Transcriptional regulatory signals define cytokine-dependent and - independent pathways in liver regeneration

Seminars in Liver Disease

Volumn 19, Issue 2, 1999, Pages 117-128

  Taub, Rebecca ^a   Greenbaum, Linda E ^a   Peng, Yong ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cytokine; Hepectomy; Liver regeneration

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

CELL CYCLE; CYTOKINE RELEASE; DNA SYNTHESIS; IMMEDIATE EARLY GENE; LIVER REGENERATION; MOUSE; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0032792814     PISSN: 02728087     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-1007104     Document Type: Review

References (86)

1. Fausto N, Webber EM. Liver regeneration. In: Arias IM, Boyer JL, Fausto N, Jakoby WB, Schachter DA, Shafritz DA, eds. The Liver: Biology and Pathobiology. 3rd ed. New York: Raven Press, 1994:1059-1084
2. Michalopoulos GK, DeFrances MC. Liver regeneration. Science 1997;276:60-66
3. Taub R. Transcriptional control of liver regeneration. FASEB J 1996;10:413-427
4. Cressman DE, Greenbaum LE, DeAngelis RA, et al. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 1996;274:1379-1383
5. Yamada Y, Kirillova I, Peschon JJ, Fausto N. Initiation of liver growth by tumor necrosis factor: Defective liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc Natl Acad Sci USA 1997;94:1441-1446
6. Baumann H, Morella KK, Campos SP, et al. Role of CCAAT enhancer binding protein isoforms in the cytokine regulation of acute-phase plasma protein genes. J Biol Chem 1992;267: 19744-19751
7. Fattori E, Cappelletti M, Costa P, et al. Defective inflammatory response in interleukin 6-deficient mice. J Exp Med 1994;180: 1243-1250
8. Tanaka T, Akira S, Yoshida L, et al. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity to macrophages. Cell 1995;80:353-361
9. Screpanti I, Romani L, Musiani P, et al. Lymphoproliferative disorder and imbalance T-helper response in C/EBPβ-deficient mice. EMBO J 1995;14:1932-1941
10. Greenbaum LE, Cressman DE, Haber BA, Taub R. Coexistence of C/EBP alpha, beta, growth-induced proteins and DNA synthesis in hepatocytes during liver regeneration. Implications for maintenance of the differentiated state during liver growth. J Clin Invest 1995;96:1351-1365
11. Greenbaum LE, Li W, Cressman D, et al. CCAAT enhancer binding protein β is required for normal hepatocyte proliferation in mice after partial hepatectomy. J Clin Invest 1998;102:996-1007
12. Diamond RH, Cressman DE, Laz TM, Abrams CS, Taub R. PRL-1, a unique nuclear protein tyrosine phosphatase, affects cell growth. Mol Cell Biol 1994;14:3752-3762
13. Peng Y, Genin A, Spinner NB, et al. The gene encoding human nuclear protein tyrosine phosphatase. PRL-1. J Biol Chem 1998; 273:17286-17295
14. Deviere J, Content J, Denys C, et al. High interleukin-6 serum levels and increased production by leucocytes in alcoholic liver cirrhosis. Correlation with IgA serum levels and lymphokines production. Clin Exp Immunol 1989;77:221-225
15. Hill DB, Marsano L, Cohen D, et al. Increased plasma interleukin-6 concentrations in alcoholic hepatitis. J Lab Clin Med 1992;119:547-552
16. Tewari M, Dobrzanski P, Mohn KL, et al. Rapid induction in regenerating liver of RL/IF-1 (an IκB that inhibits NF-κB, RellB-p50, and c-Rel-p50) and PHF, a novel kb site-binding complex. Mol Cell Biol 1992;12:2898-2908
17. Cressman DE, Greenbaum LE, Haber BA, Taub R. Rapid activation of posthepatectomy factor/nuclearfactor κB in hepatocytes, a primary response in the regenerating liver. J Biol Chem 1994; 269:30429-30435
18. Cressman DE, Greenbaum LE, Haber BA, Taub R. Rapid activation of the STAT3 transcription complex in liver regeneration. Hepatology 1995;21:1443-1449
19. Ihle JN. STATs: Signal transducers and activators of transcription. Cell 1996;84:331-334
20. Kishimoto T, Akira S, Taga T. Interleukin-6 and its receptor: A paradigm for cytokines. Science 1992;258:593-597
21. Cornell RP, Liljequist BL, Bartizal KF. Depressed liver regeneration after partial hepatectomy of germ-free, athymic and lipopolysaccharide-resistant mice. Hepatology 1990;11:916-922
22. Cornell RP. Acute phase responses after acute liver injury by partial hepatectomy in rats as indicators of cytokine release. Hepatology 1990;11:923-931
23. Rokicki M, Rokicki W. Liver regeneration in rats after complete and partial occlusion of the portal blood influx. Res Exp Med 1993;193:305-313
24. Akerman P, Cote P, Yang SQ, et al. Antibodies to tumor necrosis factor-;Ginhibit liver regeneration after partial hepatectomy. Am J Physiol 1992;263:G579-G585
25. Pfeffer K, Matsuyama T, Kundig TM, et al. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 1993;73:457-467
26. Czaja MJ, Xu J, Alt E. Prevention of carbon tetrachloride-induced rat liver injury by soluble tumor necrosis factor receptor. Gastroenterology 1995;108:1849-1854
27. Kuma S, Inaba M, Ogata H, et al. Effect of human recombinant interleukin-6 on the proliferation of mouse epatocytes in the primary culture. Immunobiology 1990;180:235-242
28. Poli V, Balena R, Fattori E, et al. Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J 1994;13:1189-1196
29. Kopf M, Baumann H, Freer G, et al. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 1994;368:339-342
30. Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D. Embryonic lethality and liver degeneration in mice lacking the Re1A component of NF-kappa B. Nature 1995;376:167-170
31. Ruff-Jamison S, Zhong Z, Wen Z, Chen K, Darnell Jr. JE, Cohen S. Epidermal growth factor and lipopolysaccharide activate STAT3 transcription factor in mouse liver. J Biol Chem 1994; 269:21933-21935
32. David M, Petricoin E, 3rd, Benjamin C, Pine R, Weber MJ, Lamer AC. Requirement for MAP kinase (ERK2) activity in interferon alpha-and interferon beta-stimulated gene expression through STAT proteins. Science 1995;269:1721-1723
33. Takeda K, Noguchi K, Shi W, et al. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci USA 1997;94:3801-3804
34. Yamada Y, Fausto N. Deficient liver regeneration after carbon tetrachloride injury in mice lacking type 1 but not type 2 tumor necrosis factor receptor. Am J Pathol 1998;152:1577-1589
35. Mohn KE, Laz TM, Melby AE, Taub R. Immediate-early gene expression differs between regenerating liver, insulin-stimulated H-35 cells, and mitogen-stimulated 3T3 cells: Liver specific induction patterns of gene 33, PEPCK, and the jun, fos and egr families. J Biol Chem 1990;265:21914-21921
36. Haber BA, Chin S, Chuang E, et al. High levels of glucose-6-phosphatase gene and protein expression reflect an adaptive response in proliferating liver and diabetes. J Clin Invest 1995; 95:832-841
37. Wu KJ, Wilson DR, Shih C, Darlington GJ. The transcription factor HNF1 acts with C/EBP alpha to synergistically activate the human albumin promoter through a novel domain. J Biol Chem 1994;269:1177-1182
38. Ray A, Hannink M, Ray BK. Concerted participation of NF-kappa B and C/EBP heteromer in lipopolysaccharide induction of serum amyloid A gene expression in liver. J Biol Chem 1995; 270:7365-7374
39. Chen P-L, Riley DJ, Chen-Kiang S, Lee W-H. Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6. Proc Natl Acad Sci USA 1996;93:464-469
40. Lee YH, Yano M, Liu SY, et al. A novel cis-acting element controlling the rat CYP2D5 gene and requiring cooperatively between C/EBP beta and an Sp1 factor. Mol Cell Biol 1994;14: 1383-1394
41. Lee YH, Williams SC, Baer M, et al. The ability of C/EBP beta but not C/EBP alpha to synergize with an Sp1 protein is specified by the leucine zipper and activation domain. Mol Cell Biol 1997;17:2038-2047
42. Stein BP, Cogeswell PC, Baldwin AS Jr. Functional and physical associations between NF-κB and C/EBP family members: A Rel domain-bZIP interaction. Mol Cell Biol 1993;13:3964-3974
43. Wang ND, Finegold MJ, Bradley A, et al. Impaired energy homeostasis in C/EBP alpha knockout mice. Science 1995; 269:1108-1112
44. Croniger C, Trus M, Lysek-Stupp K, et al. Role of the isoforms of CCAAT/enhancer-binding protein in the initiation of phosphoenolpyruvate carboxykinase (GTP) gene transcription at birth. J Biol Chem 1997;272:26306-26312
45. Umek RM, Friedman AD, McKnight SL. CCAAT/enhancer binding protein: A component of a differentiation switch. Science 1991;251:288-292
46. Freytag SO, Geddes TJ. Reciprocal regulation of adipogenesis by myc and C/EBPα. Science 1992;256:379-382
47. Lin F-T, MacDougald OA, Diehl AM, Lane MD. A 30-kDa alternative translation product of the CCAAT/enhancer binding protein α message: Transcriptional activity lacking antimitotic activity. Proc Natl Acad Sci USA 1993;90:9606-9610
48. Timchenko NA, Wilde M, Nakanishi M, et al. CCAAT/enhancer-binding protein a (C/EBPα) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein. Genes Dev 1996;10:804-815
49. Diehl AM, Johns DC, Yang S, et al. Adenovirus-mediated transfer of CCAAT/enhancer-binding protein-alpha identifies a dominant antiproliferative role for this isoform in hepatocytes. J Biol Chem 1996;271:7343-7350
50. Buck M, Turler H, Chojkier M. LAP(NF-IL-6), a tissue-specific transcriptional activator, is an an inhibitor of hepatoma cell proliferation. EMBO J 1994;13:851-860
51. Chinery R, Brockman JA, Peeler MO, et al. Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: A p53-independent induction of p21WAF1/CIP1 via C/EBPbeta. Nature Med 1997;3:1233-1241
52. Rana B, Xie Y, Mischoulon D, et al. The DNA binding activity of C/EBP transcription factors is regulated in the G1 phase of the hepatocyte cell cycle. J Biol Chem 1995;270:18123-18132
53. Trautwein C, Caelles C, van der Geer P, et al. Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain. Nature 1993;364:544-547
54. Niehof M, Manns MP, Trautwein C. CREB controls LAP/C/EBP beta transcription. Mol Cell Biol 1997;17:3600-3613
55. Cappelliti M, Alonzi T, Fattori E, et al. C/EBPβ is required for the late phases of acute phase genes in induction in the liver and for tumour necrosis factor-α, but not Interleukin-6, regulation. Cell Death Diff 1996;3:29-35
56. Nakajima T, Kinoshita S, Sasagawa T, et al. Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc Natl Acad Sci USA 1993;90:2207-2211
57. Metz R, Xiff E. cAMP stimulates the C/EBP-related transcrption factor rNFIL-6 to translocate to the nucleus and induce c-fos transcription. Genes Dev 1991;5:1754-1766
58. Wegner M, Cao Z, Rosenfeld MG. Calcium-regulated phosphorylation within the leucine zipper of C/EBPβ. Science 1992;256:370-363
59. Chinery R, Brockman JA, Dransfield DT, Coffey RJ. Antioxidant-induced nuclear translocation of CCAAT/enhancer-binding protein beta. A critical role for protein kinase A-mediated phosphorylation of Ser299 [published erratum appears in J Biol Chem 1998 Jun 12;273(24):15308]. J Biol Chem 1997;272:30356-30361
60. Akira S, Isshiki H, Sugita T, et al. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J 1990;9:1897-1906
61. Poli V, Mancini FP, Cortese R. IL-6DBP. a nuclear protein invoked in interleukin-6-signal transduction, defines a new family of leucine zipper proteins related to C/EBP. Cell 1990;63:643-653
62. Spector MS, Auer KL, Jarvis WD, et al. Differential regulation of the mitogen-activated protein and stress-activated protein kinase cascades by adrenergic agonists in quiescent and regenerating adult rat hepatocytes. Mol Cell Biol 1997;17:3556-3565
63. Daksis JI, Lu LM, Facchini WW, et al. Myc induces cyclin D1 expression in the absence of de novo protein synthesis and links mitogen-stimulated signal transduction to the cell cycle. Oncogene 1994;9:3635-3645
64. Phuchareon J, Tokuhisa T. Deregulated c-Fos/AP-1 modulates expression of the cyclin and the cdk gene in splenic B cells stimulated with lipopolysaccharide. Cancer Lett 1995;92:203-208
65. Henglein B, Brechot C. Cyclin A is requied in S phase in normal epithelial cells. Biochem Biophys Res Commun 1992;182:1144-1154
66. Factor VM, Thorgeirsson SS. Coexpression of C-myc and transforming growth factor alfa in the liver promotes earli replicative senescence and diminishes regenerative capacity after partial hepatectomy in transgenic mice. Hepatology 1997;26: 1434-1443
67. Loyer P, Cariou S, Glaise D, et al. Growth factor dependence of progression through G1 and S phases of adult rat hepatocytes in vitro. Evidence of a mitogen restriction point in mid-late G1. J Biol Chem 1996;271:11484-11492
68. Trembley JH, Ebbert JO, Kren BT, Steer CJ. Differential regulation of cyclin B1 RNA and protein expression during hepatocyte growth in vivo. Cell Growth Diff 1996;7:903-916
69. Trembley JH, Kren BT, Steer CJ. Posttranscriptional regulation of cyclin B messenger RNA expression in the regenerating rat liver. Cell Growth Diff 1994;5:99-108
70. Bennett LM, Farnham PJ, Drinkwater NR, Strain-dependent differences in DNA synthesis and gene expression in the regenerating livers of CB57BL/6J and C3H/HeJ mice. Mol Carcinog 1995;14:46-52
71. Liu Y, Michalopoulos GK, Zarnegar R. Structural and functional characterization of the mouse hepatocyte growth factor gene promoter. J Biol Chem 1994;269:4152-4160
72. Diamond RH, Peters C, Jung SP, et al. Expression of PRL-1 nuclear PTPase is associated with proliferation in liver but with differentiation in intestine. Am J Physiol 1996;271:G121-129
73. Sukhatme VP, Cao XM, Chang LC, et al. A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell 1988;53:37-43
74. Milbrandt J. A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. Science 1987;238:797-799
75. Lemaire P, Revelant O, Bravo R, Charnay P. Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells. Proc Natl Acad Sci USA 1988;85:4691-4695
76. Christy B, Nathans D. DNA binding site of the growth factor-inducible protein Zif268. Proc Natl Acad Sci USA 1989;86: 8737-8741
77. Simmons DL, Levy DB, Yannoni Y, Erikson RL. Identification of a phorbol ester-repressible v-src-inducible gene. Proc Natl Acad Sci USA 1989;86:1178-1182
78. Lim RW, Varnum BC, Herschman HR. Cloning of tetradecanoyl phorbol ester-induced "primary response" sequences and their expression in density-arrested Swiss 3T3 cells and a TPA non-proliferative variant. Oncogene 1987;1:263-270
79. Khachigian LM, Lindner V, Williams AJ, Collins T. Egr-1-induced endothelial gene expression: A common theme in vascular injury. Science 1996;271:1427-1431
80. Rudnicki MA, Jackowski G, Saggin L, McBurney MW. Actin and myosin expression during development of cardiac muscle from cultured embryonal carcinoma cells. Dev Biol 1990;138: 348-358
81. Sukhatme VP. Early transcriptional events in cell growth: The Egr family. J Am Soc Nephrol 1990;1:859-866
82. Nguyen HQ, Hoffman-Liebermann B, Liebermann DA. The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage. Cell 1993;72:197-209
83. Wright JJ, Gunter KC, Mitsuya H, et al. Expression of a zinc finger gene in HTLV-I-and HTLV-II-transformed cells. Science 1990;248:588-591
84. Lee SL, Sadovsky Y, Swirnoff AH, et al. Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGF1-A (Egr-1). Science 1996;273:1219-1221
85. Peng Y, Du K, Ramirez S, Diamond RH, Taub R. Mitogenic upregulation of the PRL-1 protein tyrosine phosphatase gene by Egr-1. J Biol Chem (in press)
86. Maione D, DiCarlo E, Li W, et al. Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver. EMBO J 1998;17:5588-5597