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Volumn 10, Issue 6, 2009, Pages 543-549

The IL-17/IL-23 axis of inflammation in cancer: Friend or foe?

Author keywords

Cancer immunity; IL 17; IL 23; Immunotherapy; Th17

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 21; INTERLEUKIN 22; INTERLEUKIN 23;

EID: 67650684023     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (68)

References (72)
  • 1
    • 0037180757 scopus 로고    scopus 로고
    • Infammation and cancer
    • Coussens LM, Werb Z: Infammation and cancer. Nature (2002) 420(6917):860-867.
    • (2002) Nature , vol.420 , Issue.6917 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 3
    • 43049157905 scopus 로고    scopus 로고
    • Infammation in the development of lung cancer: Epidemiological evidence
    • Engels EA: Infammation in the development of lung cancer: Epidemiological evidence. Expert Rev Anticancer Ther (2008) 8(4):605-615.
    • (2008) Expert Rev Anticancer Ther , vol.8 , Issue.4 , pp. 605-615
    • Engels, E.A.1
  • 8
    • 4143141823 scopus 로고    scopus 로고
    • The immunobiology of cancer immunosurveillance and immunoediting
    • Dunn GP, Old LJ, Schreiber RD: The immunobiology of cancer immunosurveillance and immunoediting. Immunity (2004) 21(2):137-148.
    • (2004) Immunity , vol.21 , Issue.2 , pp. 137-148
    • Dunn, G.P.1    Old, L.J.2    Schreiber, R.D.3
  • 9
    • 21844444831 scopus 로고    scopus 로고
    • New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions
    • Hunter CA: New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat Rev Immunol (2005) 5(7):521-531.
    • (2005) Nat Rev Immunol , vol.5 , Issue.7 , pp. 521-531
    • Hunter, C.A.1
  • 16
    • 41549135632 scopus 로고    scopus 로고
    • The biological functions of T helper 17 cell effector cytokines in infammation
    • Ouyang W, Kolls JK, Zheng Y: The biological functions of T helper 17 cell effector cytokines in infammation. Immunity (2008) 28(4):454-467.
    • (2008) Immunity , vol.28 , Issue.4 , pp. 454-467
    • Ouyang, W.1    Kolls, J.K.2    Zheng, Y.3
  • 17
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T-helper type 1 and 2 lineages
    • Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, Weaver CT: Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T-helper type 1 and 2 lineages. Nat Immunol (2005) 6(11):1123-1132.
    • (2005) Nat Immunol , vol.6 , Issue.11 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5    Murphy, K.M.6    Weaver, C.T.7
  • 19
    • 42649115767 scopus 로고    scopus 로고
    • TH17 cells in development: An updated view of their molecular identity and genetic programming
    • Dong C: TH17 cells in development: An updated view of their molecular identity and genetic programming. Nat Rev Immunol (2008) 8(5):337-348.
    • (2008) Nat Rev Immunol , vol.8 , Issue.5 , pp. 337-348
    • Dong, C.1
  • 22
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK: Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature (2006) 441(7090):235-238.
    • (2006) Nature , vol.441 , Issue.7090 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6    Weiner, H.L.7    Kuchroo, V.K.8
  • 24
    • 32244442562 scopus 로고    scopus 로고
    • TGFβ in the context of an infammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B: TGFβ in the context of an infammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity (2006) 24(2):179-189.
    • (2006) Immunity , vol.24 , Issue.2 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 29
    • 60549086638 scopus 로고    scopus 로고
    • Th17 cells promote pancreatic infammation but only induce diabetes effciently in lymphopenic hosts after conversion into Th1 cells
    • Martin-Orozco N, Chung Y, Chang SH, Wang YH, Dong C: Th17 cells promote pancreatic infammation but only induce diabetes effciently in lymphopenic hosts after conversion into Th1 cells. Eur J Immunol (2009) 39(1):216-224.
    • (2009) Eur J Immunol , vol.39 , Issue.1 , pp. 216-224
    • Martin-Orozco, N.1    Chung, Y.2    Chang, S.H.3    Wang, Y.H.4    Dong, C.5
  • 30
    • 64849103287 scopus 로고    scopus 로고
    • Cutting edge: In vitro generated Th17 cells maintain their cytokine expression program in normal but not lymphopenic hosts
    • Nurieva R, Yang XO, Chung Y, Dong C: Cutting edge: In vitro generated Th17 cells maintain their cytokine expression program in normal but not lymphopenic hosts. J Immunol (2009) 182(5):2565-2568.
    • (2009) J Immunol , vol.182 , Issue.5 , pp. 2565-2568
    • Nurieva, R.1    Yang, X.O.2    Chung, Y.3    Dong, C.4
  • 33
    • 15244344110 scopus 로고    scopus 로고
    • Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17
    • Stark MA, Huo Y, Burcin TL, Morris MA, Olson TS, Ley K: Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity (2005) 22(3):285-294.
    • (2005) Immunity , vol.22 , Issue.3 , pp. 285-294
    • Stark, M.A.1    Huo, Y.2    Burcin, T.L.3    Morris, M.A.4    Olson, T.S.5    Ley, K.6
  • 35
    • 0032538551 scopus 로고    scopus 로고
    • Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-κB
    • Shalom-Barak T, Quach J, Lotz M: Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-κB. J Biol Chem (1998) 273(42):27467-27473.
    • (1998) J Biol Chem , vol.273 , Issue.42 , pp. 27467-27473
    • Shalom-Barak, T.1    Quach, J.2    Lotz, M.3
  • 36
    • 0034599961 scopus 로고    scopus 로고
    • Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction
    • Schwandner R, Yamaguchi K, Cao Z: Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction. J Exp Med (2000) 191(7):1233-1240.
    • (2000) J Exp Med , vol.191 , Issue.7 , pp. 1233-1240
    • Schwandner, R.1    Yamaguchi, K.2    Cao, Z.3
  • 37
    • 33846022750 scopus 로고    scopus 로고
    • Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor
    • Chang SH, Park H, Dong C: Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor. J Biol Chem (2006) 281(47):35603-35607.
    • (2006) J Biol Chem , vol.281 , Issue.47 , pp. 35603-35607
    • Chang, S.H.1    Park, H.2    Dong, C.3
  • 38
    • 1642576088 scopus 로고    scopus 로고
    • Functional cooperation between interleukin-17 and tumor necrosis factor-α is mediated by CCAAT/Enhancer-binding protein family members
    • Ruddy MJ, Wong GC, Liu XK, Yamamoto H, Kasayama S, Kirkwood KL, Gaffen SL: Functional cooperation between interleukin-17 and tumor necrosis factor-α is mediated by CCAAT/Enhancer-binding protein family members. J Biol Chem (2004) 279(4):2559-2567.
    • (2004) J Biol Chem , vol.279 , Issue.4 , pp. 2559-2567
    • Ruddy, M.J.1    Wong, G.C.2    Liu, X.K.3    Yamamoto, H.4    Kasayama, S.5    Kirkwood, K.L.6    Gaffen, S.L.7
  • 41
    • 17244381180 scopus 로고    scopus 로고
    • Expression of interleukin-22 in rheumatoid arthritis: Potential role as a proinfammatory cytokine
    • Ikeuchi H, Kuroiwa T, Hiramatsu N, Kaneko Y, Hiromura K, Ueki K, Nojima Y: Expression of interleukin-22 in rheumatoid arthritis: Potential role as a proinfammatory cytokine. Arthritis Rheum (2005) 52(4):1037- 1046.
    • (2005) Arthritis Rheum , vol.52 , Issue.4 , pp. 1037-1046
    • Ikeuchi, H.1    Kuroiwa, T.2    Hiramatsu, N.3    Kaneko, Y.4    Hiromura, K.5    Ueki, K.6    Nojima, Y.7
  • 44
    • 33846940253 scopus 로고    scopus 로고
    • The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis
    • Sa SM, Valdez PA, Wu J, Jung K, Zhong F, Hall L, Kasman I, Winer J, Modrusan Z, Danilenko DM, Ouyang W et al: The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis. J Immunol (2007) 178(4):2229-2240.
    • (2007) J Immunol , vol.178 , Issue.4 , pp. 2229-2240
    • Sa, S.M.1    Valdez, P.A.2    Wu, J.3    Jung, K.4    Zhong, F.5    Hall, L.6    Kasman, I.7    Winer, J.8    Modrusan, Z.9    Danilenko, D.M.10    Ouyang, W.11
  • 46
    • 0041669594 scopus 로고    scopus 로고
    • Expression and function of pro-infammatory interleukin IL-17 and IL-17 receptor in normal, benign hyperplastic, and malignant prostate
    • Steiner GE, Newman ME, Paikl D, Stix U, Memaran-Dagda N, Lee C, Marberger MJ: Expression and function of pro-infammatory interleukin IL-17 and IL-17 receptor in normal, benign hyperplastic, and malignant prostate. Prostate (2003) 56(3):171-182.
    • (2003) Prostate , vol.56 , Issue.3 , pp. 171-182
    • Steiner, G.E.1    Newman, M.E.2    Paikl, D.3    Stix, U.4    Memaran-Dagda, N.5    Lee, C.6    Marberger, M.J.7
  • 51
    • 34249806717 scopus 로고    scopus 로고
    • Cutting edge: Th17 and regulatory T-cell dynamics and the regulation by IL-2 in the tumor microenvironment
    • Kryczek I, Wei S, Zou L, Altuwaijri S, Szeliga W, Kolls J, Chang A, Zou W: Cutting edge: Th17 and regulatory T-cell dynamics and the regulation by IL-2 in the tumor microenvironment. J Immunol (2007) 178(11):6730-6733.
    • (2007) J Immunol , vol.178 , Issue.11 , pp. 6730-6733
    • Kryczek, I.1    Wei, S.2    Zou, L.3    Altuwaijri, S.4    Szeliga, W.5    Kolls, J.6    Chang, A.7    Zou, W.8
  • 52
    • 55749098500 scopus 로고    scopus 로고
    • Generation and regulation of human CD4+ IL-17-producing T-cells in ovarian cancer
    • Miyahara Y, Odunsi K, Chen W, Peng G, Matsuzaki J, Wang RF: Generation and regulation of human CD4+ IL-17-producing T-cells in ovarian cancer. Proc Natl Acad Sci USA (2008) 105(40):15505-15510.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.40 , pp. 15505-15510
    • Miyahara, Y.1    Odunsi, K.2    Chen, W.3    Peng, G.4    Matsuzaki, J.5    Wang, R.F.6
  • 56
    • 27144449330 scopus 로고    scopus 로고
    • IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis
    • Numasaki M, Watanabe M, Suzuki T, Takahashi H, Nakamura A, McAllister F, Hishinuma T, Goto J, Lotze MT, Kolls JK, Sasaki H et al: IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J Immunol (2005) 175(9):6177-6189.
    • (2005) J Immunol , vol.175 , Issue.9 , pp. 6177-6189
    • Numasaki, M.1    Watanabe, M.2    Suzuki, T.3    Takahashi, H.4    Nakamura, A.5    McAllister, F.6    Hishinuma, T.7    Goto, J.8    Lotze, M.T.9    Kolls, J.K.10    Sasaki, H.11
  • 60
    • 33745685864 scopus 로고    scopus 로고
    • Interleukin-23 and interleukin-27 exert quite different antitumor and vaccine effects on poorly immunogenic melanoma
    • Oniki S, Nagai H, Horikawa T, Furukawa J, Belladonna ML, Yoshimoto T, Hara I, Nishigori C: Interleukin-23 and interleukin-27 exert quite different antitumor and vaccine effects on poorly immunogenic melanoma. Cancer Res (2006) 66(12):6395-6404.
    • (2006) Cancer Res , vol.66 , Issue.12 , pp. 6395-6404
    • Oniki, S.1    Nagai, H.2    Horikawa, T.3    Furukawa, J.4    Belladonna, M.L.5    Yoshimoto, T.6    Hara, I.7    Nishigori, C.8
  • 61
    • 33749032429 scopus 로고    scopus 로고
    • Induction of potent antitumor immunity by intratumoral injection of interleukin 23-transduced dendritic cells
    • Hu J, Yuan X, Belladonna ML, Ong JM, Wachsmann-Hogiu S, Farkas DL, Black KL, Yu JS: Induction of potent antitumor immunity by intratumoral injection of interleukin 23-transduced dendritic cells. Cancer Res (2006) 66(17):8887-8896.
    • (2006) Cancer Res , vol.66 , Issue.17 , pp. 8887-8896
    • Hu, J.1    Yuan, X.2    Belladonna, M.L.3    Ong, J.M.4    Wachsmann-Hogiu, S.5    Farkas, D.L.6    Black, K.L.7    Yu, J.S.8
  • 65
    • 52949129439 scopus 로고    scopus 로고
    • Interleukin-21: Biology and application to cancer therapy
    • Andorsky DJ, Timmerman JM: Interleukin-21: Biology and application to cancer therapy. Expert Opin Biol Ther (2008) 8(9):1295-1307.
    • (2008) Expert Opin Biol Ther , vol.8 , Issue.9 , pp. 1295-1307
    • Andorsky, D.J.1    Timmerman, J.M.2
  • 66
    • 27644457376 scopus 로고    scopus 로고
    • TGF-β directly targets cytotoxic T-cell functions during tumor evasion of immune surveillance
    • Thomas DA, Massague J: TGF-β directly targets cytotoxic T-cell functions during tumor evasion of immune surveillance. Cancer Cell (2005) 8(5):369-380.
    • (2005) Cancer Cell , vol.8 , Issue.5 , pp. 369-380
    • Thomas, D.A.1    Massague, J.2
  • 68
    • 33646239606 scopus 로고    scopus 로고
    • Tumor-induced expansion of regulatory T cells by conversion of CD4+CD25-lymphocytes is thymus and proliferation independent
    • Valzasina B, Piconese S, Guiducci C, Colombo MP: Tumor-induced expansion of regulatory T cells by conversion of CD4+CD25-lymphocytes is thymus and proliferation independent. Cancer Res (2006) 66(8):4488- 4495.
    • (2006) Cancer Res , vol.66 , Issue.8 , pp. 4488-4495
    • Valzasina, B.1    Piconese, S.2    Guiducci, C.3    Colombo, M.P.4
  • 69
    • 55149094300 scopus 로고    scopus 로고
    • Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells
    • Koenen HJ, Smeets RL, Vink PM, van Rijssen E, Boots AM, Joosten I: Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells. Blood (2008) 112(6):2340-2352.
    • (2008) Blood , vol.112 , Issue.6 , pp. 2340-2352
    • Koenen, H.J.1    Smeets, R.L.2    Vink, P.M.3    van Rijssen, E.4    Boots, A.M.5    Joosten, I.6
  • 70
    • 34248141100 scopus 로고    scopus 로고
    • A cytokine-mediated link between innate immunity, infammation, and cancer
    • Lin WW, Karin M: A cytokine-mediated link between innate immunity, infammation, and cancer. J Clin Invest (2007) 117(5):1175- 1183.
    • (2007) J Clin Invest , vol.117 , Issue.5 , pp. 1175-1183
    • Lin, W.W.1    Karin, M.2
  • 71
    • 47549090432 scopus 로고    scopus 로고
    • TGFβ in cancer
    • Massague J: TGFβ in cancer. Cell (2008) 134(2):215-230.
    • (2008) Cell , vol.134 , Issue.2 , pp. 215-230
    • Massague, J.1
  • 72
    • 35648995976 scopus 로고    scopus 로고
    • Interleukin-6 and its receptor in cancer: Implications for translational therapeutics
    • Hong DS, Angelo LS, Kurzrock R: Interleukin-6 and its receptor in cancer: Implications for translational therapeutics. Cancer (2007) 110(9):1911-1928.
    • (2007) Cancer , vol.110 , Issue.9 , pp. 1911-1928
    • Hong, D.S.1    Angelo, L.S.2    Kurzrock, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.