A JAK2 interdomain linker relays epo receptor engagement signals to kinase activation

Journal of Biological Chemistry

Volumn 284, Issue 39, 2009, Pages 26988-26991

  Zhao, Lequn ^a   Dong, Hongyun ^a   Zhang, Cheng Cheng ^b   Kinch, Lisa ^a   Osawa, Mitsujiro ^b   Iacovino, Michelina ^b   Grishin, Nikolai V ^a   Kyba, Michael ^b   Huang, Lily Jun Shen ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOINHIBITION; C-TERMINAL REGIONS; CYTOKINE RECEPTOR; CYTOKINE STIMULATION; CYTOKINES; INTER-DOMAIN; JANUS KINASE 2; KINASE ACTIVATION; MYELOPROLIFERATIVE DISORDERS; N-TERMINALS; PSEUDOKINASE; SRC HOMOLOGY 2;

CHEMICAL ACTIVATION;

ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; JANUS KINASE 2;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HEK293; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; ERYTHROCYTOSIS; GAIN OF FUNCTION MUTATION; GENE MUTATION; HUMAN; HUMAN CELL; MISSENSE MUTATION; MOLECULAR INTERACTION; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CELL LINE; ENZYME ACTIVATION; HUMANS; IMMUNOBLOTTING; JANUS KINASE 2; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MUTATION, MISSENSE; PHOSPHORYLATION; POLYCYTHEMIA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ERYTHROPOIETIN; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; TRANSFECTION;

MUS;

EID: 70350351539     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.011387     Document Type: Article

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