Effect of additives on protein aggregation

Current Pharmaceutical Biotechnology

Volumn 10, Issue 4, 2009, Pages 400-407

  Hamada, Hiroyuki ^a   Arakawa, Tsutomu ^b   Shiraki, Kentaro ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b ALLIANCE PROTEIN LABORATORIES   (United States)

Author keywords

Aggregation suppressor; Freeze drying; Freeze thawing; Low molecular weight additive; Preferential exclusion; Preferential interaction; Protein aggregation; Refolding

Indexed keywords

AMINO ACID DERIVATIVE; AMPHOPHILE; ARGININE; DETERGENT; ETHYLENE GLYCOL; GUANIDINE; IONIC LIQUID; MAGNESIUM CHLORIDE; OSMOLITE; POLYMER; SODIUM CHLORIDE; SUGAR; SURFACTANT; UREA; EXCIPIENT; MULTIPROTEIN COMPLEX; PROTEIN;

FREEZE DRYING; FREEZE THAWING; HEATING; MOLECULAR WEIGHT; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; REVIEW; SURFACE TENSION; CHEMISTRY; FRACTIONATION; ISOLATION AND PURIFICATION; METHODOLOGY; PHARMACEUTICS;

BIOPHARMACEUTICS; CHEMICAL FRACTIONATION; EXCIPIENTS; MULTIPROTEIN COMPLEXES; PROTEIN DENATURATION; PROTEINS; TECHNOLOGY, PHARMACEUTICAL;

EID: 69249219305     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/138920109788488941     Document Type: Review

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