Novel naphthalimide derivatives as potential apoptosis-inducing agents: Design, synthesis and biological evaluation

European Journal of Medicinal Chemistry

Volumn 44, Issue 11, 2009, Pages 4674-4680

  Wu, Aibin ^a   Xu, Yufang ^a   Qian, Xuhong ^a   Wang, Jin ^a   Liu, Jianwen ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Antitumor; Apoptosis; Cytotoxicity; G2 M arrest; Naphthalimide

Indexed keywords

2 (2 (DIMETHYLAMINO)ETHYL) 6 (THIOPHENE 2 YLMETHYLAMINO) 1H BENZO[DE]ISOQUINOLINE 1,3(2H) DIONE; 2 (2 (DIMETHYLAMINO)ETHYL) 6 [2 (PHENYLTHIO)ETHYLAMINO] 1H BENZO[DE]ISOQUINOLINE 1,3(2H) DIONE; 2 (2 (DIMETHYLAMINO)ETHYL) 6 THIOMORPHOLINO 1H BENZO[DE]ISOQUINOLINE 1,3(2H) DIONE; 2 [2 (DIMETHYLAMINO)ETHYL] 6 [4 (3,3 DIPHENYLALLYL)PIPERAZIN1 YL] 1H BENZO[DE]ISOQUINOLINE 1,3(2H) DIONE; 2 [2 (DIMETHYLAMINO)ETHYL] 6 [4 [3 [4 (DIMETHYLAMINO)PHENYL]ALLYL]PIPERAZIN 1 YL] 1H BENZO[DE]ISOQUINOLINE 1,3(2H) DIONE; 2 [2 (DIMETHYLAMINO)ETHYL] 6 [4 [4 [4 (3,3 DIPHENYLALLYL)PIPERAZIN 1 YL]BENZOYL]PIPERAZIN 1 YL] 1H BENZO[DE]ISOQUINOLINE 1,3(2H) DIONE; 4 [3 [4 [2 [2 (DIMETHYLAMINO)ETHYL] 1,3 DIOXO 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLIN 6 YL)]PIPERAZIN 1 YL]PROP 1 ENYL]BENZONITRILE; 6 (4 CINNAMYLPIPERAZIN 1 YL) 2 [2 (DIMETHYLAMINO)ETHYL] 1H BENZO[DE]ISOQUINOLINE 1,3(2H) DIONE; 6 [6 [BIS(3,3 DIPHENYLALLYL)AMINO]HEXYLAMINO] 2 [2 (DIMETHYLAMINO)ETHYL] 1H BENZO[DE]ISOQUINOLINE 1,3(2H) DIONE; AMONAFIDE; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; N [6 [2 [2 (DIMETHYLAMINO)ETHYL] 1,3 DIOXO 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLIN 6 YLAMINO]HEXYL] 4 [4 (3,3 DIPHENYLALLYL)PIPERAZIN 1YL]BENZAMIDE; NAPHTHALIMIDE DERIVATIVE; PROPIDIUM IODIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CONTROLLED STUDY; CYTOMETRY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MOUSE; NONHUMAN; STAINING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; DRUG SCREENING ASSAYS, ANTITUMOR; G2 PHASE; HL-60 CELLS; HUMANS; NAPHTHALIMIDES;

EID: 70349772961     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.07.011     Document Type: Article

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