Transcriptional profiling defines the effects of nickel in human epidermal keratinocytes

Journal of Cellular Physiology

Volumn 217, Issue 3, 2008, Pages 686-692

  Gazel, Alix ^a   Rosdy, Martin ^b   Tornier, Carine ^b   De Fraissinette, Anne De Brugerolle ^b   Blumenberg, Miroslav ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SkinEthic Laboratories   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIREGULIN; DNA; EPIDERMAL GROWTH FACTOR; GALECTIN 3; GLUCOCORTICOID; GROWTH DIFFERENTIATION FACTOR 15; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 18; NICKEL; ONCOSTATIN M; PROSTAGLANDIN F; PROTEIN C FOS; PROTEINASE; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN; TRANSCRIPTION FACTOR;

ALLERGY; ARTICLE; BINDING SITE; COMPUTER MODEL; CONTROLLED STUDY; DNA FINGERPRINTING; DNA MICROARRAY; EPIDERMIS CELL; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; KERATINOCYTE; NICKEL HYPERSENSITIVITY; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; CYTOLOGY; DRUG EFFECT; EPIDERMIS; GENE EXPRESSION PROFILING; GENETIC DATABASE; GENETIC TRANSCRIPTION; METABOLISM; TIME;

BINDING SITES; DATABASES, GENETIC; EPIDERMIS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; KERATINOCYTES; NF-KAPPA B; NICKEL; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 54049133709     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21536     Document Type: Article

References (65)

1. Banno T, Adachi M, Mukkamala L, Blumenberg M. 2003. Unique keratinocyte-specific effects of interferon-gamma that protect skin from viruses, identified using transcriptional profiling. Antivir Ther 8:541-554.
2. Banno T, Gazel A, Blumenberg M. 2004a. Effects of tumor necrosis factor-alpha (TNF alpha) in epidermal keratinocytes revealed using global transcriptional profiling. J Biol Chem 279:32633-32642.
3. Banno T, Gazel A, Blumenberg M. 2004b. The use of DNA microarrays in dermatology research. Retinoids 20:1-4.
4. Banno T, Gazel A, Blumenberg M, Adachi M, Mukkamala L. 2004c. Effects of tumor necrosis factor-{alpha} (TNF{alpha}) in epidermal keratinocytes revealed using global transcriptional profiling. J Biol Chem 279:32633-32642.
5. Banno T, Gazel A, Blumenberg M. 2005. Pathway-specific profiling identifies the NF-{kappa}B-dependent tumor necrosis factor {alpha}-regulated genes in epidermal keratinocytes. J Biol Chem 280:18973-18980.
6. Bernard FX, Barrault C, Deguercy A, De Wever B, Rosdy M. 2000. Development of a highly sensitive in vitro phototoxicity assay using the SkinEthic reconstructed human epidermis. Cell Biol Toxicol 16:391-400.
7. Blaschko A. 1889. Die Berufsdermatosen der Arbeiter: ein Beitrag zur Gewerbehygiene. I. Galvaniseur-Ekzem. Dtsch Med Wohenschr 15:925-927.
8. Blumenberg M. 2005. Skinomics. J Invest Dermatol 124:viii-x.
9. Bolstad BM, Irizarry RA, Astrand M, Speed TP. 2003. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 19:185-193.
10. Cahan P, Ahmad AM, Burke H, Fu S, Lai Y, Florea L, Dharker N, Kobrinski T, Kale P, McCaffrey TA. 2005. List of lists-annotated (LOLA): A database for annotation and comparison of published microarray gene lists. Gene 360:78-82.
11. Cavani A, Nasorri F, Ottaviani C, Sebastiani S, De Pita O, Girolomoni G. 2003. Human CD25+ regulatory T cells maintain immune tolerance to nickel in healthy, nonallergic individuals. J Immunol 171:5760-5768.
12. Chen F, Ding M, Castranova V, Shi X. 2001. Carcinogenic metals and NF-kappaB activation. Mol Cell Biochem 222:159-171.
13. Cheng RY, Zhao A, Alvord WG, Powell DA, Bare RM, Masuda A, Takahashi T, Anderson LM, Kasprzak KS. 2003. Gene expression dose-response changes in microarrays after exposure of human peripheral lung epithelial cells to nickel(II). Toxicol Appl Pharmacol 191:22-39.
14. Costa M, Yan Y, Zhao D, Salnikow K. 2003. Molecular mechanisms of nickel carcinogenesis: Gene silencing by nickel delivery to the nucleus and gene activation/inactivation by nickel-induced cell signaling. J Environ Monit 5:222-223.
15. Costa M, Davidson TL, Chen H, Ke Q, Zhang P, Yan Y, Huang C, Kluz T. 2005. Nickel carcinogenesis: Epigenetics and hypoxia signaling. Mutat Res 592:79-88.
16. Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, Lempicki RA. 2003. DAVID: Database for annotation, visualization, and integrated discovery. Genome Biol 4:P3 [Epub 2003 April 2003].
17. Ding J, Zhang X, Li J, Song L, Ouyang W, Zhang D, Xue C, Costa M, Melendez JA, Huang C. 2006. Nickel compounds render anti-apoptotic effect to human bronchial epithelial beas-2B cells by induction of cyclooxygenase-2 through an IKKbeta/p65-dependent and IKK{alpha}- and p50-independent pathway. J Biol Chem 281:39022-39032.
18. Durham TR, Snow ET. 2006. Metal ions carcinogenesis. EXS 96:97-130.
19. Finelt N, Gazel A, Gorelick S, Blumenberg M. 2005. Transcriptional responses of human epidermal keratinocytes to Oncostatin-M. Cytokine 31:305-313.
20. Gandarillas A, Watt FM. 1997. c-Myc promotes differentiation of human epidermal stem cells. Genes Dev 11:2869-2882.
21. Garner LA. 2004. Contact dermatitis to metals. Dermatol Ther 17:321-327.
22. Gazel A, Ramphal P, Rosdy M, De Wever B, Tornier C, Hosein N, Lee B, Tomic-Canic M, Blumenberg M. 2003. Transcriptional profiling of epidermal keratinocytes: Comparison of genes expressed in skin, cultured keratinocytes, and reconstituted epidermis, using large DNA microarrays. J Invest Dermatol 121:1459-1468.
23. Gazel A, Banno T, Walsh R, Blumenberg M. 2006a. Inhibition of JNK promotes differentiation of epidermal keratinocytes. J Biol Chem 281:20530-20541.
24. Gazel A, Rosdy M, Bertino B, Tornier C, Sahuc F, Blumenberg M. 2006b. A characteristic subset of psoriasis-associated genes is induced by oncostatin-M in reconstituted epidermis. J Invest Dermatol 17:17.
25. Gueniche A, Viac J, Lizard G, Charveron M, Schmitt D. 1994. Effect of nickel on the activation state of normal human keratinocytes through interleukin 1 and intercellular adhesion molecule 1 expression. Br J Dermatol 131:250-256.
26. Haider AS, Peters SB, Kaporis H, Cardinale I, Fei J, Ott J, Blumenberg M, Bowcock AM, Krueger JG, Carucci JA. 2006. Genomic analysis defines a cancer-specific gene expression signature for human squamous cell carcinoma and distinguishes malignant hyperproliferation from benign hyperplasia. J Invest Dermatol 126:869-881.
27. Hirota M, Moro O. 2006. MIP-1beta, a novel biomarker for in vitro sensitization test using human monocytic cell line. Toxicol In Vitro 20:736-742.
28. Ho Sui SJ, Mortimer JR, Arenillas DJ, Brumm J, Walsh CJ, Kennedy BP, Wasserman WW. 2005. oPOSSUM: Identification of over-represented transcription factor binding sites in co-expressed genes. Nucleic Acids Res 33:3154-3164 [Print 2005].
29. Hogenesch JB, Chan WK, Jackiw VH, Brown RC, Gu YZ, Pray-Grant M, Perdew GH, Bradfield CA. 1997. Characterization of a subset of the basic-helix-loop- helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J Biol Chem 272:8581-8593.
30. Karaczyn AA, Golebiowski F, Kasprzak KS. 2006. Ni(II) affects ubiquitination of core histones H2B and H2A. Exp Cell Res 312:3252-3259.
31. Kasprzak KS, Bal W, Karaczyn AA. 2003a. The role of chromatin damage in nickel-induced carcinogenesis. A review of recent developments. J Environ Monit 5:183-187.
32. Kasprzak KS, Sunderman FW Jr, Salnikow K. 2003b. Nickel carcinogenesis. Mutat Res 533:67-97.
33. Kowara R, Karaczyn A, Cheng RY, Salnikow K, Kasprzak KS. 2005. Microarray analysis of altered gene expression in murine fibroblasts transformed by nickel(II) to nickel(II)-resistant malignant phenotype. Toxicol Appl Pharmacol 205:1-10.
34. Krob HA, Fleischer AB Jr, D'Agostino R Jr, Haverstock CL, Feldman S. 2004. Prevalence and relevance of contact dermatitis allergens: A meta-analysis of 15 years of published T.R.U.E. test data. J Am Acad Dermatol 51:349-353.
35. Li D, Turi TG, Schuck A, Freedberg IM, Khitrov G, Blumenberg M. 2001. Rays and arrays: The transcriptional program in the response of human epidermal keratinocytes to UVB illumination. FASEB J 15:2533-2535.
36. Lisby S, Muller KM, Jongeneel CV, Saurat JH, Hauser C. 1995. Nickel and skin irritants up-regulate tumor necrosis factor-alpha mRNA in keratinocytes by different but potentially synergistic mechanisms. Int Immunol 7:343-352.
37. Marchese C, Visco V, Aimati L, Cardinali G, Kovacs D, Buttari B, Bellocci M, Torrisi MR, Picardo M. 2003. Nickel-induced keratinocyte proliferation and up-modulation of the keratinocyte growth factor receptor expression. Exp Dermatol 12:497-505.
38. Maxwell P, Salnikow K. 2004. HIF-1: An oxygen and metal responsive transcription factor. Cancer Biol Ther 3:29-35.
39. Minang JT, Arestrom I, Zuber B, Jonsson G, Troye-Blomberg M, Ahlborg N. 2006. Nickel-induced IL-10 down-regulates Th1- but not Th2-type cytokine responses to the contact allergen nickel. Clin Exp Immunol 143:494-502.
40. Molenda M, Mukkamala L, Blumenberg M. 2006. Interleukin IL-12 blocks a specific subset of the transcriptional profile responsive to UVB in epidermal keratinocytes. Mol Immunol 43:1933-1940.
41. Nestle FO, Speidel H, Speidel MO. 2002. Metallurgy: High nickel release from 1- and 2-euro coins. Nature 419:132.
42. Newman JC, Weiner AM. 2005. L2L: A simple tool for discovering the hidden significance in microarray expression data. Genome Biol 6:R81.
43. Oxholm A, Oxholm P, Avnstorp C, Bendtzen K. 1991. Keratinocyte-expression of interleukin-6 but not of tumour necrosis factor-alpha is increased in the allergic and the irritant patch test reaction. Acta Derm Venereol 71:93-98.
44. Pratt MD, Belsito DV, DeLeo VA, Fowler JF Jr, Fransway AF, Maibach HI, Marks JG, Mathias CG, Rietschel RL, Sasseville D, Sherertz EF, Storrs FJ, Taylor JS, Zug K. 2004. North American Contact Dermatitis Group patch-test results, 2001-2002 study period. Dermatitis 15:176-183.
45. Radoja N, Gazel A, Banno T, Yano S, Blumenberg M. 2006. Transcriptional profiling of epidermal differentiation. Physiol Genomics 5:5.
46. Reid TM, Feig DI, Loeb LA. 1994. Mutagenesis by metal-induced oxygen radicals. Environ Health Perspect 102:57-61.
47. Rosdy M, Clauss LC. 1990. Terminal epidermal differentiation of human keratinocytes grown in chemically defined medium on inert filter substrates at the air-liquid interface. J Invest Dermatol 95:409-414.
48. Rosdy MBB, Butet V, Gibbs S, Ponec M, Darmon M. 1997. Retinoic acid inhibits epidermal differentiation when applied topically on the stratum corneum of epidermis formed in vitro by human keratinocytes grown on defined medium. In Vitro Mol Toxicol 11:39-47.
49. Salnikow K, Kasprzak KS. 2005. Ascorbate depletion: A critical step in nickel carcinogenesis? Environ Health Perspect 113:577-584.
50. Salnikow K, Davidson T, Zhang Q, Chen LC, Su W, Costa M. 2003. The involvement of hypoxia-inducible transcription factor-1-dependent pathway in nickel carcinogenesis. Cancer Res 63:3524-3530.
51. Schoeters E, Nuijten JM, Van Den Heuvel RL, Nelissen I, Witters H, Schoeters GE, Van Tendeloo VF, Berneman ZN, Verheyen GR. 2006. Gene expression signatures in CD34+-progenitor-derived dendritic cells exposed to the chemical contact allergen nickel sulfate. Toxicol Appl Pharmacol 216:131-149.
52. Schwarz G, Boehncke WH, Braun M, Schroter CJ, Burster T, Flad T, Dressel D, Weber E, Schmid H, Kalbacher H. 2002. Cathepsin S activity is detectable in human keratinocytes and is selectively upregulated upon stimulation with interferon-gamma. J Invest Dermatol 119:44-49.
53. Sebastiani S, Albanesi C, Nasorri F, Girolomoni G, Cavani A. 2002. Nickel-specific CD4(+) and CD8(+) T cells display distinct migratory responses to chemokines produced during allergic contact dermatitis. J Invest Dermatol 118:1052-1058.
54. Serveau-Avesque C, Martino MF, Herve-Grepinet V, Hazouard E, Gauthier F, Diot E, Lalmanach G. 2006. Active cathepsins B, H, K, L. and S in human inflammatory bronchoalveolar lavage fluids. Biol Cell 98:15-22.
55. Shimono A, Okuda T, Kondoh H. 1999. N-myc-dependent repression of ndr1, a gene identified by direct subtraction of whole mouse embryo cDNAs between wild type and N-myc mutant. Mech Dev 83:39-52.
56. Stojadinovic O, Lee B, Vouthounis C, Vukelic S, Pastar I, Blumenberg M, Brem H, Tomic-Canic M. 2006. Novel genomic effects of glucocorticoids in epidermal keratinocytes: Inhibition of apoptosis, IFNgamma pathway and wound healing along with promotion of terminal differentiation. J Biol Chem 9:9.
57. Stojadinovic O, Lee B, Vouthounis C, Vukelic S, Pastar I, Blumenberg M, Brem H, Tomic-Canic M. 2007. Novel genomic effects of glucocorticoids in epidermal keratinocytes: Inhibition of apoptosis, interferon-gamma pathway, and wound healing along with promotion of terminal differentiation. J Biol Chem 282:4021-4034.
58. Tornier C, Rosdy M, Maibach HI. 2006. In vitro skin irritation testing on reconstituted human epidermis: Reproducibility for 50 chemicals tested with two protocols. Toxicol In Vitro 20:401-416.
59. Van Der Sluijs KF, Van Elden LJ, Arens R, Nijhuis M, Schuurman R, Florquin S, Kwakkel J, Akira S, Jansen HM, Lutter R, Van Der Polls T. 2005. Enhanced viral clearance in interleukin-18 gene-deficient mice after pulmonary infection with influenza A virus. Immunology 114:112-120.
60. Waikel RL, Wang XJ, Roop DR. 1999. Targeted expression of c-Myc in the epidermis alters normal proliferation, differentiation and UV-B induced apoptosis. Oncogene 18:4870-4878.
61. Wakem P, Burns RP Jr, Ramirez F, Zlotnick D, Ferbel B, Haidaris CG, Gaspari AA. 2000. Allergens and irritants transcriptionally upregulate CD80 gene expression in human keratinocytes. J Invest Dermatol 114:1085-1092.
62. Wang GL, Semenza GL. 1995. Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 270:1230-1237.
63. Wiendl H, Lautwein A, Mitsdorffer M, Krause S, Erfurth S, Wienhold W, Morgalla M, Weber E, Overkleeft HS, Lochmuller H, Melms A, Tolosa E, Driessen C. 2003. Antigen processing and presentation in human muscle: Cathepsin S is critical for MHC class II expression and upregulated in inflammatory myopathies. J Neuroimmunol 138:132-143.
64. Zhou D, Salnikow K, Costa M. 1998. Cap43, a novel gene specifically induced by Ni2+ compounds. Cancer Res 58:2182-2189.
65. Zoroddu MA, Schinocca L, Kowalik-Jankowska T, Kozlowski H, Salnikow K, Costa M. 2002. Molecular mechanisms in nickel carcinogenesis: Modeling Ni(II) binding site in histone H4. Environ Health Perspect 110:719-723.