Diphosphoinositol polyphosphates: Metabolic messengers?

Molecular Pharmacology

Volumn 76, Issue 2, 2009, Pages 236-252

  Shears, Stephen B ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPHOSPHOINOSITOL POLYPHOSPHATE; INOSITOL PHOSPHATE; PHOSPHATASE; PHOSPHOTRANSFERASE; POLYPHOSPHATE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; CELL COMPARTMENTALIZATION; CELL ENERGY; CELL LEVEL; CELL METABOLISM; HUMAN; NONHUMAN; PHOSPHATE METABOLISM; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SEQUENCE HOMOLOGY; SHORT SURVEY; TURNOVER TIME;

ANIMALS; HUMANS; INOSITOL PHOSPHATES; MOLECULAR STRUCTURE; POLYPHOSPHATES; SIGNAL TRANSDUCTION;

EID: 67650802345     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.109.055897     Document Type: Short Survey

References (171)

1. Agranoff BW (1978) Textbook errors: cyclitol confusion. Trends Biochem Sci 3:N283-N285.
2. Albert C, Safrany ST, Bembenek ME, Reddy KM, Reddy K, Falck J, Bröcker M, Shears SB, and Mayr GW (1997) Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells. Biochem J 327:553-560. (Pubitemid 27477836)
3. Auesukaree C, Tochio H, Shirakawa M, Kaneko Y, and Harashima S (2005) Plc1p, Arg82p, and Kcs1p, enzymes involved in inositol pyrophosphate synthesis, are essential for phosphate regulation and polyphosphate accumulation in saccharomyces cerevisiae. J Biol Chem 280:25127-25133. (Pubitemid 40934605)
4. Azevedo C and Saiardi A (2006) Extraction and analysis of soluble inositol polyphosphates from yeast. Nat Protoc 1:2416-2422.
5. Bain J, Plater L, Elliott M, Shpiro N, Hastie CJ, McLauchlan H, Klevernic I, Arthur JS, Alessi DR, and Cohen P (2007) The selectivity of protein kinase inhibitors: a further update. Biochem J 408:297-315.
6. Barker CJ, Wright J, Hughes PJ, Kirk CJ, and Michell RH (2004) Complex changes in cellular inositol phosphate complement accompany transit through the cell cycle. Biochem J 380:465-473. (Pubitemid 38788119)
7. Bennett M, Onnebo SM, Azevedo C, and Saiardi A (2006) Inositol pyrophosphates: metabolism and signaling. Cell Mol Life Sci 63:552-564.
8. Bhandari R, Juluri KR, Resnick AC. and Snyder SH (2008) Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis. Proc Natl Acad Sci U S A 105:2349-2353.
9. Bhandari R, Saiardi A, Ahmadibeni Y, Snowman AM, Resnick AC, Kristiansen TZ, Molina H, Pandey A, Werner JK Jr, Juluri KR, et al. (2007) Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event. Proc Natl Acad Sci U S A 104:15305-15310. (Pubitemid 47502913)
10. Biemans-Oldehinkel E, Mahmood NA, and Poolman B (2006) A sensor for intracellular ionic strength. Proc Natl Acad Sci U S A 103:10624-10629.
11. Blackburn K and Goshe MB (2009) Challenges and strategies for targeted phosphorylation site identification and quantification using mass spectrometry analysis. Brief Funct Genomic Proteomic 8:90-103.
12. Boisvert FM, van Koningsbruggen S, Navascués J, and Lamond AI (2007) The multifunctional nucleolus. Nat Rev Mol Cell Biol 8:574-585.
13. Brearley CA and Hanke DE (1996) Metabolic evidence for the order of addition of individual phosphate esters to the myo-inositol moiety of inositol hexakisphosphate in the duckweed Spirodela polyrhiza L. Biochem J 314:227-233.
14. Brehm MA, Schenk TM, Zhou X, Fanick W, Lin H, Windhorst S, Nalaskowski MM, Kobras M, Shears SB, and Mayr GW (2007) Intracellular localization of human Ins(1,3,4,5,6)P5 2-kinase. Biochem J 408:335-345.
15. Browne GJ and Proud CG (2002) Regulation of peptide-chain elongation in mammalian cells. Eur J Biochem 269:5360-5368. (Pubitemid 35365525)
16. Bunce CM, French PJ, Allen P, Mountford JC, Moor B, Greaves MF, Michell RH, and Brown G (1993) Comparison of the levels of inositol metabolites in transformed haemopoietic cells and their normal counterparts. Biochem J 289:667-673. (Pubitemid 23074947)
17. Burton A, Hu X, and Saiardi A (2009) Are inositol pyrophosphates signalling molecules? J Cell Physiol 220:8-15.
18. Caffrey JJ, Safrany ST, Yang X, and Shears SB (2000) Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family. J Biol Chem 275:12730-12736. (Pubitemid 30241425)
19. Caffrey JJ and Shears SB (2001) Genetic rationale for microheterogeneity of human diphosphoinositol polyphosphate phosphohydrolase type 2. Gene 269:53-60.
20. Campisi J and d'Adda di Fagagna F (2007) Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 8:729-740. (Pubitemid 47312822)
21. Carling D, Clarke PR, Zammit VA, and Hardie DG (1989) Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities. Eur J Biochem 186:129-136. (Pubitemid 20015135)
22. Chakraborty A, Koldobskiy MA, Sixt KM, Juluri KR, Mustafa AK, Snowman AM, van Rossum DB, Patterson RL, and Snyder SH (2008) HSP90 regulates cell survival via inositol hexakisphosphate kinase-2. Proc Natl Acad Sci U S A 105:1134-1139.
23. Chamberlain PP, Qian X, Stiles AR, Cho J, Jones DH, Lesley SA, Grabau EA, Shears SB, and Spraggon G (2007) Integration of inositol phosphate signaling pathways via human ITPK1. J Biol Chem 282:28117-28125. (Pubitemid 47529547)
24. Chen W, Levine H, and Rappel WJ (2008) A mathematical analysis of second messenger compartmentalization. Phys Biol 5:46006.
25. Choi JH, Williams J, Cho J, Falck JR, and Shears SB (2007) Purification, sequencing, and molecular identification of a mammalian PP-Insp5 kinase that is activated when cells are exposed to hyperosmotic stress. J Biol Chem 282:30763-30775. (Pubitemid 350035231)
26. Choi K, Mollapour E, Choi JH, Falck JR, and Shears SB (2008) Cellular energetic status supervises the synthesis of bis-diphosphoinositol tetrakisphosphate independently of AMP-activated protein kinase. Mol Pharmacol 74:527-536.
27. 8 operates within highly restricted contexts. Cell Signal 17:1533-1541.
28. Chu C, Alapat D, Wen X, Timo K, Burstein D, Lisanti M, Shears S, and Kohtz DS (2004) Ectopic expression of murine diphosphoinositol polyphosphate phosphohydrolase 1 attenuates signaling through the ERK1/2 pathway. Cell Signal 16:1045-1059. (Pubitemid 38798055)
29. Czornak K, Chughtai S, and Chrzanowska KH (2008) Mystery of DNA repair: the role of the MRN complex and ATM kinase in DNA damage repair. J Appl Genet 49:383-396.
30. Daval M, Diot-Dupuy F, Bazin R, Hainault I, Viollet B, Vaulont S, Hajduch E, Ferré P, and Foufelle F (2005) Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes. J Biol Chem 280:25250-25257. (Pubitemid 40934619)
31. Dephoure N, Howson RW, Blethrow JD, Shokat KM, and O'Shea EK (2005) Combining chemical genetics and proteomics to identify protein kinase substrates. Proc Natl Acad Sci U S A 102:17940-17945. (Pubitemid 41798481)
32. Detimary P, Dejonghe S, Ling Z, Pipeleers D, Schuit F, and Henquin JC (1998) The changes in adenine nucleotides measured in glucose-stimulated rodent islets occur in beta cells but not in alpha cells and are also observed in human islets. J Biol Chem 273:33905-33908. (Pubitemid 29008852)
33. Dokladda K, Green KA, Pan DA, and Hardie DG (2005) PD98059 and U0126 activate AMP-activated protein kinase by increasing the cellular AMP:ATP ratio and not via inhibition of the MAP kinase pathway [published erratum appears in FEBS Lett 579:2019, 2005]. FEBS Lett 579:236-240.
34. Downes CP, Gray A, Fairservice A, Safrany ST, Batty IH, and Fleming I (2005) The regulation of membrane to cytosol partitioning of signalling proteins by phosphoinositides and their soluble headgroups. Biochem Soc Trans 33:1303-1307. (Pubitemid 41779673)
35. Draskovic P, Saiardi A, Bhandari R, Burton A, Ilc G, Kovacevic M, Snyder SH, and Podobnik M (2008) Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups. Chem Biol 15:274-286.
36. Dubois E, Scherens B, Vierendeels F, Ho MM, Messenguy F, and Shears SB (2002) In Saccharomyces cerevisiae, the inositol polyphosphate kinase activity of Kcs1p is required for resistance to salt stress, cell wall integrity, and vacuolar morphogenesis. J Biol Chem 277:23755-23763. (Pubitemid 34952217)
37. Edwalds-Gilbert G, Veraldi KL, and Milcarek C (1997) Alternative poly(A) site selection in complex transcription units: means to an end? Nucleic Acids Res 25:2547-2561. (Pubitemid 27298148)
38. El Alami M, Messenguy F, Scherens B, and Dubois E (2003) Arg82p is a bifunctional protein whose inositol polyphosphate kinase activity is essential for nitrogen and PHO gene expression but not for Mcm1p chaperoning in yeast. Mol Microbiol 49:457-468. (Pubitemid 36851200)
39. Epperson S, Gustafsson A, Gonzalez A, Villegas S, Meszaros J and Brunton L (2005) Pharmacology of G-protein-linked signaling in cardiac fibroblasts, in Interstitial Fibrosis in Heart Failure (Villarreal FJ ed) pp 83-97, New York, Springer.
40. 3H]-inositol into inositol polyphosphates during development of Dictyostelium. Biochem Biophys Res Commun 181:191-196.
41. Feldser DM and Greider CW (2007) Short telomeres limit tumor progression in vivo by inducing senescence. Cancer Cell 11:461-469.
42. Fersht A (1985) Enzyme Structure and Mechanism. W.H. Freeman Co., San Francisco.
43. Fisher DI, Safrany ST, Strike P, McLennan AG, and Cartwright JL (2002) Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate. J Biol Chem 277:47313-47317. (Pubitemid 36159244)
44. +-selective channels gated by, inositol polyphosphates. J Biol Chem 269:17826-17832.
45. Force A, Lynch M, Pickett FB, Amores A, Yan YL, and Postlethwait J (1999) Preservation of duplicate genes by complementary, degenerative mutations. Genetics 151:1531-1545. (Pubitemid 29177561)
46. Fridy PC, Otto JC, Dollins DE, and York JD (2007) Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases. J Biol Chem 282:30754-30762.
47. Glennon MC and Shears SB (1993) Turnover of inositol pentakisphosphates, inositol hexakisphosphate and diphosphoinositol polyphosphates in primary cultured hepatocytes. Biochem J 293:583-590.
48. Hand CE and Honek JF (2007) Phosphate transfer from inositol pyrophosphates InsP5PP and InsP4(PP)2: a semi-empirical investigation. Bioorg Med Chem Lett 17:183-188.
49. Hao W, Tan Z, Prasad K, Reddy KK, Chen J, Prestwich GD, Falck JR, Shears SB, and Lafer EM (1997) Regulation of AP-3 function by inositides. Identification of phosphatidylinositol 3,4,5-trisphosphate as a potent ligand. J Biol Chem 272:6393-6398. (Pubitemid 27118117)
50. Hara A and Abiko Y (1995) Protective effect of hypoxia on mechanical and metabolic changes induced by hydrogen peroxide in rat hearts. Am J Physiol 268:H614-H620.
51. Hardie DG (2004) The AMP-activated protein kinase pathway - new players upstream and downstream. J Cell Sci 117:5479-5487.
52. Henin N, Vincent MF, and Van den Berghe G (1996) Stimulation of rat liver AMP-activated protein kinase by AMP analogues. Biochim Biophys Acta 1290:197-203. (Pubitemid 26184469)
53. Herbig U, Ferreira M, Condel L, Carey D, and Sedivy JM (2006) Cellular senescence in aging primates. Science 311:1257.
54. Hers HG and Hue L (1983) Gluconeogenesis and related aspects of glycolysis. Ann Rev Biochem 52:617-653.
55. Hidaka K, Caffrey JJ, Hua L, Zhang T, Falck JR, Nickel GC, Carrel L, Barnes LD, and Shears SB (2002) An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase. J Biol Chem 277:32730-32738. (Pubitemid 34984780)
56. 4 signaling by a reversible kinase/phosphatase. Current Biology 12:477-482.
57. Hochachka PW (1999) The metabolic implications of intracellular circulation. Proc Natl Acad Sci U S A 96:12233-12239.
58. Horigome C, Ikeda R, Okada T, Takenami K, and Mizuta K (2009) Genetic interaction between ribosome biogenesis and inositol polyphosphate metabolism in Saccharomyces cerevisiae. Biosci Biotechnol Biochem 73:443-446.
59. Hua LV, Green M, Warsh JJ, and Li PP (2001) Molecular cloning of a novel isoform of diphosphoinositol polyphosphate phosphohydrolase: a potential target of lithium therapy. Neuropsychopharmacology 24:640-651. (Pubitemid 32452212)
60. Hua LV, Hidaka K, Pesesse X, Barnes LD, and Shears SB (2003) Paralogous murine Nudt10 and Nudt11 genes have differential expression patterns but encode identical proteins that are physiologically competent diphosphoinositol polyphosphate phosphohydrolases. Biochem J 373:81-89. (Pubitemid 36819504)
61. Huang D, Friesen H, and Andrews B (2007a) Pho85, a multifunctional cyclin-dependent protein kinase in budding yeast. Mol Microbiol 66:303-314. (Pubitemid 47482378)
62. Huang D, Patrick G, Moffat J, Tsai LH, and Andrews B (1999) Mammalian Cdk5 is a functional homologue of the budding yeast Pho85 cyclin-dependent protein kinase. Proc Natl Acad Sci U S A 96:14445-14450. (Pubitemid 30000670)
63. Huang YH, Grasis JA, Miller AT, Xu R, Soonthornvacharin S, Andreotti AH, Tsoukas CD, Cooke MP, and Sauer K (2007b) Positive regulation of Itk PH domain function by soluble IP4. Science 316:886-889. (Pubitemid 46764278)
64. Illies C, Gromada J, Fiume R, Leibiger B, Yu J, Juhl K, Yang SN, Barma DK, Falck JR, Saiardi A, et al. (2007) Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cells. Science 318:1299-1302. (Pubitemid 350172894)
65. 5-pentaphosphate and diphosphoinositol polyphosphate concentrations. Biochem J 369:519-528.
66. Inoki K, Zhu T, and Guan KL (2003) TSC2 mediates cellular energy response to control cell growth and survival. Cell 115:577-590. (Pubitemid 37506046)
67. Irvine RF and Schell MJ (2001) Back in the water: the return of the inositol phosphates. Nat Rev Mol Cell Biol 2:327-338.
68. IUPAC-IUB Commission on Biochemical Nomenclature (1969) [IUPAC Commission on the Nomenclature of Organic Chemistry (CON) and IUPAC-IUB Commission on Biochemical Nomenclature (CBN). Nomenclature of cyclitol. Tentative rules.] Hoppe Seylers Z Physiol Chem 350:523-535.
69. IUPAC-IUB Commission on Biochemical Nomenclature (1977) Nomenclature of phosphorus-containing compounds of biochemical importance (Recommendations 1976). Proc Natl Acad Sci U S A 74:2222-2230.
70. Jin S, DiPaola RS, Mathew R, and White E (2007) Metabolic catastrophe as a means to cancer cell death. J Cell Sci 120:379-383. (Pubitemid 46332501)
71. Kaffman A, Herskowitz I, Tjian R, and O'Shea EK (1994) Phosphorylation of the transcription factor PHO4 by a cyclin-CDK complex, PHO80-PHO85. Science 263:1153-1156. (Pubitemid 24105964)
72. Kim K, Dimitrova DD, Carta KM, Saxena A, Daras M, and Borowiec JA (2005) Novel checkpoint response to genotoxic stress mediated by nucleolin-replication protein a complex formation. Mol Cell Biol 25:2463-2474. (Pubitemid 40354639)
73. Komander D, Fairservice A, Deak M, Kular GS, Prescott AR, Peter Downes C, Safrany ST, Alessi DR, and van Aalten DM (2004) Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates. EMBO J 23:3918-3928. (Pubitemid 39472414)
74. Kozak M (1996) Interpreting CDNA sequences: some insights from studies on translation. Mammalian Genome 7:563-574.
75. Lam TK, Pocai A, Gutierrez-Juarez R, Obici S, Bryan J, Aguilar-Bryan L, Schwartz GJ, and Rossetti L (2005) Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis. Nat Med 11:320-327. (Pubitemid 40460561)
76. Lambotte L (1977) Effect of anoxia and ATP depletion on the membrane potential and permeability of dog liver. J Physiol 269:53-76.
77. Laussmann T, Eujen R, Weisshuhn CM, Thiel U, and Vogel G (1996) Structures of diphospho-myo-inositol pentakisphosphate and bisdiphospho-myo- inositol tetrakisphosphate from Dictyostelium resolved by NMR analysis. Biochem J 315:715-720. (Pubitemid 26147593)
78. Laussmann T, Pikzack C, Thiel U, Mayr GW, and Vogel G (2000) Diphospho-myo-inositol phosphates during the life cycle of Dictyostelium and Polysphondylium. Eur J Biochem 267:2447-2451. (Pubitemid 30220093)
79. Laussmann T, Reddy KM, Reddy KK, Falck JR, and Vogel G (1997) Diphopho-myo-inositol phosphates from Dictyostelium identified as D-6-diphospho-myo-inositol pentakisphosphate and D-5,6-bisdiphospho-myo-inositol tetrakisphosphate. Biochem J 322:31-33. (Pubitemid 27095518)
80. Lee YS, Huang K, Quiocho FA, and O'Shea EK (2008) Molecular basis of cyclin-CDKCKI regulation by reversible binding of an inositol pyrophosphate. Nat Chem Biol 4:25-32. (Pubitemid 350273651)
81. Lee YS, Mulugu S, York JD, and O'Shea EK (2007) Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates. Science 316:109-112. (Pubitemid 46559529)
82. Legendre-Guillemin V, Wasiak S, Hussain NK, Angers A, and McPherson PS (2004) ENTH/ANTH proteins and clathrin-mediated membrane budding. J Cell Sci 117:9-18. (Pubitemid 38072116)
83. Leslie NR, McLennan AG, and Safrany ST (2002) Cloning and characterization of hAps1 and hAps2, human diadenosine polyphosphate- metabolising Nudix hydrolases. BMC Biochemistry 3:20.
84. Letcher AJ, Schell MJ, and Irvine RF (2008) Do mammals make all their own inositol hexakisphosphate? Biochem J 416:263-270.
85. Lewis JA, Huq A, and Najarro P (1996) Inhibition of mitochondrial function by interferon. J Biol Chem 271:13184-13190.
86. Lin H, Fridy PC, Ribeiro AA, Choi JH, Barma DK, Vogel G, Falck JR, Shears SB, York JD, and Mayr GW (2009) Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases. J Biol Chem 284:1863-1872.
87. Losito O, Szijgyarto Z, Resnick AC, and Saiardi A (2009) Inositol pyrophosphates and their unique metabolic complexity; analysis by gel filtration. PLoS ONE 4:e558.
88. Luo HR, Huang YE, Chen JC, Saiardi A, Iijima M, Ye K, Huang Y, Nagata E, Devreotes P, and Snyder SH (2003) Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions. Cell 114:559-572. (Pubitemid 37159253)
89. Luo HR, Saiardi A, Yu H, Nagata E, Ye K, and Snyder SH (2002) Inositol pyrophosphates are required for DNA hyperrecombination in protein kinase c1 mutant yeast. Biochemistry 41:2509-2515. (Pubitemid 34168919)
90. Maerkl SJ and Quake SR (2007) A systems approach to measuring the binding energy landscapes of transcription factors. Science 315:233-237.
91. Majerus PW, Zou J, Marjanovic J, Kisseleva MV, and Wilson MP (2008) The role of inositol signaling in the control of apoptosis. Adv Enzyme Regul 48:10-17.
92. Martinez P, Zvyagilskaya R, Allard P, and Persson BL (1998) Physiological regulation of the derepressible phosphate transporter in Saccharomyces cerevisiae. J Bacteriol 180:2253-2256. (Pubitemid 28212718)
93. Mayr GW (1988) A novel metal-dye detection system permits picomolar-range h.p.l.c. analysis of inositol polyphosphates from non-radioactively labelled cell or tissue specimens. Biochem J 254:585-591.
94. McLennan AG (2006) The Nudix hydrolase superfamily. Cell Mol Life Sci 63:123-143.
95. Menniti FS, Miller RN, Putney JW Jr, and Shears SB (1993) Turnover of inositol polyphosphate pyrophosphates in pancreatoma cells. J Biol Chem 268:3850-3856. (Pubitemid 23072913)
96. Merrill GF, Kurth EJ, Hardie DG, and Winder WW (1997) AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am J Physiol 273:E1107-E1112. (Pubitemid 127797955)
97. Michell RH (2008) Inositol derivatives: evolution and functions. Nat Rev Mol Cell Biol 9:151-161.
98. Mishra J and Bhalla US (2002) Simulations of inositol phosphate metabolism and its interaction with InsP(3)-mediated calcium release. Biophys J 83:1298-1316.
99. Miyoshi N, Oubrahim H, Chock PB, and Stadtman ER (2006) Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis. Proc Natl Acad Sci U S A 103:1727-1731. (Pubitemid 43228761)
100. Morrison BH, Bauer JA, Hu J, Grane RW, Ozdemir AM, Chawla-Sarkar M, Gong B, Almasan A, Kalvakolanu DV, and Lindner DJ (2002) Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics. Oncogene 21:1882-1889. (Pubitemid 34259191)
101. Morrison BH, Bauer JA, Kalvakolanu DV, and Lindner DJ (2001) Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-β in ovarian carcinoma cells. J Biol Chem 276:24965-24970. (Pubitemid 37412970)
102. Morrison BH, Bauer JA, Lupica JA, Tang Z, Schmidt H, DiDonato JA, and Lindner DJ (2007) Effect of inositol hexakisphosphate kinase 2 on transforming growth factor β-activated kinase 1 and NF-κB activation. J Biol Chem 282:15349-15356. (Pubitemid 47093294)
103. Morrison BH, Tang Z, Jacobs BS, Bauer JA, and Lindner DJ (2005) Apo2L/TRAIL induction and nuclear translocation of inositol hexakisphosphate kinase 2 during IFN-beta-induced apoptosis in ovarian carcinoma. Biochem J 385:595-603. (Pubitemid 40165094)
104. Morrison BH, Haney R, Lamarre E, Drazba J, Prestwich GD and Lindner, DJ (2009) Oncogene. doi: 10.1038/onc.2009.113.
105. Mulugu S, Bai W, Fridy PC, Bastidas RJ, Otto JC, Dollins DE, Haystead TA, Ribeiro AA, and York JD (2007) A conserved family of enzymes that phosphorylate inositol hexakisphosphate. Science 316:106-109. (Pubitemid 46559528)
106. Nagata E, Luo HR, Saiardi A, Bae BI, Suzuki N, and Snyder SH (2005) Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death. J Biol Chem 280:1634-1640.
107. Narala SR, Allsopp RC, Wells TB, Zhang G, Prasad P, Coussens MJ, Rossi DJ, Weissman IL, and Vaziri H (2008) SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity. Mol Biol Cell 19:1210-1219.
108. Oliver KG, Putney JW Jr, Obie JF, and Shears SB (1992) The interconversion of inositol 1,3,4,5,6-pentakisphosphate and inositol tetrakisphosphates in AR4-2J cells. J Biol Chem 267:21528-21534.
109. Olovnikov IA, Kravchenko JE, and Chumakov PM (2009) Homeostatic functions of the p53 tumor suppressor: regulation of energy metabolism and antioxidant defense. Semin Cancer Biol 19:32-41.
110. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, and Mann M (2006) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell 127:635-648. (Pubitemid 44647421)
111. Otto JC, Kelly P, Chiou ST, and York JD (2007) Alterations in an inositol phosphate code through synergistic activation of a G protein and inositol phosphate kinases. Proc Natl Acad Sci U S A 104:15653-15658. (Pubitemid 350035355)
112. Padmanabhan U, Dollins DE, Fridy PC, York JD, and Downes CP (2009) Characterization of a selective inhibitor of inositol hexakisphosphate kinases. Use in defining biological roles and metabolic relationships of inositol pyrophosphates. J Biol Chem 284:10571-10582
113. Pesesse X, Choi K, Zhang T, and Shears SB (2004) Signalling by higher inositolpolyphosphates. Synthesis of bis-diphosphoinositol tetrakisphosphate ("InsP8") is selectively activated by hyperosmotic stress. J Biol Chem 279:43378-43381. (Pubitemid 39390635)
114. Pittet D, Schlegel W, Lew DP, Monod A, and Mayr GW (1989) Mass changes in inositol tetrakis- and pentakisphosphate isomers induced by chemotactic peptide stimulation in HL-60 cells. J Biol Chem 264:18489-18493. (Pubitemid 19277594)
115. Ponnusamy S, Alderson NL, Hama H, Bielawski J, Jiang JC, Bhandari R, Snyder SH, Jazwinski SM, and Ogretmen B (2008) Regulation of telomere length by fatty acid elongase 3 in yeast. Involvement of inositol phosphate metabolism and Ku70/80 function. J Biol Chem 283:27514-27524.
116. Rall TW and Sutherland EW (1958) Formation of a cyclic adenine ribonucleotide by tissue particles. J Biol Chem 232:1065-1076.
117. Rando TA (2006) Prognostic value of telomere length: the long and short of it. Ann Neurol 60:155-157. (Pubitemid 44182389)
118. Robison GA, Butcher RW, and Sutherland EW (1968) Cyclic AMP. Annu Rev Biochem 37:149-174.
119. Rodríguez-Enríquez S, Marín-Hernández A, Gallardo-Pérez JC, Carreño-Fuentes L, and Moreno-Sánchez R (2009) Targeting of cancer energy metabolism. Mol Nutr Food Res 53:29-48.
120. Rolland F, Winderickx J, and Thevelein JM (2001) Glucose-sensing mechanisms in eukaryotic cells. Trends Biochem Sci 26:310-317.
121. Ruiz-Stewart I, Tiyyagura SR, Lin JE, Kazerounian S, Pitari GM, Schulz S, Martin E, Murad F, and Waldman SA (2004) Guanylyl cyclase is an ATP sensor coupling nitric oxide signaling to cell metabolism. Proc Natl Acad Sci U S A 101:37-42. (Pubitemid 38084199)
122. Sabina RL, Patterson D, and Holmes EW (1985) 5-Amino-4- imidazolecarboxamide riboside (Z-riboside) metabolism in eukaryotic cells. J Biol Chem 260:6107-6114. (Pubitemid 15071307)
123. Safrany ST, Caffrey JJ, Yang X, Bembenek ME, Moyer MB, Burkhart WA, and Shears SB (1998) A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase. EMBO J 17:6599-6607. (Pubitemid 28521794)
124. Safrany ST and Shears SB (1998) Turnover of bis-diphosphoinositol tetrakisphosphate in a smooth muscle cell line is regulated by beta2-adrenergic receptors through a cAMP-mediated, A-kinase-independent mechanism. EMBO J 17:1710-1716.
125. Saiardi A, Bhandari R, Resnick AC, Snowman AM, and Snyder SH (2004) Phosphorylation of proteins by inositol pyrophosphates. Science 306:2101-2105.
126. Saiardi A, Caffrey JJ, Snyder SH, and Shears SB (2000) The inositol hexakisphosphate kinase family. Catalytic flexibility, and function in yeast vacuole biogenesis. J Biol Chem 275:24686-24692. (Pubitemid 30626569)
127. Saiardi A, Erdjument-Bromage H, Snowman AM, Tempst P, and Snyder SH (1999) Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. Current Biology 9:1323-1326.
128. Saiardi A, Nagata E, Luo HR, Sawa A, Luo X, Snowman AM, and Snyder SH (2001a) Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate. Proc Natl Acad Sci U S A 98:2306-2311. (Pubitemid 32209478)
129. Saiardi A, Nagata E, Luo HR, Snowman AM, and Snyder SH (2001b) Identification and characterization of a novel inositol hexakisphosphate kinase. J Biol Chem 276:39179-39185. (Pubitemid 37371289)
130. Saiardi A, Resnick AC, Snowman AM, Wendland B, and Snyder SH (2005) Inositol pyrophosphates regulate cell death and telomere length via PI3K-related protein kinases. Proc Natl Acad Sci U S A 102:1911-1914. (Pubitemid 40261986)
131. Saiardi A, Sciambi C, McCaffery JM, Wendland B, and Snyder SH (2002) Inositol pyrophosphates regulate endocytic trafficking. Proc Natl Acad Sci U S A 99:14206-14211. (Pubitemid 35257650)
132. Schell MJ, Letcher AJ, Brearley CA, Biber J, Murer H, and Irvine RF (1999) PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase. FEBS Lett 461:169-172. (Pubitemid 29533327)
133. Sedivy JM (2007) Telomeres limit cancer growth by inducing senescence: long-sought in vivo evidence obtained. Cancer Cell 11:389-391.
134. Seeds AM, Bastidas RJ, and York JD (2005) Molecular definition of a novel inositol polyphosphate metabolic pathway initiated by inositol 1,4,5-trisphosphate 3-kinase activity in Saccharomyces cerevisiae. J Biol Chem 280:27654-27661.
135. Seeds AM, Sandquist JC, Spana EP, and York JD (2004) A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster. J Biol Chem 279:47222-47232.
136. Shayman JA and Kirkwood MT (1987) Bradykinin-stimulated changes in inositol phosphate mass in renal papillary collecting tubule cells. Biochem Biophys Res Commun 145:1119-1125.
137. Shears SB (1997) Measurement of inositol phosphate turnover in intact cells and cell-free systems, in Signalling by Inositides: A Practical Approach. (Shears SB ed) pp 33-52, Oxford University Press, Oxford, U.K.
138. Shears SB (2001) Assessing the omnipotence of inositol hexakisphosphate. Cell Signal 13:151-158.
139. Shears SB (2004) How versatile are inositol phosphate kinases? Biochem J 377:265-280.
140. Shears SB, Ali N, Craxton A, and Bembenek ME (1995) Synthesis and metabolism of bis-diphosphoinositol tetrakisphosphate in vitro and in vivo. J Biol Chem 270:10489-10497.
141. Sherman WR, Rasheed A, Mauck LA, and Wiecko J (1977) Incubations of testis myo-inositol-1-phosphate synthase with D-(5-18O)glucose 6-phosphate and with H218O show no evidence of Schiff base formation. J Biol Chem 252:5672-5676.
142. Soboll S, Scholz R, and Heldt HW (1978) Subcellular metabolite concentrations. Dependence of mitochondrial and cytosolic ATP systems on the metabolic state of perfused rat liver. Eur J Biochem 87:377-390. (Pubitemid 8355180)
143. Sofer A, Lei K, Johannessen CM, and Ellisen LW (2005) Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol Cell Biol 25:5834-5845. (Pubitemid 40946541)
144. Springer M, Wykoff DD, Miller N, and O'Shea EK (2003) Partially phosphorylated Pho4 activates transcription of a subset of phosphate-responsive genes. PLoS Biol 1:E28. (Pubitemid 39112168)
145. Stephens LR, Hawkins PT, Stanley AF, Moore T, Poyner DR, Morris PJ, Hanley MR, Kay RR, and Irvine RF (1991) myo-Inositol pentakisphosphates. Structure, biological occurrence and phosphorylation to myo-inositol hexakisphosphates. Biochem J 275:485-499.
146. Stephens LR and Irvine RF (1990) Stepwise phosphorylation of myo-inositol leading to myo-inositol hexakisphosphate in Dictyostelium. Nature 346:580-583. (Pubitemid 20238813)
147. Stephens L, Radenberg T, Thiel U, Vogel G, Khoo KH, Dell A, Jackson TR, Hawkins PT, and Mayr GW (1993) The detection, purification, structural characterization, and metabolism of diphosphoinositol pentakisphosphate(s) and bisdiphosphoinositol tetrakisphosphate(s). J Biol Chem 268:4009-4015. (Pubitemid 23072933)
148. 2+ from a nonmitochondrial store in pancreatic cells by inositol-1,4,5-trisphosphate. Nature 306:67-69.
149. Sutherland EW and Rall TW (1958) Fractionation and characterization of a cyclic adenine ribonucleotide formed by tissue particles. J Biol Chem 232:1077-1091.
150. Swinnen JV, Beckers A, Brusselmans K, Organe S, Segers J, Timmermans L, Vanderhoydonc F, Deboel L, Derua R, Waelkens E, et al. (2005) Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype. Cancer Res 65:2441-2448. (Pubitemid 40490156)
151. 31P NMR. Biochem Biophys Res Commun 149:874-881.
152. 2+ in T lymphocytes. J Exp Med 203:1665-1670.
153. Tan Z, Bruzik KS, and Shears SB (1997) Properties of the inositol 3,4,5,6-tetrakisphosphate 1-kinase purified from rat liver. Regulation of enzyme activity by inositol 1,3,4-trisphosphate. J Biol Chem 272:2285-2290. (Pubitemid 27058512)
154. Thomas G (2000) An encore for ribosome biogenesis in the control of cell proliferation. Nat Cell Biol 2:E71-E72. (Pubitemid 30781098)
155. Torres J, Domínguez S, CerdáMF, Obal G, Mederos A, Irvine
156. Verbsky JW, Wilson MP, Kisseleva MV, Majerus PW, and Wente SR (2002) The synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinase. J Biol Chem 277:31857-31862.
157. Voglmaier SM, Bembenek ME, Kaplin AI, Dormán G, Olszewski JD, Prestwich GD, and Snyder SH (1996) Purified inositol hexakisphosphate kinase is an ATP synthase: diphosphoinositol pentakisphosphate as a high-energy phosphate donor. Proc Natl Acad Sci U S A 93:4305-4310. (Pubitemid 26144281)
158. Wang W, Yang X, López de Silanes I, Carling D, and Gorospe M (2003) Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function. J Biol Chem 278:27016-27023. (Pubitemid 36876855)
159. Waring P and Beaver J (1996) Cyclosporin A rescues thymocytes from apoptosis induced by very low concentrations of thapsigargin: effects on mitochondrial function. Exp Cell Res 227:264-276. (Pubitemid 26320169)
160. Watts DJ (1984) Protein synthesis during development and differentiation in the cellular slime mould Dictyostelium discoideum. Biochem J 220:1-14.
161. Westheimer FH (1987) Why nature chose phosphates. Science 235:1173-1178.
162. Wilcox RA, Safrany ST, Lampe D, Mills SJ, Nahorski SR, and Potter BVL (1994) Modification at C2 of myo-inositol 1,4,5-trisphosphate produces inositol trisphosphates and tetrakisphosphates with potent biological activities. Eur J Biochem 223:115-124. (Pubitemid 24221652)
163. Wong NS, Barker CJ, Morris AJ, Craxton A, Kirk CJ, and Michell RH (1992) The inositol phosphates in WRK1 rat mammary tumour cells. Biochem J 286:459-468.
164. Yang L, Reece JM, Cho J, Bortner CD, and Shears SB (2008) The nucleolus exhibits an osmotically regulated gatekeeping activity that controls the spatial dynamics and functions of nucleolin. J Biol Chem 283:11823-11831.
165. Ye W, Ali N, Bembenek ME, Shears SB, and Lafer EM (1995) Inhibition of clathrin assembly by high affinity binding of specific inositol polyphosphates to the synapse-specific clathrin assembly protein AP-3. J Biol Chem 270:1564-1568.
166. Yin W, Mu J, and Birnbaum MJ (2003) Role of AMP-activated protein kinase in cyclic AMP-dependent lipolysis in 3T3-L1 adipocytes. J Biol Chem 278:43074-43080. (Pubitemid 37345923)
167. York JD (2006) Regulation of nuclear processes by inositol polyphosphates. Biochim Biophys Acta 1761:552-559.
168. York SJ, Armbruster BN, Greenwell P, Petes TD, and York JD (2005) Inositol diphosphate signaling regulates telomere length. J Biol Chem 280:4264-4269. (Pubitemid 40288593)
169. Zhang T, Caffrey JJ, and Shears SB (2001) The transcriptional regulator, Arg82, is a hybrid kinase with both monophosphoinositol and diphosphoinositol polyphosphate synthase activity. FEBS Lett 494:208-212. (Pubitemid 32322684)
170. Zhuo ML, Huang Y, Liu DP, and Liang CC (2005) KATP channel: relation with cell metabolism and role in the cardiovascular system. Int J Biochem Cell Biol 37:751-764. (Pubitemid 40202997)
171. Zwerschke W, Mazurek S, Stöckl P, Hütter E, Eigenbrodt E, and Jansen-Dürr P (2003) Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence. Biochem J 376:403-411. (Pubitemid 38010525)