Restoration of enzymatic activity in a Ser-49 phospholipase A2 homologue decreases its Ca2+-independent membrane-damaging activity and increases its toxicity

Biochemistry

Volumn 46, Issue 44, 2007, Pages 12795-12809

  Petan, Toni ^a   Križaj, Igor ^a   Pungerčar, Jože ^a  

^a JO EF STEFAN INSTITUTE   (Slovenia)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMATICALLY ACTIVE MUTANTS; HYDROLYZED PHOSPHOLIPID VESICLES; MYOTOXIC ACTIVITY; PHOSPHOLIPASE;

CALCIUM; CATALYSIS; CYTOTOXICITY; PHOSPHOLIPIDS;

ENZYMES;

AMMODYTIN L; AMMODYTOXIN A; CALCIUM; MUTANT PROTEIN; PHOSPHOLIPASE A2; SERINE; TRYPTOPHAN; UNCLASSIFIED DRUG; VALINE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; EVOLUTION; MEMBRANE DAMAGE; MEMBRANE FUSION; MEMBRANE VESICLE; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CALCIUM; CELL MEMBRANE; CELLS, CULTURED; CYTOTOXINS; ENZYME ACTIVATION; FLUORESCEINS; MICE; MUTANT PROTEINS; PHOSPHOLIPASES A2, SECRETORY; PHOSPHOLIPIDS; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY; SEQUENCE HOMOLOGY, AMINO ACID; SERINE; UNILAMELLAR LIPOSOMES; VIPER VENOMS;

EID: 35848957282     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi701304e     Document Type: Article

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