The hamartoma-adenoma-carcinoma sequence

Journal of Pathology

Volumn 188, Issue 1, 1999, Pages 1-2

  Bosman, F T ^a  

^a UNIVERSITY INSTITUTE OF PATHOLOGY   (Switzerland)

Author keywords

Adenoma; Colorectal carcinoma; Hamartoma; Juvenile polyp syndrome; Peutz Jeghers' syndrome

Indexed keywords

ADENOMA; CANCER GENETICS; CARCINOGENESIS; COLORECTAL CARCINOMA; FAMILIAL CANCER; GENE MUTATION; HAMARTOMA; HUMAN; JUVENILE POLYP; MOLECULAR GENETICS; PEUTZ JEGHERS SYNDROME; PRIORITY JOURNAL; REVIEW; TUMOR SUPPRESSOR GENE;

ADENOMA; CARCINOMA; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; GERM-LINE MUTATION; HAMARTOMA; HUMANS; LOSS OF HETEROZYGOSITY; PEUTZ-JEGHERS SYNDROME; PROTEIN-SERINE-THREONINE KINASES;

EID: 0032946456     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199905)188:1<1::AID-PATH327>3.0.CO;2-J     Document Type: Review

References (10)

1. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990; 61: 759-767.
2. Bronner CE, Baker SM, Morrison PT, et al. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 1994; 368: 258-261.
3. Nicolaides NC, Papadopoulos N, Liu B, et al. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature 1994; 371: 75-80.
4. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996; 87: 159-170.
5. Wang ZJ, Taylor F, Churchman M, Norbury G, Tomlinson I. Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKBI genes outside the inherited hamartoma syndromes. Am J Pathol 1998; 153: 363-366.
6. Howe JR, Roth S, Ringold JC, et al. Mutations in the SMAD4/DPC4 gene in juvenile polyposis. Science 1998; 180: 1086-1088.
7. Jacoby RF, Schlack S, Cole CE, Skarbek M, Harris C, Meisner LF. A juvenile polyposis tumour suppressor locus at 10q22 is deleted from nonepithelial cells in the lamina propria. Gastroenterology 1997; 112: 1398-1403.
8. Kinzler KW, Vogelstein B. Landscaping the cancer terrain. Science 1998; 280: 1036-1037.
9. Wang ZJ, Ellis I, Zauber P, et al. Allelic imbalance at the LKBI (STK11) locus on 19p13.3 in hamartomas, adenomas, and carcinomas from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence. J Pathol 1999; 188: 613-617.
10. Resta N, Simone C, Mareni C. et al. STK11 mutations in Peutz-Jeghers' syndrome and sporadic colon cancer. Cancer Res 1998; 58: 4799-4801.