The function of activity-regulated genes in the nervous system

Physiological Reviews

Volumn 89, Issue 4, 2009, Pages 1079-1103

  Loebrich, Sven ^a   Nedivi, Elly ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVITY REGULATED CYTOSKELETON ASSOCIATED PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLOOXYGENASE 2; GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PENTRAXIN; POLO LIKE KINASE 2; PROTEIN HOMER 1; RGS PROTEIN; SCLEROPROTEIN; SIGNAL PEPTIDE;

ADULT; BRAIN FUNCTION; CELL FUNCTION; CELL STRUCTURE; GENE CONTROL; HUMAN; IMMEDIATE EARLY GENE; LEARNING; MEMORY; NERVE CELL PLASTICITY; NERVE FIBER GROWTH; NERVOUS SYSTEM; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SYNAPTIC INHIBITION; SYNAPTIC TRANSMISSION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANIMALS; GENE EXPRESSION; GENES, IMMEDIATE-EARLY; HUMANS; NERVOUS SYSTEM PHYSIOLOGICAL PHENOMENA; NEURONAL PLASTICITY; SIGNAL TRANSDUCTION; SYNAPSES; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 70349663992     PISSN: 00319333     EISSN: 15221210     Source Type: Journal    
DOI: 10.1152/physrev.00013.2009     Document Type: Review

References (294)

1. Aid T, Kazantseva A, Piirsoo M, Palm K, Timmusk T. Mouse and rat BDNF gene structure and expression revisited. J Neurosci Res 85: 525-535, 2007. (Pubitemid 46318317)
2. Alberini CM. Transcription factors in long-term memory and synaptic plasticity. Physiol Rev 89: 121-145, 2009.
3. Alitalo K, Ramsay G, Bishop JM, Pfeifer SO, Colby WW, Levinson AD. Identification of nuclear proteins encoded by viral and cellular myc oncogenes. Nature 306: 274-277, 1983. (Pubitemid 14232359)
4. Almendral JM, Sommer D, Macdonald-Bravo H, Burckhardt J, Perera J, Bravo R. Complexity of the early genetic response to growth factors in mouse fibroblasts. Mol Cell Biol 8: 2140-2148, 1988. (Pubitemid 18123103)
5. Altar CA, Laeng P, Jurata LW, Brockman JA, Lemire A, Bullard J, Bukhman YV, Young TA, Charles V, Palfreyman MG. Electroconvulsive seizures regulate gene expression of distinct neurotrophic signaling pathways. J Neurosci 24: 2667-2677, 2004. (Pubitemid 38380943)
6. Ang XL, Seeburg DP, Sheng M, Harper JW. Regulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons. J Biol Chem 283: 29424-29432, 2008.
7. Angelastro JM, Klimaschewski L, Tang S, Vitolo OV, Weissman TA, Donlin LT, Shelanski ML, Greene LA. Identification of diverse nerve growth factor-regulated genes by serial analysis of gene expression (SAGE) profiling. Proc Natl Acad Sci USA 97:10424-10429, 2000. (Pubitemid 30707282)
8. Ango F, Pin JP, Tu JC, Xiao B, Worley PF, Bockaert J, Fagni L. Dendritic and axonal targeting of type 5 metabotropic glutamate receptor is regulated by homer1 proteins and neuronal excitation. J Neurosci 20: 8710-8716, 2000.
9. Ango F, Prezeau L, Muller T, Tu JC, Xiao B, Worley PF, Pin JP, Bockaert J, Fagni L. Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer. Nature 411: 962-965, 2001. (Pubitemid 32601494)
10. Ango F, Robbe D, Tu JC, Xiao B, Worley PF, Pin JP, Bockaert J, Fagni L. Homer-dependent cell surface expression of metabotropic glutamate receptor type 5 in neurons. Mol Cell Neurosci 20: 323-329, 2002. (Pubitemid 34762140)
11. Ayer-LeLievre C, Olson L, Ebendal T, Seiger A, Persson H. Expression of the beta-nerve growth factor gene in hippocampal neurons. Science 240: 1339-1341, 1988. (Pubitemid 18155918)
12. Balschun D, Wolfer DP, Gass P, Mantamadiotis T, Welzl H, Schutz G, Frey JU, Lipp HP. Does cAMP response element-binding protein have a pivotal role in hippocampal synaptic plasticity and hippocampus-dependent memory? J Neurosci 23: 6304-6314, 2003. (Pubitemid 36875632)
13. Baranes D, Lederfein D, Huang YY, Chen M, Bailey CH, Kandel ER. Tissue plasminogen activator contributes to the late phase of LTP and to synaptic growth in the hippocampal mossy fiber pathway. Neuron 21: 813-825, 1998. (Pubitemid 28498789)
14. Barbosa AC, Kim MS, Ertunc M, Adachi M, Nelson ED, McAnally J, Richardson JA, Kavalali ET, Monteggia LM, Bassel-Duby R, Olson EN. MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function. Proc Natl Acad Sci USA 105: 9391-9396, 2008.
15. Barde YA, Edgar D, Thoenen H. Purification of a new neurotrophic factor from mammalian brain. EMBO J 1: 549-553, 1982.
16. Barth AL, Gerkin RC, Dean KL. Alteration of neuronal firing properties after in vivo experience in a FosGFP transgenic mouse. J Neurosci 24: 6466-6475, 2004.
17. Bear MF, Huber KM, Warren ST. The mGluR theory of fragile X mental retardation. Trends Neurosci 27: 370-377, 2004. (Pubitemid 38829251)
18. Beattie EC, Carroll RC, Yu X, Morishita W, Yasuda H, von Zastrow M, Malenka RC. Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD. Nat Neurosci 3: 1291-1300, 2000. (Pubitemid 30951644)
19. Beneken J, Tu JC, Xiao B, Nuriya M, Yuan JP, Worley PF, Leahy DJ. Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition. Neuron 26: 143-154, 2000. (Pubitemid 30947707)
20. Berman DM, Gilman AG. Mammalian RGS proteins: barbarians at the gate. J Biol Chem 273: 1269-1272, 1998.
21. Berridge M. Second messenger dualism in neuromodulation and memory. Nature 323: 294-295, 1986. (Pubitemid 16033125)
22. Blendy JA, Kaestner KH, Schmid W, Gass P, Schutz G. Targeting of the CREB gene leads to up-regulation of a novel CREB mRNA isoform. EMBO J 15: 1098-1106, 1996. (Pubitemid 26077838)
23. Bliss TV, Collingridge GL. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361: 31-39, 1993. (Pubitemid 23020772)
24. Bliss TV, Lomo T. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol 232: 331-356, 1973.
25. Bolen JB, Thiele CJ, Israel MA, Yonemoto W, Lipsich LA, Brugge JS. Enhancement of cellular src gene product associated tyrosyl kinase activity following polyoma virus infection and transformation. Cell 38: 767-777, 1984.
26. Bos TJ, Monteclaro FS, Mitsunobu F, Ball AR Jr, Chang CH, Nishimura T, Vogt PK. Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and noncoding sequences. Genes Dev 4: 1677-1687, 1990. (Pubitemid 20352068)
27. Bottai D, Guzowski JF, Schwarz MK, Kang SH, Xiao B, Lanahan A, Worley PF, Seeburg PH. Synaptic activity-induced conversion of intronic to exonic sequence in Homer 1 immediate early gene expression. J Neurosci 22: 167-175, 2002. (Pubitemid 34033494)
28. Bourtchuladze R, Frenguelli B, Blendy J, Cioffi D, Schutz G, Silva AJ. Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell 79:59-68, 1994. (Pubitemid 24309513)
29. Bradbury A, Possenti R, Shooter EM, Tirone F. Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization. Proc Natl Acad Sci USA 88: 3353-3357, 1991. (Pubitemid 21916619)
30. Brakeman PR, Lanahan AA, O'Brien R, Roche K, Barnes CA, Huganir RL, Worley PF. Homer: a protein that selectively binds metabotropic glutamate receptors. Nature 386: 284-288, 1997. (Pubitemid 27142514)
31. Buonomano DV, Merzenich MM. Cortical plasticity: from synapses to maps. Annu Rev Neurosci 21: 149-186, 1998.
32. Burchett SA, Volk ML, Bannon MJ, Granneman JG. Regulators of G protein signaling: rapid changes in mRNA abundance in response to amphetamine. J Neurochem 70: 2216-2219, 1998.
33. Byrne JH. Cellular analysis of associative learning. Physiol Rev 67: 329-439, 1987.
34. Cabelli RJ, Hohn A, Shatz CJ. Inhibition of ocular dominance column formation by infusion of NT-4/5 or BDNF. Science 267: 1662-1666, 1995.
35. Cabelli RJ, Shelton DL, Segal RA, Shatz CJ. Blockade of endogenous ligands of trkB inhibits formation of ocular dominance columns. Neuron 19: 63-76, 1997.
36. Cantallops I, Cline HT. Rapid activity-dependent delivery of the neurotrophic protein CPG15 to the axon surface of neurons in intact Xenopus tadpoles. Dev Neurobiol 68: 744-759, 2008. (Pubitemid 351620768)
37. Cantallops I, Haas K, Cline HT. Postsynaptic CPG15 promotes synaptic maturation and presynaptic axon arbor elaboration in vivo. Nat Neurosci 3: 1004-1011, 2000. (Pubitemid 30749200)
38. Capdevila JH, Falck JR, Estabrook RW. Cytochrome P450 and the arachidonate cascade. FASEB J 6: 731-736, 1992.
39. Carew TJ, Hawkins RD, Kandel ER. Differential classical conditioning of a defensive withdrawal reflex in Aplysia californica. Science 219: 397-400, 1983.
40. Carroll RC, Beattie EC, Xia H, Luscher C, Altschuler Y, Nicoll RA, Malenka RC, von Zastrow M. Dynamin-dependent endocytosis of ionotropic glutamate receptors. Proc Natl Acad Sci USA 96:14112-14117, 1999.
41. Castren E, Zafra F, Thoenen H, Lindholm D. Light regulates expression of brain-derived neurotrophic factor mRNA in rat visual cortex. Proc Natl Acad Sci USA 89: 9444-9448, 1992.
42. Chiu IM, Reddy EP, Givol D, Robbins KC, Tronick SR, Aaronson SA. Nucleotide sequence analysis identifies the human c-sis proto-oncogene as a structural gene for platelet-derived growth factor. Cell 37: 123-129, 1984. (Pubitemid 14079843)
43. Cho RW, Park JM, Wolff SB, Xu D, Hopf C, Kim JA, Reddy RC, Petralia RS, Perin MS, Linden DJ, Worley PF. mGluR1/5-dependent long-term depression requires the regulated ectodomain cleavage of neuronal pentraxin NPR by TACE. Neuron 57: 858-871, 2008.
44. Chowdhury S, Shepherd JD, Okuno H, Lyford G, Petralia RS, Plath N, Kuhl D, Huganir RL, Worley PF. Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. Neuron 52: 445-459, 2006. (Pubitemid 44667430)
45. Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MR, Goodman RH. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365: 855-859, 1993. (Pubitemid 23341031)
46. Cochran BH, Reffel AC, Stiles CD. Molecular cloning of gene sequences regulated by platelet-derived growth factor. Cell 33: 939-947, 1983.
47. Cohen S, Greenberg ME. Communication between the synapse and nucleus in neuronal development, plasticity, and disease. Annu Rev Cell Dev Biol 24: 183-209, 2008.
48. Cole AJ, Saffen DW, Baraban JM, Worley PF. Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation. Nature 340: 474-476, 1989.
49. Collingridge GL, Kehl SJ, McLennan H. The antagonism of amino acid-induced excitations of rat hippocampal CA1 neurones in vitro. J Physiol 334: 19-31, 1983. (Pubitemid 13176080)
50. Colvis CM, Pollock JD, Goodman RH, Impey S, Dunn J, Mandel G, Champagne FA, Mayford M, Korzus E, Kumar A, Renthal W, Theobald DE, Nestler EJ. Epigenetic mechanisms and gene networks in the nervous system. J Neurosci 25: 10379-10389, 2005. (Pubitemid 41628442)
51. Corriveau RA, Huh GS, Shatz CJ. Regulation of class I MHC gene expression in the developing and mature CNS by neural activity. Neuron 21: 505-520, 1998.
52. Corriveau RA, Shatz CJ, Nedivi E. Dynamic regulation of cpg15 during activity-dependent synaptic development in the mammalian visual system. J Neurosci 19: 7999-8008, 1999. (Pubitemid 30225796)
53. Cottrell JR, Borok E, Horvath TL, Nedivi E. CPG2: a brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors. Neuron 44: 677-690, 2004. (Pubitemid 39531231)
54. Curran T, Franza BR Jr. Fos and Jun: the AP-1 connection. Cell 55: 395-397, 1988.
55. Curran T, Miller AD, Zokas L, Verma IM. Viral and cellular fos proteins: a comparative analysis. Cell 36: 259-268, 1984. (Pubitemid 14126218)
56. Curran T, Morgan JI. Superinduction of c-fos by nerve growth factor in the presence of peripherally active benzodiazepines. Science 229: 1265-1268, 1985. (Pubitemid 15021677)
57. Dash PK, Hochner B, Kandel ER. Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation. Nature 345: 718-721, 1990. (Pubitemid 20186548)
58. Davis HP, Squire LR. Protein synthesis and memory: a review. Psychol Bull 96: 518-559, 1984.
59. DeFeo-Jones D, Tatchell K, Robinson LC, Sigal IS, Vass WC, Lowy DR, Scolnick EM. Mammalian and yeast ras gene products: biological function in their heterologous systems. Science 228: 179-184, 1985.
60. Deisseroth K, Bito H, Tsien RW. Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity. Neuron 16: 89-101, 1996. (Pubitemid 26044732)
61. Dodds DC, Omeis IA, Cushman SJ, Helms JA, Perin MS. Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49. J Biol Chem 272: 21488-21494, 1997.
62. Doolittle RF, Hunkapiller MW, Hood LE, Devare SG, Robbins KC, Aaronson SA, Antoniades HN. Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. Science 221: 275-277, 1983.
63. Douglas RM, Dragunow M, Robertson HA. High-frequency discharge of dentate granule cells, but not long-term potentiation, induces c-fos protein. Brain Res 464: 259-262, 1988. (Pubitemid 18244352)
64. Downward J, Yarden Y, Mayes E, Scrace G, Totty N, Stockwell P, Ullrich A, Schlessinger J, Waterfield MD. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature 307: 521-527, 1984. (Pubitemid 14135812)
65. Dragunow M, Peterson MR, Robertson HA. Presence of c-fos-like immunoreactivity in the adult rat brain. Eur J Pharmacol 135: 113-114, 1987. (Pubitemid 17051020)
66. Dragunow M, Robertson HA. Generalized seizures induce c-fos protein(s) in mammalian neurons. Neurosci Lett 82: 157-161, 1987. (Pubitemid 17156757)
67. Dragunow M, Robertson HA. Kindling stimulation induces c-fos protein(s) in granule cells of the rat dentate gyrus. Nature 329: 441-442, 1987. (Pubitemid 17128313)
68. Dumuis A, Sebben M, Haynes L, Pin JP, Bockaert J. NMDA receptors activate the arachidonic acid cascade system in striatal neurons. Nature 336: 68-70, 1988. (Pubitemid 18262135)
69. Eckerdt F, Yuan J, Strebhardt K. Polo-like kinases and oncogenesis. Oncogene 24: 267-276, 2005.
70. Ehlers MD. Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting. Neuron 28: 511-525, 2000.
71. Eisenman RN, Tachibana CY, Abrams HD, Hann SR. V-myc- and c-myc-encoded proteins are associated with the nuclear matrix. Mol Cell Biol 5: 114-126, 1985.
72. Elliott RC, Miles MF, Lowenstein DH. Overlapping microarray profiles of dentate gyrus gene expression during development- and epilepsy-associated neurogenesis and axon outgrowth. J Neurosci 23: 2218-2227, 2003.
73. Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, Blundell TL, Pepys MB, Wood SP. Structure of pentameric human serum amyloid P component. Nature 367: 338-345, 1994. (Pubitemid 24062339)
74. Ernfors P, Bengzon J, Kokaia Z, Persson H, Lindvall O. Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis. Neuron 7: 165-176, 1991.
75. Ernfors P, Ibanez CF, Ebendal T, Olson L, Persson H. Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain. Proc Natl Acad Sci USA 87: 5454-5458, 1990. (Pubitemid 20260199)
76. Etter PD, Narayanan R, Navratilova Z, Patel C, Bohmann D, Jasper H, Ramaswami M. Synaptic and genomic responses to JNK and AP-1 signaling in Drosophila neurons. BMC Neurosci 6: 39, 2005. (Pubitemid 41418236)
77. Fagni L, Worley PF, Ango F. Homer as both a scaffold and transduction molecule. Sci STKE 2002: RE8, 2002.
78. Figurov A, Pozzo-Miller LD, Olafsson P, Wang T, Lu B. Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus. Nature 381: 706-709, 1996. (Pubitemid 26196571)
79. Flavell SW, Cowan CW, Kim TK, Greer PL, Lin Y, Paradis S, Griffith EC, Hu LS, Chen C, Greenberg ME. Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. Science 311: 1008-1012, 2006. (Pubitemid 43271729)
80. Flavell SW, Greenberg ME. Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system. Annu Rev Neurosci 31: 563-590, 2008.
81. Flavell SW, Kim TK, Gray JM, Harmin DA, Hemberg M, Hong EJ, Markenscoff-Papadimitriou E, Bear DM, Greenberg ME. Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selection. Neuron 60: 1022-1038, 2008.
82. Flexner JB, Flexner LB, Stellar E. Memory in mice as affected by intracerebral puromycin. Science 141: 57-59, 1963.
83. French PJ, O'Connor V, Jones MW, Davis S, Errington ML, Voss K, Truchet B, Wotjak C, Stean T, Doyere V, Maroun M, Laroche S, Bliss TV. Subfield-specific immediate early gene expression associated with hippocampal long-term potentiation in vivo. Eur J Neurosci 13: 968-976, 2001. (Pubitemid 32226148)
84. French PJ, O'Connor V, Voss K, Stean T, Hunt SP, Bliss TV. Seizure-induced gene expression in area CA1 of the mouse hippocampus. Eur J Neurosci 14: 2037-2041, 2001. (Pubitemid 35463691)
85. Frey U, Huang YY, Kandel ER. Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons. Science 260: 1661-1664, 1993. (Pubitemid 23247151)
86. Frost WN, Castellucci VF, Hawkins RD, Kandel ER. Monosynaptic connections made by the sensory neurons of the gill- and siphon-withdrawal reflex in Aplysia participate in the storage of long-term memory for sensitization. Proc Natl Acad Sci USA 82: 8266-8269, 1985.
87. Fujino T, Lee WC, Nedivi E. Regulation of cpg15 by signaling pathways that mediate synaptic plasticity. Mol Cell Neurosci 24: 538-554, 2003. (Pubitemid 37508522)
88. Gao M, Morgan I, Vogt PK. Differential and antagonistic effects of v-Jun and c-Jun. Cancer Res 56: 4229-4235, 1996. (Pubitemid 26305021)
89. Garner CC, Tucker RP, Matus A. Selective localization of messenger RNA for cytoskeletal protein MAP2 in dendrites. Nature 336: 674-677, 1988. (Pubitemid 19007947)
90. Gass P, Wolfer DP, Balschun D, Rudolph D, Frey U, Lipp HP, Schutz G. Deficits in memory tasks of mice with CREB mutations depend on gene dosage. Learn Mem 5: 274-288, 1998. (Pubitemid 29115259)
91. Gilman MZ, Wilson RN, Weinberg RA. Multiple protein-binding sites in the 5-flanking region regulate c-fos expression. Mol Cell Biol 6: 4305-4316, 1986.
92. Giorgi C, Yeo GW, Stone ME, Katz DB, Burge C, Turrigiano G, Moore MJ. The EJC factor eIF4AIII modulates synaptic strength and neuronal protein expression. Cell 130: 179-191, 2007. (Pubitemid 47031322)
93. Goelet P, Castellucci VF, Schacher S, Kandel ER. The long and the short of long-term memory - a molecular framework. Nature 322: 419-422, 1986. (Pubitemid 16034014)
94. Gonzalez GA, Montminy MR. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59: 675-680, 1989.
95. Greenberg ME, Greene LA, Ziff EB. Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells. J Biol Chem 260: 14101-14110, 1985.
96. Greenberg ME, Ziff EB. Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature 311: 433-438, 1984.
97. Guan Z, Saraswati S, Adolfsen B, Littleton JT. Genome-wide transcriptional changes associated with enhanced activity in the Drosophila nervous system. Neuron 48: 91-107, 2005. (Pubitemid 41384168)
98. Guthrie KM, Anderson AJ, Leon M, Gall C. Odor-induced increases in c-fos mRNA expression reveal an anatomical "unit" for odor processing in olfactory bulb. Proc Natl Acad Sci USA 90: 3329-3333, 1993.
99. Guzowski JF, Lyford GL, Stevenson GD, Houston FP, Mc- Gaugh JL, Worley PF, Barnes CA. Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory. J Neurosci 20: 3993-4001, 2000.
100. Guzowski JF, Timlin JA, Roysam B, McNaughton BL, Worley PF, Barnes CA. Mapping behaviorally relevant neural circuits with immediate-early gene expression. Curr Opin Neurobiol 15: 599-606, 2005. (Pubitemid 41394406)
101. Hai T, Curran T. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc Natl Acad Sci USA 88: 3720-3724, 1991. (Pubitemid 21916695)
102. Hai TW, Liu F, Coukos WJ, Green MR. Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. Genes Dev 3: 2083-2090, 1989. (Pubitemid 20023233)
103. 2+ channels. Neuron 51: 575-586, 2006.
104. Han Y, Chen X, Shi F, Li S, Huang J, Xie M, Hu L, Hoidal JR, Xu P. CPG15, a new factor upregulated after ischemic brain injury, contributes to neuronal network re-establishment after glutamate-induced injury. J Neurotrauma 24: 722-731, 2007. (Pubitemid 46996031)
105. Hann SR, Abrams HD, Rohrschneider LR, Eisenman RN. Proteins encoded by v-myc and c-myc oncogenes: identification and localization in acute leukemia virus transformants and bursal lymphoma cell lines. Cell 34: 789-798, 1983.
106. Hanover JL, Huang ZJ, Tonegawa S, Stryker MP. Brain-derived neurotrophic factor overexpression induces precocious critical period in mouse visual cortex. J Neurosci 19: RC40, 1999.
107. Harwell C, Burbach B, Svoboda K, Nedivi E. Regulation of cpg15 expression during single whisker experience in the barrel cortex of adult mice. J Neurobiol 65: 85-96, 2005. (Pubitemid 41324631)
108. Hernandez PJ, Abel T. The role of protein synthesis in memory consolidation: progress amid decades of debate. Neurobiol Learn Mem 89: 293-311, 2008. (Pubitemid 351320622)
109. Hertting G, Seregi A. Formation and function of eicosanoids in the central nervous system. Ann NY Acad Sci 559: 84-99, 1989. (Pubitemid 19215829)
110. Hevroni D, Rattner A, Bundman M, Lederfein D, Gabarah A, Mangelus M, Silverman MA, Kedar H, Naor C, Kornuc M, Hanoch T, Seger R, Theill LE, Nedivi E, Richter-Levin G, Citri Y. Hippocampal plasticity involves extensive gene induction and multiple cellular mechanisms. J Mol Neurosci 10: 75-98, 1998. (Pubitemid 28350112)
111. Hoeffler JP, Meyer TE, Yun Y, Jameson JL, Habener JF. Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. Science 242: 1430-1433, 1988. (Pubitemid 19008071)
112. Hofer M, Pagliusi SR, Hohn A, Leibrock J, Barde YA. Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain. EMBO J 9: 2459-2464, 1990. (Pubitemid 20218342)
113. Hofer MM, Barde YA. Brain-derived neurotrophic factor prevents neuronal death in vivo. Nature 331: 261-262, 1988.
114. Hofer SB, Mrsic-Flogel TD, Bonhoeffer T, Hubener M. Life-long learning: ocular dominance plasticity in mouse visual cortex. Curr Opin Neurobiol 16: 451-459, 2006. (Pubitemid 44142267)
115. Hong SJ, Li H, Becker KG, Dawson VL, Dawson TM. Identification and analysis of plasticity-induced late-response genes. Proc Natl Acad Sci USA 101: 2145-2150, 2004. (Pubitemid 38229029)
116. Hooks BM, Chen C. Critical periods in the visual system: changing views for a model of experience-dependent plasticity. Neuron 56:312-326, 2007.
117. Huang YY, Kandel ER. Recruitment of long-lasting and protein kinase A-dependent long-term potentiation in the CA1 region of hippocampus requires repeated tetanization. Learn Mem 1: 74-82, 1994.
118. Huang YY, Li XC, Kandel ER. cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase. Cell 79: 69-79, 1994. (Pubitemid 2153047)
119. Huang ZJ, Kirkwood A, Pizzorusso T, Porciatti V, Morales B, Bear MF, Maffei L, Tonegawa S. BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. Cell 98: 739-755, 1999. (Pubitemid 29446892)
120. Hubel DH, Wiesel TN. Ferrier lecture. Functional architecture of macaque monkey visual cortex. Proc R Soc Lond B Biol Sci 198:1-59, 1977. (Pubitemid 8150472)
121. Huh GS, Boulanger LM, Du H, Riquelme PA, Brotz TM, Shatz CJ. Functional requirement for class I MHC in CNS development and plasticity. Science 290: 2155-2159, 2000. (Pubitemid 32001597)
122. Hummler E, Cole TJ, Blendy JA, Ganss R, Aguzzi A, Schmid W, Beermann F, Schutz G. Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors. Proc Natl Acad Sci USA 91: 5647-5651, 1994. (Pubitemid 24174385)
123. Hunt SP, Pini A, Evan G. Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature 328: 632-634, 1987. (Pubitemid 17103967)
124. Iacoangeli A, Rozhdestvensky TS, Dolzhanskaya N, Tournier B, Schutt J, Brosius J, Denman RB, Khandjian EW, Kindler S, Tiedge H. On BC1 RNA and the fragile X mental retardation protein. Proc Natl Acad Sci USA 105: 734-739, 2008. (Pubitemid 351171777)
125. Iba H, Takeya T, Cross FR, Hanafusa T, Hanafusa H. Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblasts. Proc Natl Acad Sci USA 81: 4424-4428, 1984. (Pubitemid 14055903)
126. Impey S, Mark M, Villacres EC, Poser S, Chavkin C, Storm DR. Induction of CRE-mediated gene expression by stimuli that generate long-lasting LTP in area CA1 of the hippocampus. Neuron 16: 973-982, 1996. (Pubitemid 126335761)
127. Impey S, McCorkle SR, Cha-Molstad H, Dwyer JM, Yochum GS, Boss JM, McWeeney S, Dunn JJ, Mandel G, Goodman RH. Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions. Cell 119: 1041-1054, 2004. (Pubitemid 40037616)
128. Ingi T, Krumins AM, Chidiac P, Brothers GM, Chung S, Snow BE, Barnes CA, Lanahan AA, Siderovski DP, Ross EM, Gilman AG, Worley PF. Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity. J Neurosci 18: 7178-7188, 1998. (Pubitemid 28425805)
129. Inoue A, Sanes JR. Lamina-specific connectivity in the brain: regulation by N-cadherin, neurotrophins, and glycoconjugates. Science 276: 1428-1431, 1997. (Pubitemid 27235414)
130. Ip NY, Stitt TN, Tapley P, Klein R, Glass DJ, Fandl J, Greene LA, Barbacid M, Yancopoulos GD. Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells. Neuron 10: 137-149, 1993. (Pubitemid 23079537)
131. Isackson PJ, Huntsman MM, Murray KD, Gall CM. BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: temporal patterns of induction distinct from NGF. Neuron 6: 937-948, 1991.
132. Johnson RS, Spiegelman BM, Papaioannou V. Pleiotropic effects of a null mutation in the c-fos proto-oncogene. Cell 71: 577-586, 1992.
133. Johnsson A, Betsholtz C, von der Helm K, Heldin CH, Westermark B. Platelet-derived growth factor agonist activity of a secreted form of the v-sis oncogene product. Proc Natl Acad Sci USA 82: 1721-1725, 1985. (Pubitemid 15079464)
134. Johnsson A, Heldin CH, Wasteson A, Westermark B, Deuel TF, Huang JS, Seeburg PH, Gray A, Ullrich A, Scrace G. The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor. EMBO J 3: 921-928, 1984.
135. Jones MW, Errington ML, French PJ, Fine A, Bliss TV, Garel S, Charnay P, Bozon B, Laroche S, Davis S. A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories. Nat Neurosci 4: 289-296, 2001. (Pubitemid 32194877)
136. Kaang BK, Kandel ER, Grant SG. Activation of cAMP-responsive genes by stimuli that produce long-term facilitation in Aplysia sensory neurons. Neuron 10: 427-435, 1993.
137. Kandel ER, Schwarz JH, Jessel TM. Cellular mechanisms of learning and the biological basis of individuality. In: Principles of Neural Science (4th ed.). New York: McGraw-Hill, 2000, p. 1247-1279.
138. Kang H, Schuman EM. Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science 267: 1658-1662, 1995.
139. Karamoysoyli E, Burnand RC, Tomlinson DR, Gardiner NJ. Neuritin mediates nerve growth factor-induced axonal regeneration and is deficient in experimental diabetic neuropathy. Diabetes 57: 181-189, 2008.
140. Kaufmann WE, Worley PF, Pegg J, Bremer M, Isakson P. COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex. Proc Natl Acad Sci USA 93: 2317-2321, 1996. (Pubitemid 26104347)
141. Kaufmann WE, Yamagata K, Andreasson KI, Worley PF. Rapid response genes as markers of cellular signaling during cortical histogenesis: their potential in understanding mental retardation. Int J Dev Neurosci 12: 263-271, 1994. (Pubitemid 24217834)
142. 2+- and integrin-binding protein and are regulated dynamically with synaptic plasticity. EMBO J 18: 5528-5539, 1999.
143. Kawashima T, Okuno H, Nonaka M, Adachi-Morishima A, Kyo N, Okamura M, Takemoto-Kimura S, Worley PF, Bito H. Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons. Proc Natl Acad Sci USA 106: 316-321, 2009.
144. Kelm O, Wind M, Lehmann WD, Nigg EA. Cell cycle-regulated phosphorylation of the Xenopus polo-like kinase Plx1. J Biol Chem 277: 25247-25256, 2002. (Pubitemid 34951832)
145. Kim JY, Zeng W, Kiselyov K, Yuan JP, Dehoff MH, Mikoshiba K, Worley PF, Muallem S. Homer 1 mediates store- and inositol 1,4,5-trisphosphate receptor-dependent translocation and retrieval of TRPC3 to the plasma membrane. J Biol Chem 281: 32540-32549, 2006. (Pubitemid 46036809)
146. Kingston RE, Baldwin AS Jr, Sharp PA. Regulation of heat shock protein 70 gene expression by c-myc. Nature 312: 280-282, 1984.
147. Kitamura C, Takahashi M, Kondoh Y, Tashiro H, Tashiro T. Identification of synaptic activity-dependent genes by exposure of cultured cortical neurons to tetrodotoxin followed by its withdrawal. J Neurosci Res 85: 2385-2399, 2007. (Pubitemid 47204753)
148. Korte M, Carroll P, Wolf E, Brem G, Thoenen H, Bonhoeffer T. Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proc Natl Acad Sci USA 92: 8856-8860, 1995.
149. Kruijer W, Schubert D, Verma IM. Induction of the proto-oncogene fos by nerve growth factor. Proc Natl Acad Sci USA 82: 7330-7334, 1985. (Pubitemid 16193736)
150. Kwok RP, Lundblad JR, Chrivia JC, Richards JP, Bachinger HP, Brennan RG, Roberts SG, Green MR, Goodman RH. Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature 370: 223-226, 1994.
151. Lachance PE, Chaudhuri A. Microarray analysis of developmental plasticity in monkey primary visual cortex. J Neurochem 88: 1455-1469, 2004. (Pubitemid 38366922)
152. Lamas M, Monaco L, Zazopoulos E, Lalli E, Tamai K, Penna L, Mazzucchelli C, Nantel F, Foulkes NS, Sassone-Corsi P. CREM: a master-switch in the transcriptional response to cAMP. Philos Trans R Soc Lond B Biol Sci 351: 561-567, 1996. (Pubitemid 126745365)
153. Lanahan A, Worley P. Immediate-early genes and synaptic function. Neurobiol Learn Mem 70: 37-43, 1998.
154. Laoide BM, Foulkes NS, Schlotter F, Sassone-Corsi P. The functional versatility of CREM is determined by its modular structure. EMBO J 12: 1179-1191, 1993. (Pubitemid 23095867)
155. 1 transition of cultured mouse cells. EMBO J 4: 3145-3151, 1985.
156. Lee SH, Liu L, Wang YT, Sheng M. Clathrin adaptor AP2 and NSF interact with overlapping sites of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTD. Neuron 36: 661-674, 2002. (Pubitemid 35346759)
157. Lee WC, Nedivi E. Extended plasticity of visual cortex in dark-reared animals may result from prolonged expression of cpg15-like genes. J Neurosci 22: 1807-1815, 2002.
158. Lein ES, Hawrylycz MJ, Ao N, Ayres M, Bensinger A, Bernard A, Boe AF, Boguski MS, Brockway KS, Byrnes EJ, Chen L, Chen TM, Chin MC, Chong J, Crook BE, Czaplinska A, Dang CN, Datta S, Dee NR, Desaki AL, Desta T, Diep E, Dolbeare TA, Donelan MJ, Dong HW, Dougherty JG, Duncan BJ, Ebbert AJ, Eichele G, Estin LK, Faber C, Facer BA, Fields R, Fischer SR, Fliss TP, Frensley C, Gates SN, Glattfelder KJ, Halverson KR, Hart MR, Hohmann JG, Howell MP, Jeung DP, Johnson RA, Karr PT, Kawal R, Kidney JM, Knapik RH, Kuan CL, Lake JH, Laramee AR, Larsen KD, Lau C, Lemon TA, Liang AJ, Liu Y, Luong LT, Michaels J, Morgan JJ, Morgan RJ, Mortrud MT, Mosqueda NF, Ng LL, Ng R, Orta GJ, Overly CC, Pak TH, Parry SE, Pathak SD, Pearson OC, Puchalski RB, Riley ZL, Rockett HR, Rowland SA, Royall JJ, Ruiz MJ, Sarno NR, Schaffnit K, Shapovalova NV, Sivisay T, Slaughterbeck CR, Smith SC, Smith KA, Smith BI, Sodt AJ, Stewart NN, Stumpf KR, Sunkin SM, Sutram M, Tam A, Teemer CD, Thaller C, Thompson CL, Varnam LR, Visel A, Whitlock RM, Wohnoutka PE, Wolkey CK, Wong VY, Wood M. Genome-wide atlas of gene expression in the adult mouse brain. Nature 445: 168-176, 2007. (Pubitemid 46095716)
159. Lemmon V, Burden SM, Payne HR, Elmslie GJ, Hlavin ML. Neurite growth on different substrates: permissive versus instructive influences and the role of adhesive strength. J Neurosci 12: 818-826, 1992.
160. LeVay S, Stryker MP, Shatz CJ. Ocular dominance columns and their development in layer IV of the cat's visual cortex: a quantitative study. J Comp Neurol 179: 223-244, 1978. (Pubitemid 8373208)
161. Lim RW, Varnum BC, Herschman HR. Cloning of tetradecanoyl phorbol ester-induced "primary response" sequences and their expression in density-arrested Swiss 3T3 cells and a TPA non-proliferative variant. Oncogene 1: 263-270, 1987.
162. Lin JW, Ju W, Foster K, Lee SH, Ahmadian G, Wyszynski M, Wang YT, Sheng M. Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization. Nat Neurosci 3: 1282-1290, 2000. (Pubitemid 30951643)
163. Lin SS, Levitan IB. Concanavalin A alters synaptic specificity between cultured Aplysia neurons. Science 237: 648-650, 1987.
164. Lin SS, Levitan IB. Concanavalin A: a tool to investigate neuronal plasticity. Trends Neurosci 14: 273-277, 1991.
165. Lin Y, Bloodgood BL, Hauser JL, Lapan AD, Koon AC, Kim TK, Hu LS, Malik AN, Greenberg ME. Activity-dependent regulation of inhibitory synapse development by Npas4. Nature 455: 1198-1204, 2008.
166. Link W, Konietzko U, Kauselmann G, Krug M, Schwanke B, Frey U, Kuhl D. Somatodendritic expression of an immediate early gene is regulated by synaptic activity. Proc Natl Acad Sci USA 92: 5734-5738, 1995.
167. Liu QR, Lu L, Zhu XG, Gong JP, Shaham Y, Uhl GR. Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine. Brain Res 1067: 1-12, 2006. (Pubitemid 43133069)
168. Llamazares S, Moreira A, Tavares A, Girdham C, Spruce BA, Gonzalez C, Karess RE, Glover DM, Sunkel CE. Polo encodes a protein kinase homolog required for mitosis in Drosophila. Genes Dev 5: 2153-2165, 1991. (Pubitemid 21905906)
169. Lu J, Helton TD, Blanpied TA, Racz B, Newpher TM, Weinberg RJ, Ehlers MD. Postsynaptic positioning of endocytic zones and AMPA receptor cycling by physical coupling of dynamin-3 to Homer. Neuron 55: 874-889, 2007. (Pubitemid 47391185)
170. Lyford GL, Yamagata K, Kaufmann WE, Barnes CA, Sanders LK, Copeland NG, Gilbert DJ, Jenkins NA, Lanahan AA, Worley PF. Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites. Neuron 14: 433-445, 1995.
171. Maisonpierre PC, Belluscio L, Friedman B, Alderson RF, Wiegand SJ, Furth ME, Lindsay RM, Yancopoulos GD. NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression. Neuron 5: 501-509, 1990. (Pubitemid 20369586)
172. Majdan M, Shatz CJ. Effects of visual experience on activity-dependent gene regulation in cortex. Nat Neurosci 9: 650-659, 2006. (Pubitemid 44012263)
173. Malhotra S, Shafiq N, Pandhi P. COX-2 inhibitors: a CLASS act or Just VIGORously promoted. MedGenMed 6: 6, 2004. (Pubitemid 41349530)
174. Malinow R, Malenka RC. AMPA receptor trafficking and synaptic plasticity. Annu Rev Neurosci 25: 103-126, 2002. (Pubitemid 34748013)
175. Man HY, Lin JW, Ju WH, Ahmadian G, Liu L, Becker LE, Sheng M, Wang YT. Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization. Neuron 25: 649-662, 2000. (Pubitemid 30951830)
176. McAllister AK, Katz LC, Lo DC. Neurotrophin regulation of cortical dendritic growth requires activity. Neuron 17: 1057-1064, 1996.
177. McAllister AK, Katz LC, Lo DC. Opposing roles for endogenous BDNF and NT-3 in regulating cortical dendritic growth. Neuron 18: 767-778, 1997.
178. McAllister AK, Lo DC, Katz LC. Neurotrophins regulate dendritic growth in developing visual cortex. Neuron 15: 791-803, 1995.
179. McGaugh JL. Memory-a century of consolidation. Science 287: 248-251, 2000.
180. Merzenich MM, Recanzone GH, Jenkins WM, Grajski KA. Adaptive mechanisms in cortical networks underlying cortical contributions to learning and nondeclarative memory. Cold Spring Harb Symp Quant Biol 55: 873-887, 1990.
181. Mi R, Tang X, Sutter R, Xu D, Worley P, O'Brien RJ. Differing mechanisms for glutamate receptor aggregation on dendritic spines and shafts in cultured hippocampal neurons. J Neurosci 22: 7606-7616, 2002. (Pubitemid 35390359)
182. Mizumori SJ, Rosenzweig MR, Bennett EL. Long-term working memory in the rat: effects of hippocampally applied anisomycin. Behav Neurosci 99: 220-232, 1985.
183. Molina CA, Foulkes NS, Lalli E, Sassone-Corsi P. Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response repressor. Cell 75: 875-886, 1993. (Pubitemid 24014545)
184. Montarolo PG, Goelet P, Castellucci VF, Morgan J, Kandel ER, Schacher S. A critical period for macromolecular synthesis in long-term heterosynaptic facilitation in Aplysia. Science 234: 1249-1254, 1986. (Pubitemid 17232366)
185. Montminy MR, Sevarino KA, Wagner JA, Mandel G, Goodman RH. Identification of a cyclic-AMP-responsive element within the rat somatostatin gene. Proc Natl Acad Sci USA 83: 6682-6686, 1986.
186. Morgan JI, Cohen DR, Hempstead JL, Curran T. Mapping patterns of c-fos expression in the central nervous system after seizure. Science 237: 192-197, 1987. (Pubitemid 17095925)
187. Morgan JI, Curran T. Role of ion flux in the control of c-fos expression. Nature 322: 552-555, 1986. (Pubitemid 16049206)
188. Morris RG, Anderson E, Lynch GS, Baudry M. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature 319: 774-776, 1986. (Pubitemid 16145031)
189. Mulcahy LS, Smith MR, Stacey DW. Requirement for ras protooncogene function during serum-stimulated growth of NIH 3T3 cells. Nature 313: 241-243, 1985. (Pubitemid 15194064)
190. Muller R, Bravo R, Burckhardt J, Curran T. Induction of c-fos gene and protein by growth factors precedes activation of c-myc. Nature 312: 716-720, 1984. (Pubitemid 15195916)
191. Naeve GS, Ramakrishnan M, Kramer R, Hevroni D, Citri Y, Theill LE. Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis. Proc Natl Acad Sci USA 94: 2648-2653, 1997. (Pubitemid 27136930)
192. Naik UP, Patel PM, Parise LV. Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain. J Biol Chem 272: 4651-4654, 1997.
193. Naisbitt S, Kim E, Tu JC, Xiao B, Sala C, Valtschanoff J, Weinberg RJ, Worley PF, Sheng M. Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin. Neuron 23: 569-582, 1999. (Pubitemid 29359927)
194. Nakanishi S. Metabotropic glutamate receptors: synaptic transmission, modulation, and plasticity. Neuron 13: 1031-1037, 1994. (Pubitemid 24372123)
195. Nedivi E, Fieldust S, Theill LE, Hevron D. A set of genes expressed in response to light in the adult cerebral cortex and regulated during development. Proc Natl Acad Sci USA 93: 2048-2053, 1996. (Pubitemid 26079878)
196. Nedivi E, Hevroni D, Naot D, Israeli D, Citri Y. Numerous candidate plasticity-related genes revealed by differential cDNA cloning. Nature 363: 718-722, 1993. (Pubitemid 23227648)
197. Nedivi E, Javaherian A, Cantallops I, Cline HT. Developmental regulation of CPG15 expression in Xenopus. J Comp Neurol 435: 464-473, 2001. (Pubitemid 32574297)
198. Nedivi E, Wu GY, Cline HT. Promotion of dendritic growth by CPG15, an activity-induced signaling molecule. Science 281: 1863-1866, 1998.
199. Newton SS, Collier EF, Hunsberger J, Adams D, Terwilliger R, Selvanayagam E, Duman RS. Gene profile of electroconvulsive seizures: induction of neurotrophic and angiogenic factors. J Neurosci 23: 10841-10851, 2003. (Pubitemid 37499691)
200. Nguyen PV, Abel T, Kandel ER. Requirement of a critical period of transcription for induction of a late phase of LTP. Science 265: 1104-1107, 1994. (Pubitemid 24293080)
201. Nichols M, Weih F, Schmid W, DeVack C, Kowenz-Leutz E, Luckow B, Boshart M, Schutz G. Phosphorylation of CREB affects its binding to high and low affinity sites: implications for cAMP induced gene transcription. EMBO J 11: 3337-3346, 1992.
202. Nishimura T, Vogt PK. The avian cellular homolog of the oncogene jun. Oncogene 3: 659-663, 1988. (Pubitemid 19030376)
203. O'Brien RJ, Xu D, Petralia RS, Steward O, Huganir RL, Worley P. Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp. Neuron 23: 309-323, 1999. (Pubitemid 29315726)
204. Oliet SH, Malenka RC, Nicoll RA. Two distinct forms of longterm depression coexist in CA1 hippocampal pyramidal cells. Neuron 18: 969-982, 1997.
205. Oliveira-Dos-Santos AJ, Matsumoto G, Snow BE, Bai D, Houston FP, Whishaw IQ, Mariathasan S, Sasaki T, Wakeham A, Ohashi PS, Roder JC, Barnes CA, Siderovski DP, Penninger JM. Regulation of T cell activation, anxiety, and male aggression by RGS2. Proc Natl Acad Sci USA 97: 12272-12277, 2000. (Pubitemid 30815175)
206. Pak DT, Sheng M. Targeted protein degradation and synapse remodeling by an inducible protein kinase. Science 302: 1368-1373, 2003. (Pubitemid 37452173)
207. Pak DT, Yang S, Rudolph-Correia S, Kim E, Sheng M. Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP. Neuron 31: 289-303, 2001. (Pubitemid 32762981)
208. Park CS, Gong R, Stuart J, Tang SJ. Molecular network and chromosomal clustering of genes involved in synaptic plasticity in the hippocampus. J Biol Chem 281: 30195-30211, 2006. (Pubitemid 44537027)
209. Park S, Park JM, Kim S, Kim JA, Shepherd JD, Smith-Hicks CL, Chowdhury S, Kaufmann W, Kuhl D, Ryazanov AG, Huganir RL, Linden DJ, Worley PF. Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD. Neuron 59: 70-83, 2008. (Pubitemid 351905855)
210. Parker RC, Varmus HE, Bishop JM. Expression of v-src and chicken c-src in rat cells demonstrates qualitative differences between pp60v-src and pp60c-src. Cell 37: 131-139, 1984.
211. Patterson SL, Abel T, Deuel TA, Martin KC, Rose JC, Kandel ER. Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron 16: 1137-1145, 1996. (Pubitemid 26227235)
212. Patterson SL, Grover LM, Schwartzkroin PA, Bothwell M. Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs. Neuron 9: 1081-1088, 1992. (Pubitemid 23007179)
213. Paylor R, Johnson RS, Papaioannou V, Spiegelman BM, Wehner JM. Behavioral assessment of c-fos mutant mice. Brain Res 651: 275-282, 1994. (Pubitemid 24222877)
214. Pin JP, Duvoisin R. The metabotropic glutamate receptors: structure and functions. Neuropharmacology 34: 1-26, 1995.
215. Plath N, Ohana O, Dammermann B, Errington ML, Schmitz D, Gross C, Mao X, Engelsberg A, Mahlke C, Welzl H, Kobalz U, Stawrakakis A, Fernandez E, Waltereit R, Bick-Sander A, Therstappen E, Cooke SF, Blanquet V, Wurst W, Salmen B, Bosl MR, Lipp HP, Grant SG, Bliss TV, Wolfer DP, Kuhl D. Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories. Neuron 52: 437-444, 2006. (Pubitemid 44755254)
216. Ploski JE, Pierre VJ, Smucny J, Park K, Monsey MS, Overeem KA, Schafe GE. The activity-regulated cytoskeletal-associated protein (Arc/Arg3.1) is required for memory consolidation of pavlovian fear conditioning in the lateral amygdala. J Neurosci 28: 12383-12395, 2008.
217. Prezeau L, Gomeza J, Ahern S, Mary S, Galvez T, Bockaert J, Pin JP. Changes in the carboxyl-terminal domain of metabotropic glutamate receptor 1 by alternative splicing generate receptors with differing agonist-independent activity. Mol Pharmacol 49: 422-429, 1996. (Pubitemid 26087809)
218. Privalsky ML, Ralston R, Bishop JM. The membrane glycoprotein encoded by the retroviral oncogene v-erb-B is structurally related to tyrosine-specific protein kinases. Proc Natl Acad Sci USA 81: 704-707, 1984. (Pubitemid 14199014)
219. Prywes R, Roeder RG. Purification of the c-fos enhancer-binding protein. Mol Cell Biol 7: 3482-3489, 1987.
220. Pulipparacharuvil S, Renthal W, Hale CF, Taniguchi M, Xiao G, Kumar A, Russo SJ, Sikder D, Dewey CM, Davis MM, Greengard P, Nairn AC, Nestler EJ, Cowan CW. Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron 59: 621-633, 2008.
221. Putz U, Harwell C, Nedivi E. Soluble CPG15 expressed during early development rescues cortical progenitors from apoptosis. Nat Neurosci 8: 322-331, 2005. (Pubitemid 40300189)
222. Qian Z, Gilbert ME, Colicos MA, Kandel ER, Kuhl D. Tissue-plasminogen activator is induced as an immediate-early gene during seizure, kindling and long-term potentiation. Nature 361: 453-457, 1993. (Pubitemid 23050134)
223. Quinton EE, Kramarcy NR. Memory impairment correlates closely with cycloheximide dose and degree of inhibition of protein synthesis. Brain Res 131: 184-190, 1977.
224. Rayport SG, Schacher S. Synaptic plasticity in vitro: cell culture of identified Aplysia neurons mediating short-term habituation and sensitization. J Neurosci 6: 759-763, 1986. (Pubitemid 16134914)
225. Reichardt LF. Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci 361: 1545-1564, 2006.
226. Renz M, Verrier B, Kurz C, Muller R. Chromatin association and DNA binding properties of the c-fos proto-oncogene product. Nucleic Acids Res 15: 277-292, 1987. (Pubitemid 17222737)
227. Reymann KG, Malisch R, Schulzeck K, Brodemann R, Ott T, Matthies H. The duration of long-term potentiation in the CA1 region of the hippocampal slice preparation. Brain Res Bull 15: 249-255, 1985. (Pubitemid 16229703)
228. Rial Verde EM, Lee-Osbourne J, Worley PF, Malinow R, Cline HT. Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission. Neuron 52: 461-474, 2006. (Pubitemid 44667435)
229. Roche KW, Tu JC, Petralia RS, Xiao B, Wenthold RJ, Worley PF. Homer 1b regulates the trafficking of group I metabotropic glutamate receptors. J Biol Chem 274: 25953-25957, 1999. (Pubitemid 129530778)
230. 2+ release from internal stores in CNS neurons. Cell Mol Neurobiol 25: 283-295, 2005.
231. Saffen DW, Cole AJ, Worley PF, Christy BA, Ryder K, Baraban JM. Convulsant-induced increase in transcription factor messenger RNAs in rat brain. Proc Natl Acad Sci USA 85: 7795-7799, 1988. (Pubitemid 18256456)
232. Sagar SM, Sharp FR, Curran T. Expression of c-fos protein in brain: metabolic mapping at the cellular level. Science 240: 1328-1331, 1988. (Pubitemid 18155914)
233. Sambucetti LC, Curran T. The Fos protein complex is associated with DNA in isolated nuclei and binds to DNA cellulose. Science 234: 1417-1419, 1986. (Pubitemid 17210225)
234. Schacher S, Castellucci VF, Kandel ER. cAMP evokes long-term facilitation in Aplysia sensory neurons that requires new protein synthesis. Science 240: 1667-1669, 1988.
235. Schlimgen AK, Helms JA, Vogel H, Perin MS. Neuronal pentraxin, a secreted protein with homology to acute phase proteins of the immune system. Neuron 14: 519-526, 1995.
236. Seeburg DP, Feliu-Mojer M, Gaiottino J, Pak DT, Sheng M. Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity. Neuron 58: 571-583, 2008. (Pubitemid 351681992)
237. Seeburg DP, Pak D, Sheng M. Polo-like kinases in the nervous system. Oncogene 24: 292-298, 2005.
238. Seeburg DP, Sheng M. Activity-induced Polo-like kinase 2 is required for homeostatic plasticity of hippocampal neurons during epileptiform activity. J Neurosci 28: 6583-6591, 2008.
239. Seeds NW, Williams BL, Bickford PC. Tissue plasminogen activator induction in Purkinje neurons after cerebellar motor learning. Science 270: 1992-1994, 1995.
240. Shalizi A, Gaudilliere B, Yuan Z, Stegmuller J, Shirogane T, Ge Q, Tan Y, Schulman B, Harper JW, Bonni A. A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation. Science 311: 1012-1017, 2006. (Pubitemid 43271730)
241. Sharp JW, Sagar SM, Hisanaga K, Jasper P, Sharp FR. The NMDA receptor mediates cortical induction of fos and fos-related antigens following cortical injury. Exp Neurol 109: 323-332, 1990. (Pubitemid 20348963)
242. Shelton DL, Sutherland J, Gripp J, Camerato T, Armanini MP, Phillips HS, Carroll K, Spencer SD, Levinson AD. Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins. J Neurosci 15: 477-491, 1995.
243. Sheng M, McFadden G, Greenberg ME. Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB. Neuron 4: 571-582, 1990. (Pubitemid 20160846)
244. Shepherd JD, Rumbaugh G, Wu J, Chowdhury S, Plath N, Kuhl D, Huganir RL, Worley PF. Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors. Neuron 52: 475-484, 2006. (Pubitemid 44667431)
245. Sia GM, Beique JC, Rumbaugh G, Cho R, Worley PF, Huganir RL. Interaction of the N-terminal domain of the AMPA receptor GluR4 subunit with the neuronal pentraxin NP1 mediates GluR4 synaptic recruitment. Neuron 55: 87-102, 2007. (Pubitemid 46990823)
246. Silva AJ, Kogan JH, Frankland PW, Kida S. CREB and memory. Annu Rev Neurosci 21: 127-148, 1998.
247. Silverman MA, Benard O, Jaaro H, Rattner A, Citri Y, Seger R. CPG16, a novel protein serine/threonine kinase downstream of cAMP-dependent protein kinase. J Biol Chem 274: 2631-2636, 1999. (Pubitemid 29075340)
248. Smith WL, Marnett LJ, DeWitt DL. Prostaglandin and thromboxane biosynthesis. Pharmacol Ther 49: 153-179, 1991.
249. Snider WD. Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell 77: 627-638, 1994.
250. Sonnenberg JL, Macgregor-Leon PF, Curran T, Morgan JI. Dynamic alterations occur in the levels and composition of transcription factor AP-1 complexes after seizure. Neuron 3: 359-365, 1989.
251. Steward O, Wallace CS, Lyford GL, Worley PF. Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites. Neuron 21: 741-751, 1998. (Pubitemid 28498783)
252. Steward O, Worley PF. Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation. Neuron 30: 227-240, 2001. (Pubitemid 32441689)
253. Sukhatme VP, Cao XM, Chang LC, Tsai-Morris CH, Stamenkovich D, Ferreira PC, Cohen DR, Edwards SA, Shows TB, Curran T, et al. A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, after cellular depolarization. Cell 53: 37-43, 1988.
254. Sultan M, Schulz MH, Richard H, Magen A, Klingenhoff A, Scherf M, Seifert M, Borodina T, Soldatov A, Parkhomchuk D, Schmidt D, O'Keeffe S, Haas S, Vingron M, Lehrach H, Yaspo ML. A global view of gene activity and alternative splicing by deep sequencing of the human transcriptome. Science 321: 956-960, 2008.
255. Sunkel CE, Glover DM. polo, a mitotic mutant of Drosophila displaying abnormal spindle poles. J Cell Sci 89: 25-38, 1988.
256. Sweet RW, Yokoyama S, Kamata T, Feramisco JR, Rosenberg M, Gross M. The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity. Nature 311: 273-275, 1984. (Pubitemid 14071147)
257. 2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron 20: 709-726, 1998.
258. Tetzlaff JE, Huppenbauer CB, Tanzer L, Alexander TD, Jones KJ. Motoneuron injury and repair: new perspectives on gonadal steroids as neurotherapeutics. J Mol Neurosci 28: 53-64, 2006. (Pubitemid 43780336)
259. Topilko P, Schneider-Maunoury S, Levi G, Trembleau A, Gourdji D, Driancourt MA, Rao CV, Charnay P. Multiple pituitary and ovarian defects in Krox-24 (NGFI-A, Egr-1)-targeted mice. Mol Endocrinol 12: 107-122, 1998. (Pubitemid 28124784)
260. Treisman R. Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5′ element and c-fos 3′ sequences. Cell 42: 889-902, 1985.
261. Tropea D, Kreiman G, Lyckman A, Mukherjee S, Yu H, Horng S, Sur M. Gene expression changes and molecular pathways mediating activity-dependent plasticity in visual cortex. Nat Neurosci 9: 660-668, 2006. (Pubitemid 44012264)
262. Tsirka SE, Rogove AD, Bugge TH, Degen JL, Strickland S. An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus. J Neurosci 17: 543-552, 1997. (Pubitemid 27024567)
263. Tsui CC, Copeland NG, Gilbert DJ, Jenkins NA, Barnes C, Worley PF. Narp, a novel member of the pentraxin family, promotes neurite outgrowth and is dynamically regulated by neuronal activity. J Neurosci 16: 2463-2478, 1996. (Pubitemid 26122671)
264. Tu JC, Xiao B, Naisbitt S, Yuan JP, Petralia RS, Brakeman P, Doan A, Aakalu VK, Lanahan AA, Sheng M, Worley PF. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron 23: 583-592, 1999. (Pubitemid 29359928)
265. Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron 21: 717-726, 1998. (Pubitemid 28498781)
266. Tully T. Physiology of mutations affecting learning and memory in Drosophila - the missing link between gene product and behavior. Trends Neurosci 14: 163-164, 1991.
267. Turrigiano GG. The self-tuning neuron: synaptic scaling of excitatory synapses. Cell 135: 422-435, 2008.
268. Tzingounis AV, Nicoll RA. Arc/Arg3.1: linking gene expression to synaptic plasticity and memory. Neuron 52: 403-407, 2006.
269. Verma IM, Sassone-Corsi P. Proto-oncogene fos: complex but versatile regulation. Cell 51: 513-514, 1987. (Pubitemid 18200188)
270. 2+ transport. Neuroscience 49: 467-477, 1992.
271. Wang YT, Linden DJ. Expression of cerebellar long-term depression requires postsynaptic clathrin-mediated endocytosis. Neuron 25: 635-647, 2000.
272. Waterfield MD, Scrace GT, Whittle N, Stroobant P, Johnsson A, Wasteson A, Westermark B, Heldin CH, Huang JS, Deuel TF. Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus. Nature 304: 35-39, 1983.
273. Waung MW, Pfeiffer BE, Nosyreva ED, Ronesi JA, Huber KM. Rapid translation of Arc/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate. Neuron 59: 84-97, 2008.
274. Wiesel TN Hubel DH. Single-cell responses in striate cortex of kittens deprived of vision in one eye. J Neurophysiol 26: 1003-1017, 1963.
275. Williams JH, Errington ML, Lynch MA, Bliss TV. Arachidonic acid induces a long-term activity-dependent enhancement of synaptic transmission in the hippocampus. Nature 341: 739-742, 1989.
276. Wisden W, Errington ML, Williams S, Dunnett SB, Waters C, Hitchcock D, Evan G, Bliss TV, Hunt SP. Differential expression of immediate early genes in the hippocampus and spinal cord. Neuron 4: 603-614, 1990. (Pubitemid 20160849)
277. Worley PF, Cole AJ, Murphy TH, Christy BA, Nakabeppu Y, Baraban JM. Synaptic regulation of immediate-early genes in brain. Cold Spring Harb Symp Quant Biol 55: 213-223, 1990.
278. Xerri C. Imprinting of idiosyncratic experience in cortical sensory maps: neural substrates of representational remodeling and correlative perceptual changes. Behav Brain Res 192: 26-41, 2008.
279. 2+ entry in cultured rat cortical neurons. J Cell Physiol 212: 126-136, 2007.
280. Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Ruggiero A, Lanahan AA, Wenthold RJ, Worley PF. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron 21: 707-716, 1998. (Pubitemid 28498780)
281. Xu D, Hopf C, Reddy R, Cho RW, Guo L, Lanahan A, Petralia RS, Wenthold RJ, O'Brien RJ, Worley P. Narp and NP1 form heterocomplexes that function in developmental and activity-dependent synaptic plasticity. Neuron 39: 513-528, 2003. (Pubitemid 36937051)
282. Yalcin B, Willis-Owen SA, Fullerton J, Meesaq A, Deacon RM, Rawlins JN, Copley RR, Morris AP, Flint J, Mott R. Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nat Genet 36: 1197-1202, 2004. (Pubitemid 41288969)
283. Yamagata K, Andreasson KI, Kaufmann WE, Barnes CA, Worley PF. Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron 11: 371-386, 1993. (Pubitemid 23250354)
284. Yamagata K, Andreasson KI, Sugiura H, Maru E, Dominique M, Irie Y, Miki N, Hayashi Y, Yoshioka M, Kaneko K, Kato H, Worley PF. Arcadlin is a neural activity-regulated cadherin involved in long term potentiation. J Biol Chem 274: 19473-19479, 1999. (Pubitemid 129519383)
285. Yamagata K, Kaufmann WE, Lanahan A, Papapavlou M, Barnes CA, Andreasson KI, Worley PF. Egr3/Pilot, a zinc finger transcription factor, is rapidly regulated by activity in brain neurons and colocalizes with Egr1/zif268. Learn Mem 1: 140-152, 1994. (Pubitemid 2143751)
286. Yamagata K, Sanders LK, Kaufmann WE, Yee W, Barnes CA, Nathans D, Worley PF. rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein. J Biol Chem 269: 16333-16339, 1994. (Pubitemid 24209331)
287. Yamamoto KK, Gonzalez GA, Menzel P, Rivier J, Montminy MR. Characterization of a bipartite activator domain in transcription factor CREB. Cell 60: 611-617, 1990. (Pubitemid 20083817)
288. Yasuda S, Tanaka H, Sugiura H, Okamura K, Sakaguchi T, Tran U, Takemiya T, Mizoguchi A, Yagita Y, Sakurai T, De Robertis EM, Yamagata K. Activity-induced protocadherin arcadlin regulates dendritic spine number by triggering N-cadherin endocytosis via TAO2beta and p38 MAP kinases. Neuron 56: 456-471, 2007. (Pubitemid 350026265)
289. Yee WM, Worley PF. Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals. Mol Cell Biol 17: 921-933, 1997.
290. Yin JC, Del Vecchio M, Zhou H, Tully T. CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila. Cell 81: 107-115, 1995.
291. Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF. Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell 114: 777-789, 2003. (Pubitemid 37186771)
292. Zafra F, Hengerer B, Leibrock J, Thoenen H, Lindholm D. Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors. EMBO J 9: 3545-3550, 1990. (Pubitemid 20337384)
293. Zalfa F, Giorgi M, Primerano B, Moro A, Di Penta A, Reis S, Oostra B, Bagni C. The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses. Cell 112: 317-327, 2003. (Pubitemid 36183653)
294. Zangenehpour S, Chaudhuri A. Patchy organization and asymmetric distribution of the neural correlates of face processing in monkey inferotemporal cortex. Curr Biol 15: 993-1005, 2005. (Pubitemid 40772146)