Shared structural determinants for the calcium-independent liposome membrane permeabilization and sarcolemma depolarization in Bothropstoxin-I, a LYS49-PLA2 from the venom of Bothrops jararacussu

International Journal of Biochemistry and Cell Biology

Volumn 41, Issue 12, 2009, Pages 2588-2593

  Aragão, Elisangela Aparecida ^a   Randazzo Moura, Priscila ^b   Rostelato Ferreira, Sandro ^b   Rodrigues Simioni, Léa ^b   Ward, Richard J ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Phrenic nerve diaphragm; Scanning mutagenesis

Indexed keywords

ALANINE; BOTHROPSTOXIN I; CALCIUM; CALCIUM INDEPENDENT PHOSPHOLIPASE A2; CREATINE KINASE; LIPOSOME; MUTANT PROTEIN; SNAKE VENOM; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; ARTIFICIAL MEMBRANE; BIOLOGICAL ACTIVITY; BIOLOGICAL MODEL; BOTHROPS JARARACUSSU; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE DEPOLARIZATION; CELL PERMEABILIZATION; CONTROLLED STUDY; DIAPHRAGM; ENZYME ASSAY; ENZYME RELEASE; INTERMETHOD COMPARISON; MALE; MEMBRANE DAMAGE; MEMBRANE STEADY POTENTIAL; MEMBRANE STRUCTURE; MOUSE; NONHUMAN; PHRENIC NERVE; PROTEIN EXPRESSION; SARCOLEMMA; SENSITIVITY AND SPECIFICITY; SITE DIRECTED MUTAGENESIS; SNAKE; TOXIN ANALYSIS;

ANIMALS; BOTHROPS; CALCIUM; CELL MEMBRANE PERMEABILITY; CROTALID VENOMS; GROUP II PHOSPHOLIPASES A2; LIPOSOMES; MALE; MEMBRANE POTENTIALS; MICE; MUTANT PROTEINS; ORGAN CULTURE TECHNIQUES; PHRENIC NERVE; SARCOLEMMA;

BOTHROPS JARARACUSSU;

EID: 70350303319     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2009.08.016     Document Type: Article

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