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Volumn 8, Issue 1, 2007, Pages 113-121

Novel Bcl-2 inhibitors: Discovery and mechanism study of small organic apoptosis-inducing agents

(10) Zhang, Zhichao a Jin, Liji a Qian, Xuhong a,b Wei, Meijiao a,c Wang, Yuanyuan a Wang, Jing a Yang, Yuanyuan a Xu, Qin a Xu, Yongting d Liu, Fengyu a

a DALIAN UNIVERSITY OF TECHNOLOGY (China)

b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)

c PEKING UNIVERSITY (China)

d LIAONING NORMAL UNIVERSITY (China)

Author keywords

Apoptosis; Bcl 2; Drug design; Heterocycles; Nonintercalators

Indexed keywords

8 OXO 3 [(THIENYLMETHYL)AMINO] 8H ACENAPHTHO[1,2 B]PYRROLE 9 CARBONITRILE; 8 OXO 3 THIOMORPHOLIN 4 YL 8H ACENAPHTHOL[1,2 B]PYRROLE 9 CARBONITRILE; ANTINEOPLASTIC AGENT; APOPTOSIS INDUCING FACTOR; CASPASE 3; CASPASE 9; PROTEIN BCL 10; PROTEIN BCL 2; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; COMPUTER MODEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; ENZYME ACTIVATION; HEPATOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE; MOUSE; MYELOID LEUKEMIA; NONHUMAN; PRIORITY JOURNAL; SURVIVAL TIME;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; DNA; GENE EXPRESSION REGULATION, NEOPLASTIC; HL-60 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTO-ONCOGENE PROTEINS C-BCL-2; TIME FACTORS;

MUS;

EID: 33846305793 PISSN: 14394227 EISSN: 14397633 Source Type: Journal
DOI: 10.1002/cbic.200600305 Document Type: Article

Times cited : (73)

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