Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: Pharmacological mediation and molecular determinants

Toxicon

Volumn 41, Issue 6, 2003, Pages 667-678

  Chacur, M ^a   Longo, I ^a   Picolo, G ^a   Gutierrez J M ^b   Lomonte, B ^b   Guerra, J L ^c   Teixeira, C F P ^a   Cury, Y ^a  

^a INSTITUTO BUTANTAN   (Brazil)

^b UNIVERSIDAD DE COSTA RICA   (Costa Rica)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Biogenic amines; Bradykinin; Cytokines; Hyperalgesia; Phospholipases A2; Prostanoids; Sympathomimetic amines

Indexed keywords

4 BROMOPHENACYL BROMIDE; ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIHISTAMINIC AGENT; ASPARTIC ACID; ATENOLOL; BRADYKININ B2 RECEPTOR ANTAGONIST; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; GUANETHIDINE; HEPARIN; ICATIBANT; INDOMETACIN; INTERLEUKIN 1 ANTIBODY; LIPOXYGENASE INHIBITOR; LYSINE; METHYSERGIDE; MYOTOXIN II; MYOTOXIN III; N(G) METHYLARGININE; NITRIC OXIDE SYNTHASE INHIBITOR; PEPTIDE DERIVATIVE; PHOSPHOLIPASE A2; PRAZOSIN; PROMETHAZINE; PROSTAGLANDIN SYNTHASE INHIBITOR; SEROTONIN ANTAGONIST; SNAKE VENOM; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG; YOHIMBINE; ZILEUTON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; HYPERALGESIA; MALE; NOCICEPTION; NONHUMAN; PAIN ASSESSMENT; PRESSURE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN MODIFICATION; RAT; SNAKE; TIME;

BOTHROPS; BOTHROPS ASPER; SERPENTES;

EID: 0037408174     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(03)00007-2     Document Type: Article

References (65)

1. Allen A.C., Gammon C.M., Ousley A.H., Mccarthy K.D., Morell P. Bradykinin stimulates arachidonic acid release through the sequential actions of an sn-1 diacylglycerol lipase and a monoacylglycerol lipase. J. Neurochem. 58:1992;1130-1139.
2. 2 - a structural review. Toxicon. 34:1996;827-841.
3. 2 from Bothrops asper snake venom. Arch. Biochem. Biophys. 358:1998;343-350.
4. Calderon L., Lomonte B. Inhibition of the myotoxic activity of Bothrops asper myotoxin II in mice by immunization with its synthetic 13-mer peptide 115-129. Toxicon. 37:1999;683-687.
5. Carter G.W., Young P.R., Albert D.H., Bouska J., Dyer R., Bell R.L., Summers J.B., Brooks D.W. 5-lipoxygenase inhibitory activity of zileuton. J. Pharmacol. Exp. Ther. 256:1991;929-937.
6. 2 into the rat pleural cavity. Toxicon. 38:2000;1773-1785.
7. Chacur M., Picolo G., Gutiérrez J.M., Teixeira C.F.P., Cury Y. Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom. Toxicon. 39:2001;1173-1181.
8. 2 isolated from the venom of the snake Bothrops asper (terciopelo). Toxicon. 36:1998;1861-1869.
9. 2 on lumbar nerve root structure and function. Spine. 22:1997;1057-1064.
10. 2-induced histamine release from rat peritoneal mast cells. J. Pharmacodyn. 12:1989;517-522.
11. Cunha J.M., Cunha F.Q., Poole S., Ferreira S.H. Cytokine-mediated inflammatory hyperalgesia limited by interleukin-1 receptor antagonist. Br. J. Pharmacol. 130:2000;1418-1424.
12. Cunha F.Q., Lorenzetti B.B., Poole S., Ferreira S.H. Interleukin-8 as a mediator of sympathetic pain. Br. J. Pharmacol. 104:1991;765-767.
13. Cunha F.Q., Poole S., Lorenzetti B.B., Ferreira S.H. The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia. Br. J. Pharmacol. 107:1992;660-664.
14. 2. J. Biol. Chem. 269:1994;13057-13060.
15. Dray A., Perkins M. Bradykinin and inflammatory pain. Trends Neurosci. 16:1993;99-104.
16. Fan H.W., Cardoso J.L. Clinical toxicology of snake bites in South America. Meier J., White J. Handbook of Clinical Toxicology of Animal Venoms and Poisons. 1995;667-688 CRC Press, Boca Raton.
17. Farmer S.G., Burch R.M. Biochemical and molecular pharmacology of kinin receptors. Ann. Ver. Pharmacol. 32:1992;511-536.
18. Ferreira S.H., Lorenzetti B.B., Bristow A.F., Poole S. Interleukin-1 beta as a potent hyperalgesic agent antagonized by a tripeptide analogue. Nature. 334:1988;698-700.
19. Ferreira S.H., Lorenzetti B.B., Poole S. Bradykinin initiates cytokine-mediated inflammatory hyperalgesia. Br. J. Pharmacol. 110:1993;1227-1231.
20. Fock S., Mense S. Excitatory effects of 5-hydroxytryptamine, histamine and potassium ions on muscular group IV afferent units: a comparison with bradykinin. Brain Res. 105:1976;459-469.
21. 2. Arch. Biochem. Biophys. 284:1991;352-359.
22. Gammon C.M., Allen A.C., Morell P. Bradykinin stimulates phosphoinositide hydrolysis and mobilisation of arachidonic acid in dorsal root ganglion neurons. J. Neurochem. 53:1989;95-101.
23. Gutiérrez J.M. Clinical toxicology of snake bite in Central America. Meier J., White J. Handbook of Clinical Toxicology of Animal Venoms and Poisons. 1995;645-665 CRC Press, Boca Raton.
24. Gutiérrez J.M., Chaves F., Cerdas L. Inflammatory infiltrate in skeletal muscle injected with Bothrops asper venom. Rev. Biol. Trop. 34:1986;209-214.
25. 2 myotoxins from Bothrops snake venoms. Toxicon. 33:1995;1405-1424.
26. 2 Enzymes. Structure, Function and Mechanism. 1997;321-352 Wiley, United Kingdom.
27. Jänig W., Levine J.D., Michaelis M. Interactions of sympathetic and primary afferent neurones following nerve injury and tissue trauma. Prog. Brain Res. 113:1996;161-184.
28. Kaiser I.I., Gutiérrez J.M., Plummer D., Aird S.D., Odell G.V. The amino acid sequence of a myotoxic phospholipase from the venom of Bothrops asper. Arch. Biochem. Biophys. 278:1990;319-325.
29. 2 Enzymes: Structure, Function and Mechanism. 1997;1-28 Wiley, Chichester.
30. 2 enzymes. J. Mol. Evol. 48:1999;125-132.
31. 2 genes and in genomes of Viperidae snakes. Eur. J. Biochem. 246:1997;772-779.
32. 2 homologues: dissociation between enzymatic and biological activities. Eur. J. Pharmacol. 343:1998;257-263.
33. 2. Toxicon. 38:2000;199-208.
34. 2 purified from porcine pancreas and snake venoms. Toxicon. 31:1993;949-956.
35. Lomonte B., Gutiérrez J.M. A new muscle damaging toxin, myotoxin II, from the venom of the snake Bothrops asper (terciopelo). Toxicon. 27:1989;725-733.
36. 2 from Bothrops asper snake venom. Identification of a heparin-binding and cytolytic toxin region by the use of synthetic peptides and molecular modeling. J. Biol. Chem. 269:1994;29867-29873.
37. 2 expresses enhanced membrane-damaging activities and reproduces its in vivo myotoxic effect. Biochem. Biophys. Acta. 1461:1999;19-26.
38. 2 from Bothrops asper venom by glycosaminoglycans of the heparin/heparan sulfate family. Biochem. Pharmacol. 47:1994;1509-1518.
39. McMahon S.B. Mechanisms of sympathetic pain. J. Br. Med. Bull. 47:1991;584-600.
40. Mizumura K., Mizumura K., Minagawa M., Koda H., Kumazawa T. Influence of histamine on the bradykinin response of canine testicular polymodal receptors in vitro. Inflamm. Res. 44:1995;376-378.
41. 2-induced oedema in rat skin and histamine release in rat mast cells. Evidence for involvement of lysophospholipids in the mechanism of action. Agents Action. 36:1992;258-263.
42. 2 enzymes: regulation and physiological role. Biochem. Pharmacol. 48:1994;1-10.
43. Nakamura M., Ferreira S.H. A peripheral sympathetic component in inflammatory hyperalgesia. Eur. J. Pharmacol. 135:1987;145-153.
44. 2 from Agkistrodon piscivorus piscivorus snake venom: synthetic C-terminal peptides from Lys49, but not from Asp49 myotoxins, exert membrane-damaging activities. Toxicon. 39:2001;1587-1594.
45. Otero R., Tobon G.S., Gomes L.F., Osorio R., Valderrama R., Hoyos D., Urreta J.E., Molina S., Arboleda J.J. Acidente ofídico in Antioquia y Chocó. Aspectos clínicos y epidemiológicos. Acta. Méd. Colombiana. 17:1992;229-249.
46. 2 from Bothrops asper snake venom-synthetic Lys49 myotoxin II-(115-129)-peptide identifies its bactericidal region. Eur. J. Biochem. 253:1998;452-461.
47. Penning T.D., Talley J.J., Bertenshaw S.R., Carter J.S., Collins P.W., Docter S., Graneto M.J., Lee L.F., Malecha J.W., Miyashiro J.M., Rogers R.S., Rogier D.J., Yu S.S., Anderson G.D., Burton E.G., Cogburn J.N., Gregory S.A., Koboldt C.M., Perkins W.E., Seibert K., Veenhuizen A.W., Zhang Y.Y., Isakson P.C. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). J. Med. Chem. 40:1997;1347-1365.
48. Perkins M.N., Campbell E., Dray A. Antinociceptive activity of the bradykinin B1 and B2 receptor antagonists, des-Arg9, [Leu8]-BK and HOE 140, in two models of persistent hyperalgesia in the rat. Pain. 53:1993;191-197.
49. Poole S., Lorenzetti B.B., Cunha J.M., Cunha F.Q., Ferreira S.H. Bradykinin B1 and B2 receptors, tumour necrosis factor alpha and inflammatory hyperalgesia. Br. J. Pharmacol. 126:1999;649-656.
50. 2 activities on phagocytic functions of human polymorphonuclear and mononuclear phagocytes. Inflammation. 15:1991;127-135.
51. Randall L.O., Selitto J.J. A method for measurement of analgesia activity on inflamed tissue. Arch. Intern. Pharmacodyn. 111:1957;209-219.
52. 2 from bovine pancreas and Crotalus atrox venom. J. Biol. Chem. 260:1985;11627-11634.
53. Richardson B.P., Engel G. The pharmacology and function of 5-HT3 receptors. Trends Neurosc. 9:1986;424-427.
54. 2 induces vascular endothelial cell migration. Blood. 96:2000;3809-3815.
55. Rosenfeld G. Syntomatology, pathology and treatment of snake bites in South America. Bücherl W., Buckley E. Venomous animals and their venoms. vol. 2:1971;345-384 Academic Press, New York.
56. Sato J., Perl E.R. Adrenergic excitation of cutaneous pain receptors induced by peripheral nerve injury. Science. 251:1991;1608-1610.
57. Sato J., Suzuki S., Iseki T., Kumazawa T. Adrenergic excitation of cutaneous nociceptors in chronically inflamed rats. Neuroscience. 164:1993;225-228.
58. 2 enzymes: classification and characterization. Biochim. Biophys. Acta. 1488:2000;1-19.
59. Sokal R.R., Rohlf F.J. Biometry. 1981;Freeman WH, New York.
60. Teixeira C.F.P., Cury Y., Oga S., Jancar S. Hyperalgesia induced by Bothrops jararaca venom in rats: role of eicosanoids and platelet activating factor (PAF). Toxicon. 32:1994;419-426.
61. Treede R.D., Meyer R.A., Raja S.N., Campbell J.N. Peripheral and central mechanisms of cutaneous hyperalgesia. Prog. Neurobiol. 38:1992;397-421.
62. 2 and their receptors and binding proteins. Biochm. Biophys. 1488:2000;59-70.
63. Valerio R.M., Bray A.M., Campbell R.A., Dipasquale A., Margellis C., Rodda S.J., Geysen H.M., Maeji N.J. Multipin peptide synthesis at the micromole scale using 2-hydroxyethyl methacrylate grafted polyethylene supports. Int. J. Pept. Protein. 42:1993;1-9.
64. 2 enzymes from Trimeresurus mucrosquamatus venom. J. Pharm. Pharmacol. 44:1992;300-305.
65. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 16:1983;109-110.