Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: Involvement of spinal cord glia, proinflammatory cytokines and nitric oxide

Pain

Volumn 108, Issue 1-2, 2004, Pages 180-191

  Chacur, Marucia ^a,b   Milligan, Erin D ^b   Sloan, Evan M ^b   Wieseler Frank, Julie ^b   Barrientos, Ruth M ^b   Martin, David ^c   Poole, Stephen ^d   Lomonte, Brono ^e   Gutiérrez, Jose Maria ^e   Maier, Steven F ^b   Cury, Yara ^a   Watkins, Linda R ^b  

^a INSTITUTO BUTANTAN   (Brazil)

^b UNIVERSITY OF COLORADO   (United States)

^c AMGEN INC   (United States)

^d NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

^e UNIVERSIDAD DE COSTA RICA   (Costa Rica)

Author keywords

Allodynia; Astrocytes; Bothrops venom; Interleukin 1; Interleukin 6; Microglia

Indexed keywords

CYTOKINE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 6 ANTIBODY; NEUTRALIZING ANTIBODY; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PHOSPHOLIPASE A2; SNAKE VENOM;

ALLODYNIA; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME ISOLATION; ENZYME RELEASE; GLIA; HYPERALGESIA; INFLAMMATION; MALE; MICROGLIA; NONHUMAN; PERIPHERAL NERVE; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SCIATIC NERVE; SEQUENCE ANALYSIS; SNAKE; SPINAL CORD; SPINAL CORD DORSAL HORN;

EID: 10744222853     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2003.12.023     Document Type: Article

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