Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats

Neuroscience Letters

Volumn 332, Issue 2, 2002, Pages 146-150

  Tegeder, Irmgard ^a   Schmidtko, Achim ^a   Niederberger, Ellen ^a   Ruth, Peter ^b   Geisslinger, Gerd ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

AMPA receptor; Formalin assay; Guanosine mono phosphate; Guanosine mono phosphate dependent kinase; Nociception; Spinal cord

Indexed keywords

8 BROMO CYCLIC GMP; AMPA RECEPTOR; CATION; CATION CHANNEL; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC NUCLEOTIDE; ENZYME INHIBITOR; FORMALDEHYDE; PHOSPHODIESTERASE; PROTEIN PKG I; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DOSE CALCULATION; DOSE RESPONSE; ENZYME ACTIVATION; HYPERALGESIA; LUMBAR SPINAL CORD; MALE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; SPINAL CORD;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANALGESICS; ANIMALS; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; FORMALDEHYDE; HINDLIMB; INJECTIONS, SPINAL; ION CHANNEL GATING; MALE; NITRIC OXIDE; PAIN MEASUREMENT; PHOSPHORIC DIESTER HYDROLASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA;

EID: 0037206670     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(02)00938-2     Document Type: Article

References (20)

1. Aley K.O., McCarter G., Levine J.D. Nitric oxide signaling in pain and nociceptor sensitization in the rat. J. Neurosci. 18:1998;7008-7014.
2. Biel M., Zong X., Ludwig A., Sautter A., Hofmann F. Molecular cloning and expression of the modulatory subunit of the cyclic nucleotide-gated cation channel. J. Biol. Chem. 271:1996;6349-6355.
3. Bradley J., Zhang Y., Bakin R., Lester H.A., Ronnett G.V., Zinn K. Functional expression of the heteromeric 'olfactory' cyclic nucleotide-gated channel in the hippocampus: a potential effector of synaptic plasticity in brain neurons. J. Neurosci. 17:1997;1993-2005.
4. Chung K.M., Lee K.C., Song D.K., Huh S.O., Choi M.R., Kim Y.H., Suh H.W. Differential modulatory roles of cholera toxin and pertussis toxin in the regulation of pain responses induced by excitatory amino acids administered intrathecally in mice. Brain Res. 867:2000;246-249.
5. Gomez M.P., Nasi E. Antagonists of the cGMP-gated conductance of vertebrate rods block the photocurrent in scallop ciliary photoreceptors. J. Physiol. (Lond.). 500:1997;367-378.
6. Heil W.G., Landgraf W., Hofmann F. A catalytically active fragment of cGMP-dependent protein kinase. Occupation of its cGMP-binding sites does not affect its phosphotransferase activity. Eur. J. Biochem. 168:1987;117-121.
7. Huber A., Neuhuber W.L., Klugbauer N., Ruth P., Allescher H.D. Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle. J. Biol. Chem. 275:2000;5504-5511.
8. Kawabata A., Umeda N., Takagi H. L-arginine exerts a dual role in nociceptive processing in the brain: involvement of the kyotorphin-Met-enkephalin pathway and NO-cyclic GMP pathway. Br. J. Pharmacol. 109:1993;73-79.
9. Keil G.J. 2nd, DeLander G.E. Adenosine kinase and adenosine deaminase inhibition modulate spinal adenosine- and opioid agonist-induced antinociception in mice. Eur. J. Pharmacol. 271:1994;37-46.
10. Kingston P.A., Zufall F., Barnstable C.J. Rat hippocampal neurons express genes for both rod retinal and olfactory cyclic nucleotide-gated channels: novel targets for cAMP/cGMP function. Proc. Natl. Acad. Sci. USA. 93:1996;10440-10445.
11. Lei S., Jackson M.F., Jia Z., Roder J., Bai D., Orser B.A., MacDonald J.F. Cyclic GMP-dependent feedback inhibition of AMPA receptors is independent of PKG. Nat. Neurosci. 3:2000;559-565.
12. Lewin M.R., Walters E.T., Cyclic G.M.P. pathway is critical for inducing long-term sensitization of nociceptive sensory neurons. Nat. Neurosci. 2:1999;18-23.
13. Malmberg A.B., Yaksh T.L. Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats. Pain. 54:1993;291-300.
14. Meller S.T., Cummings C.P., Traub R.J., Gebhart G.F. The role of nitric oxide in the development and maintenance of the hyperalgesia produced by intraplantar injection of carrageenan in the rat. Neuroscience. 60:1994;367-374.
15. Niederberger E., Tegeder I., Vetter G., Schmidtko A., Schmidt H., Euchenhofer C., Bräutigam L., Grösch S., Geisslinger G. Celecoxib loses its anti-inflammatory efficacy at high doses through activation of NF-kappaB. FASEB J. 15:2001;1622-1624.
16. Soff G.A., Cornwell T.L., Cundiff D.L., Gately S., Lincoln T.M. Smooth muscle cell expression of type I cyclic GMP-dependent protein kinase is suppressed by continuous exposure to nitrovasodilators, theophylline, cyclic GMP, and cyclic AMP. J. Clin. Invest. 100:1997;2580-2587.
17. Sousa A.M., Prado W.A. The dual effect of a nitric oxide donor in nociception. Brain Res. 897:2001;9-19.
18. Tao Y.X., Hassan A., Haddad E., Johns R.A. Expression and action of cyclic GMP-dependent protein kinase Ialpha in inflammatory hyperalgesia in rat spinal cord. Neuroscience. 95:2000;525-533.
19. 2+ current in rat ventricular myocytes. Br. J. Pharmacol. 127:1999;65-74.
20. Yaksh T.L., Hua X.Y., Kalcheva I., Nozaki-Taguchi N., Marsala M. The spinal biology in humans and animals of pain states generated by persistent small afferent input. Proc. Natl. Acad. Sci. USA. 96:1999;7680-7686.