Epigenetic silencing of O6-methylguanine DNA methyltransferase gene in NiS-transformed cells

Carcinogenesis

Volumn 29, Issue 6, 2008, Pages 1267-1275

  Ji, Weidong ^a,b,c   Yang, Linqing ^b   Yu, Lei ^b   Yuan, Jianhui ^b   Hu, Dalin ^a   Zhang, Wenjuan ^a   Yang, Jianping ^a   Pang, Yaqin ^a   Li, Wenxue ^a   Lu, Jiachun ^c   Fu, Juan ^c   Chen, Jiakun ^c   Lin, Zhongning ^a   Chen, Wen ^a   Zhuang, Zhixiong ^a,b  

^a SUN YAT SEN UNIVERSITY   (China)

^b SHENZHEN CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^c GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; DNA BINDING PROTEIN 2; DNA METHYLTRANSFERASE 1; HISTONE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; NICKEL; SHORT HAIRPIN RNA; CARCINOGEN; DNA (CYTOSINE 5 ) METHYLTRANSFERASE 1; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE; MESSENGER RNA; MGMT PROTEIN, HUMAN; NICKEL SULFIDE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; BRONCHUS MUCOSA; CARCINOGENESIS; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DNA REPAIR; EPIGENETICS; GENE LOCUS; GENE SILENCING; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; MOLECULAR MECHANICS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; UPREGULATION; CELL LINE; DRUG EFFECT; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETICS; IMMUNOPRECIPITATION; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

BLOTTING, WESTERN; CARCINOGENS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DNA MODIFICATION METHYLASES; DNA REPAIR ENZYMES; GENE EXPRESSION; GENE SILENCING; HISTONES; HUMANS; IMMUNOPRECIPITATION; NICKEL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS;

EID: 46949093531     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgn012     Document Type: Article

References (50)

1. Grimsrud,T.K. et al. (2003) Lung cancer incidence among Norwegian nickel-refinery workers 1953-2000. J. Environ. Monit., 5, 190-197.
2. Report of the International Committee on Nickel Carcinogenesis in Man. Scand. J. Work Environ. Health, 16, 1-82.
3. Costa,M. et al. (2005) Nickel carcinogenesis: Epigenetics and hypoxia signaling. Mutat. Res., 592, 79-88.
4. Lu,H. et al. (2005) Carcinogenic effect of nickel compounds. Mol. Cell. Biochem., 279, 45-67.
5. Ke,Q. et al. (2006) Alterations of histone modifications and transgene silencing by nickel chloride. Carcinogenesis, 27, 1481-1488.
6. Zhao,J. et al. (2004) Nickel-induced down-regulation of serpin by hypoxic signaling. Toxicol. Appl. Pharmacol., 194, 60-68.
7. Yan,Y. et al. (2003) Analysis of specific lysine histone H3 and H4 acetylation and methylation status in clones of cells with a gene silenced by nickel exposure. Toxicol. Appl. Pharmacol., 190, 272-277.
8. Govindarajan,B. et al. (2002) Reactive oxygen-induced carcinogenesis causes hypermethylation of p16(Ink4a) and activation of MAP kinase. Mol. Med., 8, 1-8.
9. Lee,Y.W. et al. (1995) Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: A new model for epigenetic carcinogens. Mol. Cell. Biol., 15, 2547-2557.
10. Herceg,Z. (2007) Epigenetics and cancer: Towards an evaluation of the impact of environmental and dietary factors. Mutagenesis, 22 91-103.
11. Baylin,S.B. et al. (2006) Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? Nat. Rev. Cancer, 6, 107-116.
12. Hake,S.B. et al. (2007) Linking the epigenetic 'language' of covalent histone modifications to cancer. Br. J. Cancer, 96 ((suppl.)), R31-R39.
13. Brenner,C. et al. (2006) DNA methyltransferases: Facts, clues, mysteries. Curr. Top. Microbiol. Immunol., 301, 45-66.
14. Okano,M. et al. (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99, 247-257.
15. Wu,J. et al. (1993) Expression of an exogenous eukaryotic DNA methyl-transferase gene induces transformation of NIH 3T3 cells. Proc. Natl Acad. Sci. USA, 90, 9991-8895.
16. Suzuki,M. et al. (2004) RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells. Cancer Res., 64, 3137-3143.
17. Etoh,T. et al. (2004) Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers. Am. J. Pathol., 164, 689-699.
18. McCabe,M.T. et al. (2006) Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer. Cancer Res., 66, 385-392.
19. RobertM.F. et al. (2003) DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. Nat. Genet., 33, 61-65.
20. Fahmer,J.A. et al. (2002) Dependence of histone modifications and gene expression on DNA hypermethylation in cancer. Cancer Res., 62, 7213-7218.
21. Kimura,H. et al. (2003) Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1. J. Biol. Chem., 278, 4806-4812.
22. Ji,W.D. et al. (2006) Alterations of FHIT gene and P16 gene in nickel transformed human bronchial epithelial cells. Biomed. Environ. Sci., 19, 277-284.
23. Chen,C.D. et al. (2004) Crystalline nickel sulfide-induced genomic instability in transformed human bronchial epithelial cells. Clin. J. Ind. Hyg. Occup. Dis., 22, 57-59.
24. Hahn,W.C. et al. (2002) Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol. Cell. Biol., 22, 2111-2123.
25. Eads,C.A. et al. (2000) MethyLight: A high-throughput assay to measure DNA methylation. Nucleic Acids Res., 28, E32.
26. Qian,X.C. et al. (1997) Methylation hot spots in the 5′ flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene. Cancer Res., 57, 3672-3677.
27. Iwitzki,F. et al. (1998) Nickel(II) inhibits the repair of O6-methylguanine in mammalian cells. Arch. Toxicol., 72, 681-689.
28. Lopez-Serra,L. et al. (2006) A profile of methyl-CpG binding domain protein occupancy of hypermethylated promoter CpG islands of tumor suppressor genes in human cancer. Cancer Res., 66, 8342-8346.
29. Jones,P.A. et al. (2002) The fundamental role of epigenetic events in cancer. Nat. Rev. Genet., 3, 415-428.
30. Jaenisch,R. et al. (2003) Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals. Nat. Genet., 33 (suppl.), 245-254.
31. Esteller,M. et al. (1999) Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res., 59, 793-797.
32. Pegg,A.E. (2000) Repair of O(6)-alkylguanine by alkyltransferases. Mutat. Res., 462, 83-100.
33. Morita,H. et al. (1991) Mutagenicity of various chemicals including nickel and cobalt compounds in cultured mouse FM3A cells. Mutat. Res., 261, 131-137.
34. Goll,M.G. et al. (2005) Eukaryotic cytosine methyltransferases. Annu. Rev. Biochem., 74, 481-514.
35. Karpf,A.R. et al. (2005) Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells. Cancer Res., 65, 8635-8639.
36. Bakin,A.V. et al. (1999) Role of DNA 5-methylcytosine transferase in cell transformation by fos. Science, 283, 387-390.
37. Klein,C.B. et al. (1997) DNA methylation, heterochromatin and epigenetic carcinogens. Mutat. Res., 386, 163-180.
38. Ballestar,E. et al. (2001) Methyl-CpG-binding proteins. Targeting specific gene repression. Eur. J. Biochem., 268, 1-6.
39. Wade,P.A. (2001) Methyl CpG-binding proteins: Coupling chromatin architecture to gene regulation. Oncogene, 20, 3166-3173.
40. Ballestar,E. et al. (2003) Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer. EMBO J., 22, 6335-6345.
41. Nakagawachi,T. et al. (2003) Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer. Oncogene 22, 8835-8844.
42. Creusot,F. et al. (1982) Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-2′-deoxycytidine. J. Biol. Chem., 257 2041-2048.
43. Juttermann,R. et al. (1994) Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. Proc. Natl Acad. Sci. USA, 91, 11797-11801.
44. Otterson,G.A. et al. (1995) CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2′deoxycytidine. Oncogene, 11, 1211-1216.
45. Grunstein,M. (1997) Histone acetylation in chromatin structure and transcription. Nature, 389, 349-352.
46. Marks,P.A. et al. (2005) Histone deacetylase inhibitors: Discovery and development as anticancer agents. Expert Opin. Investig. Drugs 14, 1497-1511.
47. Paluszczak,J. et al. (2006) Epigenetic diagnostics of cancer - the application of DNA methylation markers. J. Appl. Genet., 47, 365-375.
48. Palmisano,W.A. et al. (2000) Predicting lung cancer by detecting aberrant promoter methylation in sputum. Cancer Res., 60, 5954-5958.
49. Field,J.K. et al. (2005) Methylation discriminators in NSCLC identified by a microarray based approach. Int. J. Oncol., 27 105-111.
50. Stirzaker,C. et al. (2004) Transcriptional gene silencing promotes DNA hypermethylation through a sequential change in chromatin modifications in cancer cells. Cancer Res., 64, 3871-3877.