Chromosomal translocations induced at specified loci in human stem cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 26, 2009, Pages 10620-10625

  Brunet, Erika ^a   Simsek, Deniz ^a   Tomishima, Mark ^a   DeKelver, Russell ^b   Choi, Vivian M ^b   Gregory, Philip ^b   Urnov, Fyodor ^b   Weinstock, David M ^a,c   Jasin, Maria ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b SANGAMO BIOSCIENCES INC   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Double strand break repair (DSB repair); Gene targeting; Mesenchymal cells; Nonhomologous end joining (NHEJ); Zinc finger nucleases

Indexed keywords

NUCLEASE; UNCLASSIFIED DRUG; ZINC FINGER NUCLEASE;

ARTICLE; CHROMOSOME 19; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION; CHROMOSOME TRANSLOCATION 19; DNA REPAIR; DOUBLE STRANDED DNA BREAK; EMBRYO; EMBRYONIC STEM CELL; GENE; GENE LOCUS; GENE TARGETING; HUMAN; HUMAN CELL; IL24GAMMA GENE; MESENCHYMAL STEM CELL; PPP1R12C GENE; PRIORITY JOURNAL; STEM CELL; X CHROMOSOME;

BASE SEQUENCE; CELL LINE; CHROMOSOME BREAKAGE; CHROMOSOMES, HUMAN, PAIR 19; CHROMOSOMES, HUMAN, PAIR 6; CHROMOSOMES, HUMAN, X; DNA BREAKS, DOUBLE-STRANDED; DNA BREAKS, SINGLE-STRANDED; DNA DAMAGE; DNA REPAIR; EMBRYONIC STEM CELLS; GENE REARRANGEMENT; GREEN FLUORESCENT PROTEINS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; POLYMERASE CHAIN REACTION; STEM CELLS; TRANSLOCATION, GENETIC;

EID: 67649757162     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0902076106     Document Type: Article

References (39)

1. Rowley JD (2008) Chromosomal translocations: Revisited yet again. Blood 112:2183-2189.
2. Greaves MF, Wiemels J (2003) Origins of chromosome translocations in childhood leukaemia. Nat Rev Cancer 3:639-649. (Pubitemid 37328819)
3. Tomlins SA, et al. (2005) Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 310:644-648. (Pubitemid 41528150)
4. Soda M, et al. (2007) Identification of the transforming EML4-ALK fusion gene in nonsmall- cell lung cancer. Nature 448:561-566. (Pubitemid 47206930)
5. Mitelman F, Johansson B, Mertens F (2004) Fusion genes and rearranged genes as a linear function of chromosome aberrations in cancer. Nat Genet 36:331-334. (Pubitemid 38437252)
6. Weinstock DM, Elliott B, Jasin M (2006) A model of oncogenic rearrangements: Differences between chromosomal translocation mechanisms and simple double-strand break repair. Blood 107:777-780. (Pubitemid 43076405)
7. Lieber MR (2008) The mechanism of human nonhomologous DNA end joining. J Biol Chem 283:1-5.
8. Weinstock DM, Brunet E, Jasin M (2007) Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70. Nat Cell Biol 9:978-981. (Pubitemid 47190453)
9. Bassing CH, Alt FW (2004) The cellular response to general and programmed DNA double strand breaks. DNA Repair 3:781-796. (Pubitemid 38997922)
10. Jankovic M, Nussenzweig A, Nussenzweig MC (2007) Antigen receptor diversification and chromosome translocations. Nat Immunol 8:801-808. (Pubitemid 47099032)
11. Callen E, et al. (2007) ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Cell 130:63-75. (Pubitemid 47031324)
12. Yan CT, et al. (2007) IgH class switching and translocations use a robust non-classical end-joining pathway. Nature 449:478-482. (Pubitemid 47509538)
13. Finnie NJ, Gottlieb TM, Blunt T, Jeggo PA, Jackson SP (1995) DNA-dependent protein kinase activity is absent in xrs-6 cells: Implications for site-specific recombination and DNA double-strand break repair. Proc Natl Acad Sci USA 92:320-324.
14. Rouet P, Smih F, Jasin M (1994) Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease. Mol Cell Biol 14:8096-8106. (Pubitemid 24373558)
15. Thierry A, Dujon B (1992) Nested chromosomal fragmentation in yeast using the meganuclease I-Sce I: A new method for physical mapping of eukaryotic genomes. Nucleic Acids Res 20:5625-5631.
16. Carroll D (2008) Progress and prospects: Zinc-finger nucleases as gene therapy agents. Gene Ther 15:1463-1468.
17. Maeder ML, et al. (2008) Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification. Mol Cell 31:294-301. (Pubitemid 352001401)
18. Esashi F, et al. (2005) CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature 434:598-604. (Pubitemid 40488546)
19. Urnov FD, et al. (2005) Highly efficient endogenous human gene correction using designed zinc-finger nucleases. Nature 435:646-651. (Pubitemid 40825505)
20. Weinstock DM, Brunet E, Jasin M (2008) Induction of chromosomal translocations in mouse and human cells using site-specific endonucleases. J Natl Cancer Inst Monogr 20-24.
21. Tsai AG, et al. (2008) Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity. Cell 135:1130-1142.
22. Pierce AJ, Johnson RD, Thompson LH, Jasin M (1999) XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes Dev 13:2633-2638. (Pubitemid 29508550)
23. Perez EE, et al. (2008) Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases. Nat Biotechnol 26:808-816. (Pubitemid 351961450)
24. Kotin RM, et al. (1990) Site-specific integration by adeno-associated virus. Proc Natl Acad Sci USA 87:2211-2215. (Pubitemid 20105286)
25. Barberi T, Willis LM, Socci ND, Studer L (2005) Derivation of multipotent mesenchymal precursors from human embryonic stem cells. PLoS Med 2:e161. (Pubitemid 40973509)
26. Riggi N, et al. (2008) EWS-FLI-1 expression triggers a Ewing's sarcoma initiation program in primary human mesenchymal stem cells. Cancer Res 68:2176-2185.
27. Ren YX, et al. (2008) Mouse mesenchymal stem cells expressing PAX-FKHR form alveolar rhabdomyosarcomas by cooperating with secondary mutations. Cancer Res 68:6587-6597.
28. Smith J, et al. (2000) Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains. Nucleic Acids Res 28:3361-3369. (Pubitemid 30662302)
29. Campbell PJ, et al. (2008) Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing. Nat Genet 40:722-729. (Pubitemid 351748860)
30. Morton J, Davis MW, Jorgensen EM, Carroll D (2006) Induction and repair of zinc-finger nuclease-targeted double-strand breaks in Caenorhabditis elegans somatic cells. Proc Natl Acad Sci USA 103:16370-16375. (Pubitemid 44715203)
31. Miller JC, et al. (2007) An improved zinc-finger nuclease architecture for highly specific genome editing. Nat Biotechnol 25:778-785. (Pubitemid 47052191)
32. Pierce AJ, Hu P, Han M, Ellis N, Jasin M (2001) Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev 15:3237-3242. (Pubitemid 34008189)
33. Delacote F, Han M, Stamato TD, Jasin M, Lopez BS (2002) An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells. Nucleic Acids Res 30:3454-3463. (Pubitemid 34851217)
34. Pruett-Miller SM, Connelly JP, Maeder ML, Joung JK, Porteus MH (2008) Comparison of zinc finger nucleases for use in gene targeting in mammalian cells. Mol Ther 16:707-717.
35. Pruett-Miller SM, Reading DW, Porter SN, Porteus MH (2009) Attenuation of zinc finger nuclease toxicity by small-molecule regulation of protein levels. PLoS Genet 5:e1000376.
36. Redondo P, et al. (2008) Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases. Nature 456:107-111.
37. Cannata F, et al. (2008) Triplex-forming oligonucleotide- orthophenanthroline conjugates for efficient targeted genome modification. Proc Natl Acad Sci USA 105:9576-9581. (Pubitemid 352031343)
38. Chin JY, Glazer PM (2008) Repair of DNA lesions associated with triplex-forming oligonucleotides. Mol Carcinog 48:389-399.
39. Richardson C, Moynahan ME, Jasin M (1998) Double-strand break repair by interchromosomal recombination: Suppression of chromosomal translocations. Genes Dev 12:3831-3842. (Pubitemid 29024846)