A mathematical analysis of second messenger compartmentalization

Physical Biology

Volumn 5, Issue 4, 2008, Pages

  Chen, Wen ^a   Levine, Herbert ^a   Rappel, Wouter Jan ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; PHOSPHODIESTERASE;

ARTICLE; CELL COMPARTMENTALIZATION; COMPUTER SIMULATION; DIFFUSION; MATHEMATICAL COMPUTING; METABOLISM; PHYSIOLOGY; SECOND MESSENGER;

CELL COMPARTMENTATION; COMPUTER SIMULATION; CYCLIC AMP; DIFFUSION; NUMERICAL ANALYSIS, COMPUTER-ASSISTED; PHOSPHORIC DIESTER HYDROLASES; SECOND MESSENGER SYSTEMS;

EID: 58149313846     PISSN: 14783967     EISSN: 14783975     Source Type: Journal    
DOI: 10.1088/1478-3975/5/4/046006     Document Type: Article

References (26)

1. Cooper D M 2003 Regulation and organization of adenylyl cyclases and cAMP Biochem. J. 375 517-29
2. Steinberg S F and Brunton L L 2001 Compartmentation of G protein-coupled signaling pathways in cardiac myocytes Ann. Rev. Pharmacol. Toxicol. 41 751-73
3. Zaccolo M and Pozzan T 2002 Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes Science 295 1711-5
4. Fischmeister R, Castro L R, Abi-Gerges A, Rochais F, Jurevicius J, Leroy J and Vandecasteele G 2006 Compartmentation of cyclic nucleotide signaling in the heart: the role of cyclic nucleotide phospho-diesterases Circ. Res. 99 816-28
5. Nikolaev V O, Bunemann M, Schmitteckert E, Lohse M J and Engelhardt S 2006 Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching beta1-adrenergic but locally confined beta2-adrenergic receptor-mediated signaling Circ. Res. 99 1084-91
6. Leroy J, Abi-Gerges A, Nikolaev V O, Richter W, Lechene P, Mazet J L, Conti M, Fischmeister R and Vandecasteele G 2008 Spatiotemporal dynamics of beta-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: role of phosphodiesterases Circ. Res. 102 1091-100
7. Rich T C, Fagan K A, Tse T E, Schaack J, Cooper D M and Karpen J W 2001 A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell Proc. Natl. Acad. Sci. USA 98 13049-54
8. Davare M A, Avdonin V, Hall D D, Peden E M, Burette A, Weinberg R J, Horne M C, Hoshi T and Hell J W 2001 A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2 Science 293 98-101
9. Brunton L L, Hayes J S and Mayer S E 1981 Functional compartmentation of cyclic AMP and protein kinase in heart Adv. Cyclic. Nucleotide Res. 14 391-7
10. Terrin A et al 2006 PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases J. Cell. Biol. 175 441-51
11. Zaccolo M, Benedetto G D, Lissandron V, Mancuso L, Terrin A and Zamparo I 2006 Restricted diffusion of a freely diffusible second messenger: mechanisms underlying compartmentalized cAMP signalling Biochem. Soc. Trans. 34 495-7
12. Mongillo M et al 2004 Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases Circ. Res. 95 67-75
13. Mongillo M et al 2006 Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway Circ. Res. 98 226-34
14. Wong W and Scott J D 2004 AKAP signalling complexes: focal points in space and time Nat. Rev. Mol. Cell. Biol. 5 959-70
15. Saucerman J J, Brunton L L, Michailova A P and McCulloch A D 2003 Modeling beta-adrenergic control of cardiac myocyte contractility in silico J. Biol. Chem. 278 47997-8003
16. Xin W, Tran T M, Richter W, Clark R B and Rich T C 2008 Roles of GRK and PDE4 activities in the regulation of beta2 adrenergic signaling J. Gen. Physiol. 131 349-64
17. Neves S R et al 2008 Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks Cell 133 666-80
18. Abramowitz M and Stegun I A 1964 Handbook of Mathematical Functions with Formulas, Graphs, and Mathematical Tables (New York: Dover)
19. Reeves M L, Leigh B K and England P J 1987 The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors Biochem. J. 241 535-41
20. Bode D C, Kanter J R and Brunton L L 1991 Cellular distribution of phosphodiesterase isoforms in rat cardiac tissue Circ. Res. 68 1070-9
21. Takeuchi A, Tatsumi S, Sarai N, Terashima K, Matsuoka S and Noma A 2006 Ionic mechanisms of cardiac cell swelling induced by blocking Na +/K+ pump as revealed by experiments and simulation J. Gen. Physiol. 128 495-507
22. Post S R, Hilal-Dandan R, Urasawa K, Brunton L L and Insel P A 1995 Quantification of signalling components and amplification in the beta-adrenergic-receptor-adenylate cyclase pathway in isolated adult rat ventricular myocytes Biochem. J. 311 75-80
23. Beavo J A, Bechtel P J and Krebs E G 1974 Activation of protein kinase by physiological concentrations of cyclic AMP Proc. Natl Acad. Sci. USA 71 3580-3
24. Dessauer C W and Gilman A G 1996 Purification and characterization of a soluble form of mammalian adenylyl cyclase J. Biol. Chem. 271 16967-74
25. Rich T C, Fagan K A, Nakata H, Schaack J, Cooper D M and Karpen J W 2000 Cyclic nucleotide-gated channels colocalize with adenylyl cyclase in regions of restricted cAMP diffusion J. Gen. Physiol. 116 147-61
26. Saucerman J J, Zhang J, Martin J C, Peng L X, Stenbit A E, Tsien R Y and McCulloch A D 2006 Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes Proc. Natl Acad Sci. USA 103 12923-8