Novel naphthalimide-amino acid conjugates with flexible leucine moiety as side chain: Design, synthesis and potential antitumor activity

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 2, 2009, Pages 592-599

  Wu, Aibin ^a   Xu, Yufang ^a   Qian, Xuhong ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Antitumor; Leucine; MCF 7; Naphthalimide

Indexed keywords

2 [1,3 DIOXO 6 [2 (PHENYLTHIO)ETHYLAMINO] 1H BENZO[DE]ISOQUINOLIN 2(3H) YL] 4 METHYL N (4 SULFAMOYLPHENYL)PENTANAMIDE; AMINO ACID DERIVATIVE; BOVINE SERUM ALBUMIN; INTERCALATING AGENT; LEUCINE; N (4' AMINO 3,3' DIMETHOXYBIPHENYL 4 YL) 2 [1,3 DIOXO 6 [2 (PHENYLTHIO)ETHYLAMINO] 1H BENZO[DE]ISOQUINOLIN 2(3H) YL] 4 METHYLPENTANAMIDE; N [4 (4 AMINOPHENYLSULFONYL)PHENYL] 2 [1,3 DIOXO 6 [2 (PHENYLTHIO)ETHYLAMIDO] 1H BENZO[DE]ISOQUINOLIN 2(3H) YL] 4 METHYLPENTANAMIDE; NAPHTHALIMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL STRAIN MCF 7; CONJUGATE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG DNA BINDING; DRUG SYNTHESIS; HELA CELL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

AMINO ACIDS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; DRUG DESIGN; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; INTERCALATING AGENTS; LEUCINE; NAPHTHALIMIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 58549117087     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.11.080     Document Type: Article

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