Structure-activity relationships of Bak derived peptides: Affinity and specificity modulations by amino acid replacement

European Journal of Medicinal Chemistry

Volumn 43, Issue 5, 2008, Pages 966-972

  Frey, Virginie ^a,b   Viaud, Julien ^a,b   Subra, Guy ^a,b   Cauquil, Nicolas ^c   Guichou, Jean François ^a,b   Casara, Patrick ^c   Grassy, Gérard ^a,b   Chavanieu, Alain ^a,b  

^a INSERM   (France)

^b CENTRE DE BIOCHIMIE STRUCTURALE   (France)

^c INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

Apoptosis; Bcl 2; Bcl xL; Selectivity; Structure activity relationships

Indexed keywords

FENCLONINE; PEPTIDE DERIVATIVE; PROTEIN BAK; PROTEIN BCL 2; PROTEIN BCL XL;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG STRUCTURE; FLUORESCENCE POLARIZATION IMMUNOASSAY; PHYSICAL CHEMISTRY; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION;

AMINO ACID SUBSTITUTION; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-X PROTEIN; CIRCULAR DICHROISM; FLUORESCENCE POLARIZATION; MUTATION; OLIGOPEPTIDES; PEPTIDES, CYCLIC; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-BCL-2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 43049124214     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.06.008     Document Type: Article

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