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Volumn 35, Issue 2, 2009, Pages 200-208

Connective tissue growth factor: Context-dependent functions and mechanisms of regulation

Author keywords

Angiogenesis; Connective tissue growth factor; Epigenetic

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA; ANGIOGENESIS INHIBITOR;

EID: 67349168833     PISSN: 09516433     EISSN: None     Source Type: Journal    
DOI: 10.1002/biof.30     Document Type: Review
Times cited : (126)

References (112)
  • 1
    • 59649107705 scopus 로고    scopus 로고
    • Functions and mechanisms of action of CCN matricellular proteins
    • 10.1016/j.biocel.2008.00260x
    • Chen, C. C., and Lau, L. F. Functions and mechanisms of action of CCN matricellular proteins. Int. J. Biochem. Cell Biol. 10.1016/j.biocel.2008. 00260x.
    • Int. J. Biochem. Cell Biol
    • Chen, C.C.1    Lau, L.F.2
  • 2
    • 42549131051 scopus 로고    scopus 로고
    • Connective tissue growth factor: Structure-function relationships of a mosaic, multifunctional protein
    • de Winter, P., Leoni, P., and Abraham, D. (2008)Connective tissue growth factor: structure-function relationships of a mosaic, multifunctional protein. Growth Factors 26, 80-91.
    • (2008) Growth Factors , vol.26 , pp. 80-91
    • De Winter, P.1    Leoni, P.2    Abraham, D.3
  • 3
    • 33847627603 scopus 로고    scopus 로고
    • CCN family proteins and angiogenesis: From embryo to adulthood
    • Kubota, S., and Takigawa, M. (2007) CCN family proteins and angiogenesis: from embryo to adulthood. Angiogenesis 10, 1-11.
    • (2007) Angiogenesis , vol.10 , pp. 1-11
    • Kubota, S.1    Takigawa, M.2
  • 4
    • 9944251355 scopus 로고    scopus 로고
    • Structural basis and therapeutic implication of the interaction of CCN proteins with glycoconjugates
    • Desnoyers, L. (2004) Structural basis and therapeutic implication of the interaction of CCN proteins with glycoconjugates. Curr. Pharm. Des. 10, 3913-3928.
    • (2004) Curr. Pharm. Des. , vol.10 , pp. 3913-3928
    • Desnoyers, L.1
  • 5
    • 18144380288 scopus 로고    scopus 로고
    • Individual domains of connective tissue growth factor regulate fibroblast proliferation and myofibroblast differentiation
    • Grotendorst, G. R., and Duncan, M. R. (2005) Individual domains of connective tissue growth factor regulate fibroblast proliferation and myofibroblast differentiation. FASEB J. 19, 729-738.
    • (2005) FASEB J. , vol.19 , pp. 729-738
    • Grotendorst, G.R.1    Duncan, M.R.2
  • 6
    • 0036775425 scopus 로고    scopus 로고
    • Matricellular proteins: Extracellular modulators of cell function
    • Bornstein, P., and Sage, E. H. (2002) Matricellular proteins: extracellular modulators of cell function. Curr. Opin. Cell. Biol. 14, 608-616.
    • (2002) Curr. Opin. Cell. Biol. , vol.14 , pp. 608-616
    • Bornstein, P.1    Sage, E.H.2
  • 7
    • 20444504753 scopus 로고    scopus 로고
    • Structural and functional properties of CCN proteins
    • Rachfal, A. W., and Brigstock, D. R. (2005) Structural and functional properties of CCN proteins. Vitam. Horm. 70, 69-103.
    • (2005) Vitam. Horm. , vol.70 , pp. 69-103
    • Rachfal, A.W.1    Brigstock, D.R.2
  • 8
    • 65849445411 scopus 로고    scopus 로고
    • Connective tissue growth factor: Growth factor, matricellular organizer, fibrotic biomarker or molecular target for anti-fibrotic therapy in SSc?
    • Abraham, D. Connective tissue growth factor: growth factor, matricellular organizer, fibrotic biomarker or molecular target for anti-fibrotic therapy in SSc?Rheumatology (Oxford) 2008;47 (Suppl 5), v8-v9.
    • (2008) Rheumatology (Oxford) , vol.47 , Issue.SUPPL 5
    • Abraham, D.1
  • 9
    • 40749107501 scopus 로고    scopus 로고
    • Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis
    • Shi-Wen, X., Leask, A., and Abraham, D. (2008) Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis. Cytokine Growth Factor Rev. 19, 133-144.
    • (2008) Cytokine Growth Factor Rev. , vol.19 , pp. 133-144
    • Shi-Wen, X.1    Leask, A.2    Abraham, D.3
  • 10
    • 33845906843 scopus 로고    scopus 로고
    • All in the CCN family: Essential matricellular signaling modulators emerge from the bunker
    • Leask, A., and Abraham, D. J. (2006) All in the CCN family: essential matricellular signaling modulators emerge from the bunker. J. Cell. Sci. 119, 4803-4810.
    • (2006) J. Cell. Sci. , vol.119 , pp. 4803-4810
    • Leask, A.1    Abraham, D.J.2
  • 12
    • 57449108288 scopus 로고    scopus 로고
    • CCN family 2/connective tissue growth factor (CCN2/ CTGF) regulates the expression of Vegf through Hif-1alpha expression in a chondrocytic cell line, HCS-2/8, under hypoxic condition
    • Nishida, T., Kondo, S., Maeda, A., Kubota, S., Lyons, K. M., and Takigawa, M. (2009) CCN family 2/connective tissue growth factor (CCN2/ CTGF) regulates the expression of Vegf through Hif-1alpha expression in a chondrocytic cell line, HCS-2/8, under hypoxic condition. Bone 44, 24-31.
    • (2009) Bone , vol.44 , pp. 24-31
    • Nishida, T.1    Kondo, S.2    Maeda, A.3    Kubota, S.4    Lyons, K.M.5    Takigawa, M.6
  • 14
    • 0035841946 scopus 로고    scopus 로고
    • Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line
    • Shimo, T., Kubota, S., Kondo, S., Nakanishi, T., Sasaki, A., Mese, H., Matsumura, T., and Takigawa, M. (2001) Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line. Cancer Lett. 174, 57-64.
    • (2001) Cancer Lett. , vol.174 , pp. 57-64
    • Shimo, T.1    Kubota, S.2    Kondo, S.3    Nakanishi, T.4    Sasaki, A.5    Mese, H.6    Matsumura, T.7    Takigawa, M.8
  • 16
    • 0037840309 scopus 로고    scopus 로고
    • Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteinerich 61 (CYR61)
    • Brigstock, D. R. (2002) Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteinerich 61 (CYR61). Angiogenesis 5, 153-165.
    • (2002) Angiogenesis , vol.5 , pp. 153-165
    • Brigstock, D.R.1
  • 19
    • 0037183997 scopus 로고    scopus 로고
    • Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165
    • Hashimoto, G., Inoki, I., Fujii, Y., Aoki, T., Ikeda, E., and Okada, Y. (2002) Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165. J. Biol. Chem. 277, 36288-36295.
    • (2002) J. Biol. Chem. , vol.277 , pp. 36288-36295
    • Hashimoto, G.1    Inoki, I.2    Fujii, Y.3    Aoki, T.4    Ikeda, E.5    Okada, Y.6
  • 20
    • 36048938981 scopus 로고    scopus 로고
    • The VEGF angiogenic switch of fibroblasts is regulated by MMP-7 from cancer cells
    • Ito, T. K., Ishii, G., Chiba, H., and Ochiai, A. (2007) The VEGF angiogenic switch of fibroblasts is regulated by MMP-7 from cancer cells. Oncogene 26, 7194-7203.
    • (2007) Oncogene , vol.26 , pp. 7194-7203
    • Ito, T.K.1    Ishii, G.2    Chiba, H.3    Ochiai, A.4
  • 21
    • 37549068908 scopus 로고    scopus 로고
    • Identification of Candidate Angiogenic Inhibitors Processed by MMP-2 in Cell Based Proteomic Screens: Disruption of VEGF/HARP (Pleiotrophin) and VEGF / CTGF Angiogenic Inhibitory Complexes by MMP-2 Proteolysis
    • Dean, R. A., Butler, G. S., Hamma-Kourbali, Y., Delbe, J., Brigstock, D. R., Courty, J., and Overall, C. M. (2007) Identification of Candidate Angiogenic Inhibitors Processed by MMP-2 in Cell Based Proteomic Screens: Disruption of VEGF/HARP (Pleiotrophin) and VEGF / CTGF Angiogenic Inhibitory Complexes by MMP-2 Proteolysis. Mol. Cell Biol. 27, 8454-8465.
    • (2007) Mol. Cell Biol. , vol.27 , pp. 8454-8465
    • Dean, R.A.1    Butler, G.S.2    Hamma-Kourbali, Y.3    Delbe, J.4    Brigstock, D.R.5    Courty, J.6    Overall, C.M.7
  • 25
    • 0034528616 scopus 로고    scopus 로고
    • Induction of connective tissue growth factor by activation of heptahelical receptors. Modulation by rho proteins and the actin cytoskeleton
    • Hahn, A., Heusinger-Ribeiro, J., Lanz, T., Zenkel, S., Goppelt-Struebe, M. (2000) Induction of connective tissue growth factor by activation of heptahelical receptors. Modulation by rho proteins and the actin cytoskeleton. J. Biol. Chem. 275, 37429-37435.
    • (2000) J. Biol. Chem. , vol.275 , pp. 37429-37435
    • Hahn, A.1    Heusinger-Ribeiro, J.2    Lanz, T.3    Zenkel, S.4    Goppelt-Struebe, M.5
  • 27
    • 33244456090 scopus 로고    scopus 로고
    • Hypoxic regulation of stability of connective tissue growth factor/CCN2 mRNA by 30-untranslated region interacting with a cellular protein in human chondrosarcoma cells
    • Kondo, S., Kubota, S., Mukudai, Y., Moritani, N., Nishida, T., Matsushita, H., Matsumoto, S., Sugahara, T., and Takigawa, M. (2006) Hypoxic regulation of stability of connective tissue growth factor/CCN2 mRNA by 30-untranslated region interacting with a cellular protein in human chondrosarcoma cells. Oncogene 25, 1099-1110.
    • (2006) Oncogene , vol.25 , pp. 1099-1110
    • Kondo, S.1    Kubota, S.2    Mukudai, Y.3    Moritani, N.4    Nishida, T.5    Matsushita, H.6    Matsumoto, S.7    Sugahara, T.8    Takigawa, M.9
  • 28
    • 33745216653 scopus 로고    scopus 로고
    • Connective tissue growth factor: A role in airway remodelling in asthma?
    • Burgess, J. K. (2005) Connective tissue growth factor: a role in airway remodelling in asthma?Clin. Exp. Pharmacol. Physiol. 32, 988-994.
    • (2005) Clin. Exp. Pharmacol. Physiol. , vol.32 , pp. 988-994
    • Burgess, J.K.1
  • 29
    • 0027229995 scopus 로고
    • Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair
    • Igarashi, A., Okochi, H., Bradham, D. M., and Grotendorst, G. R. (1993) Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair. Mol. Cell Biol. 4, 637-645.
    • (1993) Mol. Cell Biol. , vol.4 , pp. 637-645
    • Igarashi, A.1    Okochi, H.2    Bradham, D.M.3    Grotendorst, G.R.4
  • 30
    • 0033802165 scopus 로고    scopus 로고
    • Brady: Connective tissue growth factor: Potential role in glomerulosclerosis and tubulointerstitial fibrosis
    • Gupta, S., Clarkson, M. R., Duggan, J. (2000) Brady: Connective tissue growth factor: potential role in glomerulosclerosis and tubulointerstitial fibrosis. Kidney Int. 58, 1389-1399.
    • (2000) Kidney Int. , vol.58 , pp. 1389-1399
    • Gupta, S.1    Clarkson, M.R.2    Duggan, J.3
  • 31
    • 0031225015 scopus 로고    scopus 로고
    • Connective tissue growth factor: A mediator of TGF-beta action on fibroblasts
    • Grotendorst, G. R. (1997) Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts. Cytokine Growth Factor Rev. 8, 171-179.
    • (1997) Cytokine Growth Factor Rev. , vol.8 , pp. 171-179
    • Grotendorst, G.R.1
  • 32
    • 0035824518 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3
    • Fu, M., Zhang, J., Zhu, X., Myles, D. E., Willson, T. M., Liu, X., and Chen, Y. E. (2001) Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3. J. Biol. Chem. 276, 45888-45894.
    • (2001) J. Biol. Chem. , vol.276 , pp. 45888-45894
    • Fu, M.1    Zhang, J.2    Zhu, X.3    Myles, D.E.4    Willson, T.M.5    Liu, X.6    Chen, Y.E.7
  • 33
    • 0033957976 scopus 로고    scopus 로고
    • Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis
    • Riser, B. L., Denichilo, M., Cortes, P., Baker, C., Grondin, J. M., Yee, J., and Narins, R. G. (2000) Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis. J. Am. Soc. Nephrol. 11, 25-38.
    • (2000) J. Am. Soc. Nephrol. , vol.11 , pp. 25-38
    • Riser, B.L.1    Denichilo, M.2    Cortes, P.3    Baker, C.4    Grondin, J.M.5    Yee, J.6    Narins, R.G.7
  • 34
    • 0036786249 scopus 로고    scopus 로고
    • Connective tissue growth factor and regulation of the mesangial cell cycle: Role in cellular hypertrophy
    • Abdel-Wahab, N., Weston, B. S., Roberts, T., and Mason, R. M. (2002) Connective tissue growth factor and regulation of the mesangial cell cycle: role in cellular hypertrophy. J. Am. Soc. Nephrol. 13, 2437-2445.
    • (2002) J. Am. Soc. Nephrol. , vol.13 , pp. 2437-2445
    • Abdel-Wahab, N.1    Weston, B.S.2    Roberts, T.3    Mason, R.M.4
  • 35
    • 53249097208 scopus 로고    scopus 로고
    • Activation of TGF-beta within cultured hepatocytes and in liver injury leads to intracrine signaling with expression of connective tissue growth factor
    • 10.1111/j.1582-4934.2008.00260.x
    • Gressner, O. A., Lahme, B., Siluschek, M., Rehbein, K., Herrmann, J., Weiskirchen, R., Gressner, A. M. Activation of TGF-beta within cultured hepatocytes and in liver injury leads to intracrine signaling with expression of connective tissue growth factor. J. Cell Mol. Med. 10.1111/j.1582-4934.2008. 00260.x.
    • J. Cell Mol. Med.
    • Gressner, O.A.1    Lahme, B.2    Siluschek, M.3    Rehbein, K.4    Herrmann, J.5    Weiskirchen, R.6    Gressner, A.M.7
  • 36
    • 60749111516 scopus 로고    scopus 로고
    • Regulation of connective tissue growth factor (CTGF) by hepatocyte growth factor in human tubular epithelial cells
    • 10.1093/ndt/gfn530
    • Kroening, S., Solomovitch, S., Sachs, M., Wullich, B., and Goppelt- Struebe, M. Regulation of connective tissue growth factor (CTGF) by hepatocyte growth factor in human tubular epithelial cells. Nephrol. Dial. Transplant., 10.1093/ndt/gfn530.
    • Nephrol. Dial. Transplant.
    • Kroening, S.1    Solomovitch, S.2    Sachs, M.3    Wullich, B.4    Goppelt- Struebe, M.5
  • 40
    • 30744478450 scopus 로고    scopus 로고
    • The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFbeta1 responses in human proximaltubule epithelial cells
    • Phanish, M. K., Wahab, N. A., Colville-Nash, P., Hendry, B. M., and Dockrell, M. E. (2006) The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFbeta1 responses in human proximaltubule epithelial cells. Biochem. J. 393, 601-607.
    • (2006) Biochem. J. , vol.393 , pp. 601-607
    • Phanish, M.K.1    Wahab, N.A.2    Colville-Nash, P.3    Hendry, B.M.4    Dockrell, M.E.5
  • 42
    • 0035815683 scopus 로고    scopus 로고
    • CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling
    • Holmes, A., Abraham, D. J., Sa, S., Shiwen, X., Black, C. M., and Leask, A. (2001) CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling. J. Biol. Chem. 276, 10594-10601.
    • (2001) J. Biol. Chem. , vol.276 , pp. 10594-10601
    • Holmes, A.1    Abraham, D.J.2    Sa, S.3    Shiwen, X.4    Black, C.M.5    Leask, A.6
  • 43
    • 0038644847 scopus 로고    scopus 로고
    • Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts
    • Leask, A., Holmes, A., Black, C. M., and Abraham, D. J. (2003) Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts. J. Biol. Chem. 278, 13008-13015.
    • (2003) J. Biol. Chem. , vol.278 , pp. 13008-13015
    • Leask, A.1    Holmes, A.2    Black, C.M.3    Abraham, D.J.4
  • 44
    • 0029808645 scopus 로고    scopus 로고
    • A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene
    • Grotendorst, G. R., Okochi, H., and Hayashi, N. (1996) A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene. Cell Growth Differ. 7, 469-480.
    • (1996) Cell Growth Differ. , vol.7 , pp. 469-480
    • Grotendorst, G.R.1    Okochi, H.2    Hayashi, N.3
  • 45
    • 0036378148 scopus 로고    scopus 로고
    • CTGF expression in mesangial cells: Involvement of SMADs, MAP kinase, and PKC
    • Chen, Y., Blom, I. E., Sa, S., Goldschmeding, R., Abraham, D. J., and Leask, A. (2002) CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC. Kidney Int. 62, 1149-1159.
    • (2002) Kidney Int. , vol.62 , pp. 1149-1159
    • Chen, Y.1    Blom, I.E.2    Sa, S.3    Goldschmeding, R.4    Abraham, D.J.5    Leask, A.6
  • 46
    • 54949125004 scopus 로고    scopus 로고
    • Analysis of CCN2 promoter activity in PANC-1 cells: Regulation by ras/MEK/ERK
    • Pickles, M., and Leask, A. (2007) Analysis of CCN2 promoter activity in PANC-1 cells: regulation by ras/MEK/ERK. J. Cell. Commun. Signal 1, 85-90.
    • (2007) J. Cell. Commun. Signal , vol.1 , pp. 85-90
    • Pickles, M.1    Leask, A.2
  • 48
    • 0034870254 scopus 로고    scopus 로고
    • Expression of connective tissue growth factor in human renal fibroblasts: Regulatory roles of RhoA and cAMP
    • Heusinger-Ribeiro, J., Eberlein, M., Wahab, N. A., Goppelt-Struebe, M. (2001) Expression of connective tissue growth factor in human renal fibroblasts: regulatory roles of RhoA and cAMP. J. Am. Soc. Nephrol. 12, 1853-1861.
    • (2001) J. Am. Soc. Nephrol. , vol.12 , pp. 1853-1861
    • Heusinger-Ribeiro, J.1    Eberlein, M.2    Wahab, N.A.3    Goppelt-Struebe, M.4
  • 49
    • 21344470149 scopus 로고    scopus 로고
    • TGF-beta1-induced connective tissue growth factor (CCN2) expression in human renal proximal tubule epithelial cells requires Ras/MEK/ERK and Smad signaling
    • Phanish, M. K., Wahab, N. A., Hendry, B. M., and Dockrell, M. E. (2005) TGF-beta1-induced connective tissue growth factor (CCN2) expression in human renal proximal tubule epithelial cells requires Ras/MEK/ERK and Smad signalling. Nephron Exp. Nephrol. 100, e156-165.
    • (2005) Nephron Exp. Nephrol. , vol.100
    • Phanish, M.K.1    Wahab, N.A.2    Hendry, B.M.3    Dockrell, M.E.4
  • 50
    • 26244458018 scopus 로고    scopus 로고
    • TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
    • Kasai, H., Allen, J. T., Mason, R. M., Kamimura, T., and Zhang, Z. (2005) TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir. Res. 6, 56.
    • (2005) Respir. Res. , vol.6 , pp. 56
    • Kasai, H.1    Allen, J.T.2    Mason, R.M.3    Kamimura, T.4    Zhang, Z.5
  • 51
    • 34848865661 scopus 로고    scopus 로고
    • Differential effects of TGF-beta on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes
    • Gressner, O. A., Lahme, B., Demirci, I., Gressner, A. M., and Weiskirchen, R. (2007) Differential effects of TGF-beta on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes. J. Hepatol. 47, 699-710.
    • (2007) J. Hepatol. , vol.47 , pp. 699-710
    • Gressner, O.A.1    Lahme, B.2    Demirci, I.3    Gressner, A.M.4    Weiskirchen, R.5
  • 53
    • 34447525522 scopus 로고    scopus 로고
    • Tissue-specific mechanisms for CCN2/CTGF persistence in fibrotic gingiva: Interactions between cAMP and MAPK signaling pathways, and prostaglandin E2-EP3 receptor mediated activation of the c- JUN N-terminal kinase
    • Black, S. A., Jr., Palamakumbura, A. H., Stan, M., and Trackman, P. C. (2007) Tissue-specific mechanisms for CCN2/CTGF persistence in fibrotic gingiva: interactions between cAMP and MAPK signaling pathways, and prostaglandin E2-EP3 receptor mediated activation of the c- JUN N-terminal kinase. J. Biol. Chem. 282, 15416-15429.
    • (2007) J. Biol. Chem. , vol.282 , pp. 15416-15429
    • Black Jr., S.A.1    Palamakumbura, A.H.2    Stan, M.3    Trackman, P.C.4
  • 54
    • 8644245963 scopus 로고    scopus 로고
    • Connective Tissue Growth Factor expression and induction by Transforming Growth Factor {beta}, is abrogated by Simvastatin via a Rho signalling mechanism
    • Watts, K. L., and Spiteri, M. A. (2004) Connective Tissue Growth Factor expression and induction by Transforming Growth Factor {beta}, is abrogated by Simvastatin via a Rho signalling mechanism. Am. J. Physiol. Lung Cell Mol. Physiol. 287, L1323-L1332.
    • (2004) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.287
    • Watts, K.L.1    Spiteri, M.A.2
  • 57
    • 42249093297 scopus 로고    scopus 로고
    • The role of matrix stiffness in regulating cell behavior
    • Wells, R. G. (2008) The role of matrix stiffness in regulating cell behavior. Hepatology 47, 1394-1400.
    • (2008) Hepatology , vol.47 , pp. 1394-1400
    • Wells, R.G.1
  • 59
    • 33746751471 scopus 로고    scopus 로고
    • Mechanical regulation of the Cyr61/CCN1 and CTGF/CCN2 proteins
    • Chaqour, B., and Goppelt-Struebe, M. (2006) Mechanical regulation of the Cyr61/CCN1 and CTGF/CCN2 proteins. FEBS J. 273, 3639-3649.
    • (2006) FEBS J. , vol.273 , pp. 3639-3649
    • Chaqour, B.1    Goppelt-Struebe, M.2
  • 61
    • 49049121661 scopus 로고    scopus 로고
    • Serial analysis of the vascular endothelial transcriptome under static and shear stress conditions
    • Chu, T. J., and Peters, D. G. (2008) Serial analysis of the vascular endothelial transcriptome under static and shear stress conditions. Physiol. Genomics 34, 185-192.
    • (2008) Physiol. Genomics , vol.34 , pp. 185-192
    • Chu, T.J.1    Peters, D.G.2
  • 63
    • 33746010588 scopus 로고    scopus 로고
    • Mechanical stretch modulates the promoter activity of the profibrotic factor CCN2 through increased actin polymerization and NF-kappa B activation
    • Chaqour, B., Yang, R., and Sha, Q. (2006) Mechanical stretch modulates the promoter activity of the profibrotic factor CCN2 through increased actin polymerization and NF-kappa B activation. J. Biol. Chem. 281, 20608-20622.
    • (2006) J. Biol. Chem. , vol.281 , pp. 20608-20622
    • Chaqour, B.1    Yang, R.2    Sha, Q.3
  • 67
    • 1842535528 scopus 로고    scopus 로고
    • Endothelial cell cytochrome P450 1A1 and 1B1: Up-regulation by shear stress
    • Eskin, S. G., Turner, N. A., and McIntire, L. V. (2004) Endothelial cell cytochrome P450 1A1 and 1B1: up-regulation by shear stress. Endothelium 11, 1-10.
    • (2004) Endothelium , vol.11 , pp. 1-10
    • Eskin, S.G.1    Turner, N.A.2    McIntire, L.V.3
  • 69
    • 38049027778 scopus 로고    scopus 로고
    • Pharmacological inhibition of RhoA signaling prevents connective tissue growth factor induction in endothelial cells exposed to non-uniform shear stress
    • Cicha, I., Goppelt-Struebe, M., Muehlich, S., Yilmaz, A., Raaz, D., Daniel, W. G., and Garlichs, C. D. (2008) Pharmacological inhibition of RhoA signaling prevents connective tissue growth factor induction in endothelial cells exposed to non-uniform shear stress. Atherosclerosis 196, 136-145.
    • (2008) Atherosclerosis , vol.196 , pp. 136-145
    • Cicha, I.1    Goppelt-Struebe, M.2    Muehlich, S.3    Yilmaz, A.4    Raaz, D.5    Daniel, W.G.6    Garlichs, C.D.7
  • 70
    • 12344306644 scopus 로고    scopus 로고
    • The role of shear stress in the pathogenesis of atherosclerosis
    • Cunningham, K. S., and Gotlieb, A. I. (2005) The role of shear stress in the pathogenesis of atherosclerosis. Lab. Invest. 85, 9-23.
    • (2005) Lab. Invest. , vol.85 , pp. 9-23
    • Cunningham, K.S.1    Gotlieb, A.I.2
  • 72
    • 33646112154 scopus 로고    scopus 로고
    • Mechanisms of low-density lipoprotein-induced expression of connective tissue growth factor in human aortic endothelial cells
    • Sohn, M., Tan, Y., Wang, B., Klein, R. L., Trojanowska, M., and Jaffa, A. A. (2006) Mechanisms of low-density lipoprotein-induced expression of connective tissue growth factor in human aortic endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 290, H1624-1634.
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.290
    • Sohn, M.1    Tan, Y.2    Wang, B.3    Klein, R.L.4    Trojanowska, M.5    Jaffa, A.A.6
  • 74
    • 0034535271 scopus 로고    scopus 로고
    • Connective tissue growth factor (CTGF) stimulates vascular smooth muscle cell growth and migration in vitro. [In Process Citation]
    • Fan, W. H., Pech, M., and Karnovsky, M. J. (2000) Connective tissue growth factor (CTGF) stimulates vascular smooth muscle cell growth and migration in vitro. [In Process Citation].Eur. J. Cell Biol. 79, 915-923.
    • (2000) Eur. J. Cell Biol. , vol.79 , pp. 915-923
    • Fan, W.H.1    Pech, M.2    Karnovsky, M.J.3
  • 75
    • 3242696973 scopus 로고    scopus 로고
    • Induction of connective tissue growth factor (CTGF) in human endothelial cells by lysophosphatidic acid, sphingosine-1-phosphate, and platelets
    • Muehlich, S., Schneider, N., Hinkmann, F., Garlichs, C. D., Goppelt- Struebe, M. (2004) Induction of connective tissue growth factor (CTGF) in human endothelial cells by lysophosphatidic acid, sphingosine- 1-phosphate, and platelets. Atherosclerosis 175, 261-268.
    • (2004) Atherosclerosis , vol.175 , pp. 261-268
    • Muehlich, S.1    Schneider, N.2    Hinkmann, F.3    Garlichs, C.D.4    Goppelt- Struebe, M.5
  • 77
    • 29144485387 scopus 로고    scopus 로고
    • Differential involvement of the integrin-linked kinase (ILK) RhoA-dependent rearrangement of F-actin fibers and induction of connective tissue growth factor (CTGF)
    • Graness, A., Giehl, K., Goppelt-Struebe, M. (2006) Differential involvement of the integrin-linked kinase (ILK) in RhoA-dependent rearrangement of F-actin fibers and induction of connective tissue growth factor (CTGF). Cell Signal 18, 433-440.
    • (2006) Cell Signal , vol.18 , pp. 433-440
    • Graness, A.1    Giehl, K.2    Goppelt-Struebe, M.3
  • 78
    • 0242582448 scopus 로고    scopus 로고
    • Modulation of the Expression of Connective Tissue Growth Factor by Alterations of the Cytoskeleton
    • DOI 10.1074/jbc.M309140200
    • Ott, C., Iwanciw, D., Graness, A., Giehl, K., Goppelt-Struebe, M. (2003) Modulation of the expression of connective tissue growth factor by alterations of the cytoskeleton. J. Biol. Chem. 278, 44305-44311. (Pubitemid 37377176)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.45 , pp. 44305-44311
    • Ott, C.1    Iwanciw, D.2    Graness, A.3    Giehl, K.4    Goppelt-Struebe, M.5
  • 82
    • 44449142302 scopus 로고    scopus 로고
    • Nuclear actin dynamics--from form to function
    • Vartiainen, M. K. (2008) Nuclear actin dynamics--from form to function. FEBS Lett. 582, 2033-2040.
    • (2008) FEBS Lett. , vol.582 , pp. 2033-2040
    • Vartiainen, M.K.1
  • 83
    • 41749091574 scopus 로고    scopus 로고
    • Applications for ROCK kinase inhibition
    • Olson, M. F. (2008) Applications for ROCK kinase inhibition. Curr. Opin. Cell. Biol. 20, 242-248.
    • (2008) Curr. Opin. Cell. Biol. , vol.20 , pp. 242-248
    • Olson, M.F.1
  • 85
    • 53849089211 scopus 로고    scopus 로고
    • Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension
    • Oka, M., Fagan, K. A., Jones, P. L., and McMurtry, I. F. (2008) Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension. Br. J. Pharmacol. 155, 444-454.
    • (2008) Br. J. Pharmacol. , vol.155 , pp. 444-454
    • Oka, M.1    Fagan, K.A.2    Jones, P.L.3    McMurtry, I.F.4
  • 86
    • 12344323503 scopus 로고    scopus 로고
    • Cardioprotective mechanisms of Rho-kinase inhibition associated with eNOS and oxidative stress-LOX-1 pathway in Dahl salt-sensitive hypertensive rats
    • Mita, S., Kobayashi, N., Yoshida, K., Nakano, S., and Matsuoka, H. (2005) Cardioprotective mechanisms of Rho-kinase inhibition associated with eNOS and oxidative stress-LOX-1 pathway in Dahl salt-sensitive hypertensive rats. J. Hypertens. 23, 87-96.
    • (2005) J. Hypertens. , vol.23 , pp. 87-96
    • Mita, S.1    Kobayashi, N.2    Yoshida, K.3    Nakano, S.4    Matsuoka, H.5
  • 88
    • 73249125357 scopus 로고    scopus 로고
    • Upregulation of connective tissue growth factor (CTGF/CCN2) in endothelial cells by the microtubule destabilizing agent combretastatin A- 4
    • MCR-08-0292v1
    • Samarin, J., Rehm, M., Krueger, B., Waschke, J., Goppelt-Struebe, M.: Upregulation of connective tissue growth factor (CTGF/CCN2) in endothelial cells by the microtubule destabilizing agent combretastatin A- 4. Mol. Cancer. Res. 1541-7786.MCR-08-0292v1.
    • Mol. Cancer. Res. , pp. 1541-7786
    • Samarin, J.1    Rehm, M.2    Krueger, B.3    Waschke, J.4    Goppelt-Struebe, M.5
  • 89
    • 0034888856 scopus 로고    scopus 로고
    • Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins)
    • Eberlein, M., Heusinger-Ribeiro, J., Goppelt-Struebe, M. (2001) Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins). Br. J. Pharmacol. 133, 1172-1180. (Pubitemid 32762429)
    • (2001) British Journal of Pharmacology , vol.133 , Issue.7 , pp. 1172-1180
    • Eberlein, M.1    Heusinger-Ribeiro, J.2    Goppelt-Struebe, M.3
  • 90
    • 0346040260 scopus 로고    scopus 로고
    • Fluvastatin prevents nephropathy likely through suppression of connective tissue growth factor-mediated extracellular matrix accumulation
    • Song, Y., Li, C., and Cai, L. (2004) Fluvastatin prevents nephropathy likely through suppression of connective tissue growth factor-mediated extracellular matrix accumulation. Exp. Mol. Pathol. 76, 66-75.
    • (2004) Exp. Mol. Pathol. , vol.76 , pp. 66-75
    • Song, Y.1    Li, C.2    Cai, L.3
  • 92
    • 17444374941 scopus 로고    scopus 로고
    • Long term Rho-kinase inhibition ameliorates endothelial dysfunction in LDL-Receptor deficient mice
    • Steioff, K., Rutten, H., Busch, A. E., Plettenburg, O., Ivashchenko, Y., and Lohn, M. (2005) Long term Rho-kinase inhibition ameliorates endothelial dysfunction in LDL-Receptor deficient mice. Eur. J. Pharmacol. 512, 247-249.
    • (2005) Eur. J. Pharmacol. , vol.512 , pp. 247-249
    • Steioff, K.1    Rutten, H.2    Busch, A.E.3    Plettenburg, O.4    Ivashchenko, Y.5    Lohn, M.6
  • 93
    • 44849087809 scopus 로고    scopus 로고
    • Transforming growth factor- beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independen,t Rac1/Cdc42-dependent mechanism: Statins with forskolin block TGFbeta1-induced CCN2/CTGF expression
    • Black, S. A., Jr., and Trackman, P. C. (2008) Transforming growth factor- beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGFbeta1-induced CCN2/CTGF expression. J. Biol. Chem. 283, 10835-10847.
    • (2008) J. Biol. Chem. , vol.283 , pp. 10835-10847
    • Black Jr., S.A.1    Trackman, P.C.2
  • 94
    • 38849155113 scopus 로고    scopus 로고
    • The small GTPase Rac-1 is a regulator of mesangial cell morphology and thrombospondin-1 expression
    • Giehl, K., Graness, A., and Goppelt-Struebe, M. (2008) The small GTPase Rac-1 is a regulator of mesangial cell morphology and thrombospondin- 1 expression. Am. J. Physiol. Renal. Physiol. 294, F407-413.
    • (2008) Am. J. Physiol. Renal. Physiol. , vol.294
    • Giehl, K.1    Graness, A.2    Goppelt-Struebe, M.3
  • 95
    • 56349143203 scopus 로고    scopus 로고
    • Connective tissue growth factor (CTGF) and cancer progression
    • Chu, C. Y., Chang, C. C., Prakash, E., and Kuo, M. L. Connective tissue growth factor (CTGF) and cancer progression. J. Biomed. Sci. 15, 675-685.
    • J. Biomed. Sci. , vol.15 , pp. 675-685
    • Chu, C.Y.1    Chang, C.C.2    Prakash, E.3    Kuo, M.L.4
  • 96
    • 43049105333 scopus 로고    scopus 로고
    • Demethylation of (Cytosine-5-C-methyl) DNA and regulation of transcription in the epigenetic pathways of cancer development
    • Patra, S. K., Patra, A., Rizzi, F., Ghosh, T. C., and Bettuzzi, S. (2008) Demethylation of (Cytosine-5-C-methyl) DNA and regulation of transcription in the epigenetic pathways of cancer development. Cancer Metastasis Rev. 27, 315-334.
    • (2008) Cancer Metastasis Rev. , vol.27 , pp. 315-334
    • Patra, S.K.1    Patra, A.2    Rizzi, F.3    Ghosh, T.C.4    Bettuzzi, S.5
  • 97
    • 34547631272 scopus 로고    scopus 로고
    • Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer
    • Kikuchi, R., Tsuda, H., Kanai, Y., Kasamatsu, T., Sengoku, K., Hirohashi, S., Inazawa, J., and Imoto, I. (2007) Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer. Cancer Res. 67, 7095-7105.
    • (2007) Cancer Res. , vol.67 , pp. 7095-7105
    • Kikuchi, R.1    Tsuda, H.2    Kanai, Y.3    Kasamatsu, T.4    Sengoku, K.5    Hirohashi, S.6    Inazawa, J.7    Imoto, I.8
  • 101
    • 26844509641 scopus 로고    scopus 로고
    • Dynamic chromatin: Concerted nucleosome remodelling and acetylation
    • Eberharter, A., Ferreira, R., and Becker, P. (2005) Dynamic chromatin: concerted nucleosome remodelling and acetylation. Biol. Chem. 386, 745-751.
    • (2005) Biol. Chem. , vol.386 , pp. 745-751
    • Eberharter, A.1    Ferreira, R.2    Becker, P.3
  • 103
    • 34547549214 scopus 로고    scopus 로고
    • Epigenetic therapy in cancer: Molecular background and clinical development of histone deacetylase and DNA methyltransferase inhibitors
    • Schneider-Stock, R., and Ocker, M. (2007) Epigenetic therapy in cancer: molecular background and clinical development of histone deacetylase and DNA methyltransferase inhibitors. IDrugs 10, 557-561.
    • (2007) IDrugs , vol.10 , pp. 557-561
    • Schneider-Stock, R.1    Ocker, M.2
  • 104
    • 24944496184 scopus 로고    scopus 로고
    • Role of histone and transcription factor acetylation in diabetes pathogenesis
    • Gray, S. G., De Meyts, P. (2005) Role of histone and transcription factor acetylation in diabetes pathogenesis. Diabetes Metab. Res. Rev. 21, 416-433.
    • (2005) Diabetes Metab. Res. Rev. , vol.21 , pp. 416-433
    • Gray, S.G.1    De Meyts, P.2
  • 106
    • 34547886153 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase on ventricular remodeling in infarcted rats
    • Lee, T. M., Lin, M. S., and Chang, N. C. (2007) Inhibition of histone deacetylase on ventricular remodeling in infarcted rats. Am. J. Physiol. Heart. Circ. Physiol. 293, H968-977.
    • (2007) Am. J. Physiol. Heart. Circ. Physiol. , vol.293
    • Lee, T.M.1    Lin, M.S.2    Chang, N.C.3
  • 107
    • 4344639284 scopus 로고    scopus 로고
    • Cell Growth Inhibition and gene expression induced by the histone deacetylase inhibitor, Trichostatin, A., on Human Hepatoma Cells
    • Chiba, T., Yokosuka, O., Fukai, K., Kojima, H., Tada, M., Arai, M., Imazeki, F., and Saisho, H. (2004) Cell Growth Inhibition and Gene Expression Induced by the Histone Deacetylase Inhibitor, Trichostatin, A., on Human Hepatoma Cells. Oncology 66, 481-491.
    • (2004) Oncology , vol.66 , pp. 481-491
    • Chiba, T.1    Yokosuka, O.2    Fukai, K.3    Kojima, H.4    Tada, M.5    Arai, M.6    Imazeki, F.7    Saisho, H.8
  • 108
    • 1842830815 scopus 로고    scopus 로고
    • Microarray profiling of the effects of histone deacetylase inhibitors on gene expression in cancer cell lines
    • Gray, S. G., Qian, C. N., Furge, K., Guo, X., and Teh, B. T. (2004) Microarray profiling of the effects of histone deacetylase inhibitors on gene expression in cancer cell lines. Int. J. Oncol. 24, 773-795.
    • (2004) Int. J. Oncol. , vol.24 , pp. 773-795
    • Gray, S.G.1    Qian, C.N.2    Furge, K.3    Guo, X.4    Teh, B.T.5
  • 109
    • 67349235683 scopus 로고    scopus 로고
    • Differential Regulation of Connective Tissue Growth Factor in Renal Cells by Histone Deacetylase Inhibitors
    • 10.1111/j.1582-4934.2008.00674.x
    • Komorowsky, C., Ocker, M., and Goppelt-Struebe, M. Differential Regulation of Connective Tissue Growth Factor in Renal Cells by Histone Deacetylase Inhibitors. J. Cell. Mol. Med. 10.1111/j.1582-4934.2008.00674.x.
    • J. Cell. Mol. Med.
    • Komorowsky, C.1    Ocker, M.2    Goppelt-Struebe, M.3
  • 110
    • 0032873465 scopus 로고    scopus 로고
    • Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: Down-regulation by cAMP
    • Duncan, M. R., Frazier, K. S., Abramson, S., Williams, S., Klapper, H., Huang, X., and Grotendorst, G. R. (1999) Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP. FASEB J. 13, 1774-1786.
    • (1999) FASEB J. , vol.13 , pp. 1774-1786
    • Duncan, M.R.1    Frazier, K.S.2    Abramson, S.3    Williams, S.4    Klapper, H.5    Huang, X.6    Grotendorst, G.R.7
  • 112
    • 53249092406 scopus 로고    scopus 로고
    • Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways
    • Gressner, O. A., Lahme, B., Rehbein, K., Siluschek, M., Weiskirchen, R., and Gressner, A. M. (2008) Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways. J. Hepatol. 49, 758-767.
    • (2008) J. Hepatol. , vol.49 , pp. 758-767
    • Gressner, O.A.1    Lahme, B.2    Rehbein, K.3    Siluschek, M.4    Weiskirchen, R.5    Gressner, A.M.6


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