M2-A induces apoptosis and G2-M arrest via inhibiting PI3 K/Akt pathway in HL60 cells

Cancer Letters

Volumn 283, Issue 2, 2009, Pages 193-202

  Wang, Jin ^a   Wu, Aibin ^a   Xu, Yufang ^a   Liu, Jianwen ^a   Qian, Xuhong ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Amonafide; Apoptosis; G2 M phase growth arrest; Inhibit PI3 K Akt pathway; M2 A

Indexed keywords

2 [2 (DIMETHYLAMINO)ETHYL] 6 (THIOPHENE 2 YLMETHYLAMINO) 1H BENZO[DE]ISOQUINOLINE 1,3(2H) DIONE; CASPASE 3; CASPASE 9; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NAPHTHALIMIDE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P85; UNCLASSIFIED DRUG; AMONAFIDE; ANTINEOPLASTIC AGENT;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CELL STRAIN HL 60; CELL STRAIN MCF 7; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HELA CELL; HUMAN; HUMAN CELL; IC 50; LEUKEMIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; UPREGULATION; CHEMISTRY; DRUG EFFECT; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; DNA FRAGMENTATION; FLOW CYTOMETRY; G2 PHASE; HL-60 CELLS; HUMANS; MICROSCOPY, FLUORESCENCE; NAPHTHALIMIDES; PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 69849107875     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2009.03.039     Document Type: Article

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