Design, synthesis, and computational studies of inhibitors of Bcl-X L

Journal of the American Chemical Society

Volumn 128, Issue 50, 2006, Pages 16206-16212

  Park, Cheol Min ^a,b   Oie, Tetsuro ^a,c   Petros, Andrew M ^a,c   Zhang, Haichao ^a,b   Nimmer, Paul M ^a,b   Henry, Rodger F ^a,c   Elmore, Steven W ^a,b  

^a ABBOTT LABORATORIES   (United States)

^b Cancer Research   (United States)

^c Advanced Technologies

Author keywords

[No Author keywords available]

Indexed keywords

BINDING AFFINITY; GLOBAL ENERGY; INHIBITION CONSTANT; PROTEIN INHIBITORS; STERIC INTERACTIONS;

CONFORMATIONS; NUCLEAR MAGNETIC RESONANCE; QUANTUM THEORY; STABILIZATION; UREA; X RAY CRYSTALLOGRAPHY;

PROTEINS;

POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PROTEIN BCL XL; PROTEIN INHIBITOR; UREA DERIVATIVE;

ARTICLE; BINDING AFFINITY; CALCULATION; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENERGY; GEOMETRY; HYDROGEN BOND; LIGAND BINDING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION; PROTEIN INTERACTION; QUANTUM MECHANICS; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

BCL-X PROTEIN; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY;

EID: 33845570247     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0650347     Document Type: Article

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