Innate immunity in inflammatory bowel disease: State of the art

Current Opinion in Gastroenterology

Volumn 24, Issue 4, 2008, Pages 448-454

  Hisamatsu, Tadakazu ^a   Ogata, Haruhiko ^a   Hibi, Toshifumi ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Autophagy; Crohn's disease; Dendritic cells; Flora; Genome wide scanning; Inflammatory bowel disease; Innate immunity; Intestinal epithelial cells; Macrophages; Ulcerative colitis

Indexed keywords

ALPHA DEFENSIN; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CYTOKINE; INTERLEUKIN 23; MURAMYL DIPEPTIDE; POLYPEPTIDE ANTIBIOTIC AGENT; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

AUTOPHAGY; BACTERIAL FLORA; BACTERIAL GENOME; BACTERIAL INFECTION; CELL INTERACTION; CHRONIC DISEASE; COLON CROHN DISEASE; CROHN DISEASE; DENDRITIC CELL; ESCHERICHIA COLI; GENETIC SUSCEPTIBILITY; HOMEOSTASIS; HUMAN; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOPATHOGENESIS; INFLAMMATION; INNATE IMMUNITY; INTESTINE; INTESTINE EPITHELIUM CELL; INTESTINE FLORA; MACROPHAGE; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; TRICHURIS; ULCERATIVE COLITIS;

HUMANS; IMMUNITY, INNATE; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; SIGNAL TRANSDUCTION;

EID: 67649784384     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOG.0b013e3282ff8b0c     Document Type: Review

References (45)

1. Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007; 448:427-434.
2. Hugot JP, Chamaillard M, Zouali H, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001; 411:599-603.
3. Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001; 411:603-606.
4. Cario E, Gerken G, Podolsky DK. Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Gastroenterology 2007; 132:1359-1374.
5. Zeissig S, Burgel N,Gunzel D, et al. Changes in expression and distribution ofclaudin 2,5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 2007; 56:61 -72.
6. Sugimoto K, Ogawa A, Mizoguchi E, et al. IL-22 ameliorates intestinalinflammation in a mouse model of ulcerative colitis. J Clin Invest 2008; 118:534-544.
7. Nuding S, Fellermann K, Wehkamp J, Stange EF. Reduced mucosal antimicrobial activity in Crohn's disease of the colon. Gut 2007; 56:1 240-1247.
8. Wehkamp J, Salzman NH, Porter E, et al. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci USA 2005; 102:181 29-18134.
9. Wehkamp J, WangG, KublerI, et al.The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4. J Immunol 2007; 179:3109-3118.
10. Tanabe H, Ayabe T, Maemoto A, et al. Denatured human alpha-defensin attenuates the bactericidal activity and the stability against enzymatic digestion. Biochem Biophys Res Commun 2007; 358:349-355.
11. Shi J, Aono S, Lu W, et al. A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion. J Immunol 2007; 179:1245-1253.
12. Nenci A, Becker C, Wullaert A, et al. Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature 2007; 446:557-561.
13. Zaph C, Troy AE, Taylor BC, et al. Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature 2007; 446:552-556. 14 Rimoldi M, Chieppa M, Salucci V, et al. Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nat Immunol 2005; 6:507-514.
14. Garrett WS, Lord GM, Punit S, et al. Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell 2007; 131:33-45.
15. Kotlowski R, Bernstein CN, Sepehri S, Krause DO. High prevalence of Escherichia coli belonging to the B2+D phylogenetic group in inflammatory bowel disease. Gut 2007; 56:669-675.
16. Sepehri S, Kotlowski R, Bernstein CN, Krause DO. Microbial diversity of inflamed and noninflamed gut biopsy tissues in inflammatory bowel disease. Inflamm Bowel Dis 2007; 13:675-683.
17. Takaishi H, Matsuki T, Nakazawa A, et al. Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease. Int J Med Microbiol 2007; 24 September [Epub ahead of print].
18. Kim SC, Tonkonogy SL, Karrasch T, et al. Dual-association of gnotobiotic IL-10-/- mice with 2 nonpathogenic commensal bacteria induces aggressive pancolitis. Inflamm Bowel Dis 2007; 13:1457-1466.
19. Karrasch T, Kim JS, Muhlbauer M, et al.Gnotobiotic IL-10-/-;NF-kappa B(EGFP) mice reveal the critical role of TLR/NF-kappa B signaling in commensal bacteria-induced colitis. J Immunol 2007; 178:6522-6532.
20. Henckaerts L, Pierik M, Joossens M, et al. Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease. Gut 2007; 56:1536-1542.
21. Yang Z, Fuss IJ, Watanabe T, et al.NOD2 transgenic mice exhibit enhanced MDP-mediated down-regulation of TLR2 responses and resistance to colitis induction. Gastroenterology 2007; 133:1510-1521.
22. Watanabe T, Asano N, Murray PJ, et al. Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimentalcolitis. J Clin Invest 2008; 118:545-559.
23. van Beelen AJ, Zelinkova Z, Taanman-Kueter EW, et al. Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promoteinterleukin-17 production in human memory T cells. Immunity 2007; 27: 660-669.
24. Pan Q, Mathison J, FearnsC, et al. MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3. J Leukoc Biol 2007; 82:177-183. MDP-induced IL-1 β release required NOD2 and CLAS1/NALP3. In contrast, MDP-dependent IL-6 production only required NOD2 and RIP2.
25. Schenk M, Bouchon A, Seibold F, Mueller C. TREM-1-expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases. J Clin Invest 2007; 117:3097-3106.
26. Kamada N, Hisamatsu T, Okamoto S, et al. Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria. J Immunol 2005; 175:6900-6908.
27. Smythies LE, Sellers M, Clements RH, et al. Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity. J Clin Invest 2005; 115:66-75.
28. Hirotani T, Lee PY, Kuwata H, et al. The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria. J Immunol 2005; 174:3650-3657.
29. Denning TL, Wang YC, Patel SR, et al. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol 2007; 8:1086-1094.
30. Mizoguchi A, OgawaA, Takedatsu H, et al. Dependence of intestinal granuloma formation on unique myeloid DC-like cells. J Clin Invest 2007; 117:605-615. A unique CD11c+F4/80+dendritic-like cell produced a large amount of IL-23 and induced the development of granuloma in am IL-4 triple knockout mice. Granuloma formation was dependent on IL-12p40, but not interferon-7. Interestingly, granuloma-derived unique dendritic-like cells injected in several organs of recipient mice (am IL-4 triple knockout) also induced the development of granuloma in the cecum and the kidney of the recipient.
31. McGeachy MJ, Bak-Jensen KS, Chen Y, et al. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat Immunol 2007; 8:1390-1397.
32. Elson CO, Cong Y, Weaver CT, et al. Monoclonal antiinterleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology 2007; 132:2359-2370.
33. Wilson NJ, Boniface K, Chan JR, et al. Development, cytokine profile and function of human interleukin 17-producing helperT cells. Nat Immunol 2007;8:950-957.
34. Duerr RH, Taylor KD, Brant SR, et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 2006; 314: a1461 -1463.
35. Dubinsky MC, Wang D, Picornell Y, et al. IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease. Inflamm Bowel Dis 2007; 13: 511 -515.
36. Oliver J, Rueda B, Lopez-Nevot MA, et al. Replication of an association between IL23R gene polymorphism with inflammatory bowel disease. Clin Gastroenterol Hepatol 2007; 5:977-981.
37. McGovern D, Powrie F. The IL23 axis plays a key role in the pathogenesis of IBD. Gut 2007; 56:1333-1336.
38. Hampe J, Franke A, Rosenstiel P, et al. A genom-e-wide association scan ofnonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG1 6L1. Nat Genet 2007; 39:207-211.
39. RiouxJD,XavierRJ, Taylor KD, et al. Genome-wide association study identifiesnew susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet 2007; 39:596-604.
40. Prescott NJ, Fisher SA, Franke A, et al. A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5. Gastroenterology 2007; 132:1665-1671.
41. Parkes M, Barrett JC, Prescott NJ, et al. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's diseasesusceptibility. Nat Genet 2007; 39:830-832.
42. Yamazaki K, Onouchi Y, Takazoe M, et al. Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients. J Hum Genet 2007; 52:575-583.
43. Inoue N, Tamura K, Kinouchi Y, et al. Lack of common NOD2 variants in Japanese patients with Crohn's disease. Gastroenterology 2002; 123:86-91.
44. CollazoCM,YapGS, SempowskiGD, et al. Inactivationof LRG-47and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogenspecific roles in resistance to infection. J Exp Med 2001; 194:181 -188.
45. Singh SB, Davis AS, Taylor GA, Deretic V. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 2006; 313:1438-1441.