Nickel requires hypoxia-inducible factor-1α, not redox signaling, to induce plasminogen activator inhibitor-1

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 281, Issue 3 25-3, 2001, Pages

  Andrew, Angeline S ^a   Klei, Linda R ^a   Barchowsky, Aaron ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

Airway epithelium; Mitogen activated protein kinase; Nickel subsulfide; Pulmonary fibrosis; Reduced nicotinamide adenine dinucleotide phosphate oxidase

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ANTIOXIDANT; ANTISENSE OLIGONUCLEOTIDE; HYPOXIA INDUCIBLE FACTOR 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NICKEL; NICKEL SUBSULFIDE; OXIDOREDUCTASE INHIBITOR; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ARTICLE; CONTROLLED STUDY; FIBRINOLYSIS; HUMAN; HUMAN CELL; LUNG FIBROSIS; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN DETERMINATION; RESPIRATORY EPITHELIUM; RNA ANALYSIS; SIGNAL TRANSDUCTION;

EID: 0034822202     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.2001.281.3.l607     Document Type: Article

References (58)

1. Indications to an NADPH oxidase as a possible pO2 sensor in the rat carotid body
2. Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity
3. The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia
4. Nickel-induced plasminogen activator inhibitor-1 expression inhibits the fibrinolytic activity of human airway epithelial cells
5. Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor-1 by low oxygen tension
6. Increased focal adhesion kinase- and urokinase-type plasminogen activator receptor-associated cell signaling in endothelial cells exposed to asbestos
7. Expression and activity of urokinase and its receptor in endothelial and pulmonary epithelial cells exposed to asbestos
8. Comparative inhalation toxicity of nickel subsulfide to F344/N rats and B 6C3F1 mice exposed for 12 days
9. Signaling angiogenesis via p42/p 44 MAP kinase and hypoxia
10. Erythropoietin: A model system for studying oxygen-dependent gene regulation
11. Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)
12. Mitochondrial reactive Oxygen species trigger hypoxia-induced transcription
13. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: A mechanism of O2 sensing
14. Association between oxidative stress and cytokine production in nickel-treated rats
15. Proinflammatory cytokines stimulate mitogen-activated protein kinase subfamilies, increase phosphorylation of c-Jun and ATF2 and upregulate c-Jun protein in neonatal rat ventricular myocytes
16. Toxicity and carcinogenicity of nickel compounds
17. Phagocytosis, cellular distribution, and carcinogenic activity of particulate nickel compounds in tissue culture
18. N-acetylcysteine: Pharmacological considerations and experimental and clinical applications
19. Hypoxia-induced transcriptional activation of vascular endothelial growth factor is inhibited by serum
20. Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein
21. Role of hydrogen peroxide in hypoxia-induced erythropoietin production
22. Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia. Implications for the mechanism of oxygen sensing
23. Activation of nuclear factor-kappa B and gene expression in human endothelial cells by the common haptens nickel and cobalt
24. Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein
25. Structure of a biological oxygen sensor: A new mechanism for heme-driven signal transduction
26. The PAS super-family: Sensors of environmental and developmental signals
27. Non-cancer risk assessment for nickel compounds: Issues associated with dose-response modeling of inhalation and oral exposures
28. Effects of transition metals on the expression of the erythropoietin gene: Further evidence that the oxygen sensor is a heme protein
29. Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway
30. Nickel induces increased oxidants in intact cultured mammalian cells as detected by dichlorofluorescein fluorescence
31. Crystalline Ni3S2 specifically enhances the formation of oxidants in the nuclei of CHO cells as detected by dichlorofluorescein
32. A possible involvement of oxidative lung injury in endotoxin-induced bronchial hyperresponsiveness to substance P in guinea pigs
33. Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
34. Chronic exposure to iron oxide, chromium oxide, and nickel oxide fumes of metal dressers in a steelworks
35. Nickel(III) chemistry and properties of the peptide complexes of Ni(II) and Ni(III)
36. ERK activation upon hypoxia: Involvement in HIF-1 activation
37. Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells
38. Hypoxia-induced protein binding to O2-responsive sequences on the tyrosine hydroxylase gene
39. Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase
40. Carcinogenicity assessment of selected nickel compounds
41. Preferential DNA-protein cross-linking by NiCl2 in magnesium-insoluble regions of fractionated Chinese hamster ovary cell chromatin
42. Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition
43. The influence of nickel and cobalt on putative members of the oxygen-sensing pathway of erythropoietin-producing HepG2 cells
44. p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1
45. Biology of free radical scavengers: An evaluation of ascorbate
46. Carcinogenic nickel induces genes involved with hypoxic stress
47. Altered oxidative stress responses in nickel-resistant mammalian cells
48. Carcinogenic metals induce hypoxia-inducible factor-stimulated transcription by reactive oxygen species-independent mechanism
49. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1
50. Expression of hypoxia-inducible factor 1: Mechanisms and consequences
51. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
52. Pathway of nickel uptake influences its interaction with heterochromatic DNA
53. Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol
54. Lung lesions induced by intratracheal instillation of nickel fumes and nickel-oxide powder in rats
55. Differences in the extent of inflammation caused by intratracheal exposure to three ultrafine metals: Role of free radicals
56. Differential effects of some cell signaling inhibitors upon nitric oxide synthase expression and nuclear factor-kappa B activation induced by lipopolysaccharide in rat aortic smooth muscle cells
57. Loss of PTEN facilitates HIF-1-mediated gene expression