY S. Mutations in ligands and receptor of the leptin-melanocortin pathway that lead to obesity. Nat Clin Pract 2008; 4: 569-77.
    • (2008) Nat Clin Pract , vol.4 , pp. 569-77
    • Farooqi, I.S.1    Órahilly, S.2
  • 30
    • 59849121365 scopus 로고    scopus 로고
    • Obesity and eating behaviour in a three- generation Chilean family with carriers of the Thr150Ile mutation in the melanocortin-4 receptor gene
    • SANTOS J.L., AMADOR P., VALLADARES M., ALBALA C., MARTINEZ J.A., MARTI A. Obesity and eating behaviour in a three- generation Chilean family with carriers of the Thr150Ile mutation in the melanocortin-4 receptor gene. J Physiol Biochem 2008; 64: 205-10.
    • (2008) J Physiol Biochem , vol.64 , pp. 205-10
    • Santos, J.L.1    Amador, P.2    Valladares, M.3    Albala, C.4    Martinez, J.A.5    Marti, A.6
  • 32
    • 0033818103 scopus 로고    scopus 로고
    • Inactivation of the mouse melanocor-tin-3 receptor results in increased fat mass and reduced lean body mass
    • CHEN A.S., MARSH D.J., TRUMBAUER M.E., FRAZIER E.G., GUAN X.M., YU H. ET AL. Inactivation of the mouse melanocor-tin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet 2000; 26: 97-102.
    • (2000) Nat Genet , vol.26 , pp. 97-102
    • Chen, A.S.1    Marsh, D.J.2    Trumbauer, M.E.3    Frazier, E.G.4    Guan, X.M.5    Yu, H.6
  • 33
    • 31544465224 scopus 로고    scopus 로고
    • The melanocortin system and energy balance
    • BUTLER A. The melanocortin system and energy balance. Peptides 2006; 27: 281-90.
    • (2006) Peptides , vol.27 , pp. 281-90
    • Butler, A.1
  • 35
    • 0032863468 scopus 로고    scopus 로고
    • Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
    • YASWEN L., DIEHL N., BRENNAN M.B., HOCHGESCHWENDER U. Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nat Med 1999; 5: 1066-70.
    • (1999) Nat Med , vol.5 , pp. 1066-70
    • Yaswen, L.1    Diehl, N.2    Brennan, M.B.3    Hochgeschwender, U.4
  • 36
    • 2942631413 scopus 로고    scopus 로고
    • O'RAHILLY S. Proopiomelanocortin and energy balance: Insights from human and murine genetics
    • COLL A.P., FAROOQI I.S., CHALLIS B.G., YEO G.S., O'RAHILLY S. Proopiomelanocortin and energy balance: insights from human and murine genetics. J Clin Endocrinol Metab 2004; 89: 2557-62.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2557-62
    • Coll, A.P.1    Farooqi, I.S.2    Challis, B.G.3    Yeo, G.S.4
  • 37
    • 0242320429 scopus 로고    scopus 로고
    • Obesity due to proopiomelanocortin deficiency: Three new cases and treatment trials with thyroid hormone and ACTH4-10
    • KRUDE H., BIEBERMANN H., SCHNABEL D., TANSEK M.Z., THEUNISSEN P., MULLIS P.E. ET AL. Obesity due to proopiomelanocortin deficiency: three new cases and treatment trials with thyroid hormone and ACTH4-10. J Clin Endocrinol Metab 2003; 88: 4633-40.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 4633-40
    • Krude, H.1    Biebermann, H.2    Schnabel, D.3    Tansek, M.Z.4    Theunissen, P.5    Mullis, P.E.6
  • 38
    • 33645048441 scopus 로고    scopus 로고
    • A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance
    • LEE Y.S., CHALLIS B.G., THOMPSON D.A., YEO G.S., KEOGH J.M., MADONNA M.E. ET AL. A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance. Cell Metab 2006; 3: 135-40.
    • (2006) Cell Metab , vol.3 , pp. 135-40
    • Lee, Y.S.1    Challis, B.G.2    Thompson, D.A.3    Yeo, G.S.4    Keogh, J.M.5    Madonna, M.E.6
  • 39
    • 35348848018 scopus 로고    scopus 로고
    • The role of proopiomelanocortin (POMC) neurones in feeding behaviour
    • MILLINGTON G.W.M. The role of proopiomelanocortin (POMC) neurones in feeding behaviour. Nutr Metab 2007; 4: 18.
    • (2007) Nutr Metab , vol.4 , pp. 18
    • Millington, G.W.M.1
  • 40
    • 0346096721 scopus 로고    scopus 로고
    • Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency
    • JACKSON R.S., CREEMERS J.W., FAROOQI I.S., RAFFIN-SANSON M.L., VARRO A., DOCKRAY G.J. ET AL. Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. J Clin Invest 2003; 112: 1550-60.
    • (2003) J Clin Invest , vol.112 , pp. 1550-60
    • Jackson, R.S.1    Creemers, J.W.2    Farooqi, I.S.3    Raffin-Sanson, M.L.4    Varro, A.5    Dockray, G.J.6
  • 41
    • 0036679173 scopus 로고    scopus 로고
    • Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine pep-tide processing defects
    • ZHU X., ZHOU A., DEY A., NORRBOM C., CARROLL R., ZHANG C. ET AL. Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine pep-tide processing defects. Proc Natl Acad Sci USA 2002; 99: 10293-8.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 10293-8
    • Zhu, X.1    Zhou, A.2    Dey, A.3    Norrbom, C.4    Carroll, R.5    Zhang, C.6
  • 43
    • 0032857322 scopus 로고    scopus 로고
    • From Agouti to Pomc-100 years of fat blonde mice
    • BARSH G. From Agouti to Pomc-100 years of fat blonde mice. Nat Med 1999; 5: 984-5.
    • (1999) Nat Med , vol.5 , pp. 984-5
    • Barsh, G.1
  • 45
    • 33947310031 scopus 로고    scopus 로고
    • Environmental epigenomics and disease susceptibility
    • JIRTLE R.L., SKINNER M.K. Environmental epigenomics and disease susceptibility. Nat Rev Genet 2007; 8: 253-62.
    • (2007) Nat Rev Genet , vol.8 , pp. 253-62
    • Jirtle, R.L.1    Skinner, M.K.2
  • 46
    • 25144441651 scopus 로고    scopus 로고
    • The Agoutirelated protein and its role in energy homeostasis
    • STUTZ A., MORRISON C., ARGYROPOULOS G. The Agoutirelated protein and its role in energy homeostasis. Peptides 2005; 26: 1771-81.
    • (2005) Peptides , vol.26 , pp. 1771-81
    • Stutz, A.1    Morrison, C.2    Argyropoulos, G.3
  • 47
    • 27344431720 scopus 로고    scopus 로고
    • NPY/ AGRP neurons are essential for feeding in adult mice but can be ablated in neonates
    • LUQUET S., PÉREZ F.A., HNASKO T.S., PALMITER R.D. NPY/ AGRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 2005; 310: 683-5.
    • (2005) Science , vol.310 , pp. 683-5
    • Luquet, S.1    Pérez, F.A.2    Hnasko, T.S.3    Palmiter, R.D.4
  • 48
    • 0035942777 scopus 로고    scopus 로고
    • Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
    • COWLEY M.A., SMART J.L., RUBINSTEIN M., CERDÁN M.G., DIANO S., HORVATH T.L. ET AL. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 2001; 411: 480-4.
    • (2001) Nature , vol.411 , pp. 480-4
    • Cowley, M.A.1    Smart, J.L.2    Rubinstein, M.3    Cerdán, M.G.4    Diano, S.5    Horvath, T.L.6
  • 49
    • 2942733252 scopus 로고    scopus 로고
    • Leptin receptor signalling in POMC neurons is required for normal body weight homeostasis
    • BALTHASAR N., COPPARI R., MCMINN J., LIU S.M., LEE C.E., TANG V. ET AL. Leptin receptor signalling in POMC neurons is required for normal body weight homeostasis. Neuron 2004; 42: 983-91.
    • (2004) Neuron , vol.42 , pp. 983-91
    • Balthasar, N.1    Coppari, R.2    McMinn, J.3    Liu, S.M.4    Lee, C.E.5    Tang, V.6
  • 50
    • 23844542825 scopus 로고    scopus 로고
    • Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through extracellular signal-regulated kinase signaling in rat solitary nucleus
    • SUTTON G.M., DUOS B., PATTERSON L.M., BERTHOUD H.R. Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through extracellular signal-regulated kinase signaling in rat solitary nucleus. Endocrinology 2005; 146: 3739-47.
    • (2005) Endocrinology , vol.146 , pp. 3739-47
    • Sutton, G.M.1    Duos, B.2    Patterson, L.M.3    Berthoud, H.R.4
  • 51
    • 33745978779 scopus 로고    scopus 로고
    • Serotonin reciprocally regulates melanocortin neurons to modulate food intake
    • HEISLER L.K., JOBST E.E., SUTTON G.M., ZHOU L., BOROK E., THORNTON-JONES Z. ET AL. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron 2006; 51: 239-49.
    • (2006) Neuron , vol.51 , pp. 239-49
    • Heisler, L.K.1    Jobst, E.E.2    Sutton, G.M.3    Zhou, L.4    Borok, E.5    Thornton-Jones, Z.6
  • 52
    • 33750712047 scopus 로고    scopus 로고
    • Keeping the fat off with nesfatin
    • MYERS M.G. Keeping the fat off with nesfatin. Nat Med 2006; 12: 1248-9.
    • (2006) Nat Med , vol.12 , pp. 1248-9
    • Myers, M.G.1
  • 53
    • 0038392755 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
    • XU B., GOULDING E.H., ZANG K., CEPOI D., CONE R.D., JONES K.R. ET AL. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci 2003; 6: 736-42.
    • (2003) Nat Neurosci , vol.6 , pp. 736-42
    • Xu, B.1    Goulding, E.H.2    Zang, K.3    Cepoi, D.4    Cone, R.D.5    Jones, K.R.6
  • 54
    • 37549055474 scopus 로고    scopus 로고
    • SENA-ESTEVES M., RIOS M. Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity
    • UNGER T.J., CALDERON G.A., BRADLEY L.C., SENA-ESTEVES M., RIOS M. Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity. J Neurosci 2007; 27: 14265-74.
    • (2007) J Neurosci , vol.27 , pp. 14265-74
    • Unger, T.J.1    Calderon, G.A.2    Bradley, L.C.3
  • 55
    • 33845530762 scopus 로고    scopus 로고
    • Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene
    • GRAY J., YEO G.S., COX J.J., MORTON J., ADLAM A.L., KEOGH J.M. ET AL. Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene. Diabetes 2006; 55: 3366-71.
    • (2006) Diabetes , vol.55 , pp. 3366-71
    • Gray, J.1    Yeo, G.S.2    Cox, J.J.3    Morton, J.4    Adlam, A.L.5    Keogh, J.M.6
  • 57
    • 7044262828 scopus 로고    scopus 로고
    • A de novo mutation affecting human TrkB associated with severe obesity and developmental delay
    • YEO G.S., CONNIE HUNG C.C., ROCHFORD J., KEOGH J., GRAY J., SIVARAMAKRISHNAN S. ET AL. A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. Nat Neurosci 2004; 7: 1187-9.
    • (2004) Nat Neurosci , vol.7 , pp. 1187-9
    • Yeo, G.S.1    Connie Hung, C.C.2    Rochford, J.3    Keogh, J.4    Gray, J.5    Sivaramakrishnan, S.6
  • 59
    • 0034801977 scopus 로고    scopus 로고
    • Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors
    • MAAMRA M., BIDLINGMAIER M., POSTEL-VINAY M.C., WU Z., STRASBURGER C.J., ROSS R.J. ET AL. Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors. Endocrinology 2001; 142: 4389-93.
    • (2001) Endocrinology , vol.142 , pp. 4389-93
    • Maamra, M.1    Bidlingmaier, M.2    Postel-Vinay, M.C.3    Wu, Z.4    Strasburger, C.J.5    Ross, R.J.6
  • 61
    • 0029844267 scopus 로고    scopus 로고
    • Effect of fasting on serum leptin in normal human subjects
    • BODEN G., CHEN X., MOZZOLI M., RYAN I. Effect of fasting on serum leptin in normal human subjects. J Clin Endocrinol Metab 1996; 81: 3419-23.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3419-23
    • Boden, G.1    Chen, X.2    Mozzoli, M.3    Ryan, I.4
  • 62
    • 0036168190 scopus 로고    scopus 로고
    • Characterization of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity
    • HILEMAN S.M., PIERROZ D.D., MASUZAKI H., BJØRBAEK C., EL-HASCHIMI K., BANKS WA H. ET AL. Characterization of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. Endocrinology 2002; 143: 775-83.
    • (2002) Endocrinology , vol.143 , pp. 775-83
    • Hileman, S.M.1    Pierroz, D.D.2    Masuzaki, H.3    Bjørbaek, C.4    El-Haschimi, K.5    Banks Wu, H.6
  • 63
    • 0030594830 scopus 로고    scopus 로고
    • Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
    • CARO J.F., KOLACZYNSKI J.W., NYCE M.R., OHANNESIAN J.P., OPENTANOVA I., GOLDMAN W.H. ET AL. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 1996; 348: 159-61.
    • (1996) Lancet , vol.348 , pp. 159-61
    • Caro, J.F.1    Kolaczynski, J.W.2    Nyce, M.R.3    Ohannesian, J.P.4    Opentanova, I.5    Goldman, W.H.6
  • 64
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • THE WELLCOME TRUST CASE CONTROL CONSORTIUM
    • THE WELLCOME TRUST CASE CONTROL CONSORTIUM. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007: 447: 661-78.
    • (2007) Nature , vol.447 , pp. 661-78
  • 65
    • 58149163142 scopus 로고    scopus 로고
    • Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
    • WILLER C.J., SPELIOTES E.K., LOOS R.J., LI S., LINDGREN C.M., HEID I.M. ET AL. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009; 41: 25-34.
    • (2009) Nat Genet , vol.41 , pp. 25-34
    • Willer, C.J.1    Speliotes, E.K.2    Loos, R.J.3    Li, S.4    Lindgren, C.M.5    Heid, I.M.6
  • 67
    • 44349142294 scopus 로고    scopus 로고
    • Common variants near MC4R are associated with fat mass, weight and risk of obesity
    • LOOS R.J., LINDGREN C.M., LI S., WHEELER E., ZHAO J.H., PROKOPENKO I. ET AL. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008; 40: 768-75.
    • (2008) Nat Genet , vol.40 , pp. 768-75
    • Loos, R.J.1    Lindgren, C.M.2    Li, S.3    Wheeler, E.4    Zhao, J.H.5    Prokopenko, I.6
  • 69
    • 0032747280 scopus 로고    scopus 로고
    • Recombinant leptin for weight loss in obese and lean adults: A randomized, controlled, dose-escalation trial
    • HEYMSFIELD S.B., GREENBERG A.S., FUJIOKA K., DIXON R.M., KUSHNER R., HUNT T.K. ET AL. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 1999; 282: 1568-75.
    • (1999) JAMA , vol.282 , pp. 1568-75
    • Heymsfield, S.B.1    Greenberg, A.S.2    Fujioka, K.3    Dixon, R.M.4    Kushner, R.5    Hunt, T.K.6
  • 70
    • 69749086148 scopus 로고    scopus 로고
    • Enhanced weight loss with pramlintide/metreleptin: An integrated neurohormonal approach to obesity pharmacotherapy
    • [Epub ahead of print]
    • RAVUSSIN E., SMITH S.R., MITCHELL J.A., SHRINGARPURE R., SHAN K., MAIER H. ET AL. Enhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy. Obesity 2009 [Epub ahead of print].
    • (2009) Obesity
    • Ravussin, E.1    Smith, S.R.2    Mitchell, J.A.3    Shringarpure, R.4    Shan, K.5    Maier, H.6
  • 71
    • 0037687348 scopus 로고    scopus 로고
    • Recombinant variant of ciliary neurotrophic factor for weight loss in obese adults: A randomized, dose-ranging study
    • ETTINGER M.P., LITTLEJOHN T.W., SCHWARTZ S.L., WEISS S.R., MCILWAIN H.H., HEYMSFIELD S.B. ET AL. Recombinant variant of ciliary neurotrophic factor for weight loss in obese adults: a randomized, dose-ranging study. JAMA 2003; 289: 1826-32.
    • (2003) JAMA , vol.289 , pp. 1826-32
    • Ettinger, M.P.1    Littlejohn, T.W.2    Schwartz, S.L.3    Weiss, S.R.4    McIlwain, H.H.5    Heymsfield, S.B.6
  • 72
    • 57849115277 scopus 로고    scopus 로고
    • Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance
    • OZCAN L., ERGIN A.S., LU A., CHUNG J., SARKAR S., NIE D. ET AL. Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance. Cell Metabolism 2009; 9: 35-51.
    • (2009) Cell Metabolism , vol.9 , pp. 35-51
    • Ozcan, L.1    Ergin, A.S.2    Lu, A.3    Chung, J.4    Sarkar, S.5    Nie, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.