Designing evolvable libraries using multi-body potentials

Current Opinion in Biotechnology

Volumn 20, Issue 4, 2009, Pages 437-446

  Lappe, Michael ^a   Bagler, Ganesh ^a   Filippis, Ioannis ^a   Stehr, Henning ^a   Duarte, Jose M ^a   Sathyapriya, Rajagopal ^a  

^a MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTATIONAL DESIGN; DIRECTED EVOLUTION; EFFICIENT SAMPLING; ENERGY FUNCTIONS; ENERGY LANDSCAPE; EVOLVABLE; EXPERIMENTAL STRATEGY; HIGH-THROUGHPUT TECHNOLOGIES; LIBRARY DESIGNS; MULTI-BODY; PHYSICS-BASED; PROBABILISTIC CONSTRAINTS; SEQUENCE SPACE; STRUCTURE PREDICTION;

KNOWLEDGE BASED SYSTEMS;

LIBRARIES;

BETA LACTAMASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

AMINO ACID SEQUENCE; BIOINFORMATICS; COMPUTER MODEL; COMPUTER PREDICTION; DIRECTED MOLECULAR EVOLUTION; GENE MUTATION; MOLECULAR LIBRARY; MUTAGENESIS; PRIORITY JOURNAL; PROBABILITY; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN STRUCTURE; REVIEW; THERMOSTABILITY;

COMBINATORIAL CHEMISTRY TECHNIQUES; DIRECTED MOLECULAR EVOLUTION; DRUG EVALUATION, PRECLINICAL; MODELS, MOLECULAR; PROBABILITY; THERMODYNAMICS;

EID: 70349769486     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.copbio.2009.07.008     Document Type: Review

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