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Volumn 85, Issue , 2009, Pages 207-219

Chapter 16 Mechanism of Allodynia Evoked by Intrathecal Morphine-3-Glucuronide in Mice

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; DYNORPHIN; GLUTAMIC ACID; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MORPHINE; MORPHINE 3 GLUCURONIDE; NEUROKININ 1 RECEPTOR; NITRIC OXIDE; SUBSTANCE P; MORPHINE DERIVATIVE; MORPHINE-3-GLUCURONIDE;

EID: 67650229961     PISSN: 00747742     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0074-7742(09)85016-2     Document Type: Review
Times cited : (13)

References (102)
  • 1
    • 0022446921 scopus 로고
    • Hyperalgesic response in a patient receiving high concentrations of spinal morphine
    • Ali N.M.K. Hyperalgesic response in a patient receiving high concentrations of spinal morphine. Anesthesiology 65 (1986) 449
    • (1986) Anesthesiology , vol.65 , pp. 449
    • Ali, N.M.K.1
  • 2
    • 0031646358 scopus 로고    scopus 로고
    • Comparison of the effects of calmidazolium, morphine and bupivacaine on N-methyl-d-aspartate- and septide-induced nociceptive behaviour
    • Alvarez-Vega M., Baamonde A., Gutierrez M., Hidalgo A., and Menendes L. Comparison of the effects of calmidazolium, morphine and bupivacaine on N-methyl-d-aspartate- and septide-induced nociceptive behaviour. Naunyn-Schmiedeberg's Arch. Pharmacol. 358 (1998) 628-634
    • (1998) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.358 , pp. 628-634
    • Alvarez-Vega, M.1    Baamonde, A.2    Gutierrez, M.3    Hidalgo, A.4    Menendes, L.5
  • 4
    • 0032981277 scopus 로고    scopus 로고
    • Dynorphine A increases substance P release from trigeminal primary afferent C-fibers
    • Arcaya J.L., Cano G., Gómez G., Maixner W., and Suárez-Roca H. Dynorphine A increases substance P release from trigeminal primary afferent C-fibers. Eur. J. Pharmacol. 366 (1999) 27-34
    • (1999) Eur. J. Pharmacol. , vol.366 , pp. 27-34
    • Arcaya, J.L.1    Cano, G.2    Gómez, G.3    Maixner, W.4    Suárez-Roca, H.5
  • 5
    • 0023895008 scopus 로고
    • Clinical experience of long-term treatment with epidural opioids-A nationwide survey
    • Arner S., Rawal N., and Gustafsson L.L. Clinical experience of long-term treatment with epidural opioids-A nationwide survey. Acta Anaesthesiol. Scand. 32 (1988) 253-259
    • (1988) Acta Anaesthesiol. Scand. , vol.32 , pp. 253-259
    • Arner, S.1    Rawal, N.2    Gustafsson, L.L.3
  • 6
    • 0028017873 scopus 로고
    • Pharmacology of morphine and morphine-3-glucronide at opioid, excitatory amino acis, GABA and glycine binding site
    • Bartlett S.E., Dodd P.R., and Smith M.T. Pharmacology of morphine and morphine-3-glucronide at opioid, excitatory amino acis, GABA and glycine binding site. Pharmacol. Toxicol. 75 (1994) 73-81
    • (1994) Pharmacol. Toxicol. , vol.75 , pp. 73-81
    • Bartlett, S.E.1    Dodd, P.R.2    Smith, M.T.3
  • 7
    • 0027397544 scopus 로고
    • Inositol trisphosphate and calcium signaling
    • Berridge M.J. Inositol trisphosphate and calcium signaling. Nature 361 (1993) 315-325
    • (1993) Nature , vol.361 , pp. 315-325
    • Berridge, M.J.1
  • 8
    • 0033549244 scopus 로고    scopus 로고
    • Loss of anti nociceptive spinal/supraspinal morphine synergy in nerve-injured rats; restoration by MK-801 or dynorphine antiserum
    • Bian D.S., Ossipov M.H., Ibrahim M., Raffa R.B., Tallarida R.J., Malan Jr. T.P., Lai J., and Porreca F. Loss of anti nociceptive spinal/supraspinal morphine synergy in nerve-injured rats; restoration by MK-801 or dynorphine antiserum. Brain Res. 831 (1999) 55-63
    • (1999) Brain Res. , vol.831 , pp. 55-63
    • Bian, D.S.1    Ossipov, M.H.2    Ibrahim, M.3    Raffa, R.B.4    Tallarida, R.J.5    Malan Jr. T.P.6    Lai, J.7    Porreca, F.8
  • 9
    • 0016802610 scopus 로고
    • The metabolism of morphine and heroin in man
    • Boerner U., Abbott S., and Roe R.L. The metabolism of morphine and heroin in man. Drug Metab. Rev. 4 (1975) 39-73
    • (1975) Drug Metab. Rev. , vol.4 , pp. 39-73
    • Boerner, U.1    Abbott, S.2    Roe, R.L.3
  • 10
    • 28644433404 scopus 로고    scopus 로고
    • Activation of the ERK signaling pathway contributes naloxone-precipitated withdrawal in morphine-dependent rats
    • Cao J.L., He J.H., Ding H.L., and Zeng Y.M. Activation of the ERK signaling pathway contributes naloxone-precipitated withdrawal in morphine-dependent rats. Pain 228 (2005) 336-349
    • (2005) Pain , vol.228 , pp. 336-349
    • Cao, J.L.1    He, J.H.2    Ding, H.L.3    Zeng, Y.M.4
  • 11
    • 33746268078 scopus 로고    scopus 로고
    • Cross talk between nitric oxide and ERK1/2 signaling pathway in the spinal cord mediates naloxone-precipitated withdrawal in morphine-dependent rats
    • Cao J.L., Liu H.L., Wang J.K., and Zeng Y.M. Cross talk between nitric oxide and ERK1/2 signaling pathway in the spinal cord mediates naloxone-precipitated withdrawal in morphine-dependent rats. Neuropharmacology 51 (2006) 315-326
    • (2006) Neuropharmacology , vol.51 , pp. 315-326
    • Cao, J.L.1    Liu, H.L.2    Wang, J.K.3    Zeng, Y.M.4
  • 12
    • 0030859754 scopus 로고    scopus 로고
    • Dissociation of microglial activation and neuropathic behaviors following peripheral nerve injury in the rat
    • Colburn R.W., DeLeo J.A., Rickman A.J., Yeager M.P., Kwon P., and Hickey W.F. Dissociation of microglial activation and neuropathic behaviors following peripheral nerve injury in the rat. J. Neuroimmunol 79 (1997) 163-175
    • (1997) J. Neuroimmunol , vol.79 , pp. 163-175
    • Colburn, R.W.1    DeLeo, J.A.2    Rickman, A.J.3    Yeager, M.P.4    Kwon, P.5    Hickey, W.F.6
  • 13
    • 31344448048 scopus 로고    scopus 로고
    • Activation of p38 mitogen-activated protein kinase in spinal microglia mediated morphine antinociceptive tolerance
    • Cui Y., Chen Y., Zhi J.L., Guo R.X., Feng J.Q., and Chen P.X. Activation of p38 mitogen-activated protein kinase in spinal microglia mediated morphine antinociceptive tolerance. Brain Res. 1069 (2006) 235-243
    • (2006) Brain Res. , vol.1069 , pp. 235-243
    • Cui, Y.1    Chen, Y.2    Zhi, J.L.3    Guo, R.X.4    Feng, J.Q.5    Chen, P.X.6
  • 14
  • 15
    • 0026601969 scopus 로고
    • Dynorphine increases extracellular levels of excitatory amino acids in the brain through a non-opioid mechanism
    • Faden A.I. Dynorphine increases extracellular levels of excitatory amino acids in the brain through a non-opioid mechanism. J. Neurosci. 12 (1992) 425-429
    • (1992) J. Neurosci. , vol.12 , pp. 425-429
    • Faden, A.I.1
  • 16
    • 0026724017 scopus 로고
    • Further evidence that morphine-6β-glucronide is a more potent opioid antagonist than morphine
    • Frances B., Gout R., Monsarrat B., Cros J., and Zajac J.M. Further evidence that morphine-6β-glucronide is a more potent opioid antagonist than morphine. J. Pharmacol. Exp. Ther. 262 (1992) 25-31
    • (1992) J. Pharmacol. Exp. Ther. , vol.262 , pp. 25-31
    • Frances, B.1    Gout, R.2    Monsarrat, B.3    Cros, J.4    Zajac, J.M.5
  • 17
    • 0033577464 scopus 로고    scopus 로고
    • Micloglial reactions after subcutaneous formalin injection into the rat hind paw
    • Fu K.Y., Light A.R., Matusshima G.K., and Maixner W. Micloglial reactions after subcutaneous formalin injection into the rat hind paw. Neuroscience 825 (1999) 59-67
    • (1999) Neuroscience , vol.825 , pp. 59-67
    • Fu, K.Y.1    Light, A.R.2    Matusshima, G.K.3    Maixner, W.4
  • 18
    • 0028255858 scopus 로고
    • Carrageenan induced inflammation alters the content of i-cGMP and i-cAMP in the dorsal horn of the spinal cord
    • Garry M.G., Richardson J.D., and Hargreaves K.M. Carrageenan induced inflammation alters the content of i-cGMP and i-cAMP in the dorsal horn of the spinal cord. Brain Res. 646 (1994) 135-139
    • (1994) Brain Res. , vol.646 , pp. 135-139
    • Garry, M.G.1    Richardson, J.D.2    Hargreaves, K.M.3
  • 19
    • 0023899468 scopus 로고
    • Myoclonic spasms following intrathecal morphine
    • Glavina M.J., and Robertshaw R. Myoclonic spasms following intrathecal morphine. Anaesthesia 43 (1988) 389-390
    • (1988) Anaesthesia , vol.43 , pp. 389-390
    • Glavina, M.J.1    Robertshaw, R.2
  • 21
    • 33646439133 scopus 로고    scopus 로고
    • Activated microglia contribute to the maintenance of chronic pain after spinal cord injury
    • Hains B.C., and Waxman S.G. Activated microglia contribute to the maintenance of chronic pain after spinal cord injury. J. Neurosci. 26 (2006) 4308-4317
    • (2006) J. Neurosci. , vol.26 , pp. 4308-4317
    • Hains, B.C.1    Waxman, S.G.2
  • 22
    • 0035287432 scopus 로고    scopus 로고
    • Glia: Listening and talking to synapse
    • Haydon P.G. Glia: Listening and talking to synapse. Nat. Rev. Neurosci. 2 (2001) 185-193
    • (2001) Nat. Rev. Neurosci. , vol.2 , pp. 185-193
    • Haydon, P.G.1
  • 24
    • 0034130227 scopus 로고    scopus 로고
    • Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons
    • Honore P., Rogers S.D., Schwei M.J., Salak-Johnson J.L., Luger N.M., Sabino M.C., Clohisy D.R., and Mantyh P.W. Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons. Neuroscience 98 (2000) 585-598
    • (2000) Neuroscience , vol.98 , pp. 585-598
    • Honore, P.1    Rogers, S.D.2    Schwei, M.J.3    Salak-Johnson, J.L.4    Luger, N.M.5    Sabino, M.C.6    Clohisy, D.R.7    Mantyh, P.W.8
  • 25
    • 0141856610 scopus 로고    scopus 로고
    • ERK integrates PKA and PKC signaling in superficial dorsal horn neurons. I: Modulation of A-type K currents
    • Hu H., Glauner K.S., and Gereau R.W. ERK integrates PKA and PKC signaling in superficial dorsal horn neurons. I: Modulation of A-type K currents. J. Neurophysiol. 90 (2003) 1671-1679
    • (2003) J. Neurophysiol. , vol.90 , pp. 1671-1679
    • Hu, H.1    Glauner, K.S.2    Gereau, R.W.3
  • 27
    • 0033136259 scopus 로고    scopus 로고
    • Making new concentration: Role of ERK/MAP kinase signaling in neuronal plasticity
    • Impey S., Obrietan K., and Storm D.R. Making new concentration: Role of ERK/MAP kinase signaling in neuronal plasticity. Neuron 23 (1999) 11-14
    • (1999) Neuron , vol.23 , pp. 11-14
    • Impey, S.1    Obrietan, K.2    Storm, D.R.3
  • 28
    • 7944238825 scopus 로고    scopus 로고
    • Cell signaling and the genesis of neuropathic pain
    • Ji R.R., and Strichartz G. Cell signaling and the genesis of neuropathic pain. Sci. STKE 252 (2004) reE14
    • (2004) Sci. STKE , vol.252
    • Ji, R.R.1    Strichartz, G.2
  • 29
    • 0035116529 scopus 로고    scopus 로고
    • Neuronal plasticity and signal transduction in nociceptive neurons: Implications for the initiation and maintenance of pathological pain
    • Ji R.R., and Woolf C.J. Neuronal plasticity and signal transduction in nociceptive neurons: Implications for the initiation and maintenance of pathological pain. Neurobiol. Dis. 8 (2001) 1-10
    • (2001) Neurobiol. Dis. , vol.8 , pp. 1-10
    • Ji, R.R.1    Woolf, C.J.2
  • 30
    • 0033490464 scopus 로고    scopus 로고
    • Nociceptive specific activation of ERK in spinal neurons contributes to pain hypersensitivity
    • Ji R.R., Baba H., Brenner G.J., and Woolf C.J. Nociceptive specific activation of ERK in spinal neurons contributes to pain hypersensitivity. Nat. Neurosci. 2 (1999) 1114-1119
    • (1999) Nat. Neurosci. , vol.2 , pp. 1114-1119
    • Ji, R.R.1    Baba, H.2    Brenner, G.J.3    Woolf, C.J.4
  • 31
    • 0037080003 scopus 로고    scopus 로고
    • ERK MAP kinase activation in superficial spinal cord neurons induced prodynorphine and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity
    • Ji R.R., Befort K., Brenner G.J., and Woolf C.J. ERK MAP kinase activation in superficial spinal cord neurons induced prodynorphine and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity. J. Neurosci. 22 (2002) 478-485
    • (2002) J. Neurosci. , vol.22 , pp. 478-485
    • Ji, R.R.1    Befort, K.2    Brenner, G.J.3    Woolf, C.J.4
  • 32
    • 0242475309 scopus 로고    scopus 로고
    • Central sensitization and longterm potentiation-Do pain and memory share similar mechanism?
    • Ji R.R., Kohno T., Moore K.A., and Woolf C.J. Central sensitization and longterm potentiation-Do pain and memory share similar mechanism?. Trends Neurosci. 26 (2003) 696-705
    • (2003) Trends Neurosci. , vol.26 , pp. 696-705
    • Ji, R.R.1    Kohno, T.2    Moore, K.A.3    Woolf, C.J.4
  • 34
    • 0035371317 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice
    • Karim F., Wang C.C., and Gereau R.W. Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice. J. Neurosci. 21 (2001) 3771-3779
    • (2001) J. Neurosci. , vol.21 , pp. 3771-3779
    • Karim, F.1    Wang, C.C.2    Gereau, R.W.3
  • 35
    • 4644312225 scopus 로고    scopus 로고
    • Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization
    • Kawasaki Y., Kohno T., Zhuang Z.Y., Brenner G.J., Wang H., Van Der Meer C., Befort K., Woolf C.J., and Ji R.R. Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization. J. Neurosci. 24 (2004) 8310-8321
    • (2004) J. Neurosci. , vol.24 , pp. 8310-8321
    • Kawasaki, Y.1    Kohno, T.2    Zhuang, Z.Y.3    Brenner, G.J.4    Wang, H.5    Van Der Meer, C.6    Befort, K.7    Woolf, C.J.8    Ji, R.R.9
  • 36
    • 1242291761 scopus 로고    scopus 로고
    • Nonopioid actions of intrathecal dynorphine evoke spinal excitatory amino acids and prodstaglandin E2 release mediated by cyclooxygenase-1 and -2
    • Koetzner L., Hua X.Y., Lai J., Porreca F., and Yaksh T. Nonopioid actions of intrathecal dynorphine evoke spinal excitatory amino acids and prodstaglandin E2 release mediated by cyclooxygenase-1 and -2. J. Neurosci. 24 (2004) 1451-1458
    • (2004) J. Neurosci. , vol.24 , pp. 1451-1458
    • Koetzner, L.1    Hua, X.Y.2    Lai, J.3    Porreca, F.4    Yaksh, T.5
  • 37
    • 34047134223 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase (ERK) and nitric oxide synthase mediate intrathecal morphine-induced nociceptive behavior
    • Komatsu T., Sakurada C., Sasaki M., Sanai K., Tsuzuki M., Bagetta G., Sakurada S., and Sakurada T. Extracellular signal-regulated kinase (ERK) and nitric oxide synthase mediate intrathecal morphine-induced nociceptive behavior. Neuropharmacology 52 (2007) 1237-1243
    • (2007) Neuropharmacology , vol.52 , pp. 1237-1243
    • Komatsu, T.1    Sakurada, C.2    Sasaki, M.3    Sanai, K.4    Tsuzuki, M.5    Bagetta, G.6    Sakurada, S.7    Sakurada, T.8
  • 39
    • 67650236257 scopus 로고    scopus 로고
    • Involvemet of spinal cord astroglia in allodynia induced by morphine-3-glucronide
    • Komatsu T., Shiohira H., Sanai K., Sakurada C., Sakurada S., and Sakurada T. Involvemet of spinal cord astroglia in allodynia induced by morphine-3-glucronide. J. Pharmacol. Sci. 106 Suppl. I (2008) 225
    • (2008) J. Pharmacol. Sci. , vol.106 , Issue.SUPPL. I , pp. 225
    • Komatsu, T.1    Shiohira, H.2    Sanai, K.3    Sakurada, C.4    Sakurada, S.5    Sakurada, T.6
  • 40
    • 0021816535 scopus 로고
    • Continuous infusion of spinally administered narcotics for pain due to malignant disorder
    • Krames E.S., Gershow J., Glassberg A., Kenefick T., Lyons A., Taylor P., and Wilkie D. Continuous infusion of spinally administered narcotics for pain due to malignant disorder. Cancer 56 (1985) 696-702
    • (1985) Cancer , vol.56 , pp. 696-702
    • Krames, E.S.1    Gershow, J.2    Glassberg, A.3    Kenefick, T.4    Lyons, A.5    Taylor, P.6    Wilkie, D.7
  • 41
    • 0030879183 scopus 로고    scopus 로고
    • Spinally administered dynorphin A produces long-lasting allodynia: Involvement of NMDA but not opioid receptors
    • Laughlin T.M., Vanderah T.W., Lashbrook J.M., Nichols M.L., Ossipov M.H., Porreca F., and Wilcox G.L. Spinally administered dynorphin A produces long-lasting allodynia: Involvement of NMDA but not opioid receptors. Pain 72 (1997) 253-260
    • (1997) Pain , vol.72 , pp. 253-260
    • Laughlin, T.M.1    Vanderah, T.W.2    Lashbrook, J.M.3    Nichols, M.L.4    Ossipov, M.H.5    Porreca, F.6    Wilcox, G.L.7
  • 42
    • 0142188665 scopus 로고    scopus 로고
    • The signaling components of sensory fiber transmission involved in the activation of ERK MAP kinase in the mouse dorsal horn
    • Lever I.J., Pezet S., McMahon S.B., and Malcangio M. The signaling components of sensory fiber transmission involved in the activation of ERK MAP kinase in the mouse dorsal horn. Mol. Cell. Neurosci. 24 (2003) 259-270
    • (2003) Mol. Cell. Neurosci. , vol.24 , pp. 259-270
    • Lever, I.J.1    Pezet, S.2    McMahon, S.B.3    Malcangio, M.4
  • 43
    • 0037101970 scopus 로고    scopus 로고
    • Function and regulation of CREB family transcription factors in the nervous system
    • Lonze B.E., and Ginty D.D. Function and regulation of CREB family transcription factors in the nervous system. Neuron 35 (2002) 605-623
    • (2002) Neuron , vol.35 , pp. 605-623
    • Lonze, B.E.1    Ginty, D.D.2
  • 44
    • 0029948720 scopus 로고    scopus 로고
    • Morphine-6-O-β-d-glucronide but not morphine-3-O-β-d-glucronide binds to μ-, δ-, and κ-supecific opioid binding sites in cerebral membranes
    • Loser S.V., Meyer J., Freudenthaler S., Sattler M., Desel C., Meineke I., and Gundert Remy U. Morphine-6-O-β-d-glucronide but not morphine-3-O-β-d-glucronide binds to μ-, δ-, and κ-supecific opioid binding sites in cerebral membranes. Naunyn-Schmiedeberg's Arch. Pharmacol. 354 (1996) 192-197
    • (1996) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.354 , pp. 192-197
    • Loser, S.V.1    Meyer, J.2    Freudenthaler, S.3    Sattler, M.4    Desel, C.5    Meineke, I.6    Gundert Remy, U.7
  • 45
    • 0035783434 scopus 로고    scopus 로고
    • Chronic morphine exposure increases the phosphorylation of MAP kinases and the transcription factor CREB in dorsal root ganglion neurons; an in vitro and in vivo study
    • Ma W., Zheng W.H., Powell K., Jhamandas K., and Quirion R. Chronic morphine exposure increases the phosphorylation of MAP kinases and the transcription factor CREB in dorsal root ganglion neurons; an in vitro and in vivo study. Eur. J. Neurosci. 14 (2001) 1091-1104
    • (2001) Eur. J. Neurosci. , vol.14 , pp. 1091-1104
    • Ma, W.1    Zheng, W.H.2    Powell, K.3    Jhamandas, K.4    Quirion, R.5
  • 46
    • 0034193926 scopus 로고    scopus 로고
    • Extraterritorial neuropathic pain correlates with multisegmental elevation of spinal dynorphin in nerve-injured rats
    • Malan T.P., Ossipov M.H., Gardell L.R., Ibrahim M., Bian D., Lai J., and Porreca F. Extraterritorial neuropathic pain correlates with multisegmental elevation of spinal dynorphin in nerve-injured rats. Pain 86 (2000) 185-194
    • (2000) Pain , vol.86 , pp. 185-194
    • Malan, T.P.1    Ossipov, M.H.2    Gardell, L.R.3    Ibrahim, M.4    Bian, D.5    Lai, J.6    Porreca, F.7
  • 48
    • 0242384719 scopus 로고    scopus 로고
    • Regulation of gene expression and cocaine reward by CREB and Delta FosB
    • McClung C.A., and Nestler E.J. Regulation of gene expression and cocaine reward by CREB and Delta FosB. Nat. Neurosci. 6 (2003) 1208-1215
    • (2003) Nat. Neurosci. , vol.6 , pp. 1208-1215
    • McClung, C.A.1    Nestler, E.J.2
  • 49
    • 0027502194 scopus 로고
    • Nitric oxide (NO) and nociceptive processing in the spinal cord
    • Meller S.T., and Gebhart G.F. Nitric oxide (NO) and nociceptive processing in the spinal cord. Pain 52 (1993) 127-136
    • (1993) Pain , vol.52 , pp. 127-136
    • Meller, S.T.1    Gebhart, G.F.2
  • 50
    • 0028027868 scopus 로고
    • The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat
    • Meller S.T., Dykstra C., Grzybycki D., Murphy S., and Gebhart G.F. The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat. Neuropharmacology 33 (1994) 1471-1478
    • (1994) Neuropharmacology , vol.33 , pp. 1471-1478
    • Meller, S.T.1    Dykstra, C.2    Grzybycki, D.3    Murphy, S.4    Gebhart, G.F.5
  • 52
    • 47949133637 scopus 로고    scopus 로고
    • Glycinergic mediation of tactile allodynia induced by platelet-activating factor (PAF) through glutamate-NO-cyclic GMP signalling in spinal cord in mice
    • Morita K., Kitayama T., Morioka N., and Dohi T. Glycinergic mediation of tactile allodynia induced by platelet-activating factor (PAF) through glutamate-NO-cyclic GMP signalling in spinal cord in mice. Pain 138 (2008) 525-536
    • (2008) Pain , vol.138 , pp. 525-536
    • Morita, K.1    Kitayama, T.2    Morioka, N.3    Dohi, T.4
  • 54
    • 0033580841 scopus 로고    scopus 로고
    • Circadian regulation of cAMP response element-mediated gene expression in the suparachiasmatic nuclei
    • Obrietan K., Impey S., Smith D., Athos J., and Storm D.R. Circadian regulation of cAMP response element-mediated gene expression in the suparachiasmatic nuclei. J. Biol. Chem. 274 (1999) 17748-17756
    • (1999) J. Biol. Chem. , vol.274 , pp. 17748-17756
    • Obrietan, K.1    Impey, S.2    Smith, D.3    Athos, J.4    Storm, D.R.5
  • 55
    • 0033637570 scopus 로고    scopus 로고
    • Morphine-6β-glucronide has a higher efficacy than morphine as mu-opioid receptor agonist in the rat locus coeruleus
    • Osborne P.B., Chieng B., and Christie M.J. Morphine-6β-glucronide has a higher efficacy than morphine as mu-opioid receptor agonist in the rat locus coeruleus. Br. J. Pharmacol. 131 (2000) 1422-1428
    • (2000) Br. J. Pharmacol. , vol.131 , pp. 1422-1428
    • Osborne, P.B.1    Chieng, B.2    Christie, M.J.3
  • 56
    • 0025209851 scopus 로고
    • Myoclonic seizure activity with chronic high-dose spinal opioid administration
    • Parkinson S.K., Bailey S.L., Little W.L., and Mueller J.B. Myoclonic seizure activity with chronic high-dose spinal opioid administration. Anesthesiology 72 (1990) 743-745
    • (1990) Anesthesiology , vol.72 , pp. 743-745
    • Parkinson, S.K.1    Bailey, S.L.2    Little, W.L.3    Mueller, J.B.4
  • 58
    • 0024369341 scopus 로고
    • Pharmacological characterization of morphine-6-glucuronide, a very potent morphine metabolite
    • Paul D., Standifer K.M., Intrurrisi C.E., and Pasternak G.W. Pharmacological characterization of morphine-6-glucuronide, a very potent morphine metabolite. J. Pharmacol. Exp. Ther. 251 (1989) 477-483
    • (1989) J. Pharmacol. Exp. Ther. , vol.251 , pp. 477-483
    • Paul, D.1    Standifer, K.M.2    Intrurrisi, C.E.3    Pasternak, G.W.4
  • 59
    • 0023278495 scopus 로고
    • Chronic intrathecal morphine for intractable pain
    • Penn R., and Paice J. Chronic intrathecal morphine for intractable pain. J. Neurosurg. 67 (1987) 182-186
    • (1987) J. Neurosurg. , vol.67 , pp. 182-186
    • Penn, R.1    Paice, J.2
  • 60
    • 0024970939 scopus 로고
    • Myoclonus associated with treatment with high doses of morphine: The role of supplemental drugs
    • Potter J.M., Reid D.B., Shaw R.J., Hackett P., and Hickmann P.E. Myoclonus associated with treatment with high doses of morphine: The role of supplemental drugs. Br. Med. J. 299 (1989) 150-153
    • (1989) Br. Med. J. , vol.299 , pp. 150-153
    • Potter, J.M.1    Reid, D.B.2    Shaw, R.J.3    Hackett, P.4    Hickmann, P.E.5
  • 61
  • 62
    • 0037112041 scopus 로고    scopus 로고
    • The role of spinal neuroimmune activation in morphine tolerance/hyperalgesia in neuropathic and sham-operated rats
    • Raghavendra V., Tanga F.Y., and DeLeo J.A. The role of spinal neuroimmune activation in morphine tolerance/hyperalgesia in neuropathic and sham-operated rats. J. Neurosci. 22 (2002) 9980-9989
    • (2002) J. Neurosci. , vol.22 , pp. 9980-9989
    • Raghavendra, V.1    Tanga, F.Y.2    DeLeo, J.A.3
  • 63
    • 0037622717 scopus 로고    scopus 로고
    • Inhibition of micloglia activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy
    • Raghavendra V., Tanga F.Y., and DeLeo J.A. Inhibition of micloglia activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy. J. Pharmacol. Exp. Ther. 306 (2003) 624-630
    • (2003) J. Pharmacol. Exp. Ther. , vol.306 , pp. 624-630
    • Raghavendra, V.1    Tanga, F.Y.2    DeLeo, J.A.3
  • 64
    • 3242758909 scopus 로고    scopus 로고
    • Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS
    • Raghavendra V., Tanga F.Y., and DeLeo J.A. Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS. Eur. J. Neurosci. 20 (2004) 467-473
    • (2004) Eur. J. Neurosci. , vol.20 , pp. 467-473
    • Raghavendra, V.1    Tanga, F.Y.2    DeLeo, J.A.3
  • 65
    • 0030591471 scopus 로고    scopus 로고
    • Spinally-mediated behavioral responses evoked by intrathecal high-dose morphine: Possible involvement of substance P in the mouse spinal cord
    • Sakurada T., Wako K., Sakurada C., Manome Y., Tan-No K., Sakurada S., and Kisara K. Spinally-mediated behavioral responses evoked by intrathecal high-dose morphine: Possible involvement of substance P in the mouse spinal cord. Brain Res. 724 (1996) 213-221
    • (1996) Brain Res. , vol.724 , pp. 213-221
    • Sakurada, T.1    Wako, K.2    Sakurada, C.3    Manome, Y.4    Tan-No, K.5    Sakurada, S.6    Kisara, K.7
  • 66
    • 0030245813 scopus 로고    scopus 로고
    • Involvement of nitric oxide in spinally mediated capsaicin- and glutamate-induced behavioural responses in the mouse
    • Sakurada T., Sugiyama A., Sakurada C., Tan-No K., Sakurada S., Kisara K., Hara A., and Abiko Y. Involvement of nitric oxide in spinally mediated capsaicin- and glutamate-induced behavioural responses in the mouse. Neurchem. Int. 29 (1996) 271-278
    • (1996) Neurchem. Int. , vol.29 , pp. 271-278
    • Sakurada, T.1    Sugiyama, A.2    Sakurada, C.3    Tan-No, K.4    Sakurada, S.5    Kisara, K.6    Hara, A.7    Abiko, Y.8
  • 67
    • 0035105760 scopus 로고    scopus 로고
    • Antinociceptive effect of spinally injected L-NAME on the acute nociceptive response induced by low concentrations of formalin
    • Sakurada C., Sugiyama A., Nakayama M., Yonezawa A., Sakurada S., Tan-No K., Kisara K., and Sakurada S. Antinociceptive effect of spinally injected L-NAME on the acute nociceptive response induced by low concentrations of formalin. Neurochem. Int. 38 (2001) 417-423
    • (2001) Neurochem. Int. , vol.38 , pp. 417-423
    • Sakurada, C.1    Sugiyama, A.2    Nakayama, M.3    Yonezawa, A.4    Sakurada, S.5    Tan-No, K.6    Kisara, K.7    Sakurada, S.8
  • 69
  • 70
    • 0037333607 scopus 로고    scopus 로고
    • Inhibition of cyclic guanosine 5′-monophosphate-dependent protein kinase I (PKG-I) in lumbar spinal cord reduces formalin-induced hyperalgesia and PKG upregulation
    • Schmidtko A., Ruth P., Geisslinger G., and Tegeder I. Inhibition of cyclic guanosine 5′-monophosphate-dependent protein kinase I (PKG-I) in lumbar spinal cord reduces formalin-induced hyperalgesia and PKG upregulation. Nitric Oxide 8 (2003) 89-94
    • (2003) Nitric Oxide , vol.8 , pp. 89-94
    • Schmidtko, A.1    Ruth, P.2    Geisslinger, G.3    Tegeder, I.4
  • 71
    • 35548937457 scopus 로고    scopus 로고
    • The neuropathic pain triad: Neurons, immune cells and glia
    • Scholz J., and Woolf C.J. The neuropathic pain triad: Neurons, immune cells and glia. Nat. Neurosci. 10 (2007) 1361-1368
    • (2007) Nat. Neurosci. , vol.10 , pp. 1361-1368
    • Scholz, J.1    Woolf, C.J.2
  • 72
    • 0030606802 scopus 로고    scopus 로고
    • Alterations in rat spinal cord cGMP by peripheral nerve injury and adrenal medullary transplantation
    • Siegan J.B., Hama A.T., and Sagen J. Alterations in rat spinal cord cGMP by peripheral nerve injury and adrenal medullary transplantation. Neurosci. Lett. 215 (1996) 49-52
    • (1996) Neurosci. Lett. , vol.215 , pp. 49-52
    • Siegan, J.B.1    Hama, A.T.2    Sagen, J.3
  • 73
    • 0027527448 scopus 로고
    • Hyperalgesia and myoclonus in terminal cancer patients treated with continuous intravenous morphine
    • Sjogren P., Jonsson T., Jensen N.H., Drenck N.E., and Jensen T.S. Hyperalgesia and myoclonus in terminal cancer patients treated with continuous intravenous morphine. Pain 55 (1993) 93-97
    • (1993) Pain , vol.55 , pp. 93-97
    • Sjogren, P.1    Jonsson, T.2    Jensen, N.H.3    Drenck, N.E.4    Jensen, T.S.5
  • 74
    • 0026605218 scopus 로고
    • Selective potentiation of NMDA-induced activity and release of excitatory amino acids by dynorphine: Possible roles in paralysis and neurotoxicity
    • Skilling S.R., Sun X., Kurtz H.J., and Larson A.A. Selective potentiation of NMDA-induced activity and release of excitatory amino acids by dynorphine: Possible roles in paralysis and neurotoxicity. Brain Res. 575 (1992) 272-278
    • (1992) Brain Res. , vol.575 , pp. 272-278
    • Skilling, S.R.1    Sun, X.2    Kurtz, H.J.3    Larson, A.A.4
  • 75
    • 0034053670 scopus 로고    scopus 로고
    • Neuroexcitatory effects of morphine and hydromorphine: Evidence implicating the 3-glucuronide metabolites
    • Smith M.T. Neuroexcitatory effects of morphine and hydromorphine: Evidence implicating the 3-glucuronide metabolites. Clin. Exp. Pharmacol. Physiol. 27 (2000) 524-528
    • (2000) Clin. Exp. Pharmacol. Physiol. , vol.27 , pp. 524-528
    • Smith, M.T.1
  • 76
    • 3042561735 scopus 로고    scopus 로고
    • Intrathecal interleukin-1beta administration induces themal hyperalgesia by activating inducible nitric oxide synthase expression in the rat spinal cord
    • Sung C.S., Wen Z.H., Chang W.K., Ho S.T., Tsai S.K., Chang Y.C., and Wong C.S. Intrathecal interleukin-1beta administration induces themal hyperalgesia by activating inducible nitric oxide synthase expression in the rat spinal cord. Brain Res. 1051 (2004) 145-153
    • (2004) Brain Res. , vol.1051 , pp. 145-153
    • Sung, C.S.1    Wen, Z.H.2    Chang, W.K.3    Ho, S.T.4    Tsai, S.K.5    Chang, Y.C.6    Wong, C.S.7
  • 77
    • 0035857748 scopus 로고    scopus 로고
    • Intrathecal interleukin-1 receptor antagonist in combunation with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain
    • Sweitzer S., Martin D., and DeLeo J.A. Intrathecal interleukin-1 receptor antagonist in combunation with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain. Neuroscience 103 (2001) 529-539
    • (2001) Neuroscience , vol.103 , pp. 529-539
    • Sweitzer, S.1    Martin, D.2    DeLeo, J.A.3
  • 78
    • 33746809553 scopus 로고    scopus 로고
    • Amitriptyline suppresses neuroinflammation and up regulates glutamate transporters in morphine-tolerant rats
    • Tai Y.H., Wang Y.H., Wang J.J., Tao P.L., Tung C.S., and Wong C.S. Amitriptyline suppresses neuroinflammation and up regulates glutamate transporters in morphine-tolerant rats. Pain 124 (2006) 77-86
    • (2006) Pain , vol.124 , pp. 77-86
    • Tai, Y.H.1    Wang, Y.H.2    Wang, J.J.3    Tao, P.L.4    Tung, C.S.5    Wong, C.S.6
  • 79
    • 0018227414 scopus 로고
    • Comparison of subcutaneous and spinal subarachnoid injections of morphine and naloxone in analgesic tests in rat
    • Tang A.H., and Schoenfeld H.J. Comparison of subcutaneous and spinal subarachnoid injections of morphine and naloxone in analgesic tests in rat. Eur. J. Pharmacol. 52 (1978) 215-223
    • (1978) Eur. J. Pharmacol. , vol.52 , pp. 215-223
    • Tang, A.H.1    Schoenfeld, H.J.2
  • 80
    • 0032714373 scopus 로고    scopus 로고
    • Expression and action of cyclic GMP-dependent protein kinase Ialpha in inflammatory hyperalgesia in rat spinal cord
    • Tao Y.X., Hassan A., Haddad E., and Johns R.A. Expression and action of cyclic GMP-dependent protein kinase Ialpha in inflammatory hyperalgesia in rat spinal cord. Neuroscience 95 (2000) 525-533
    • (2000) Neuroscience , vol.95 , pp. 525-533
    • Tao, Y.X.1    Hassan, A.2    Haddad, E.3    Johns, R.A.4
  • 81
    • 0037206670 scopus 로고    scopus 로고
    • Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats
    • Tegeder I., Schmidtko A., Niederberger E., Ruth P., and Geisslinger G. Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats. Neurosci. Lett. 332 (2002) 146-150
    • (2002) Neurosci. Lett. , vol.332 , pp. 146-150
    • Tegeder, I.1    Schmidtko, A.2    Niederberger, E.3    Ruth, P.4    Geisslinger, G.5
  • 83
    • 13144276331 scopus 로고    scopus 로고
    • Neuropathic pain and spinal microglia: A big problem from molecules in "small" glia
    • Tsuda M., Inoue K., and Salter M.W. Neuropathic pain and spinal microglia: A big problem from molecules in "small" glia. Trends Neurosci. 28 (2005) 101-107
    • (2005) Trends Neurosci. , vol.28 , pp. 101-107
    • Tsuda, M.1    Inoue, K.2    Salter, M.W.3
  • 84
    • 17344385566 scopus 로고    scopus 로고
    • Single intrathecal injections of dynorphin A or des-Tyr-dynorphins produce long-lasting allodynia on rats: Blockade by MK-801 but not naloxone
    • Vanderah T.W., Laughlin T.M., Lashbrook J.M., Nichols M.L., Wilcox G.L., Ossipov M.H., Malan T.P., and Porreca F. Single intrathecal injections of dynorphin A or des-Tyr-dynorphins produce long-lasting allodynia on rats: Blockade by MK-801 but not naloxone. Pain 68 (1996) 275-281
    • (1996) Pain , vol.68 , pp. 275-281
    • Vanderah, T.W.1    Laughlin, T.M.2    Lashbrook, J.M.3    Nichols, M.L.4    Wilcox, G.L.5    Ossipov, M.H.6    Malan, T.P.7    Porreca, F.8
  • 86
    • 0029670427 scopus 로고    scopus 로고
    • Pre-emptive dynorphine and N-methyl-d-asparatate glutamate receptor antagonism alters spinal immunocytochemistry but not allodynia following complete peripheral nerve injury
    • Wagner R., and Deleo J.A. Pre-emptive dynorphine and N-methyl-d-asparatate glutamate receptor antagonism alters spinal immunocytochemistry but not allodynia following complete peripheral nerve injury. Neurocsience 72 (1996) 527-534
    • (1996) Neurocsience , vol.72 , pp. 527-534
    • Wagner, R.1    Deleo, J.A.2
  • 88
    • 0344305586 scopus 로고    scopus 로고
    • The role of spinal nitric oxide and glutamate in nociceptive behaviour evoked by high-dose intrathecal morphine in rats
    • Watanabe C., Sakurada T., Okuda K., Sakurada C., Ando R., and Sakurada S. The role of spinal nitric oxide and glutamate in nociceptive behaviour evoked by high-dose intrathecal morphine in rats. Pain 106 (2003) 269-283
    • (2003) Pain , vol.106 , pp. 269-283
    • Watanabe, C.1    Sakurada, T.2    Okuda, K.3    Sakurada, C.4    Ando, R.5    Sakurada, S.6
  • 89
    • 0141918795 scopus 로고    scopus 로고
    • Evidence that nitric oxide-glutamate cascade modulates spinal antinociceptive effect of morphine: A behavioural and microdialysis study in rats
    • Watanabe C., Okuda K., Sakurada C., Ando R., Sakurada T., and Sakurada S. Evidence that nitric oxide-glutamate cascade modulates spinal antinociceptive effect of morphine: A behavioural and microdialysis study in rats. Brain Res. 990 (2003) 77-86
    • (2003) Brain Res. , vol.990 , pp. 77-86
    • Watanabe, C.1    Okuda, K.2    Sakurada, C.3    Ando, R.4    Sakurada, T.5    Sakurada, S.6
  • 90
    • 0347169249 scopus 로고    scopus 로고
    • Glia: Novel drug discovery target for clinical pain
    • Watkins L.R., and Maier S.F. Glia: Novel drug discovery target for clinical pain. Nat. Rev. Drug Discov. 2 (2003) 973-985
    • (2003) Nat. Rev. Drug Discov. , vol.2 , pp. 973-985
    • Watkins, L.R.1    Maier, S.F.2
  • 91
    • 0035426434 scopus 로고    scopus 로고
    • Glial activation: A driving force for pathological pain
    • Watkins L.R., Milligan E.D., and Maier S.F. Glial activation: A driving force for pathological pain. Trends Neurosci. 24 (2001) 450-455
    • (2001) Trends Neurosci. , vol.24 , pp. 450-455
    • Watkins, L.R.1    Milligan, E.D.2    Maier, S.F.3
  • 92
    • 0038748399 scopus 로고    scopus 로고
    • Glial proinflammatory cytokines mediate exaggerated pain states: Implications for clinical pain
    • Watkins L.R., Milligan E.D., and Maier S.F. Glial proinflammatory cytokines mediate exaggerated pain states: Implications for clinical pain. Adv. Exp. Med. Biol. 521 (2003) 1-21
    • (2003) Adv. Exp. Med. Biol. , vol.521 , pp. 1-21
    • Watkins, L.R.1    Milligan, E.D.2    Maier, S.F.3
  • 93
    • 0020078102 scopus 로고
    • Opiate alkaloids antagonize postsynaptic glycine and GABA responses: Correlation with convulsant action
    • Wert M.A., and MacDonald R.L. Opiate alkaloids antagonize postsynaptic glycine and GABA responses: Correlation with convulsant action. Brain Res. 236 (1982) 107-119
    • (1982) Brain Res. , vol.236 , pp. 107-119
    • Wert, M.A.1    MacDonald, R.L.2
  • 94
    • 0035888084 scopus 로고    scopus 로고
    • Nerve injury proximal or distal to the DRG induces similar spinal glial activation and selective cytokine expression but differential behavioral responses to pharmacologic treatment
    • Winkelstein B.A., Rutkowski M.D., Sweitzer S.M., Pahl J.L., and Deleo J.A. Nerve injury proximal or distal to the DRG induces similar spinal glial activation and selective cytokine expression but differential behavioral responses to pharmacologic treatment. J. Comp Neurol. 439 (2001) 127-139
    • (2001) J. Comp Neurol. , vol.439 , pp. 127-139
    • Winkelstein, B.A.1    Rutkowski, M.D.2    Sweitzer, S.M.3    Pahl, J.L.4    Deleo, J.A.5
  • 95
    • 0019524261 scopus 로고
    • Intrathecal high dose morphine produces hyperalgesia in the rat
    • Woolf F.J. Intrathecal high dose morphine produces hyperalgesia in the rat. Brain Res. 209 (1981) 491-495
    • (1981) Brain Res. , vol.209 , pp. 491-495
    • Woolf, F.J.1
  • 96
    • 0032498806 scopus 로고    scopus 로고
    • Nitric oxide contributes to central sensitization following intradermal injection of capsaicin
    • Wu J., Lin Q., McAdoo D.J., and Willis W.D. Nitric oxide contributes to central sensitization following intradermal injection of capsaicin. NeuroReport 9 (1998) 589-592
    • (1998) NeuroReport , vol.9 , pp. 589-592
    • Wu, J.1    Lin, Q.2    McAdoo, D.J.3    Willis, W.D.4
  • 97
    • 0023829817 scopus 로고
    • Parmacology of the allodynia in rats evoked by high dose intrathecal morphine
    • Yaksh T.L., and Harty G.J. Parmacology of the allodynia in rats evoked by high dose intrathecal morphine. J. Pharmacol. Exp. Ther. 244 (1988) 501-507
    • (1988) J. Pharmacol. Exp. Ther. , vol.244 , pp. 501-507
    • Yaksh, T.L.1    Harty, G.J.2
  • 98
    • 0022558928 scopus 로고
    • High doses of spinal morphine produce a nonopiate receptor-mediated hyperesthesia: Clinical and theoretical implications
    • Yaksh T.L., Harty G.J., Burton M., and Onofrio B.M. High doses of spinal morphine produce a nonopiate receptor-mediated hyperesthesia: Clinical and theoretical implications. Anesthesiology 64 (1986) 590-597
    • (1986) Anesthesiology , vol.64 , pp. 590-597
    • Yaksh, T.L.1    Harty, G.J.2    Burton, M.3    Onofrio, B.M.4
  • 99
    • 1642513343 scopus 로고    scopus 로고
    • Formation of highly analgesic morphine-6-gluclonide following physiologic concentration of morphine in human brain
    • Yamada H., Ishii K., Ishii Y., Ieiri I., Nishio S., Morioka T., and Oguri K. Formation of highly analgesic morphine-6-gluclonide following physiologic concentration of morphine in human brain. J. Toxicol. Sci. 28 (2003) 395-401
    • (2003) J. Toxicol. Sci. , vol.28 , pp. 395-401
    • Yamada, H.1    Ishii, K.2    Ishii, Y.3    Ieiri, I.4    Nishio, S.5    Morioka, T.6    Oguri, K.7
  • 100
    • 0037435884 scopus 로고    scopus 로고
    • Involvement of NMDA-nitric oxide pathways in the development of tactile hypersensitivity evoked by the loose-ligation of inferior alveolar nerves in rats
    • Yonehara N., Kudo C., and Kamisaki Y. Involvement of NMDA-nitric oxide pathways in the development of tactile hypersensitivity evoked by the loose-ligation of inferior alveolar nerves in rats. Brain Res. 963 (2003) 232-243
    • (2003) Brain Res. , vol.963 , pp. 232-243
    • Yonehara, N.1    Kudo, C.2    Kamisaki, Y.3
  • 101
    • 40049094003 scopus 로고    scopus 로고
    • IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats
    • Zhang R.X., Li S., Liu B., Wang L., Ren K., Zhang H., Berman B.M., and Lao L. IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats. Pain 135 (2008) 232-239
    • (2008) Pain , vol.135 , pp. 232-239
    • Zhang, R.X.1    Li, S.2    Liu, B.3    Wang, L.4    Ren, K.5    Zhang, H.6    Berman, B.M.7    Lao, L.8
  • 102
    • 0037162696 scopus 로고    scopus 로고
    • Ras and Rap control AMPA receptor trafficking during synaptic plasticity
    • Zhu J.J., Qin Y., Zhao M., Van Aelst L., and Malinow R. Ras and Rap control AMPA receptor trafficking during synaptic plasticity. Cell 110 (2002) 443-455
    • (2002) Cell , vol.110 , pp. 443-455
    • Zhu, J.J.1    Qin, Y.2    Zhao, M.3    Van Aelst, L.4    Malinow, R.5


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