Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus

Human Molecular Genetics

Volumn 16, Issue 5, 2007, Pages 547-554

  Heijmans, Bastiaan T ^a   Kremer, Dennis ^a   Tobi, Elmar W ^a   Boomsma, Dorret I ^b   Slagboom, P Eline ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GENE PRODUCT; PROTEIN H19; SOMATOMEDIN B; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGE; ARTICLE; BODY SIZE; CONTROLLED STUDY; CPG ISLAND; DIZYGOTIC TWINS; DNA METHYLATION; ENVIRONMENTAL FACTOR; EPIGENETICS; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HERITABILITY; HUMAN; MASS SPECTROMETRY; MONOZYGOTIC TWINS; PRIORITY JOURNAL; QUANTITATIVE TRAIT; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICS;

ADOLESCENT; ADULT; AGING; BODY SIZE; CPG ISLANDS; DNA METHYLATION; ENVIRONMENT; GENOME, HUMAN; HUMANS; INSULIN-LIKE GROWTH FACTOR II; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PRINCIPAL COMPONENT ANALYSIS; QUANTITATIVE TRAIT, HERITABLE; STOCHASTIC PROCESSES; TWINS; VARIATION (GENETICS);

EID: 34047142805     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddm010     Document Type: Article

References (32)

1. Jaenisch, R. and Bird, A. (2003) Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals. Nat. Genet., 33 (suppl.), 245-254.
2. Jones, P.A. and Baylin, S.B. (2002) The fundamental role of epigenetic events in cancer. Nat. Rev. Genet., 3, 415-428.
3. Petronis, A. (2006) Epigenetics and twins: Three variations on the theme. Trends Genet., 22, 347-350.
4. Waterland, R.A. and Jirtle, R.L. (2003) Transposable elements: Targets for early nutritional effects on epigenetic gene regulation. Mol. Cell Biol., 23, 5293-5300.
5. Jacob, R.A., Gretz, D.M., Taylor, P.C., James, S.J., Pogribny, I.P., Miller, B.J., Henning, S.M. and Swendseid, M.E. (1998) Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women. J. Nutr., 128, 1204-1212.
6. Rampersaud, G.C., Kauwell, G.P., Hutson, A.D., Cerda, J.J. and Bailey, L.B. (2000) Genomic DNA methylation decreases in response to moderate folate depletion in elderly women. Am. J. Clin. Nutr., 72, 998-1003.
7. Fraga, M.F., Ballestar, E., Paz, M.F., Ropero, S., Setien, F., Ballestar, M.L., Heine-Suner, D., Cigudosa, J.C., Urioste, M., Benitez, J. et al. (2005) Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl Acad. Sci. USA, 102, 10604-10609.
8. Cui, H., Cruz-Correa, M., Giardiello, F.M., Hutcheon, D.F., Kafonek, D.R., Brandenburg, S., Wu, Y., He, X., Powe, N.R. and Feinberg, A.P. (2003) Loss of IGF2 imprinting: A potential marker of colorectal cancer risk. Science, 299, 1753-1755.
9. Cruz-Correa, M., Cui, H., Giardiello, F.M., Powe, N.R., Hylind, L., Robinson, A., Hutcheon, D.F., Kafonek, D.R., Brandenburg, S., Wu, Y. et al. (2004) Loss of imprinting of insulin growth factor II gene: A potential heritable biomarker for colon neoplasia predisposition. Gastroenterology, 126, 964-970.
10. Robertson, K.D. (2005) DNA methylation and human disease. Nat. Rev. Genet., 6, 597-610.
11. O'Dell, S.D., Miller, G.J., Cooper, J.A., Hindmarsh, P.C., Pringle, P.J., Ford, H., Humphries, S.E. and Day, I.N. (1997) Apal polymorphism in insulin-like growth factor II (IGF2) gene and weight in middle-aged males. Int. J. Obes. Relat. Metab. Disord., 21, 822-825.
12. Van Laere, A.S., Nguyen, M., Braunschweig, M., Nezer, C., Collette, C., Moreau, L., Archibald, A.L., Haley, C.S., Buys, N., Tally, M. et al. (2003) A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig. Nature, 425, 832-836.
13. Zaina, S., Pettersson, L., Ahren, B., Branen, L., Hassan, A.B., Lindholm, M., Mattsson, R., Thyberg, J. and Nilsson, J. (2002) Insulin-like growth factor II plays a central role in atherosclerosis in a mouse model. J. Biol. Chem., 277, 4505-4511.
14. Vu, T.H., Li, T., Nguyen, D., Nguyen, B.T., Yao, X.M., Hu, J.F. and Hoffman, A.R. (2000) Symmetric and asymmetric DNA methylation in the human IGF2-H19 imprinted region. Genomics, 64, 132-143.
15. Ehrich, M., Nelson, M.R., Stanssens, P., Zabeau, M., Liloglou, T., Xinarianos, G., Cantor, C.R., Field, J.K. and van den, B.D. (2005) Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry. Proc. Natl Acad. Sci. USA, 102, 15785-15790.
16. Friso, S., Choi, S.W., Girelli, D., Mason, J.B., Dolnikowski, G.G., Bagley, P.J., Olivieri, O., Jacques, P.F., Rosenberg, I.H., Corrocher, R. et al. (2002) A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc. Natl Acad. Sci. USA, 99, 5606-5611.
17. Castro, R., Rivera, I., Ravasco, P., Camilo, M.E., Jakobs, C., Blom, H.J. and de Almeida, I.T. (2004) 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C→.T and 1298A→.C mutations are associated with DNA hypomethylation. J. Med. Genet., 41, 454-458.
18. Sandovici, I., Kassovska-Bratinova, S., Loredo-Osti, J.C., Leppert, M., Suarez, A., Stewart, R., Bautista, F.D., Schiraldi, M. and Sapienza, C. (2005) Interindividual variability and parent of origin DNA methylation differences at specific human Alu elements. Hum. Mol. Genet., 14, 2135-2143.
19. Bjornsson, H.T., Fallin, M.D. and Feinberg, A.P. (2004) An integrated epigenetic and genetic approach to common human disease. Trends Genet., 20, 350-358.
20. Sandovici, I., Leppert, M., Hawk, P.R., Suarez, A., Linares, Y. and Sapienza, C. (2003) Familial aggregation of abnormal methylation of parental alleles at the IGF2/H19 and IGF2R differentially methylated regions. Hum. Mol. Genet., 12, 1569-1578.
21. Bock, C., Paulsen, M., Tierling, S., Mikeska, T., Lengauer, T. and Walter, J. (2006) CpG island methylation in human lymphocytes is highly correlated with DNA sequence, repeats, and predicted DNA structure. PLoS Genet., 2, e26.
22. Feltus, F.A., Lee, E.K., Costello, J.F., Plass, C. and Vertino, P.M. (2006) DNA motifs associated with aberrant CpG island methylation. Genomics, 87, 572-579.
23. Morgan, H.D., Santos, F., Green, K., Dean, W. and Reik, W. (2005) Epigenetic reprogramming in mammals. Hum. Mol. Genet., 14 (Spec no. 1), R47-R58.
24. Waterland, R.A. and Jirtle, R.L. (2004) Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition, 20, 63-68.
25. Jiang, Y.H., Bressler, J. and Beaudet, A.L. (2004) Epigenetics and human disease. Annu. Rev. Genomics Hum. Genet., 5, 479-510.
26. Martin, G.M. (2005) Epigenetic drift in aging identical twins. Proc. Natl Acad. Sci. USA, 102, 10413-10414.
27. Boomsma, D.I., Kaptein, A., Kempen, H.J., Gevers Leuven, J.A. and Princen, H.M. (1993) Lipoprotein(a): Relation to other risk factors and genetic heritability. Results from a Dutch parent-twin study. Atherosclerosis, 99, 23-33.
28. Snieder, H., van Doornen, L.J. and Boomsma, D.I. (1997) The age dependency of gene expression for plasma lipids, lipoproteins, and apolipoproteins. Am. J. Hum. Genet., 60, 638-650.
29. Heijmans, B.T., Beekman, M., Putter, H., Lakenberg, N., van der Wijk, H.J., Whitfield, J.B., Posthuma, D., Pedersen, N.L., Martin, N.G., Boomsma, D.I. et al. (2005) Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions. Eur. J. Hum. Genet., 13, 1143-1153.
30. Petry, C.J., Ong, K.K., Barratt, B.J., Wingate, D., Cordell, H.J., Ring, S.M., Pembrey, M.E., Reik, W., Todd, J.A. and Dunger, D.B. (2005) Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans. BMC Genet., 6, 22.
31. Abecasis, G.R. and Cookson, W.O. (2000) GOLD - graphical overview of linkage disequilibrium. Bioinformatics, 16, 182-183.
32. Barrett, J.C., Fry, B., Maller, J. and Daly, M.J. (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics, 21, 263-265.