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Volumn 101, Issue 5, 2009, Pages 343-351

Cytokines - Their pathogenic and therapeutic role in chronic viral hepatitis

Author keywords

Chronic hepatitis; Cytokines; HBV; HCV; Immunopathogenesis

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; GAMMA INTERFERON; INTERLEUKIN 10; PEGINTERFERON ALPHA; RIBAVIRIN;

EID: 70349976676     PISSN: 11300108     EISSN: None     Source Type: Journal    
DOI: 10.4321/S1130-01082009000500006     Document Type: Review
Times cited : (23)

References (72)
  • 2
    • 0035811625 scopus 로고    scopus 로고
    • Hepatitis C virus infection
    • Lauer GM, Walker BD. Hepatitis C virus infection. N Engl J Med 2001; 345: 41-52.
    • (2001) N Engl J Med , vol.345 , pp. 41-52
    • Lauer, G.M.1    Walker, B.D.2
  • 3
    • 1542316127 scopus 로고    scopus 로고
    • Hepatitis B Virus Infection - Natural History and Clinical Consequences
    • DOI 10.1056/NEJMra031087
    • Ganem D, Prince AM. Hepatitis B virus infection-natural history and clinical consequences. N Eng J Med 2004; 350: 1118-1129 (Pubitemid 38298992)
    • (2004) New England Journal of Medicine , vol.350 , Issue.11 , pp. 1118-1129
    • Ganem, D.1    Prince, A.M.2
  • 5
    • 0035062597 scopus 로고    scopus 로고
    • Noncytolytic control of viral infections by the innate and adaptive immune response
    • DOI 10.1146/annurev.immunol.19.1.65
    • Guidotti LG, Chisari FV. Noncytolitic control of viral infections by the innate and adaptative immune response. Annu Rev Immunol 2001; 19: 65-91. (Pubitemid 32368030)
    • (2001) Annual Review of Immunology , vol.19 , pp. 65-91
    • Guidotti, L.G.1    Chisari, F.V.2
  • 6
    • 0036884423 scopus 로고    scopus 로고
    • Natural killer cells and dendritic cells: Rendezvous in abused tissues
    • DOI 10.1038/nri956
    • Moretta A. Natural killer cells and dendritic cells: rendezvous in abused tissues. Nat Rev Immunol 2002; 12: 957-964 (Pubitemid 37323216)
    • (2002) Nature Reviews Immunology , vol.2 , Issue.12 , pp. 957-964
    • Moretta, A.1
  • 7
    • 15444363620 scopus 로고    scopus 로고
    • IL-12 or IL-4 prime human NK cells to mediate functionally divergent interactions with dendritic cells or tumors
    • Marcenaro E, Della Chiesa M, Bellora F, Parolini S, Millo R, Moretta L, et al. IL-12 or IL-4 prime human NK cells to mediate functionally divergent interactions with dendritic cells or tumors. J Immunol 2005; 174: 3992-3998 (Pubitemid 40395974)
    • (2005) Journal of Immunology , vol.174 , Issue.7 , pp. 3992-3998
    • Marcenaro, E.1    Della Chiesa, M.2    Bellora, F.3    Parolini, S.4    Millo, R.5    Moretta, L.6    Moretta, A.7
  • 9
    • 0036518287 scopus 로고    scopus 로고
    • Mouse and human dendritic cell subtypes
    • Shortman K, Liu YJ. Mouse and human dendritic cell subtypes. Nat Rev Immunol 2002; 2: 151-161 (Pubitemid 37336516)
    • (2002) Nature Reviews Immunology , vol.2 , Issue.3 , pp. 151-161
    • Shortman, K.1    Liu, Y.-J.2
  • 10
    • 32144454172 scopus 로고    scopus 로고
    • The many roles of chemokines and chemokine receptors in inflammation
    • Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Eng J Med 2006; 354: 610-621
    • (2006) N Eng J Med , vol.354 , pp. 610-621
    • Charo, I.F.1    Ransohoff, R.M.2
  • 11
    • 0033485942 scopus 로고    scopus 로고
    • Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver
    • Shields PL, Morland CM, Salmon M, Qin S, Hubscher SG, Adams DH. Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver. J Immunol 1999; 163: 6236-6243
    • (1999) J Immunol , vol.163 , pp. 6236-6243
    • Shields, P.L.1    Morland, C.M.2    Salmon, M.3    Qin, S.4    Hubscher, S.G.5    Adams, D.H.6
  • 12
    • 0032754504 scopus 로고    scopus 로고
    • Direct ex vivo analysis of hepatitis B virus-specific CD8(+) T cells associated with the control of infection
    • Maini MK, Boni C, Ogg GS, King AS, Reignat S, Lee CK, et al. Direct ex vivo analysis of hepatitis B virus-specific CD8(+) T cells associated with the control of infection. Gastroenterology 1999; 117: 1386-1396
    • (1999) Gastroenterology , vol.117 , pp. 1386-1396
    • Maini, M.K.1    Boni, C.2    Ogg, G.S.3    King, A.S.4    Reignat, S.5    Lee, C.K.6
  • 14
    • 70349965747 scopus 로고    scopus 로고
    • Chemokine receptor expression and cytokine production of HBV-specific CD8 cells
    • Larrubia JR, Herberg JA, Reignat S, Webster G, Williams R, Maini M, et al. Chemokine receptor expression and cytokine production of HBV-specific CD8 cells. J Hepatol 2000;32(S2): 90.
    • (2000) J Hepatol , vol.32 , Issue.S2 , pp. 90
    • Larrubia, J.R.1    Herberg, J.A.2    Reignat, S.3    Webster, G.4    Williams, R.5    Maini, M.6
  • 15
  • 16
    • 0034126609 scopus 로고    scopus 로고
    • Protection or damage: A dual role for the virus-specific cytotoxic T lymphocyte response in hepatitis B and C infection?
    • A Bertoletti, MK Maini. Protection or damage: a dual role for the virus-specific cytotoxic T lymphocyte response in hepatitis B and C infection? Curr Opin Immunol 2000; 12: 403-408
    • (2000) Curr Opin Immunol , vol.12 , pp. 403-408
    • Bertoletti, A.1    Maini, M.K.2
  • 17
    • 0026573138 scopus 로고
    • Search for hepatitis B virus cell receptors reveals binding sites for interleukin 6 on virus envelope protein
    • Neurath AR, Strick N, Sproul P. Search for hepatitis B virus cell receptors reveals binding sites for interleukin 6 on virus envelope protein. J Exp Med 1992; 175: 461-469
    • (1992) J Exp Med , vol.175 , pp. 461-469
    • Neurath, A.R.1    Strick, N.2    Sproul, P.3
  • 18
    • 0034767753 scopus 로고    scopus 로고
    • Antiviral actions of interferons
    • Samuel CE. Antiviral actions of interferons. Clin Microbiol Rev 2001; 14: 778-809.
    • (2001) Clin Microbiol Rev , vol.14 , pp. 778-809
    • Samuel, C.E.1
  • 19
    • 0034948009 scopus 로고    scopus 로고
    • DNA microarray analysis of chimpanzee liver during acute resolving hepatitis C virus infection
    • Bigger CB, Brasky KM, Landford RE. DNA microarray analysis of chimpanzee liver during acute resolving hepatitis C virus infection. J Virol 2001; 75: 7059-7066
    • (2001) J Virol , vol.75 , pp. 7059-7066
    • Bigger, C.B.1    Brasky, K.M.2    Landford, R.E.3
  • 22
    • 0034969251 scopus 로고    scopus 로고
    • Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response
    • DOI 10.1128/JVI.75.13.6095-6106.2001
    • Polyak SJ, Khabar KS, Paschal DM, Ezelle HJ, Duverlie G, Barber GN, et al. Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response. J Virol 2001; 75: 6095-6106 (Pubitemid 32553140)
    • (2001) Journal of Virology , vol.75 , Issue.13 , pp. 6095-6106
    • Polyak, S.J.1    Khabar, K.S.A.2    Paschal, D.M.3    Ezelle, H.J.4    Duverlie, G.5    Barber, G.N.6    Levy, D.E.7    Mukaida, N.8    Gretch, D.R.9
  • 27
    • 0023879634 scopus 로고
    • The replication cycle of hepatitis B viruses
    • Summers J. The replication cycle of hepatitis B viruses. Cancer 1988; 61: 1957-1962.
    • (1988) Cancer , vol.61 , pp. 1957-1962
    • Summers, J.1
  • 29
    • 0033617583 scopus 로고    scopus 로고
    • Viral clearance without destruction of infected cells during acute HBV infection
    • DOI 10.1126/science.284.5415.825
    • Guidotti LG, Rochford R, Chung J, Shapiro M, Purcell R, Chisari FV. Viral clearance without destruction of infected cells during acute HBV infection. Science 1999; 284: 825-829 (Pubitemid 29291352)
    • (1999) Science , vol.284 , Issue.5415 , pp. 825-829
    • Guidotti, L.G.1    Rochford, R.2    Chung, J.3    Shapiro, M.4    Purcell, R.5    Chisari, F.V.6
  • 30
    • 0037213545 scopus 로고    scopus 로고
    • + T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection
    • DOI 10.1128/JVI.77.1.68-76.2003
    • Thimme R, Wieland S, Steiger C, Ghrayeb J, Reimann KA, Purcell RH, et al. CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J Virol 2003; 77: 68-76. (Pubitemid 36004947)
    • (2003) Journal of Virology , vol.77 , Issue.1 , pp. 68-76
    • Thimme, R.1    Wieland, S.2    Steiger, C.3    Ghrayeb, J.4    Reimann, K.A.5    Purcell, R.H.6    Chisari, F.V.7
  • 32
    • 0037033363 scopus 로고    scopus 로고
    • Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions
    • DOI 10.1084/jem.20011145
    • Tseng CT, Klimpel GR. Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions. J Exp Med 2002; 195: 43-49 (Pubitemid 34074495)
    • (2002) Journal of Experimental Medicine , vol.195 , Issue.1 , pp. 43-49
    • Tseng, C.-T.K.1    Klimpel, G.R.2
  • 35
    • 22644432777 scopus 로고    scopus 로고
    • Subversion of plasmacytoid and myeloid dendritic cell functions in chronic HCV infection
    • DOI 10.1016/j.imbio.2005.05.018, PII S0171298505000914
    • Szabo G, Dolganiuc A. Subversion of plasmacytoid and myeloid dendritic cell functions in chronic HCV infection. Immunobiology 2005; 210: 237-247 (Pubitemid 41025165)
    • (2005) Immunobiology , vol.210 , Issue.2-4 , pp. 237-247
    • Szabo, G.1    Dolganiuc, A.2
  • 37
    • 0034278725 scopus 로고    scopus 로고
    • Dendritic cell regulation of Th1-Th2 development
    • Moser M, Murphy KM. Dendritic cell regulation of Th1-Th2 development. Nat Immunol 2001; 1: 199-203
    • (2001) Nat Immunol , vol.1 , pp. 199-203
    • Moser, M.1    Murphy, K.M.2
  • 41
    • 0036139684 scopus 로고    scopus 로고
    • Frequencies of HCV-specific effector CD4+ T cells by flow cytometry: Correlation with clinical disease stages
    • DOI 10.1053/jhep.2002.30293
    • Rosen HR, Miner C, Sasaki AW, Lewinsohn DM, Conrad AJ, Bakke A, et al. Frequencies of HCV-specific effector CD4+ T cells by flow cytometry: correlation with clinical disease stages. Hepatology 2002; 35: 190-198 (Pubitemid 34032560)
    • (2002) Hepatology , vol.35 , Issue.1 , pp. 190-198
    • Rosen, H.R.1    Miner, C.2    Sasaki, A.W.3    Lewinsohn, D.M.4    Conrad, A.J.5    Bakke, A.6    Bouwer, H.G.A.7    Hinrichs, D.J.8
  • 45
    • 0033690901 scopus 로고    scopus 로고
    • Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation
    • Kittlesen DJ, Chianese-Bullock KA, Yao ZQ, Braciale TJ, Hahn YS. Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation. J Clin Invest 2000; 106: 1239-1249
    • (2000) J Clin Invest , vol.106 , pp. 1239-1249
    • Kittlesen, D.J.1    Chianese-Bullock, K.A.2    Yao, Z.Q.3    Braciale, T.J.4    Hahn, Y.S.5
  • 47
    • 34548191951 scopus 로고    scopus 로고
    • + T cells associated with reversible immune dysfunction
    • DOI 10.1128/JVI.00409-07
    • Golden-Mason L, Palmer B, Klarquist J, Mengshol JA, Castelblanco N, Rosen HR. Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction. J Virol 2007; 81: 9249-9258 (Pubitemid 47311467)
    • (2007) Journal of Virology , vol.81 , Issue.17 , pp. 9249-9258
    • Golden-Mason, L.1    Palmer, B.2    Klarquist, J.3    Mengshol, J.A.4    Castelblanco, N.5    Rosen, H.R.6
  • 49
    • 44649166448 scopus 로고    scopus 로고
    • Dynamic programmed death 1 expression by virus-specific CD8 T cells correlates with the outcome of acute hepatitis B
    • Zhang Z, Zhang JY, Wherry EJ, Jin B, Xu B, Zou ZS, et al. Dynamic programmed death 1 expression by virus-specific CD8 T cells correlates with the outcome of acute hepatitis B. Gastroenterology 2008; 134: 1938-1949
    • (2008) Gastroenterology , vol.134 , pp. 1938-1949
    • Zhang, Z.1    Zhang, J.Y.2    Wherry, E.J.3    Jin, B.4    Xu, B.5    Zou, Z.S.6
  • 50
    • 7044247947 scopus 로고    scopus 로고
    • + regulatory T lymphocytes in hepatitis C virus infection
    • DOI 10.1002/hep.20454
    • Cabrera R, Tu Z, Xu Y, Firpi RJ, Rosen HR, Liu C, et al. An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection. Hepatology 2004; 40: 1062-1071 (Pubitemid 39425561)
    • (2004) Hepatology , vol.40 , Issue.5 , pp. 1062-1071
    • Cabrera, R.1    Tu, Z.2    Xu, Y.3    Firpi, R.J.4    Rosen, H.R.5    Liu, C.6    Nelson, D.R.7
  • 51
    • 14744271751 scopus 로고    scopus 로고
    • Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with hepatitis B virus infection
    • Franzese O, Kennedy PT, Gehring AJ, Gotto J, Williams R, Maini MK, et al. Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with hepatitis B virus infection. J Virol 2005; 79: 3322-3328
    • (2005) J Virol , vol.79 , pp. 3322-3328
    • Franzese, O.1    Kennedy, P.T.2    Gehring, A.J.3    Gotto, J.4    Williams, R.5    Maini, M.K.6
  • 53
    • 0034712874 scopus 로고    scopus 로고
    • Antibody and virus: Binding and neutralization
    • Burton DR, Williamson RA, Parren PW. Antibody and virus: binding and neutralization. Virology 2000; 270:1-3.
    • (2000) Virology , vol.270 , pp. 1-3
    • Burton, D.R.1    Williamson, R.A.2    Parren, P.W.3
  • 55
    • 63449102214 scopus 로고    scopus 로고
    • Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis C virus infection
    • Larrubia JR, Benito-Martínez S, Calvino M, Sanz de Villalobos E, Parra-Cid T. Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis C virus infection. World J Gastroenterol 2008; 14(47): 7149-7159
    • (2008) World J Gastroenterol , vol.14 , Issue.47 , pp. 7149-7159
    • Larrubia, J.R.1    Benito-Martínez, S.2    Calvino, M.3    De Sanz Villalobos, E.4    Parra-Cid, T.5
  • 56
    • 0036841051 scopus 로고    scopus 로고
    • Increased expression of T cell chemokines and their receptors in chronic hepatitis C: Relationship with the histological activity of liver disease
    • PII S0002927002054710
    • Apolinario A, Majano PL, Alvarez-Perez E, Saez A, Lozano C, Vargas J, et al. Increased expression of T cell chemokines and their receptors in chronic hepatitis C: relationship with the histological activity of liver disease. Am J Gastroenterol 2002; 97: 2861-2870 (Pubitemid 35265441)
    • (2002) American Journal of Gastroenterology , vol.97 , Issue.11 , pp. 2861-2870
    • Apolinario, A.1    Majano, P.L.2    Alvarez-Perez, E.3    Saez, A.4    Lozano, C.5    Vargas, J.6    Garcia-Monzon, C.7
  • 57
    • 70349964040 scopus 로고    scopus 로고
    • Chemokine receptor expression on T cells according to inflammatory activity and liver fibrosis in chronic hepatitis C virus infection
    • Calvino M, Larrubia JR, Sanz E, Perna C, Pérez J, Benito S, et al. Chemokine receptor expression on T cells according to inflammatory activity and liver fibrosis in chronic hepatitis C virus infection. J Hepatol 2006; 44(S2):161.
    • (2006) J Hepatol , vol.44 , Issue.S2 , pp. 161
    • Calvino, M.1    Larrubia, J.R.2    Sanz, E.3    Perna, C.4    Pérez, J.5    Benito, S.6
  • 59
    • 0035905411 scopus 로고    scopus 로고
    • Blocking chemokine responsive to γ-2/interferon (IFN)-γ inducible protein and monokine induced by IFN-γ activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T lymphocytes
    • DOI 10.1084/jem.194.12.1755
    • Kakimi K, Lane TE, Wieland S, Asensio VC, Campbell IL, Chisari FV, et al. Blocking chemokine responsive to gamma-2/interferon (IFN)-gamma inducible protein and monokine induced by IFN-gamma activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T lymphocytes. J Exp Med 2001; 194: 1755-1766 (Pubitemid 34028655)
    • (2001) Journal of Experimental Medicine , vol.194 , Issue.12 , pp. 1755-1766
    • Kakimi, K.1    Lane, T.E.2    Wieland, S.3    Asensio, V.C.4    Campbell, I.L.5    Chisari, F.V.6    Guidotti, L.G.7
  • 60
    • 70349937521 scopus 로고    scopus 로고
    • Analysis of CCR5 receptor expression on CD8 T cells during chronic hepatitis C virus infection. Role of pegylated-interferon a2b plus ribavirine treatment
    • Calvino M, Larrubia JR, Parra T, Sanz de Villalobos E, González F, Perna C, et al. Analysis of CCR5 receptor expression on CD8 T cells during chronic hepatitis C virus infection. Role of pegylated-interferon a2b plus ribavirine treatment. J Hepatol 2005; 42(S2): 155.
    • (2005) J Hepatol , vol.42 , Issue.S2 , pp. 155
    • Calvino, M.1    Larrubia, J.R.2    Parra, T.3    De Sanz Villalobos, E.4    González, F.5    Perna, C.6
  • 62
    • 0032792814 scopus 로고    scopus 로고
    • Transcriptional regulatory signals define cytokine-dependent and - Independent pathways in liver regeneration
    • Taub R, Greenbaum LE, Peng Y. Transcriptional regulatory signals define cytokine-dependent and -independent pathways in liver regeneration. Semin Liver Dis 1999; 19: 117-127 (Pubitemid 29326119)
    • (1999) Seminars in Liver Disease , vol.19 , Issue.2 , pp. 117-128
    • Taub, R.1    Greenbaum, L.E.2    Peng, Y.3
  • 63
    • 4444300866 scopus 로고    scopus 로고
    • Inflammation, damage repair, immune cells, and liver fibrosis: Specific or nonspecific, this is the question
    • DOI 10.1053/j.gastro.2004.07.041, PII S0016508504013496
    • Ramadori G, Saile B. Inflammation, damage repair, immune cells, and liver fibrosis: specific or nonspecific, this is the question. Gastroenterology 2004; 127: 997-1000. (Pubitemid 39208434)
    • (2004) Gastroenterology , vol.127 , Issue.3 , pp. 997-1000
    • Ramadori, G.1    Saile, B.2
  • 64
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferonalfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
    • DOI 10.1016/S0140-6736(01)06102-5
    • Manns MP, McHutchison JG, Gordon SC, Rustgi VK, Shiffman M, Reindollar R, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001; 358: 958-965 (Pubitemid 32913521)
    • (2001) Lancet , vol.358 , Issue.9286 , pp. 958-965
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3    Rustgi, V.K.4    Shiffman, M.5    Reindollar, R.6    Goodman, Z.D.7    Koury, K.8    Ling, M.-H.9    Albrecht, J.K.10
  • 66
    • 0029949897 scopus 로고    scopus 로고
    • Immunoregulatory cytokines in chronic hepatitis C virus infection: Pre- And posttreatment with interferon alfa
    • DOI 10.1053/jhep.1996.v24.pm0008707283
    • Cacciarelli TV, Martinez OM, Gish RG, Villanueva JC, Krams SM. Immunoregulatory cytokines in chronic hepatitis C virus infection: preand posttreatment with interferon alfa. Hepatology 1996; 24: 6-9. (Pubitemid 26249404)
    • (1996) Hepatology , vol.24 , Issue.1 , pp. 6-9
    • Cacciarelli, T.V.1    Martinez, O.M.2    Gish, R.G.3    Villanueva, J.C.4    Krams, S.M.5
  • 67
    • 0036788253 scopus 로고    scopus 로고
    • Peginterferon alone or with ribavirin enhances HCV-specific CD4 T-helper 1 responses in patients with chronic hepatitis C
    • Kamal SM, Fehr J, Roesler B, Peters T, Rasenack JW. Peginterferon alone or with ribavirin enhances HCV-specific CD4 T-helper 1 responses in patients with chronic hepatitis C. Gastroenterology 2002; 123: 1070-1083
    • (2002) Gastroenterology , vol.123 , pp. 1070-1083
    • Kamal, S.M.1    Fehr, J.2    Roesler, B.3    Peters, T.4    Rasenack, J.W.5
  • 71
    • 30944449094 scopus 로고    scopus 로고
    • Lamivudine plus interleukin-12 combination therapy in chronic hepatitis B: Antiviral and immunological activity
    • DOI 10.1002/hep.20888
    • Rigopoulou EI, Suri D, Chokshi S, Mullerova I, Rice S, Tedder RS, et al. Lamivudine plus interleukin-12 combination therapy in chronic hepatitis B: antiviral and immunological activity. Hepatology 2005; 42: 1028-1036 (Pubitemid 43112669)
    • (2005) Hepatology , vol.42 , Issue.5 , pp. 1028-1036
    • Rigopoulou, E.I.1    Suri, D.2    Chokshi, S.3    Mullerova, I.4    Rice, S.5    Tedder, R.S.6    Williams, R.7    Naoumov, N.V.8
  • 72
    • 0034022483 scopus 로고    scopus 로고
    • Interleukin 10 treatment reduces fibrosis in patients with chronic hepatitis C: A pilot trial of interferon nonresponders
    • Nelson DR, Lauwers GY, Lau JY, Davis GL. Interleukin 10 treatment reduces fibrosis in patients with chronic hepatitis C: a pilot trial of interferon nonresponders. Gastroenterology 2000; 118: 655-660 (Pubitemid 30171614)
    • (2000) Gastroenterology , vol.118 , Issue.4 , pp. 655-660
    • Nelson, D.R.1    Lauwers, G.Y.2    Lau, J.Y.N.3    Davis, G.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.