Multiple signaling pathways regulate NF-κB-dependent transcription of the monocyte chemoattractant protein-1 gene in primary endothelial cells

Blood

Volumn 97, Issue 1, 2001, Pages 46-55

  Goebeler, Matthias ^a   Gillitzer, Reinhard ^a   Kilian, Karin ^a   Utzel, Kathrin ^a   Bröcker, Eva Bettina ^a   Rapp, Ulf R ^a   Ludwig, Stephan ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; NICKEL CHLORIDE; PHOSPHOLIPASE INHIBITOR; SYNAPTOPHYSIN; TRICYCLO[4.3.0.1]DECAN 9 YL XANTHOGENATE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA BINDING; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0035163198     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.1.46     Document Type: Article

References (51)

1. The monocyte chemoattractant protein family
2. Human chemokines: An update
3. A soluble gradient of endogenous monocyte chemoattractant protein-1 promotes the transendothelial migration of monocytes in vitro
4. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions
5. Abnormalities in monocyte recruitment and cytokine expression in monocyte-chemoattractant protein 1-deficient mice
6. Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor
7. Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice
8. Inhibition of T cell recruitment and cutaneous delayed-type hypersensitivity-induced inflammation with antibodies to monocyte-chemoattractant protein-1
9. NF-kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene
10. Transcriptional regulation of the human monocyte chemoattractant protein-1 gene: Cooperation of two NF-κ B sites and NF-κ B/Rel subunit specificity
11. The beginning of the end: Iκ B kinase (IKK) and NF-κ B activation
12. Phosphorylation of NF-κ B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300
13. Transcriptional activation by NF-κ B requires multiple coactivators
14. TNF activales NF-κ B by phosphatidylcoline-specific phospholipase C-induced "acidic" sphingomyelin breakdown
15. The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis in response to tumour necrosis factor
16. Activation of transcription factor NF-κ B and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways
17. Iκ Bα degradation and nuclear factor-κ B DNA binding are insufficient for interleukin-1β and tumor necrosis factor-α-induced κ B-dependent transcription
18. The MKK6/p38 stress kinase cascade is critical for tumor necrosis factor-α-induced expression of monocyte-chemoattractant protein-1 in endothelial cells
19. p38 MAPK signalling cascades in inflammatory diseases
20. p38 mitogen activated protein kinase regulates endothelial VCAM-1 expression at the post-transcriptional level
21. Induction of interleukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine- or stress-activated signal transduction pathways
22. Cell stress and MKK6b mediated p38 MAP kinase activation inhibit tumor necrosis factor-induced Iκ B phosphorylation and NF-κ B activation
23. Nickel chloride and cobalt chloride two common contact sensitizers, directly induce expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and endothelial leukocyte adhesion molecule (ELAM-1) by endothelial cells
24. Activation of nuclear factor-κ B and gene expression in human endothelial cells by the common haptens nickel and cobalt
25. Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity
26. The chemokine repertoire of human dermal microvascular endothelial cells and its regulation by inflammatory cytokines
27. The p65 subunit is responsible for the strong transcription activating potential of NF-κ B
28. Quantitative study of monocyte chemoattractant protein-1 (MCP-1) in cerebrospinal fluid and cyst fluid from patients with malignant glioma
29. Interleukin-13 selectively induces monocyte chemoattractant protein-1 synthesis and secretion by human endothelial cells: Involvement of IL-4Rα and Stat6 phosphorylation
30. 3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways
31. Human monocyte chemoattractant protein-1 (MCP-1): Full length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE
32. Activation and homologous desensitization of human endothelial cells by CD40 ligand, tumor necrosis factor, and interleukin 1
33. Distinct NF-κ B/Rel transcription factors are responsible for tissue-specific and inducible gene activation
34. Tumor necrosis factor-α activates NF-κ B in acid sphingomyelinase-deficient mouse embryonic fibroblasts
35. A functional role of Iκ B-ε in endothelial cell activation
36. Novel inhibitors of cytokine-induced Iκ Bα phosphorylation and endothelial adhesion molecule expression show antiinflammatory effects in vivo
37. Activation of nuclear factor-κ B-dependent transactivation by tumor necrosis factor-α is mediated through phosphorylation of RelA/p65 on serine 529
38. Cobalt(II) and nickel(II) ions as promoters of free radicals in vivo: Detected directly using electron spin resonance spectrometry in circulating blood in rats
39. Nickel induces a signature mutation for oxygen free radical damage
40. Nickel(II)- and cobalt(II)-dependent damage by hydrogen peroxide to the DNA bases in isolated human chromatin
41. Role of p38-mitogen-activated protein kinase in spontaneous apoptosis of human neutrophils
42. Stimulation of stress-activated protein kinase and p38 HOG1 kinase in murine keratinocytes following photodynamic therapy with benzoporphyrin derivative
43. Regulation of ceramide production and apoptosis
44. Signalling sphingomyelinases: Which, where, how and why?
45. Activation of the p38 mitogen-activated protein kinase pathway by Epstein-Barr virus encoded latent membrane protein 1 coregulates interleukin-6 and interleukin-8 production
46. D609, a phosphatidylcholine-specific phospholipase C inhibitor, blocks interleukin-1β-induced vascular cell adhesion molecule 1 gene expression in human endothelial cells
47. Elevated cyclic AMP inhibits NF-κ B-dependent transcription in human monocytic cells and endothelial cells
48. p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-κ B p65 transactivation by tumor necrosis factor
49. The p38 mitogen-activated protein kinase is required for NF-κB-dependent gene expression: The role of TATA-binding protein (TBP)
50. CREB-binding protein activates transciption through multiple domains