The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase

Human Molecular Genetics

Volumn 8, Issue 8, 1999, Pages 1479-1485

  Smith, Darrin P ^a   Spicer, James ^a   Smith, Amanda ^a   Swift, Sally ^a   Ashworth, Alan ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; NUCLEAR PROTEIN; PROTEIN KINASE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMOSOME 10; CONTROLLED STUDY; DNA TRANSFECTION; GENE; GENE MAPPING; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; NUCLEOTIDE SEQUENCE; PEUTZ JEGHERS SYNDROME; PRIORITY JOURNAL; SEQUENCE HOMOLOGY;

ANIMALIA;

EID: 0032815880     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/8.8.1479     Document Type: Article

References (31)

1. Peutz, J.L. (1921) On a very remarkable case of familial polyposis of the mucous membrane of the intestinal tract and nasopharynx accompanied by peculiar pigmentation of the skin and mucous membrane. Ned. Tijdschr. Geneeska., 10, 134-146.
2. Jeghers, H., McKusick, V.A. and Katz, K.H. (1949) Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits: a syndrome of diagnostic significance. N. Engl. J. Med., 241, 992-1005.
3. Boardman, M.D., Thibodean, S.N., Schaid. D.J., Lindov, N.M., McDonnell, M.S., Burgart, L.J., Ahlquist, D.A., Podratz, K.C., Pittelkow, M. and Hartmann, L.C. (1998) Increased risk for cancer in patients with the Peutz-Jeghers Syndrome. Ann. Intern. Med., 128, 896-899.
4. Spigelman, A.D., Murday, V. and Phillips, R.K. (1989) Cancer and the Peutz-Jeghers syndrome. Gut. 30, 1588-1590.
5. Hemminki, A., Tomlinson, I., Markie, D., Jarvinen, H., Sistonen, P., Bjorkqvist, A.M., Knuutila, S., Salovaara, R., Bodmer, W., Shibata, D., de la Chapelle, A. and Aaltonen, L.A. (1997) Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis. Nature Genet., 15, 87-90.
6. Hemminki, A., Markie, D., Tomlinson, I., Avizienyte, E., Roth, S., Loukola, A., Bignell, G., Warren, W., Aminoff, M., Hoglund, P., Jarvinen, H., Kristo, P., Pelin, K., Ridanpaa, M., Salovaara, R., Toro, T., Bodmer, W., Giardiello, F.M., Hamilton, S.R., Gruber, S.B., Olschwang, S., Olsen, A., Stratton, M.R., de la Chapelle, A. and Aaltonen, L.A. (1998) Germline mutations in a serine/threonine kinase homologue in a human cancer predisposition syndrome. Nature, 391, 184-187.
7. Nezu, J. (1996) Molecular cloning of a novel serine/threonine protein kinase expressed in human fetal liver (http://www.ncbi.nlm.nih.gov/irx/cgibin/brx_doc?genbank+441522).
8. Su, J.-Y., Erikson, E. and Maller, J.L. (1996) Cloning and characterization of a novel serine/threonine protein kinase expressed in early Xenopus embyos. J. Biol. Chem., 271, 14430-14437.
9. Jeanne, D.E., Reimann, H., Nezu, J.-I., Friedel, W., Loff, S., Jeschke, R., Muller, O., Buck, W. and Zimmer, M. (1998) Peutz-Jeghers Syndrome is caused by mutations in a novel serine threonine kinase. Nature Genet., 18, 38-43.
10. Mehenni, H., Gehrig, C., Nezu, J.I., Oku, A., Shiman, M., Rossier, C., Guex, N., Blouin, J.L., Scott, H.S. and Antonarkis, S.E. (1998) Loss of LKB1 kinase activity in Peutz-Jeghers Syndrome, and evidence for allelic and locus heterogenity. Am. J. Hum. Genet., 63, 1641-1650.
11. Ylikorkala, A., Avizienyte, E., Tomlinson, I.P.M., Tianinen, M., Roth, S., Loukola, A., Hemminki, A., Johansson, M., Sistonen, P., Markie, D., Neale, K., Phellips, R., Zauber, P., Twama, T., Sampson, J., Jarvinen, H., Makela, T.P. and Aaltonen, L.A. (1999) Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and sporadic testicular cancer. Hum. Mol. Genet., 8, 45-51.
12. Kozak, M. (1989) The scanning model for translation: an update. J. Cell Biol., 108, 229-241.
13. Hall, S.L. and Padgett, R.A. (1994) Conserved sequences in a class of rare eukaryotic nuclear introns with non-consensus splice sites. J. Mol. Biol., 239, 357-365.
14. Nagy, E. and Maquat, L.E. (1998) A rule for termination-codon position within intron containing genes: when nonsense affects RNA abundance. Trends Biochem. Sci., 23, 198-199.
15. The European Backcross Collaborative Group (1994) Towards high resolution maps of the mouse and human genomes - a facility for ordering markers to 0.1 cm resolution. Hum. Mol. Genet., 3, 621-627.
16. Williams, T. and Fried, M. (1986) A mouse locus at which transcription from both DNA strands produces mRNAs complementary at their 3'-ends. Nature, 322, 275-279.
17. Laudet, V., Begue, A., Henry-Duthoit, C., Joubel, A., Martin, P., Stehelin, D. and Saule, S. (1991) Genomic organisation of the human thyroid hormone α (c-erbA-1) gene. Nucleic Acids Res., 19, 1105-1112.
18. Ashworth, A. (1993) Two acetyl-CoA acetyltransferase genes located in the t-complex region of mouse chromosome 17 partially overlap the Tcp-1 and Tcp-1x genes. Genomics, 18, 195-198.
19. Amariglio, F., Tchang, F., Prioleau, M.N., Soussi, T., Cibert, C. and Mechali, M.A (1997) functional analysis of p53 during early development of Xenopus laevis. Oncogene, 15, 2191-2199.
20. Gusse, M., Ghysdael, J., Evan, G., Soussi, T. and Mechali, M. (1989) Translocation of a store of maternal cytoplasmic c-MYC protein into nuclei during early development. Mol. Cell. Biol., 9, 5395-5403.
21. Smith, O.P. and Old, R.W. (1991) Xenopus leavis OCT-1 does not bind to certain histone-H2B gene promoter octamer motifs for which a novel octamer-binding factor has high affinity. Nucleic Acids Res., 19, 815-821.
22. Yoneda, Y. (1997) How proteins are transported from cytoplasm to the nucleus. J. Biochem., 121, 811-817.
23. Shaw, P.J. and Jordan, E.G. (1995) The nucleolus. Annu. Rev. Cell Dev. Biol., 11, 93-121.
24. JiangR. and Carlson, M. (1996) Glucose regulates protein interactions within the yeast SNF1 protein kinase complex. Genes Dev., 10, 3105-3115.
25. Randez Gil, F., Bojunga, N., Proft, M. and Entian, K.D. (1997) Glucose derepression of gluconeogenic enzymes in Saccharomyces cerevisiae correlates with phosphorylation of the gene activator Cat8p. Mol. Cell. Biol., 17, 2502-2510.
26. Vincent, O. and Carlson, M. (1998) Sip4, a Snf1 kinase-dependent transcriptional activator, binds to the carbon source-responsive element of gluconeogenic genes. EMBO J., 17, 7002-7008.
27. Polakis, P. (1997) The adenomatous polyposis coli (APC) tumour suppressor. Biochim. Biophys. Acta, 1332, 127-147.
28. Howe, J.R., Roth, S., Ringold, J.C., Summer, R.W., Jarvinen, H.J., Sistonen, P., Tomlinson, I.P.M., Houlston, R.S., Bevan, S., Mitros, F.A., Stone, E.M. and Aaltonen, L.A. (1998) Mutations in the SMAD4/DPC4 gene in juvenile polyposis. Science, 280, 1086-1088.
29. He, T.C., Sparks, A.B., Rago, C., Hermeking, H., Zawel, L., daCosta, L.T., Morin, P.J., Vogelstein, B. and Kinzler, K.W. (1998) Identification of c-MYC as a target of the APC pathway. Science, 281, 1509-1512.
30. Lorenzo, M.J., Gish, G.D., Houghton, C., Storehouse, T.J., Pawson, T., Ponder, B.A.J. and Smith, D.P. (1997) RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2. Oncogene, 14, 763-771.
31. Thompson, J.D., Higgins, D.G. and Gibson, T.J. (1994) Clustal W - improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res., 22, 4673-4680.