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Volumn 35, Issue 5, 2009, Pages 449-461

Review: Autophagy in neurodegeneration: Firefighter and/or incendiarist?

Author keywords

Apoptosis; Autophagy; Necrosis; Neurodegeneration; Neuroprotection

Indexed keywords

GREEN FLUORESCENT PROTEIN;

EID: 69949175897     PISSN: 03051846     EISSN: 13652990     Source Type: Journal    
DOI: 10.1111/j.1365-2990.2009.01034.x     Document Type: Review
Times cited : (101)

References (83)
  • 1
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972 26 : 239 257
    • (1972) Br J Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 2
    • 0032404536 scopus 로고    scopus 로고
    • The central executioners of apoptosis: Caspases or mitochondria?
    • Green D, Kroemer G. The central executioners of apoptosis: caspases or mitochondria? Trends Cell Biol 1998 8 : 267 271
    • (1998) Trends Cell Biol , vol.8 , pp. 267-271
    • Green, D.1    Kroemer, G.2
  • 3
    • 0034849783 scopus 로고    scopus 로고
    • Autophagic cell death and its execution by lysosomal cathepsins
    • Uchiyama Y. Autophagic cell death and its execution by lysosomal cathepsins. Arch Histol Cytol 2001 64 : 233 246
    • (2001) Arch Histol Cytol , vol.64 , pp. 233-246
    • Uchiyama, Y.1
  • 4
    • 4344629590 scopus 로고    scopus 로고
    • Apoptotic and necrotic death mechanisms are concomitantly activated in the same cell after cerebral ischemia
    • Unal-Cevik I, Kilinc M, Can A, Gursoy-Ozdemir Y, Dalkara T. Apoptotic and necrotic death mechanisms are concomitantly activated in the same cell after cerebral ischemia. Stroke 2004 35 : 2189 2194
    • (2004) Stroke , vol.35 , pp. 2189-2194
    • Unal-Cevik, I.1    Kilinc, M.2    Can, A.3    Gursoy-Ozdemir, Y.4    Dalkara, T.5
  • 6
    • 0038309329 scopus 로고    scopus 로고
    • The molecular mechanism of autophagy
    • Wang CW, Klionsky DJ. The molecular mechanism of autophagy. Mol Med 2003 9 : 65 76
    • (2003) Mol Med , vol.9 , pp. 65-76
    • Wang, C.W.1    Klionsky, D.J.2
  • 8
    • 0034537290 scopus 로고    scopus 로고
    • Autophagy as a regulated pathway of cellular degradation
    • Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science 2000 290 : 1717 1721
    • (2000) Science , vol.290 , pp. 1717-1721
    • Klionsky, D.J.1    Emr, S.D.2
  • 9
    • 19444382327 scopus 로고    scopus 로고
    • The dynamics of autophagy visualized in live cells: From autophagosome formation to fusion with endo/lysosomes
    • Bampton ET, Goemans CG, Niranjan D, Mizushima N, Tolkovsky AM. The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo/lysosomes. Autophagy 2005 1 : 23 36
    • (2005) Autophagy , vol.1 , pp. 23-36
    • Bampton, E.T.1    Goemans, C.G.2    Niranjan, D.3    Mizushima, N.4    Tolkovsky, A.M.5
  • 10
    • 1442324707 scopus 로고    scopus 로고
    • Friedreich ataxia mouse models with progressive cerebellar and sensory ataxia reveal autophagic neurodegeneration in dorsal root ganglia
    • Simon D, Seznec H, Gansmuller A, Carelle N, Weber P, Metzger D, Rustin P, Koenig M, Puccio H. Friedreich ataxia mouse models with progressive cerebellar and sensory ataxia reveal autophagic neurodegeneration in dorsal root ganglia. J Neurosci 2004 24 : 1987 1995
    • (2004) J Neurosci , vol.24 , pp. 1987-1995
    • Simon, D.1    Seznec, H.2    Gansmuller, A.3    Carelle, N.4    Weber, P.5    Metzger, D.6    Rustin, P.7    Koenig, M.8    Puccio, H.9
  • 11
    • 38949099761 scopus 로고    scopus 로고
    • Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
    • Simonsen A, Cumming RC, Brech A, Isakson P, Schubert DR, Finley KD. Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy 2007 4 : 176 184
    • (2007) Autophagy , vol.4 , pp. 176-184
    • Simonsen, A.1    Cumming, R.C.2    Brech, A.3    Isakson, P.4    Schubert, D.R.5    Finley, K.D.6
  • 12
    • 34247172582 scopus 로고    scopus 로고
    • Aup1p, a yeast mitochondrial protein homolog phosphatase is required for efficient stationary phase mitophagy and cell survival
    • Tal R, Winter G, Ecker N, Klionsky DJ, Abeliovich H. Aup1p, a yeast mitochondrial protein homolog phosphatase is required for efficient stationary phase mitophagy and cell survival. J Biol Chem 2007 282 : 5617 5624
    • (2007) J Biol Chem , vol.282 , pp. 5617-5624
    • Tal, R.1    Winter, G.2    Ecker, N.3    Klionsky, D.J.4    Abeliovich, H.5
  • 13
    • 0036479052 scopus 로고    scopus 로고
    • Mitochondrial disappearance from cells: A clue to the role of autophagy in programmed cell death and disease?
    • Tolkovsky AM, Xue L, Fletcher GC, Borutaite V. Mitochondrial disappearance from cells: a clue to the role of autophagy in programmed cell death and disease? Biochimie 2002 84 : 233 240
    • (2002) Biochimie , vol.84 , pp. 233-240
    • Tolkovsky, A.M.1    Xue, L.2    Fletcher, G.C.3    Borutaite, V.4
  • 14
    • 34247379570 scopus 로고    scopus 로고
    • Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans
    • DOI 10.1242/jcs.03401
    • Toth ML, Simon P, Kovacs AL, Vellai T. Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans. J Cell Sci 2007 120 : 1134 1141 (Pubitemid 46638525)
    • (2007) Journal of Cell Science , vol.120 , Issue.6 , pp. 1134-1141
    • Toth, M.L.1    Simon, P.2    Kovacs, A.L.3    Vellai, T.4
  • 16
    • 53549083213 scopus 로고    scopus 로고
    • Selective mitochondrial autophagy during erythroid maturation
    • Chen M, Sandoval H, Wang J. Selective mitochondrial autophagy during erythroid maturation. Autophagy 2008 4 : 926 928
    • (2008) Autophagy , vol.4 , pp. 926-928
    • Chen, M.1    Sandoval, H.2    Wang, J.3
  • 17
  • 18
    • 0037109770 scopus 로고    scopus 로고
    • Methamphetamine-induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis
    • Larsen KE, Fon EA, Hastings TG, Edwards RH, Sulzer D. Methamphetamine-induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis. J Neurosci 2002 22 : 8951 8960
    • (2002) J Neurosci , vol.22 , pp. 8951-8960
    • Larsen, K.E.1    Fon, E.A.2    Hastings, T.G.3    Edwards, R.H.4    Sulzer, D.5
  • 20
    • 1842583789 scopus 로고    scopus 로고
    • Development by self-digestion: Molecular mechanisms and biological functions of autophagy
    • Levine B, Klionsky DJ. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 2004 6 : 463 477
    • (2004) Dev Cell , vol.6 , pp. 463-477
    • Levine, B.1    Klionsky, D.J.2
  • 21
    • 8344242220 scopus 로고    scopus 로고
    • Autophagy in health and disease: A double-edged sword
    • Shintani T, Klionsky DJ. Autophagy in health and disease: a double-edged sword. Science 2004 306 : 990 995
    • (2004) Science , vol.306 , pp. 990-995
    • Shintani, T.1    Klionsky, D.J.2
  • 22
    • 0035286734 scopus 로고    scopus 로고
    • Molecular dissection of autophagy: Two ubiquitin-like systems
    • Ohsumi Y. Molecular dissection of autophagy: two ubiquitin-like systems. Nat Rev Mol Cell Biol 2001 2 : 211 216
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 211-216
    • Ohsumi, Y.1
  • 23
    • 0037005133 scopus 로고    scopus 로고
    • Autophagy in yeast: A review of the molecular machinery
    • Huang WP, Klionsky DJ. Autophagy in yeast: a review of the molecular machinery. Cell Struct Funct 2002 27 : 409 420
    • (2002) Cell Struct Funct , vol.27 , pp. 409-420
    • Huang, W.P.1    Klionsky, D.J.2
  • 24
    • 34447132925 scopus 로고    scopus 로고
    • Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells
    • Kim EH, Sohn S, Kwon HJ, Kim SU, Kim MJ, Lee SJ, Choi KS. Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells. Cancer Res 2007 67 : 6314 6324
    • (2007) Cancer Res , vol.67 , pp. 6314-6324
    • Kim, E.H.1    Sohn, S.2    Kwon, H.J.3    Kim, S.U.4    Kim, M.J.5    Lee, S.J.6    Choi, K.S.7
  • 25
    • 34248578374 scopus 로고    scopus 로고
    • Autophagy, mitochondria and cell death in lysosomal storage diseases
    • Kiselyov K, Jennigs JJ Jr., Rbaibi Y, Chu CT. Autophagy, mitochondria and cell death in lysosomal storage diseases. Autophagy 2007 3 : 259 262
    • (2007) Autophagy , vol.3 , pp. 259-262
    • Kiselyov, K.1    Jennigs, Jr.J.J.2    Rbaibi, Y.3    Chu, C.T.4
  • 27
    • 33845874899 scopus 로고    scopus 로고
    • Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death
    • Scott RC, Juhasz G, Neufeld TP. Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death. Curr Biol 2007 17 : 1 11
    • (2007) Curr Biol , vol.17 , pp. 1-11
    • Scott, R.C.1    Juhasz, G.2    Neufeld, T.P.3
  • 29
    • 37349037902 scopus 로고    scopus 로고
    • Autophagy is required for necrotic cell death in Caenorhabditis elegans
    • Samara C, Syntichaki P, Tavernarakis N. Autophagy is required for necrotic cell death in Caenorhabditis elegans. Cell Death Differ 2008 15 : 105 112
    • (2008) Cell Death Differ , vol.15 , pp. 105-112
    • Samara, C.1    Syntichaki, P.2    Tavernarakis, N.3
  • 30
    • 33846915925 scopus 로고    scopus 로고
    • Kainic acid induces early and transient autophagic stress in mouse hippocampus
    • Shacka JJ, Lu J, Xie ZL, Uchiyama Y, Roth KA, Zhang J. Kainic acid induces early and transient autophagic stress in mouse hippocampus. Neurosci Lett 2007 414 : 57 60
    • (2007) Neurosci Lett , vol.414 , pp. 57-60
    • Shacka, J.J.1    Lu, J.2    Xie, Z.L.3    Uchiyama, Y.4    Roth, K.A.5    Zhang, J.6
  • 32
    • 34548188741 scopus 로고    scopus 로고
    • Self-eating and self-killing: Crosstalk between autophagy and apoptosis
    • Maiuri MC, Zalckvar E, Kimchi A, Kroemer G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 2007 8 : 741 752
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 741-752
    • Maiuri, M.C.1    Zalckvar, E.2    Kimchi, A.3    Kroemer, G.4
  • 34
    • 35848944122 scopus 로고    scopus 로고
    • Aberrant membranes and double-membrane structures accumulate in the axons of Atg5-null Purkinje cells before neuronal death
    • Nishiyama J, Miura E, Mizushima N, Watanabe M, Yuzaki M. Aberrant membranes and double-membrane structures accumulate in the axons of Atg5-null Purkinje cells before neuronal death. Autophagy 2007 3 : 591 596
    • (2007) Autophagy , vol.3 , pp. 591-596
    • Nishiyama, J.1    Miura, E.2    Mizushima, N.3    Watanabe, M.4    Yuzaki, M.5
  • 37
    • 36148960499 scopus 로고    scopus 로고
    • Induction of autophagy in neurite degeneration of mouse superior cervical ganglion neurons
    • Yang Y, Fukui K, Koike T, Zheng X. Induction of autophagy in neurite degeneration of mouse superior cervical ganglion neurons. Eur J Neurosci 2007 26 : 2979 2988
    • (2007) Eur J Neurosci , vol.26 , pp. 2979-2988
    • Yang, Y.1    Fukui, K.2    Koike, T.3    Zheng, X.4
  • 38
    • 33845407202 scopus 로고    scopus 로고
    • Atg22 recycles amino acids to link the degradative and recycling functions of autophagy
    • Yang Z, Huang J, Geng J, Nair U, Klionsky DJ. Atg22 recycles amino acids to link the degradative and recycling functions of autophagy. Mol Biol Cell 2006 17 : 5094 5104
    • (2006) Mol Biol Cell , vol.17 , pp. 5094-5104
    • Yang, Z.1    Huang, J.2    Geng, J.3    Nair, U.4    Klionsky, D.J.5
  • 46
    • 0036326071 scopus 로고    scopus 로고
    • Stimulatory effect of vitamin C on autophagy in glial cells
    • Martin A, Joseph JA, Cuervo AM. Stimulatory effect of vitamin C on autophagy in glial cells. J Neurochem 2002 82 : 538 549
    • (2002) J Neurochem , vol.82 , pp. 538-549
    • Martin, A.1    Joseph, J.A.2    Cuervo, A.M.3
  • 48
    • 34247161367 scopus 로고    scopus 로고
    • Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein
    • Sarkar S, Davies JE, Huang Z, Tunnacliffe A, Rubinsztein DC. Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J Biol Chem 2007 282 : 5641 5652
    • (2007) J Biol Chem , vol.282 , pp. 5641-5652
    • Sarkar, S.1    Davies, J.E.2    Huang, Z.3    Tunnacliffe, A.4    Rubinsztein, D.C.5
  • 50
    • 37849042536 scopus 로고    scopus 로고
    • A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin
    • Sarkar S, Krishna G, Imarisio S, Saiki S, O'Kane CJ, Rubinsztein DC. A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin. Hum Mol Genet 2008 17 : 170 178
    • (2008) Hum Mol Genet , vol.17 , pp. 170-178
    • Sarkar, S.1    Krishna, G.2    Imarisio, S.3    Saiki, S.4    O'Kane, C.J.5    Rubinsztein, D.C.6
  • 51
    • 0037194894 scopus 로고    scopus 로고
    • A novel protein complex linking the delta 2 glutamate receptor and autophagy: Implications for neurodegeneration in lurcher mice
    • Yue Z, Horton A, Bravin M, DeJager PL, Selimi F, Heintz N. A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice. Neuron 2002 35 : 921 933
    • (2002) Neuron , vol.35 , pp. 921-933
    • Yue, Z.1    Horton, A.2    Bravin, M.3    Dejager, P.L.4    Selimi, F.5    Heintz, N.6
  • 52
    • 34548492271 scopus 로고    scopus 로고
    • ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration
    • Lee JA, Beigneux A, Ahmad ST, Young SG, Gao FB. ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration. Curr Biol 2007 17 : 1561 1567
    • (2007) Curr Biol , vol.17 , pp. 1561-1567
    • Lee, J.A.1    Beigneux, A.2    Ahmad, S.T.3    Young, S.G.4    Gao, F.B.5
  • 53
    • 16844366524 scopus 로고    scopus 로고
    • Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging
    • Lemasters JJ. Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuvenation Res 2005 8 : 3 5
    • (2005) Rejuvenation Res , vol.8 , pp. 3-5
    • Lemasters, J.J.1
  • 54
    • 3442884830 scopus 로고    scopus 로고
    • Ultrastructural neuronal pathology in transgenic mice expressing mutant (P301L) human tau
    • Lin WL, Lewis J, Yen SH, Hutton M, Dickson DW. Ultrastructural neuronal pathology in transgenic mice expressing mutant (P301L) human tau. J Neurocytol 2003 32 : 1091 1095
    • (2003) J Neurocytol , vol.32 , pp. 1091-1095
    • Lin, W.L.1    Lewis, J.2    Yen, S.H.3    Hutton, M.4    Dickson, D.W.5
  • 55
    • 14844310312 scopus 로고    scopus 로고
    • Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells
    • Canu N, Tufi R, Serafino AL, Amadoro G, Ciotti MT, Calissano P. Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells. J Neurochem 2005 92 : 1228 1242
    • (2005) J Neurochem , vol.92 , pp. 1228-1242
    • Canu, N.1    Tufi, R.2    Serafino, A.L.3    Amadoro, G.4    Ciotti, M.T.5    Calissano, P.6
  • 57
    • 33644540193 scopus 로고    scopus 로고
    • Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway
    • Yamamoto A, Cremona ML, Rothman JE. Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway. J Cell Biol 2006 172 : 719 731
    • (2006) J Cell Biol , vol.172 , pp. 719-731
    • Yamamoto, A.1    Cremona, M.L.2    Rothman, J.E.3
  • 58
    • 0032870475 scopus 로고    scopus 로고
    • Autophagy is activated by apoptotic signalling in sympathetic neurons: An alternative mechanism of death execution
    • Xue L, Fletcher GC, Tolkovsky AM. Autophagy is activated by apoptotic signalling in sympathetic neurons: an alternative mechanism of death execution. Mol Cell Neurosci 1999 14 : 180 198
    • (1999) Mol Cell Neurosci , vol.14 , pp. 180-198
    • Xue, L.1    Fletcher, G.C.2    Tolkovsky, A.M.3
  • 59
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a central controller of cell growth
    • Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell 2000 103 : 253 262
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 61
    • 0033429554 scopus 로고    scopus 로고
    • Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
    • Navé BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR. Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem J 1999 344 : 427 431
    • (1999) Biochem J , vol.344 , pp. 427-431
    • Navé, B.T.1    Ouwens, M.2    Withers, D.J.3    Alessi, D.R.4    Shepherd, P.R.5
  • 62
    • 0036566266 scopus 로고    scopus 로고
    • Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy
    • Ravikumar B, Duden R, Rubinsztein DC. Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum Mol Genet 2002 11 : 1107 1117
    • (2002) Hum Mol Genet , vol.11 , pp. 1107-1117
    • Ravikumar, B.1    Duden, R.2    Rubinsztein, D.C.3
  • 65
    • 33846210657 scopus 로고    scopus 로고
    • Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans
    • Jia K, Hart AC, Levine B. Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans. Autophagy 2007 3 : 21 5
    • (2007) Autophagy , vol.3 , pp. 21-5
    • Jia, K.1    Hart, A.C.2    Levine, B.3
  • 66
    • 0141987860 scopus 로고    scopus 로고
    • The ubiquitin proteasome system in neurodegenerative diseases: Sometimes the chicken, sometimes the egg
    • Ciechanover A, Brundin P. The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg. Neuron 2003 40 : 427 446
    • (2003) Neuron , vol.40 , pp. 427-446
    • Ciechanover, A.1    Brundin, P.2
  • 67
    • 53549118274 scopus 로고    scopus 로고
    • Alpha-synuclein degradation by autophagic pathways: A potential key to Parkinson's disease pathogenesis
    • Xilouri M, Vogiatzi T, Vekrellis K, Stefanis L. Alpha-synuclein degradation by autophagic pathways: a potential key to Parkinson's disease pathogenesis. Autophagy 2008 4 : 917 919
    • (2008) Autophagy , vol.4 , pp. 917-919
    • Xilouri, M.1    Vogiatzi, T.2    Vekrellis, K.3    Stefanis, L.4
  • 69
    • 33845577972 scopus 로고    scopus 로고
    • Chaperone-mediated autophagy in aging and neurodegeneration: Lessons from alpha-synuclein
    • Bandhyopadhyay U, Cuervo AM. Chaperone-mediated autophagy in aging and neurodegeneration: lessons from alpha-synuclein. Exp Gerontol 2007 42 : 120 128
    • (2007) Exp Gerontol , vol.42 , pp. 120-128
    • Bandhyopadhyay, U.1    Cuervo, A.M.2
  • 71
    • 38349046973 scopus 로고    scopus 로고
    • Autophagy, amyloidogenesis and Alzheimer disease
    • Nixon RA. Autophagy, amyloidogenesis and Alzheimer disease. J Cell Sci 2007 120 : 4081 4091
    • (2007) J Cell Sci , vol.120 , pp. 4081-4091
    • Nixon, R.A.1
  • 72
    • 0030045552 scopus 로고    scopus 로고
    • Properties of the endosomal-lysosomal system in the human central nervous system: Disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease
    • Cataldo AM, Hamilton DJ, Barnett JL, Paskevich PA, Nixon RA. Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease. J Neurosci 1996 16 : 186 199
    • (1996) J Neurosci , vol.16 , pp. 186-199
    • Cataldo, A.M.1    Hamilton, D.J.2    Barnett, J.L.3    Paskevich, P.A.4    Nixon, R.A.5
  • 73
    • 51449119611 scopus 로고    scopus 로고
    • Disruption of neuronal autophagy by infected microglia results in neurodegeneration
    • Alirezaei M, Kiosses WB, Flynn CT, Brady NR, Fox HS. Disruption of neuronal autophagy by infected microglia results in neurodegeneration. PLoS ONE 2008 3 : 2906
    • (2008) PLoS ONE , vol.3 , pp. 2906
    • Alirezaei, M.1    Kiosses, W.B.2    Flynn, C.T.3    Brady, N.R.4    Fox, H.S.5
  • 74
    • 33747391594 scopus 로고    scopus 로고
    • Synaptic remodeling during aging and in Alzheimer's disease
    • Masliah E, Crews L, Hansen L. Synaptic remodeling during aging and in Alzheimer's disease. J Alzheimers Dis 2006 9 : 91 9
    • (2006) J Alzheimers Dis , vol.9 , pp. 91-9
    • Masliah, E.1    Crews, L.2    Hansen, L.3
  • 77
    • 36549041882 scopus 로고    scopus 로고
    • Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death
    • Rami A, Langhagen A, Steiger S. Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death. Neurobiol Dis 2008 29 : 132 141
    • (2008) Neurobiol Dis , vol.29 , pp. 132-141
    • Rami, A.1    Langhagen, A.2    Steiger, S.3
  • 78
    • 38949123720 scopus 로고    scopus 로고
    • Upregulation of Beclin 1 in the ischemic penumbra
    • Rami A. Upregulation of Beclin 1 in the ischemic penumbra. Autophagy 2008 4 : 1 3
    • (2008) Autophagy , vol.4 , pp. 1-3
    • Rami, A.1
  • 79
    • 33646119185 scopus 로고    scopus 로고
    • Expression of the gene encoding the pro-apoptotic BNIP3 protein and stimulation of hypoxia-inducible factor-1alpha (HIF-1alpha) protein following focal cerebral ischemia in rats
    • Althaus J, Bernaudin M, Petit E, Toutain J, Touzani O, Rami A. Expression of the gene encoding the pro-apoptotic BNIP3 protein and stimulation of hypoxia-inducible factor-1alpha (HIF-1alpha) protein following focal cerebral ischemia in rats. Neurochem Intern 2006 48 : 687 695
    • (2006) Neurochem Intern , vol.48 , pp. 687-695
    • Althaus, J.1    Bernaudin, M.2    Petit, E.3    Toutain, J.4    Touzani, O.5    Rami, A.6
  • 80
    • 0038725886 scopus 로고    scopus 로고
    • Ischemic neuronal death in the rat hippocampus: The calpain-calpastatin- caspase hypothesis
    • Rami A. Ischemic neuronal death in the rat hippocampus: the calpain-calpastatin-caspase hypothesis. Neurobiol Dis 2003 13 : 75 88
    • (2003) Neurobiol Dis , vol.13 , pp. 75-88
    • Rami, A.1
  • 81
    • 33846531305 scopus 로고    scopus 로고
    • The interplay between pro-death and pro-survival signaling pathways in myocardial ischemia/reperfusion injury: Apoptosis meets autophagy
    • Hamacher-Brady A, Brady NR, Gottlieb RA. The interplay between pro-death and pro-survival signaling pathways in myocardial ischemia/reperfusion injury: apoptosis meets autophagy. Cardiovasc Drugs Ther 2006 20 : 445 462
    • (2006) Cardiovasc Drugs Ther , vol.20 , pp. 445-462
    • Hamacher-Brady, A.1    Brady, N.R.2    Gottlieb, R.A.3
  • 83
    • 57649228468 scopus 로고    scopus 로고
    • Autophagy and cell death in model organisms
    • Kourtis N, Tavernarakis N. Autophagy and cell death in model organisms. Cell Death Differ 2009 16 : 21 30
    • (2009) Cell Death Differ , vol.16 , pp. 21-30
    • Kourtis, N.1    Tavernarakis, N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.