Nickel essentiality, toxicity, and carcinogenicity

Critical Reviews in Oncology/Hematology

Volumn 42, Issue 1, 2002, Pages 35-56

  Denkhaus, E ^a   Salnikow, K ^b  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Nickel carcinogenicity; Nickel essentiality; Nickel toxicity

Indexed keywords

NICKEL; OXIDE;

BIOACCUMULATION; CALCIUM HOMEOSTASIS; CARCINOGENESIS; CARCINOGENICITY; CELL TRANSFORMATION; DRUG ADMINISTRATION ROUTE; HEALTH HAZARD; HUMAN; INTOXICATION; NONHUMAN; POLLUTION; REVIEW; TOXICITY TESTING;

ANIMALS; BODY FLUIDS; CALCIUM; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; COCARCINOGENESIS; DRUG ADMINISTRATION ROUTES; ENVIRONMENTAL EXPOSURE; FEMALE; HOMEOSTASIS; HUMANS; MALE; METALLOPROTEINS; MICE; NEOPLASMS; NEOPLASMS, EXPERIMENTAL; NICKEL; OXIDATIVE STRESS; RATS; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY; TRANSCRIPTION, GENETIC;

EID: 0036118827     PISSN: 10408428     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1040-8428(01)00214-1     Document Type: Review

References (249)

1. The coordination chemistry of nickel: an introductory survey
2. Natural sources of metals to the environment
3. Introduction on environmental chemistry and global cycles of chromium, nickel, cobalt, beryllium, arsenic, cadmium, and selenium, and their derivatives
4. Nickel
5. Nickel
6. Respiratory cancer in Welsh nickel refiners: which nickel compounds are responsible?
7. Recent follow up of nickel refining workers in Norway and respiratory cancer
8. Cancer mortality in Ontario nickel workers, 1950-1984
9. Report of the International Committee on nickel carcinogenesis in man
10. Nickel
11. Environmental nickel pathways to man
12. Nickel
13. The biological importance of nickel in the food chain
14. Nickel deficiency in rats
15. Contents and distribution of Fe, Cu, Zn, Ni, and Mn in fetuses amniotic fluid, placenta, and uterus of rats
16. The essentiality of nickel for animal growth
17. Nickel influences iron metabolism through physiologic, pharmacologic, and toxicologic mechanisms in the rat
18. Effects of dietary nickel and protein on growth, nitrogen metabolism and tissue concentrations of nickel, iron, zinc, manganese, and copper in calves
19. Nickel concentrations in serum of patients with acute mycardinal infarction or unstable angina pectoris
20. Nutritional requirements for boron, silicon, vanadium, nickel, and arsenic: current knowledge and speculation
21. Nickel deficiency alters liver lipid metabolism in rats
22. Nickel in biology: nickel as an essential trace element
23. Nickel biochemistry
24. Structure function relationships in nickel metallobiochemistry
25. Metallocenter assembly in nickel-containing enzymes
26. Nickel-binding proteins
27. Characteristics of Helicobacter pylori variants selected for urease deficiency
28. Characterization of Helicobacter pylori urease mutants
29. Deliberations and evaluations of the approaches, endpoints and paradigms for dietary recommendations of the other trace elements
30. Are nickel, vanadium, silicon, fluorine, and tin essential for man? A review
31. Nickel: an essential element
32. Determination of nickel by GC, GC-MS, and AAS in biological materials in a case of lethal poisoning
33. Nickel poisoning: II. Studies on patients suffering from acute exposure to vapors of nickel carbonyl
34. Nickel carbonyl: toxicity and human health
35. Acute nickel carbonyl poisoning: a report of 179 cases
36. Nasal histology and nickel concentrations in plasma and urine after improvements in working environment at a nickel refinery in Norway
37. Occupational asthma caused by nickel sulfate
38. Occupational asthma from nickel sensitivity: I. Human serum albumin in the antigenic determinant
39. Positive patch test reactions to nickel, cobalt and potassium dichromate in a series of 576 patients
40. Contact sensitivity to nickel and other metals in jewelry reactors
41. Occupational contact dermatitis in the UK: a surveillance report from EPIDERM and OPRA
42. Chronic allergic-like dermatopathies in nickel-sensitive patients: results of dietary restrictions and challenge with nickel salts
43. Biochemical renal changes in workers exposed to soluble nickel compounds
44. Chronic nephrotoxicity of soluble nickel in rats
45. Contribution of toxic nephropathies to end-stage renal failure in Europe: a report from the EDTA-ERA registry
46. Reproduction toxicology of nickel, 1st communication: effect of excessive nickel amounts on magnesium content of organs and tissues
47. Reproduction toxicology of nickel, 2nd communication: effect of excessive nickel amounts on manganese content of organs and tissues
48. Teratogenic effects of nickel offers exceeding the requirement in hens
49. Congenital defects, abortion and other health effects in nickel refinery workers
50. Direct and indirect nickel-specific stimulation of T lymphocytes from patients with allergic contact dermatitis to nickel
51. Immune parameters and blood and urine trace elements in nonallergic and nickel-sensitised humans
52. Phagocytosis, cellular distribution, and carcinogenic activity of particulate nickel compounds in tissue culture
53. Surface reduction of amorphous NiS particles potentiates their phagocytosis and subsequent induction of morphological transformation in Syrian hamster embryo cells
54. Phagocytosis of particulate nickel compounds by rat peritoneal macrophages in vitro
55. Factors influencing the phagocytosis, neoplastic transformation, and cytotoxicity of particulate nickel compounds in tissue culture systems
56. The distribution and metabolism of nickel carbonyl in mice
57. The metabolism of nickel-63 carbonyl
58. Nickel mobilization by sodium diethyldithiocarbamate in nickel-carbonyl treated mice
59. 4
60. 2 in mice
61. 63Ni[II] into lung and liver subcallular fractions of Balb/C mice
62. Haemodynamic effect of nickel chloride in pregnant rats
63. Bioavailability of nickel in man: effects of foods and chemically-defined dietary constituents on the absorption of inorganic nickel
64. Fecal nickel excretion by healthy adults
65. Nickel content of food and estimation of dietary intake
66. Intake of nickel and vanadium by humans
67. Manganese, cobalt, nickel, silicon, and aluminium in human milk during early lactation
68. Nickel absorption and kinetics in human volunteers
69. Reference values for nickel concentrations in human tissues and bile
70. A pilgrimage into the archives of nickel toxicology
71. Application of mathematical modelling for assessing the biological half-times of chromium and nickel in field studies
72. Nickel concentrations in nasal mucosa, plasma, and urine in active and retired nickel workers
73. Nickel dermatitis
74. Spread of nickel dermatitis
75. Nickel sensitivity in the general population
76. Carcinogenicity of nickel compounds in animals
77. Toxicity and carcinogenicity of nickel compounds
78. Metal carcinogenesis. II. A study on the carcinogenic activity of cobalt, copper, iron, and nickel compounds
79. Cylindrical laminated bodies in nickel-subsulphide-induced rhabdomyosarcoma in rabbits
80. Carcinogenicity of nickel subsulfide in Fischer rats and Syrian hamsters after administration by various routes
81. Nickel sulphide-induced rhabdomyosarcomata in rats
82. Carcinogenicity of nickel(II)hydroxides and nickel(II)sulfate in Wistar rats and its relation to the in vitro dissolution rates
83. 2)
84. 63Ni(II) in rats and rabbits
85. Fate of nickel subsulfide during carcinogenesis studied by autoradiography and X-ray powder diffraction
86. Carcinogenicity assessment of selected nickel compounds
87. Nickel poisoning. IX. Carcinogenesis in rats exposed to nickel carbonyl
88. Inhalation studies of nickel sulfide in pulmonary carcinogenesis of rats
89. Development of malignant tumors in rats under the influence of nickel-containing aerosols
90. Carcinogenicity of nickel subsulfide for respiratory tract mucosa
91. Comparative carcinogenic effects of nickel subsulfide, nickel oxide, or nickel sulfate hexahydrate chronic exposures in the lung
92. Test for carcinogenicity of metallic compounds by the pulmonary tumor response in strain A mice
93. Initiation by nickel acetate and promotion by sodium barbital of renal cortical epithelial tumors in male F344 rats
94. Renal carcinomas and erythrocytosis in rats following intrarenal injection of nickel subsulfide
95. The topical effects of nickel subsulfide on renal parenchyma
96. Induction of renal cancers in rats by intrarenal injection of nickel subsulfide
97. 2
98. 2
99. Association between erythrocytosis and renal cancers in rats following intrarenal injection of nickel compounds
100. Induction of testicular sarcoma in Fischer rats by intratesticular injection of nickel subsulfide
101. Histopathological and immunohistochemical studies on nickel sulfide-induced tumors in F344 rats
102. Induction of ocular neoplasms in Fischer rats by intraocular injection of nickel subsulfide
103. Induction of ocular tumor by nickel subsulfide in the Japanese common newt, Cynops pyrrhogaster
104. Rapid induction of sarcomas in rats by combination of nickel sulfide and 3,4-benzpyrene
105. Organ and species specificity in nickel subsulfide carcinogenesis
106. Strain differences in the response of rats to the injection of nickel sulphide
107. Lifetime effects of intratracheally instilled nickel subsulfide on B6C3F1 mice
108. Nickel-induced lipid peroxidation in the liver of different strains of mice and its relation to nickel effects on antioxidant systems
109. Relative susceptibilities of C57BL/6, (C57BL/6×C3H/He)F1, and C3H/He mice to acute toxicity and carcinogenicity of nickel subsulfide
110. Metallothionein induction and pulmonary responses to inhaled cadmium chloride in rats and mice
111. Carcinogenic metals induce hypoxia-inducible factor-stimulated transcription by reactive oxygen species-independent mechanism
112. Use of the Syrian hamster embryo cell transformation assay for determining the carcinogenic potential of heavy metal compounds
113. Quantitative studies of in vitro morphological transformation of Syrian hamster cells by inorganic metal salts
114. Induction of anchorage independence in human diploid foreskin fibroblasts by carcinogenic metal salts
115. Transformation of rat tracheal epithelial cells to immortal growth variants by particulate and soluble nickel compounds
116. Mechanisms of nickel genotoxicity and carcinogenicity
117. Induction of sarcomas in nude mice by implantation of Syrian hamster fetal cells exposed in vitro to nickel subsulfide
118. Mechanisms involved in the immortalization of mammalian cells by ionizing radiation and chemical carcinogens
119. Oncogenic transformation and cell lysis in C3H/10T 1/2 cells and increased sister chromatid exchange in human lymphocytes by nickel subsulfide
120. Immortalization of normal human kidney epithelial cells by nickel (II)
121. Transformation of human kidney epithelial cells to tumorigenicity by nickel (II) and v-Ha-ras oncogene
122. Inhibition of intercellular communication by nickel (II): antagonistic effect of magnesium
123. Metal salts as promoters of in vitro morphological transformation of hamster embryo cells initiated by benzo[a]pyrene
124. On the mechanism of nickel absorption in the rat jejunum
125. Surface binding and uptake of nickel(II) in human epithelial kidney cells: modulation by ionomycin, nicardipine and metals
126. Effect of selected inhibitors on cadmium, nickel, and benzo[a]pyrene uptake into brown cells of Mercenaria mercenaria
127. 2+ impairs thrombin-induced signal transduction by acting on the agonist and/or receptor in human platelets
128. Carcinogenic activity of particulate nickel compounds is proportional to their cellular uptake
129. Video time-lapse microscopy of phagocytosis and intracellular fate of crystalline nickel sulfide particles in cultured mammalian cells
130. Toxicity, uptake, and mutagenicity of particulate and soluble nickel compounds
131. Comparison of the localization of chromosome damage induced by calcium chromate and nickel compounds
132. Nonrandom chromosomal alterations in nickel-transformed Chinese hamster embryo cells
133. Incidence and localization of sister chromatid exchanges induced by nickel and chromium compounds
134. Effects of nickel sulfate, lead sulfate, and sodium arsenite alone and with UV light on sister chromatid exchanges in cultured human lymphocytes
135. 2
136. 2 in magnesium-insoluble regions of fractionated Chinese hamster ovary cell chromatin
137. The role of oxidative damage in metal carcinogenicity
138. Nickel(II) interferes with the incision step in nucleotide excision repair in mammalian cells
139. Assessment of the uptake and mutagenicity of nickel chloride in Salmonella tester strains
140. Mutagenic responses of nickel oxides and nickel sulfides in Chinese hamster V79 cell lines as the xanthine-guanine phosphoribosyl transferase locus
141. Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: a new model for epigenetic carcinogens
142. Nickel subsulfide is genotoxic in vitro but shows no mutagenic potential in respiratory tract tissues of Big Blue rats and Muta Mouse mice in vivo after inhalation
143. Role of Ni(II) in mutation
144. Nickel-induced heritable alterations in retroviral transforming gene expression
145. Nickel mutagenesis: alteration of the MuSVts110 thermosensitive splicing phenotype by a nickel-induced duplication of the 3′ splice site
146. Nickel compounds are novel inhibitors of histone H4 acetylation
147. Loss of thrombospondin transcriptional activity in nickel-transformed cells
148. Induction of activating transcription factor I by nickel and its role as a negative regulator of thrombospondin I gene expression
149. CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals
150. Nickel-induced transformation shifts the balance between HIF-1α and p53 transcription factors
151. 2 homeostasis by hypoxia-inducible factor 1
152. 2-dependent degradation domain via the ubiquitin-proteasome pathway
153. Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
154. Regulation of the erythropoietin gene: evidence that the oxigene sensor is a heme protein
155. Properties of chemically modified Ni(II)-Fe(II) hybrid hemoglobins. Ni(II) protoporphyrin IX as a model for a permanent deoxy-heme
156. 2 homeostasis by hypoxia-inducible factor 1
157. HIF-1 alpha is required for solid tumor formation and embryonic vascularization
158. Effects of transition metals on the expression of the erythropoietin gene: further evidence that the oxygen sensor is a heme protein
159. Hypoxia regulation of endothelial glyceraldehyde-3-phosphate dehydrogenase
160. Carcinogenic nickel induces genes involved with hypoxic stress
161. Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells
162. Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin
163. Erythropoietin gene regulation depends on heme-dependent oxygen sensing and assembly of interacting transcription factors
164. Increased serum erythropoietin activity in rats following intrarenal injection of nickel subsulfide
165. 2+ compounds
166. Effects of nickel chloride and nickel carbonyl upon glucose metabolism in rats
167. On respiratory impairment in cancer cells
168. An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: role in tumor cell glycolysis and the Warburg effect
169. c-Myc transactivation of LDH-A: implications for tumor metabolism and growth
170. Nickel chloride and cobalt chloride, two common contact sensitizers, directly induce expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and endothelial leukocyte adhesion molecule (ELAM-1) by endothelial cells
171. Activation of nuclear factor-kappa B and gene expression in human endothelial cells by the common haptens nickel and cobalt
172. IARC p53 mutation database: a relational database to compile and analyze p53 mutations in human tumors and cell lines
173. Altered p53 gene structure and expression in human epithelial cells after exposure to nickel
174. Low incidence of point mutations detected in the p53 tumor suppressor gene from chemically induced rat renal mesenchymal tumors
175. Identification and characterization of a p53 gene mutation in a human osteosarcoma cell line
176. Transformation of immortal, non-tumorigenic osteoblast-like human osteosarcoma cells to the tumorigenic phenotype by nickel sulfate
177. Transformation of human osteoblasts to anchorage-independent growth by insoluble nickel particles
178. Nickel-induced transformation of human cells causes loss of the phosphorylation of the retinoblastoma protein
179. Transformation of human osteoblast cells to the tumorigenic phenotype by depleted uranium-uranyl chloride
180. Cell cycle arrest, apoptosis and p53 expression in nickel (II) acetate-treated Chinese hamster ovary cells
181. Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha
182. Studies on the human retinoblastoma susceptibility gene
183. Transcriptional control by the retinoblastoma protein
184. Molecular and cellular physiology of intracellular calcium stores
185. Calcium regulation of gene expression
186. The role of calcium in apoptosis
187. Effect of nickel on enzymatic activities in the mouse pancreas
188. Alteration by malignant transformation of the calcium requirements for cell proliferation in vitro
189. Age-related and carcinogen-induced alterations of the extracellular growth factor requirements for cell proliferation in vitro
190. Inhibition by magnesium and calcium acetates of lead subacetate- and nickel acetate-induced lung tumors in strain A mice
191. 2+ in the regulation of nickel-inducible Cap43 gene expression
192. The mechanism of nickel uptake by rat primary hepatocyte cultures: role of calcium channels
193. Nickel block of a family of neuronal calcium channels: subtype- and subunit-dependent action at multiple sites
194. Cadmium evokes inositol polyphosphate formation and calcium mobilization. Evidence for a cell surface receptor that cadmium stimulates and zinc antagonizes
195. Possible role of oxidative damage in metal-induced carcinogenesis
196. The role of oxidative processes in metal carcinogenesis
197. 2 specifically enhances the formation of oxidants in the nuclei of CHO cells as detected by dichlorofluorescein
198. Altered oxidative stress responses in nickel resistant mammalian cells
199. Carcinogenic metals induce hypoxia-inducible factor-stimulated transcription by reactive oxygen species-independent mechanism
200. Nickel effects on hepatic amino acids
201. Alterations in cytoskeletal protein sulfhydryls and cellular glutathione in cultured cells exposed to cadmium and nickel ions
202. Site-specific DNA damage induced by nickel(II) ion in the presence of hydrogen peroxide
203. Nickel induces a signature mutation for oxygen free radical damage
204. Ni(II) specifically cleaves the C-terminal tail of the major variant of histone H2A and forms an oxidative damage-mediating complex with the cleaved-off octapeptide
205. Heterochromatic proteins specifically enhance nickel-induced 8-oxo-dG formation
206. Protein oxidation and amino acid-DNA crosslinking by nickel compounds in intact cultured cells
207. Intracellular glutathione levels regulate fos/jun induction and activation of glutathione S-transferase gene expression
208. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
209. 2 and antioxidants have opposite effects on activation of NFkB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor
210. 6×His-Ni-NTA chromatography as a superior technique in recombinant protein expression/purification
211. Isolation of a nickel alpha 2-macroglobulin from rabbit serum
212. 63Ni(II) to ultrafiltrable constituents of rabbit serum in vivo and in vitro
213. Identification of the serum binding proteins for iron, zinc, cadmium, nickel, and calcium
214. Nickel(II) transport in human blood serum: studies of nickel(II)-binding human albumin and to native-sequence peptide, and ternary complex formation with L-histidine
215. Sites of binding of nickel(II) ion by peptide (1-24) of bovine serum albumin
216. The amino acid sequence of peptide (1-24) of rat and human serum albumin
217. Studies of serum protein complexes with nickel using crossed immunoelectrophoresis
218. 63Ni[II] into lung and liver subcallular fractions of Balb/C mice
219. Biological transport of nickel
220. Peptide and carbohydrate complexes in human kidney
221. 2+
222. Overexpression of DAN gene product in normal rat fibroblasts causes a retardation of the entry into the S phase
223. Characterization of pNiXa, a serpin of Xenopus laevis oocytes and embryos, and its histidine-rich, Ni(II)-binding domain
224. (2+)-binding protein (pNiXc) on Western blots of Xenopus laevis oocytes and embryos is the monomer of fructose-1,6-bisphosphate aldolase A
225. Lipovitellin 2 beta is the 31 kD Ni(2+)-binding protein (pNiXb) in Xenopus oocytes and embryos
226. Isolation of a protein that is essential for the first step of nuclear protein import
227. Sample collection guidelines for trace elements in blood and urine
228. Content of trace elements in the serum of patients with carcinoma of the larynx
229. Serum trace elements in lung cancer
230. Concentrations of Cu, Cd, Ni, and Pb in the blood and tissues of cancerous persons in a Pakistani population
231. Determination of the trace elements zinc, copper, nickel and chromium in bone marrow and plasma of patients with Non-Hodgkin-lymphomas
232. Increased chromium and nickel content in lung tissue and bronchial carcinoma
233. Investigations on the quantitative determination of nickel and chromium in human lung tissue
234. Biomonitoring of nickel and chromium in human pulmonary tissue
235. Discriminant analysis of trace element distribution of normal and malignant human tissues
236. An elemental correlation study in cancerous breast tissue by total reflection X-ray fluorescence
237. Transition metals in human cancer I. Oesophagus and bone marrow
238. Mechanisms of nickel carcinogenesis