Phosphorylation of Jak2 on Ser523 inhibits Jak2-dependent leptin receptor signaling

Molecular and Cellular Biology

Volumn 26, Issue 11, 2006, Pages 4063-4073

  Ishida Takahashi, Ryoko ^a   Rosario, Felicia ^b   Gong, Yusong ^a   Kopp, Keely ^a   Stancheva, Zlatina ^a   Chen, Xiaohong ^b   Feener, Edward P ^b   Myers Jr , Martin G ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b JOSLIN DIABETES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; CYTOKINE RECEPTOR; JANUS KINASE 2; LEPTIN RECEPTOR; SERINE; TYROSINE; CELL SURFACE RECEPTOR; GLUTAMIC ACID; JAK2 PROTEIN, HUMAN; JAK2 PROTEIN, MOUSE; ONCOPROTEIN; PHOSPHOSERINE; PROTEIN TYROSINE KINASE;

ANIMAL TISSUE; ARTICLE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SPLEEN; TANDEM MASS SPECTROMETRY; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; ENZYME ACTIVATION; ENZYME SPECIFICITY; GENE EXPRESSION REGULATION; GENETICS; MASS SPECTROMETRY; METABOLISM; MUTATION; PHOSPHORYLATION;

ANIMALS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTAMIC ACID; HUMANS; JANUS KINASE 2; MASS SPECTROMETRY; MICE; MUTATION; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

EID: 33646865516     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01589-05     Document Type: Article

References (36)

1. Argetsinger, L. S., J. L. Kouadio, H. Steen, A. Stensballe, O. N. Jensen, and C. Carter-Su. 2004. Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity. Mol. Cell. Biol. 24:4955-4967.
2. Banks, A. S., S. M. Davis, S. H. Bates, and M. G. Myers, Jr. 2000. Activation of downstream signals by the long form of the leptin receptor. J. Biol. Chem. 275:14563-14572.
3. Bjorbaek, C., H. J. Lavery, S. H. Bates, R. K. Olson, S. M. Davis, J. S. Flier, and M. G. Myers, Jr. 2000. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J. Biol. Chem. 275:40649-40657.
4. s6k phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases. Mol. Cell. Biol. 16: 6242-6251.
5. Dunn, S. L., M. Bjornholm, S. H. Bates, Z. Chen, M. Seifert, and M. G. Myers, Jr. 2005. Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3. Mol. Endocrinol. 19:925-938.
6. Feener, E. P., F. Rosario, S. L. Dunn, Z. Stancheva, and M. G. Myers, Jr. 2004. Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling. Mol. Cell. Biol. 24:4968-4978.
7. 1007 in the kinase activation loop. Mol. Cell. Biol. 17:2497-2501.
8. Flier, J. S., and E. Maratos-Flier. 1998. Obesity and the hypothalamus: novel peptides for new pathways. Cell 92:437-440.
9. Frank, S. J., W. Yi, Y. Zhao, J. F. Goldsmith, G. Gillíland, J. Jiang, I. Sakaí, and A. S. Kraft. 1995. Regions of the Jak2 tyrosine kinase required for coupling to the growth hormone receptor. J. Biol. Chem. 270:14776-14785.
10. Friedman, J. M. 2002. The function of leptin in nutrition, weight, and physiology. Nutr. Rev. 60:S1-S14.
11. Gadina, M., D. Hilton, J. A. Johnston, A. Morinobu, A. Lighvani, Y. J. Zhou, R. Visconti, and J. J. O'Shea. 2001. Signaling by type I and II cytokine receptors: ten years after. Curr. Opin. Immunol. 13:363-373.
12. Gandíno, L., M. F. Di Renzo, S. Giordano, F. Bussolino, and P. M. Comoglio. 1990. Protein kinase-c activation inhibits tyrosine phosphorylation of the c-mct protein. Oncogene 5:721-725.
13. Gerber, S. A., J. Rush, O. Stemman, M. W. Kirschner, and S. P. Gygi. 2003. Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS. Proc. Natl. Acad. Sci. USA 100:6940-6945.
14. Giordanetto, F., and R. T. Kroemer. 2002. Prediction of the structure of human Janus kinase 2 (JAK2) comprising JAK homology domains 1 through 7. Protein Eng. 15:727-737.
15. Herrington, J., and C. Carter-Su. 2001. Signaling pathways activated by the growth hormone receptor. Trends Endocrinol. Metab. 12:252-257.
16. Ihle, J. N., W. Thierfelder, S. Teglund, D. Stravapodis, D. Wang, J. Feng, and E. Parganas. 1998. Signaling by the cytokine receptor superfamily. Ann. N. Y. Acad. Sci. 865:1-9.
17. Kloek, C., A. K. Haq, S. L. Dunn, H. J. Lavery, A. S. Banks, and M. G. Myers, Jr. 2002. Regulation of Jak kinases by intracellular leptin receptor sequences. J. Biol. Chem. 277:41547-41555.
18. Kovanen, P. E., I. Juntlila, K. Takaluoma, P. Saharinen, L. Valmu, W. Li, and O. Silvennoinen. 2000. Regulation of Jak2 tyrosine kinase by protein kinase C during macrophage differentiation of IL-3-dependent myeloid progenitor cells. Blood 95:1626-1632.
19. Kurzer, J. H., L. S. Argetsinger, Y.-J. Zhou, J.-L. Kouadio, J. J. O'Shea, and C. Carter-Su. 2004. Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-Bβ. Mol. Cell. Biol. 24:4557-4570.
20. Livak, K. J., and T. D. Schmittgen. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔC(T)) method. Methods 25:402-408.
21. Luo, H., P. Rose, D. Barber, W. P. Hanratty, S. Lee, T. M. Roberts, A. D. D'Andrea, and C. R. Dearolf. 1997. Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways. Mol. Cell. Biol. 17:1562-1571.
22. 21a. Mazurkiewicz-Munoz, A. M., L. S. Argetsinger, J.-L. K. Kouadio, A. Stensballe, O. N. Jensen, J. M. Cline, and C. Carter-Su. 2006. Phosphorylation of JAK2 at serine 523: a negative regulator of JAK2 that is stimulated by growth hormone and epidermal growth factor. Mol. Cell. Biol. 26:4052-4062.
23. Munzberg, H., and M. G. Myers, Jr. 2005. Molecular and anatomical determinants of central leptin resistance. Nat. Neurosci. 8:566-570.
24. Myers, M. G., Jr. 2004. Leptin receptor signaling and the regulation of mammalian physiology. Recent Prog. Horm. Res. 59:287-304.
25. Myers, M. G., Jr., L. M. Wang, X. J. Sun, Y. Zhang, L. Yenush, J. Schlessinger, J. H. Pierce, and M. F. White. 1994. The role of IRS-1/GRB2 complexes in insulin signaling. Mol. Cell. Biol. 14:3577-3587.
26. O'Shea, J. J., A. Ma, and P. Lipsky. 2002. Cytokines and autoimmunity. Nat. Rev. Immunol. 2:37-45.
27. Rui, L., V. Aguirre, J. K. Kim, G. I. Shulman, A. Lee, A. Corbould, A. Dunaif, and M. F. White. 2001. Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways. J. Clin. Investig. 107:181-189.
28. Saatcioglu, F., G. Lopez, B. L. West, E. Zandi, W. Feng, H. Lu, A. Esmaili, J. W. Apriletti, P. J. Kushner, J. D. Baxter, and M. Karin. 1997. Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity. Mol. Cell. Biol. 17:4687-4695.
29. Saharinen, P., and O. Silvennoinen. 2002. The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction. J. Biol. Chem. 277:47954-47963.
30. Takayama, S., M. F. White, and C. R. Kahn. 1988. Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity. J. Biol. Chem. 263:3440-3447.
31. Tanti, J. F., T. Gremeaux, E. Van Obberghen, and Y. Le Marchand-Brustel. 1994. Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling. J. Biol. Chem. 269:6051-6057.
32. Tartaglia, L. A. 1997. The leptin receptor. J. Biol. Chem. 272:6093-6096.
33. Velazquez, L., K. E. Mogensen, G. Barbieri, M. Fellous, G. Uze, and S. Pellegrini. 1995. Distinct domains of the protein tyrosine kinase tyk2 required for binding of interferon-α/β and for signal transduction. J. Biol. Chem. 270:3327-3334.
34. Yeh, T. C., E. Dondi, G. Uze, and S. Pellegrini. 2000. A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-alpha signaling. Proc. Natl. Acad. Sci. USA 97:8991-8996.
35. Zhao, Y., F. Wagner, S. J. Frank, and A. S. Kraft. 1995. The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain. J. Biol. Chem. 270:13814-13818.
36. Zhou, Y. J., M. Chen, N. A. Cusack, L. H. Kimmel, K. S. Magnuson, J. G. Boyd, W. Lin, J. L. Roberts, A. Lengi, R. H. Buckley, R. L. Geahlen, F. Candotti, M. Gadina, P. S. Changelian, and J. J. O'Shea. 2001. Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases. Mol. Cell 8:959-969.