-
1
-
-
59649107705
-
Functions and mechanisms of action of CCN matricellular proteins
-
10.1016/j.biocel.2008.00260x
-
Chen, C. C., and Lau, L. F. Functions and mechanisms of action of CCN matricellular proteins. Int. J. Biochem. Cell Biol. 10.1016/j.biocel.2008. 00260x.
-
Int. J. Biochem. Cell Biol
-
-
Chen, C.C.1
Lau, L.F.2
-
2
-
-
42549131051
-
Connective tissue growth factor: Structure-function relationships of a mosaic, multifunctional protein
-
de Winter, P., Leoni, P., and Abraham, D. (2008)Connective tissue growth factor: structure-function relationships of a mosaic, multifunctional protein. Growth Factors 26, 80-91.
-
(2008)
Growth Factors
, vol.26
, pp. 80-91
-
-
De Winter, P.1
Leoni, P.2
Abraham, D.3
-
3
-
-
33847627603
-
CCN family proteins and angiogenesis: From embryo to adulthood
-
Kubota, S., and Takigawa, M. (2007) CCN family proteins and angiogenesis: from embryo to adulthood. Angiogenesis 10, 1-11.
-
(2007)
Angiogenesis
, vol.10
, pp. 1-11
-
-
Kubota, S.1
Takigawa, M.2
-
4
-
-
9944251355
-
Structural basis and therapeutic implication of the interaction of CCN proteins with glycoconjugates
-
Desnoyers, L. (2004) Structural basis and therapeutic implication of the interaction of CCN proteins with glycoconjugates. Curr. Pharm. Des. 10, 3913-3928.
-
(2004)
Curr. Pharm. Des.
, vol.10
, pp. 3913-3928
-
-
Desnoyers, L.1
-
5
-
-
18144380288
-
Individual domains of connective tissue growth factor regulate fibroblast proliferation and myofibroblast differentiation
-
Grotendorst, G. R., and Duncan, M. R. (2005) Individual domains of connective tissue growth factor regulate fibroblast proliferation and myofibroblast differentiation. FASEB J. 19, 729-738.
-
(2005)
FASEB J.
, vol.19
, pp. 729-738
-
-
Grotendorst, G.R.1
Duncan, M.R.2
-
6
-
-
0036775425
-
Matricellular proteins: Extracellular modulators of cell function
-
Bornstein, P., and Sage, E. H. (2002) Matricellular proteins: extracellular modulators of cell function. Curr. Opin. Cell. Biol. 14, 608-616.
-
(2002)
Curr. Opin. Cell. Biol.
, vol.14
, pp. 608-616
-
-
Bornstein, P.1
Sage, E.H.2
-
7
-
-
20444504753
-
Structural and functional properties of CCN proteins
-
Rachfal, A. W., and Brigstock, D. R. (2005) Structural and functional properties of CCN proteins. Vitam. Horm. 70, 69-103.
-
(2005)
Vitam. Horm.
, vol.70
, pp. 69-103
-
-
Rachfal, A.W.1
Brigstock, D.R.2
-
8
-
-
65849445411
-
Connective tissue growth factor: Growth factor, matricellular organizer, fibrotic biomarker or molecular target for anti-fibrotic therapy in SSc?
-
Abraham, D. Connective tissue growth factor: growth factor, matricellular organizer, fibrotic biomarker or molecular target for anti-fibrotic therapy in SSc?Rheumatology (Oxford) 2008;47 (Suppl 5), v8-v9.
-
(2008)
Rheumatology (Oxford)
, vol.47
, Issue.SUPPL 5
-
-
Abraham, D.1
-
9
-
-
40749107501
-
Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis
-
Shi-Wen, X., Leask, A., and Abraham, D. (2008) Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis. Cytokine Growth Factor Rev. 19, 133-144.
-
(2008)
Cytokine Growth Factor Rev.
, vol.19
, pp. 133-144
-
-
Shi-Wen, X.1
Leask, A.2
Abraham, D.3
-
10
-
-
33845906843
-
All in the CCN family: Essential matricellular signaling modulators emerge from the bunker
-
Leask, A., and Abraham, D. J. (2006) All in the CCN family: essential matricellular signaling modulators emerge from the bunker. J. Cell. Sci. 119, 4803-4810.
-
(2006)
J. Cell. Sci.
, vol.119
, pp. 4803-4810
-
-
Leask, A.1
Abraham, D.J.2
-
11
-
-
0038093327
-
Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development
-
Ivkovic, S., Yoon, B. S., Popoff, S. N., Safadi, F. F., Libuda, D. E., Stephenson, R. C., Daluiski, A., and Lyons, K. M. (2003) Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development 130, 2779-2791.
-
(2003)
Development
, vol.130
, pp. 2779-2791
-
-
Ivkovic, S.1
Yoon, B.S.2
Popoff, S.N.3
Safadi, F.F.4
Libuda, D.E.5
Stephenson, R.C.6
Daluiski, A.7
Lyons, K.M.8
-
12
-
-
57449108288
-
CCN family 2/connective tissue growth factor (CCN2/ CTGF) regulates the expression of Vegf through Hif-1alpha expression in a chondrocytic cell line, HCS-2/8, under hypoxic condition
-
Nishida, T., Kondo, S., Maeda, A., Kubota, S., Lyons, K. M., and Takigawa, M. (2009) CCN family 2/connective tissue growth factor (CCN2/ CTGF) regulates the expression of Vegf through Hif-1alpha expression in a chondrocytic cell line, HCS-2/8, under hypoxic condition. Bone 44, 24-31.
-
(2009)
Bone
, vol.44
, pp. 24-31
-
-
Nishida, T.1
Kondo, S.2
Maeda, A.3
Kubota, S.4
Lyons, K.M.5
Takigawa, M.6
-
13
-
-
0032817965
-
Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo
-
Shimo, T., Nakanishi, T., Nishida, T., Asano, M., Kanyama, M., Kuboki, T., Tamatani, T., Tezuka, K., Takemura, M., Matsumura, T., and Takigawa, M. (1999) Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo. J. Biochem. (Tokyo)126, 137-145.
-
(1999)
J. Biochem. (Tokyo)
, vol.126
, pp. 137-145
-
-
Shimo, T.1
Nakanishi, T.2
Nishida, T.3
Asano, M.4
Kanyama, M.5
Kuboki, T.6
Tamatani, T.7
Tezuka, K.8
Takemura, M.9
Matsumura, T.10
Takigawa, M.11
-
14
-
-
0035841946
-
Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line
-
Shimo, T., Kubota, S., Kondo, S., Nakanishi, T., Sasaki, A., Mese, H., Matsumura, T., and Takigawa, M. (2001) Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line. Cancer Lett. 174, 57-64.
-
(2001)
Cancer Lett.
, vol.174
, pp. 57-64
-
-
Shimo, T.1
Kubota, S.2
Kondo, S.3
Nakanishi, T.4
Sasaki, A.5
Mese, H.6
Matsumura, T.7
Takigawa, M.8
-
15
-
-
41849131820
-
Cyr61/CCN1 and CTGF/CCN2 mediate the proangiogenic activity of VHL-mutant renal carcinoma cells
-
Chintalapudi, M. R., Markiewicz, M., Kose, N., Dammai, V., Champion, K. J., Hoda, R. S., Trojanowska, M., and Hsu, T. (2008) Cyr61/CCN1 and CTGF/CCN2 mediate the proangiogenic activity of VHL-mutant renal carcinoma cells. Carcinogenesis 29, 696-703.
-
(2008)
Carcinogenesis
, vol.29
, pp. 696-703
-
-
Chintalapudi, M.R.1
Markiewicz, M.2
Kose, N.3
Dammai, V.4
Champion, K.J.5
Hoda, R.S.6
Trojanowska, M.7
Hsu, T.8
-
16
-
-
0037840309
-
Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteinerich 61 (CYR61)
-
Brigstock, D. R. (2002) Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteinerich 61 (CYR61). Angiogenesis 5, 153-165.
-
(2002)
Angiogenesis
, vol.5
, pp. 153-165
-
-
Brigstock, D.R.1
-
17
-
-
33746776975
-
Effect of connective tissue growth factor on hypoxia-inducible factor 1alpha degradation and tumor angiogenesis
-
Chang, C. C., Lin, M. T., Lin, B. R., Jeng, Y. M., Chen, S. T., Chu, C. Y., Chen, R. J., Chang, K. J., Yang, P. C., and Kuo, M. L. (2006) Effect of connective tissue growth factor on hypoxia-inducible factor 1alpha degradation and tumor angiogenesis. J. Natl. Cancer Inst. 98, 984-995.
-
(2006)
J. Natl. Cancer Inst.
, vol.98
, pp. 984-995
-
-
Chang, C.C.1
Lin, M.T.2
Lin, B.R.3
Jeng, Y.M.4
Chen, S.T.5
Chu, C.Y.6
Chen, R.J.7
Chang, K.J.8
Yang, P.C.9
Kuo, M.L.10
-
18
-
-
0036481769
-
Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis
-
Inoki, I., Shiomi, T., Hashimoto, G., Enomoto, H., Nakamura, H., Makino, K., Ikeda, E., Takata, S., Kobayashi, K., and Okada, Y. (2002) Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis. FASEB J. 16, 219-221.
-
(2002)
FASEB J.
, vol.16
, pp. 219-221
-
-
Inoki, I.1
Shiomi, T.2
Hashimoto, G.3
Enomoto, H.4
Nakamura, H.5
Makino, K.6
Ikeda, E.7
Takata, S.8
Kobayashi, K.9
Okada, Y.10
-
19
-
-
0037183997
-
Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165
-
Hashimoto, G., Inoki, I., Fujii, Y., Aoki, T., Ikeda, E., and Okada, Y. (2002) Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165. J. Biol. Chem. 277, 36288-36295.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 36288-36295
-
-
Hashimoto, G.1
Inoki, I.2
Fujii, Y.3
Aoki, T.4
Ikeda, E.5
Okada, Y.6
-
20
-
-
36048938981
-
The VEGF angiogenic switch of fibroblasts is regulated by MMP-7 from cancer cells
-
Ito, T. K., Ishii, G., Chiba, H., and Ochiai, A. (2007) The VEGF angiogenic switch of fibroblasts is regulated by MMP-7 from cancer cells. Oncogene 26, 7194-7203.
-
(2007)
Oncogene
, vol.26
, pp. 7194-7203
-
-
Ito, T.K.1
Ishii, G.2
Chiba, H.3
Ochiai, A.4
-
21
-
-
37549068908
-
Identification of Candidate Angiogenic Inhibitors Processed by MMP-2 in Cell Based Proteomic Screens: Disruption of VEGF/HARP (Pleiotrophin) and VEGF / CTGF Angiogenic Inhibitory Complexes by MMP-2 Proteolysis
-
Dean, R. A., Butler, G. S., Hamma-Kourbali, Y., Delbe, J., Brigstock, D. R., Courty, J., and Overall, C. M. (2007) Identification of Candidate Angiogenic Inhibitors Processed by MMP-2 in Cell Based Proteomic Screens: Disruption of VEGF/HARP (Pleiotrophin) and VEGF / CTGF Angiogenic Inhibitory Complexes by MMP-2 Proteolysis. Mol. Cell Biol. 27, 8454-8465.
-
(2007)
Mol. Cell Biol.
, vol.27
, pp. 8454-8465
-
-
Dean, R.A.1
Butler, G.S.2
Hamma-Kourbali, Y.3
Delbe, J.4
Brigstock, D.R.5
Courty, J.6
Overall, C.M.7
-
22
-
-
35548992259
-
Angiogenesis is not impaired in Connective Tissue Growth Factor (CTGF) knock out mice
-
Kuiper, E. J., Roestenberg, P., Ehlken, C., Lambert, V., Bloys van Treslong- de, G., Lyons, K. M., Agostini, H. J., Rakic, J. M., Klaassen, I., Van Noorden, C. J., Goldschmeding, R., and Schlingemann, R. O. (2007) Angiogenesis Is Not Impaired in Connective Tissue Growth Factor (CTGF) Knock Out Mice. J. Histochem. Cytochem. 55, 1139-1147.
-
(2007)
J. Histochem. Cytochem.
, vol.55
, pp. 1139-1147
-
-
Kuiper, E.J.1
Roestenberg, P.2
Ehlken, C.3
Lambert, V.4
Bloys Van Treslong-De, G.5
Lyons, K.M.6
Agostini, H.J.7
Rakic, J.M.8
Klaassen, I.9
Van Noorden, C.J.10
Goldschmeding, R.11
Schlingemann, R.O.12
-
23
-
-
50549089040
-
The angio-fibrotic switch of VEGF and CTGF in proliferative diabetic retinopathy
-
Kuiper, E. J., Van Nieuwenhoven, F. A., de Smet, M. D., van Meurs, J. C., Tanck, M. W., Oliver, N., Klaassen, I., Van Noorden, C. J., Goldschmeding, R., and Schlingemann, R. O. (2008) The angio-fibrotic switch of VEGF and CTGF in proliferative diabetic retinopathy. PLoS ONE 3, e2675.
-
(2008)
PLoS ONE
, vol.3
-
-
Kuiper, E.J.1
Van Nieuwenhoven, F.A.2
De Smet, M.D.3
Van Meurs, J.C.4
Tanck, M.W.5
Oliver, N.6
Klaassen, I.7
Van Noorden, C.J.8
Goldschmeding, R.9
Schlingemann, R.O.10
-
24
-
-
47249122645
-
Connective tissue growth factor is necessary for retinal capillary basal lamina thickening in diabetic mice
-
Kuiper, E. J., van Zijderveld, R., Roestenberg, P., Lyons, K. M., Goldschmeding, R., Klaassen, I., Van Noorden, C. J., and Schlingemann, R. O. (2008) Connective tissue growth factor is necessary for retinal capillary basal lamina thickening in diabetic mice. J. Histochem. Cytochem. 56, 785-792.
-
(2008)
J. Histochem. Cytochem.
, vol.56
, pp. 785-792
-
-
Kuiper, E.J.1
Van Zijderveld, R.2
Roestenberg, P.3
Lyons, K.M.4
Goldschmeding, R.5
Klaassen, I.6
Van Noorden, C.J.7
Schlingemann, R.O.8
-
25
-
-
0034528616
-
Induction of connective tissue growth factor by activation of heptahelical receptors. Modulation by rho proteins and the actin cytoskeleton
-
Hahn, A., Heusinger-Ribeiro, J., Lanz, T., Zenkel, S., Goppelt-Struebe, M. (2000) Induction of connective tissue growth factor by activation of heptahelical receptors. Modulation by rho proteins and the actin cytoskeleton. J. Biol. Chem. 275, 37429-37435.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 37429-37435
-
-
Hahn, A.1
Heusinger-Ribeiro, J.2
Lanz, T.3
Zenkel, S.4
Goppelt-Struebe, M.5
-
26
-
-
0034638612
-
Characterization of a mouse ctgf 3′-UTR segment that mediates repressive regulation of gene expression
-
Kondo, S., Kubota, S., Eguchi, T., Hattori, T., Nakanishi, T., Sugahara, T., and Takigawa, M. (2000) Characterization of a mouse ctgf 3′-UTR segment that mediates repressive regulation of gene expression. Biochem. Biophys. Res. Commun. 278, 119-124.
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.278
, pp. 119-124
-
-
Kondo, S.1
Kubota, S.2
Eguchi, T.3
Hattori, T.4
Nakanishi, T.5
Sugahara, T.6
Takigawa, M.7
-
27
-
-
33244456090
-
Hypoxic regulation of stability of connective tissue growth factor/CCN2 mRNA by 30-untranslated region interacting with a cellular protein in human chondrosarcoma cells
-
Kondo, S., Kubota, S., Mukudai, Y., Moritani, N., Nishida, T., Matsushita, H., Matsumoto, S., Sugahara, T., and Takigawa, M. (2006) Hypoxic regulation of stability of connective tissue growth factor/CCN2 mRNA by 30-untranslated region interacting with a cellular protein in human chondrosarcoma cells. Oncogene 25, 1099-1110.
-
(2006)
Oncogene
, vol.25
, pp. 1099-1110
-
-
Kondo, S.1
Kubota, S.2
Mukudai, Y.3
Moritani, N.4
Nishida, T.5
Matsushita, H.6
Matsumoto, S.7
Sugahara, T.8
Takigawa, M.9
-
28
-
-
33745216653
-
Connective tissue growth factor: A role in airway remodelling in asthma?
-
Burgess, J. K. (2005) Connective tissue growth factor: a role in airway remodelling in asthma?Clin. Exp. Pharmacol. Physiol. 32, 988-994.
-
(2005)
Clin. Exp. Pharmacol. Physiol.
, vol.32
, pp. 988-994
-
-
Burgess, J.K.1
-
29
-
-
0027229995
-
Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair
-
Igarashi, A., Okochi, H., Bradham, D. M., and Grotendorst, G. R. (1993) Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair. Mol. Cell Biol. 4, 637-645.
-
(1993)
Mol. Cell Biol.
, vol.4
, pp. 637-645
-
-
Igarashi, A.1
Okochi, H.2
Bradham, D.M.3
Grotendorst, G.R.4
-
30
-
-
0033802165
-
Brady: Connective tissue growth factor: Potential role in glomerulosclerosis and tubulointerstitial fibrosis
-
Gupta, S., Clarkson, M. R., Duggan, J. (2000) Brady: Connective tissue growth factor: potential role in glomerulosclerosis and tubulointerstitial fibrosis. Kidney Int. 58, 1389-1399.
-
(2000)
Kidney Int.
, vol.58
, pp. 1389-1399
-
-
Gupta, S.1
Clarkson, M.R.2
Duggan, J.3
-
31
-
-
0031225015
-
Connective tissue growth factor: A mediator of TGF-beta action on fibroblasts
-
Grotendorst, G. R. (1997) Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts. Cytokine Growth Factor Rev. 8, 171-179.
-
(1997)
Cytokine Growth Factor Rev.
, vol.8
, pp. 171-179
-
-
Grotendorst, G.R.1
-
32
-
-
0035824518
-
Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3
-
Fu, M., Zhang, J., Zhu, X., Myles, D. E., Willson, T. M., Liu, X., and Chen, Y. E. (2001) Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3. J. Biol. Chem. 276, 45888-45894.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 45888-45894
-
-
Fu, M.1
Zhang, J.2
Zhu, X.3
Myles, D.E.4
Willson, T.M.5
Liu, X.6
Chen, Y.E.7
-
33
-
-
0033957976
-
Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis
-
Riser, B. L., Denichilo, M., Cortes, P., Baker, C., Grondin, J. M., Yee, J., and Narins, R. G. (2000) Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis. J. Am. Soc. Nephrol. 11, 25-38.
-
(2000)
J. Am. Soc. Nephrol.
, vol.11
, pp. 25-38
-
-
Riser, B.L.1
Denichilo, M.2
Cortes, P.3
Baker, C.4
Grondin, J.M.5
Yee, J.6
Narins, R.G.7
-
34
-
-
0036786249
-
Connective tissue growth factor and regulation of the mesangial cell cycle: Role in cellular hypertrophy
-
Abdel-Wahab, N., Weston, B. S., Roberts, T., and Mason, R. M. (2002) Connective tissue growth factor and regulation of the mesangial cell cycle: role in cellular hypertrophy. J. Am. Soc. Nephrol. 13, 2437-2445.
-
(2002)
J. Am. Soc. Nephrol.
, vol.13
, pp. 2437-2445
-
-
Abdel-Wahab, N.1
Weston, B.S.2
Roberts, T.3
Mason, R.M.4
-
35
-
-
53249097208
-
Activation of TGF-beta within cultured hepatocytes and in liver injury leads to intracrine signaling with expression of connective tissue growth factor
-
10.1111/j.1582-4934.2008.00260.x
-
Gressner, O. A., Lahme, B., Siluschek, M., Rehbein, K., Herrmann, J., Weiskirchen, R., Gressner, A. M. Activation of TGF-beta within cultured hepatocytes and in liver injury leads to intracrine signaling with expression of connective tissue growth factor. J. Cell Mol. Med. 10.1111/j.1582-4934.2008. 00260.x.
-
J. Cell Mol. Med.
-
-
Gressner, O.A.1
Lahme, B.2
Siluschek, M.3
Rehbein, K.4
Herrmann, J.5
Weiskirchen, R.6
Gressner, A.M.7
-
36
-
-
60749111516
-
Regulation of connective tissue growth factor (CTGF) by hepatocyte growth factor in human tubular epithelial cells
-
10.1093/ndt/gfn530
-
Kroening, S., Solomovitch, S., Sachs, M., Wullich, B., and Goppelt- Struebe, M. Regulation of connective tissue growth factor (CTGF) by hepatocyte growth factor in human tubular epithelial cells. Nephrol. Dial. Transplant., 10.1093/ndt/gfn530.
-
Nephrol. Dial. Transplant.
-
-
Kroening, S.1
Solomovitch, S.2
Sachs, M.3
Wullich, B.4
Goppelt- Struebe, M.5
-
37
-
-
34047156556
-
TGF-beta signaling in vascular fibrosis
-
Ruiz-Ortega, M., Rodriguez-Vita, J., Sanchez-Lopez, E., Carvajal, G., and Egido, J. (2007) TGF-beta signaling in vascular fibrosis. Cardiovasc. Res. 74, 196-206.
-
(2007)
Cardiovasc. Res.
, vol.74
, pp. 196-206
-
-
Ruiz-Ortega, M.1
Rodriguez-Vita, J.2
Sanchez-Lopez, E.3
Carvajal, G.4
Egido, J.5
-
38
-
-
34548389503
-
Influence of endothelial cells on vascular smooth muscle cells phenotype after irradiation: Implication in radiation-induced vascular damages
-
Milliat, F., Francois, A., Isoir, M., Deutsch, E., Tamarat, R., Tarlet, G., Atfi, A., Validire, P., Bourhis, J., Sabourin, J. C., and Benderitter, M. (2006) Influence of endothelial cells on vascular smooth muscle cells phenotype after irradiation: implication in radiation-induced vascular damages. Am. J. Pathol. 169, 1484-1495.
-
(2006)
Am. J. Pathol.
, vol.169
, pp. 1484-1495
-
-
Milliat, F.1
Francois, A.2
Isoir, M.3
Deutsch, E.4
Tamarat, R.5
Tarlet, G.6
Atfi, A.7
Validire, P.8
Bourhis, J.9
Sabourin, J.C.10
Benderitter, M.11
-
39
-
-
41949091777
-
Molecular requirements for induction of CTGF expression by TGF-beta1 in primary osteoblasts
-
Arnott, J. A., Zhang, X., Sanjay, A., Owen, T. A., Smock, S. L., Rehman, S., DeLong, W. G., Safadi, F. F., and Popoff, S. N. (2008) Molecular requirements for induction of CTGF expression by TGF-beta1 in primary osteoblasts. Bone 42, 871-885.
-
(2008)
Bone
, vol.42
, pp. 871-885
-
-
Arnott, J.A.1
Zhang, X.2
Sanjay, A.3
Owen, T.A.4
Smock, S.L.5
Rehman, S.6
Delong, W.G.7
Safadi, F.F.8
Popoff, S.N.9
-
40
-
-
30744478450
-
The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFbeta1 responses in human proximaltubule epithelial cells
-
Phanish, M. K., Wahab, N. A., Colville-Nash, P., Hendry, B. M., and Dockrell, M. E. (2006) The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFbeta1 responses in human proximaltubule epithelial cells. Biochem. J. 393, 601-607.
-
(2006)
Biochem. J.
, vol.393
, pp. 601-607
-
-
Phanish, M.K.1
Wahab, N.A.2
Colville-Nash, P.3
Hendry, B.M.4
Dockrell, M.E.5
-
41
-
-
70350607865
-
The induction of CCN2 by TGFbeta1 involves Ets-1
-
Van Beek, J. P., Kennedy, L., Rockel, J. S., Bernier, S. M., and Leask, A. (2006) The induction of CCN2 by TGFbeta1 involves Ets-1. Arthritis Res. Ther. 8, R36.
-
(2006)
Arthritis Res. Ther.
, vol.8
-
-
Van Beek, J.P.1
Kennedy, L.2
Rockel, J.S.3
Bernier, S.M.4
Leask, A.5
-
42
-
-
0035815683
-
CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling
-
Holmes, A., Abraham, D. J., Sa, S., Shiwen, X., Black, C. M., and Leask, A. (2001) CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling. J. Biol. Chem. 276, 10594-10601.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 10594-10601
-
-
Holmes, A.1
Abraham, D.J.2
Sa, S.3
Shiwen, X.4
Black, C.M.5
Leask, A.6
-
43
-
-
0038644847
-
Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts
-
Leask, A., Holmes, A., Black, C. M., and Abraham, D. J. (2003) Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts. J. Biol. Chem. 278, 13008-13015.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 13008-13015
-
-
Leask, A.1
Holmes, A.2
Black, C.M.3
Abraham, D.J.4
-
44
-
-
0029808645
-
A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene
-
Grotendorst, G. R., Okochi, H., and Hayashi, N. (1996) A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene. Cell Growth Differ. 7, 469-480.
-
(1996)
Cell Growth Differ.
, vol.7
, pp. 469-480
-
-
Grotendorst, G.R.1
Okochi, H.2
Hayashi, N.3
-
45
-
-
0036378148
-
CTGF expression in mesangial cells: Involvement of SMADs, MAP kinase, and PKC
-
Chen, Y., Blom, I. E., Sa, S., Goldschmeding, R., Abraham, D. J., and Leask, A. (2002) CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC. Kidney Int. 62, 1149-1159.
-
(2002)
Kidney Int.
, vol.62
, pp. 1149-1159
-
-
Chen, Y.1
Blom, I.E.2
Sa, S.3
Goldschmeding, R.4
Abraham, D.J.5
Leask, A.6
-
46
-
-
54949125004
-
Analysis of CCN2 promoter activity in PANC-1 cells: Regulation by ras/MEK/ERK
-
Pickles, M., and Leask, A. (2007) Analysis of CCN2 promoter activity in PANC-1 cells: regulation by ras/MEK/ERK. J. Cell. Commun. Signal 1, 85-90.
-
(2007)
J. Cell. Commun. Signal
, vol.1
, pp. 85-90
-
-
Pickles, M.1
Leask, A.2
-
47
-
-
2542456517
-
Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK
-
Xu, S. W., Howat, S. L., Renzoni, E. A., Holmes, A., Pearson, J. D., Dashwood, M. R., Bou-Gharios, G., Denton, C. P., du Bois, R. M., Black, C. M., Leask, A., and Abraham, D. J. (2004) Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK. J. Biol. Chem. 279, 23098-23103.
-
(2004)
J. Biol. Chem.
, Issue.279
, pp. 23098-23103
-
-
Xu, S.W.1
Howat, S.L.2
Renzoni, E.A.3
Holmes, A.4
Pearson, J.D.5
Dashwood, M.R.6
Bou-Gharios, G.7
Denton, C.P.8
Du Bois, R.M.9
Black, C.M.10
Leask, A.11
Abraham, D.J.12
-
48
-
-
0034870254
-
Expression of connective tissue growth factor in human renal fibroblasts: Regulatory roles of RhoA and cAMP
-
Heusinger-Ribeiro, J., Eberlein, M., Wahab, N. A., Goppelt-Struebe, M. (2001) Expression of connective tissue growth factor in human renal fibroblasts: regulatory roles of RhoA and cAMP. J. Am. Soc. Nephrol. 12, 1853-1861.
-
(2001)
J. Am. Soc. Nephrol.
, vol.12
, pp. 1853-1861
-
-
Heusinger-Ribeiro, J.1
Eberlein, M.2
Wahab, N.A.3
Goppelt-Struebe, M.4
-
49
-
-
21344470149
-
TGF-beta1-induced connective tissue growth factor (CCN2) expression in human renal proximal tubule epithelial cells requires Ras/MEK/ERK and Smad signaling
-
Phanish, M. K., Wahab, N. A., Hendry, B. M., and Dockrell, M. E. (2005) TGF-beta1-induced connective tissue growth factor (CCN2) expression in human renal proximal tubule epithelial cells requires Ras/MEK/ERK and Smad signalling. Nephron Exp. Nephrol. 100, e156-165.
-
(2005)
Nephron Exp. Nephrol.
, vol.100
-
-
Phanish, M.K.1
Wahab, N.A.2
Hendry, B.M.3
Dockrell, M.E.4
-
50
-
-
26244458018
-
TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
-
Kasai, H., Allen, J. T., Mason, R. M., Kamimura, T., and Zhang, Z. (2005) TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir. Res. 6, 56.
-
(2005)
Respir. Res.
, vol.6
, pp. 56
-
-
Kasai, H.1
Allen, J.T.2
Mason, R.M.3
Kamimura, T.4
Zhang, Z.5
-
51
-
-
34848865661
-
Differential effects of TGF-beta on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes
-
Gressner, O. A., Lahme, B., Demirci, I., Gressner, A. M., and Weiskirchen, R. (2007) Differential effects of TGF-beta on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes. J. Hepatol. 47, 699-710.
-
(2007)
J. Hepatol.
, vol.47
, pp. 699-710
-
-
Gressner, O.A.1
Lahme, B.2
Demirci, I.3
Gressner, A.M.4
Weiskirchen, R.5
-
52
-
-
35848957047
-
Expression of connective tissue growth factor in pancreatic cancer cell lines
-
Kwon, S., Munroe, X., Crawley, S. C., Lee, H. Y., Spong, S., Bradham, D., Gum, J. R., Jr., Sleisenger, M. H., and Kim, Y. S. (2007) Expression of connective tissue growth factor in pancreatic cancer cell lines. Int. J. Oncol. 31, 693-703.
-
(2007)
Int. J. Oncol.
, vol.31
, pp. 693-703
-
-
Kwon, S.1
Munroe, X.2
Crawley, S.C.3
Lee, H.Y.4
Spong, S.5
Bradham, D.6
Gum Jr., J.R.7
Sleisenger, M.H.8
Kim, Y.S.9
-
53
-
-
34447525522
-
Tissue-specific mechanisms for CCN2/CTGF persistence in fibrotic gingiva: Interactions between cAMP and MAPK signaling pathways, and prostaglandin E2-EP3 receptor mediated activation of the c- JUN N-terminal kinase
-
Black, S. A., Jr., Palamakumbura, A. H., Stan, M., and Trackman, P. C. (2007) Tissue-specific mechanisms for CCN2/CTGF persistence in fibrotic gingiva: interactions between cAMP and MAPK signaling pathways, and prostaglandin E2-EP3 receptor mediated activation of the c- JUN N-terminal kinase. J. Biol. Chem. 282, 15416-15429.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 15416-15429
-
-
Black Jr., S.A.1
Palamakumbura, A.H.2
Stan, M.3
Trackman, P.C.4
-
54
-
-
8644245963
-
Connective Tissue Growth Factor expression and induction by Transforming Growth Factor {beta}, is abrogated by Simvastatin via a Rho signalling mechanism
-
Watts, K. L., and Spiteri, M. A. (2004) Connective Tissue Growth Factor expression and induction by Transforming Growth Factor {beta}, is abrogated by Simvastatin via a Rho signalling mechanism. Am. J. Physiol. Lung Cell Mol. Physiol. 287, L1323-L1332.
-
(2004)
Am. J. Physiol. Lung Cell Mol. Physiol.
, vol.287
-
-
Watts, K.L.1
Spiteri, M.A.2
-
55
-
-
33748075143
-
A FoxO-Smad synexpression group in human keratinocytes
-
Gomis, R. R., Alarcon, C., He, W., Wang, Q., Seoane, J., Lash, A., and Massague, J. (2006) A FoxO-Smad synexpression group in human keratinocytes. Proc. Natl. Acad. Sci. USA 103, 12747-12752.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 12747-12752
-
-
Gomis, R.R.1
Alarcon, C.2
He, W.3
Wang, Q.4
Seoane, J.5
Lash, A.6
Massague, J.7
-
56
-
-
36148950528
-
Gene regulation by mechanotransduction in fibroblasts
-
Chiquet, M., Tunc-Civelek, V., Sarasa-Renedo, A. (2007) Gene regulation by mechanotransduction in fibroblasts. Appl. Physiol. Nutr. Metab. 32, 967-973.
-
(2007)
Appl. Physiol. Nutr. Metab.
, vol.32
, pp. 967-973
-
-
Chiquet, M.1
Tunc-Civelek, V.2
Sarasa-Renedo, A.3
-
57
-
-
42249093297
-
The role of matrix stiffness in regulating cell behavior
-
Wells, R. G. (2008) The role of matrix stiffness in regulating cell behavior. Hepatology 47, 1394-1400.
-
(2008)
Hepatology
, vol.47
, pp. 1394-1400
-
-
Wells, R.G.1
-
58
-
-
40149087864
-
Mechanotransduction and fracture repair
-
Morgan, E. F., Gleason, R. E., Hayward, L. N., Leong, P. L., and Palomares, K. T. (2008) Mechanotransduction and fracture repair. J. Bone Joint Surg. Am. 90 (Suppl 1), 25-30.
-
(2008)
J. Bone Joint Surg. Am.
, vol.90
, Issue.SUPPL. 1
, pp. 25-30
-
-
Morgan, E.F.1
Gleason, R.E.2
Hayward, L.N.3
Leong, P.L.4
Palomares, K.T.5
-
59
-
-
33746751471
-
Mechanical regulation of the Cyr61/CCN1 and CTGF/CCN2 proteins
-
Chaqour, B., and Goppelt-Struebe, M. (2006) Mechanical regulation of the Cyr61/CCN1 and CTGF/CCN2 proteins. FEBS J. 273, 3639-3649.
-
(2006)
FEBS J.
, vol.273
, pp. 3639-3649
-
-
Chaqour, B.1
Goppelt-Struebe, M.2
-
60
-
-
33644802781
-
Arteriolar myogenic signalling mechanisms: Implications for local vascular function
-
Hill, M. A., Davis, M. J., Meininger, G. A., Potocnik, S. J., and Murphy, T. V. (2006) Arteriolar myogenic signalling mechanisms: Implications for local vascular function. Clin. Hemorheol. Microcirc. 34, 67-79.
-
(2006)
Clin. Hemorheol. Microcirc.
, vol.34
, pp. 67-79
-
-
Hill, M.A.1
Davis, M.J.2
Meininger, G.A.3
Potocnik, S.J.4
Murphy, T.V.5
-
61
-
-
49049121661
-
Serial analysis of the vascular endothelial transcriptome under static and shear stress conditions
-
Chu, T. J., and Peters, D. G. (2008) Serial analysis of the vascular endothelial transcriptome under static and shear stress conditions. Physiol. Genomics 34, 185-192.
-
(2008)
Physiol. Genomics
, vol.34
, pp. 185-192
-
-
Chu, T.J.1
Peters, D.G.2
-
62
-
-
20144380821
-
Monocrotaline-induced pulmonary hypertension correlates with upregulation of connective tissue growth factor expression in the lung
-
Lee, Y. S., Byun, J., Kim, J. A., Lee, J. S., Kim, K. L., Suh, Y. L., Kim, J. M., Jang, H. S., Lee, J. Y., Shin, I. S., Suh, W., Jeon, E. S., and Kim, D. K. (2005) Monocrotaline-induced pulmonary hypertension correlates with upregulation of connective tissue growth factor expression in the lung. Exp. Mol. Med. 37, 27-35.
-
(2005)
Exp. Mol. Med.
, vol.37
, pp. 27-35
-
-
Lee, Y.S.1
Byun, J.2
Kim, J.A.3
Lee, J.S.4
Kim, K.L.5
Suh, Y.L.6
Kim, J.M.7
Jang, H.S.8
Lee, J.Y.9
Shin, I.S.10
Suh, W.11
Jeon, E.S.12
Kim, D.K.13
-
63
-
-
33746010588
-
Mechanical stretch modulates the promoter activity of the profibrotic factor CCN2 through increased actin polymerization and NF-kappa B activation
-
Chaqour, B., Yang, R., and Sha, Q. (2006) Mechanical stretch modulates the promoter activity of the profibrotic factor CCN2 through increased actin polymerization and NF-kappa B activation. J. Biol. Chem. 281, 20608-20622.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 20608-20622
-
-
Chaqour, B.1
Yang, R.2
Sha, Q.3
-
64
-
-
0036242563
-
Large scale isolation of non-uniform shear stress-responsive genes from cultured human endothelial cells through the preparation of a subtracted cDNA library
-
Yoshisue, H., Suzuki, K., Kawabata, A., Ohya, T., Zhao, H., Sakurada, K., Taba, Y., Sasaguri, T., Sakai, N., Yamashita, S., Matsuzawa, Y., and Nojima, H. (2002) Large scale isolation of non-uniform shear stress-responsive genes from cultured human endothelial cells through the preparation of a subtracted cDNA library. Atherosclerosis 162, 323-334.
-
(2002)
Atherosclerosis
, vol.162
, pp. 323-334
-
-
Yoshisue, H.1
Suzuki, K.2
Kawabata, A.3
Ohya, T.4
Zhao, H.5
Sakurada, K.6
Taba, Y.7
Sasaguri, T.8
Sakai, N.9
Yamashita, S.10
Matsuzawa, Y.11
Nojima, H.12
-
65
-
-
0036975683
-
Microarray analysis of shear stressed endothelial cells
-
McCormick, S. M., Frye, S. R., Eskin, S. G., Teng, C. L., Lu, C. M., Russell, C. G., Chittur, K. K., and McIntire, L. V. (2003) Microarray analysis of shear stressed endothelial cells. Biorheology 40, 5-11.
-
(2003)
Biorheology
, vol.40
, pp. 5-11
-
-
McCormick, S.M.1
Frye, S.R.2
Eskin, S.G.3
Teng, C.L.4
Lu, C.M.5
Russell, C.G.6
Chittur, K.K.7
McIntire, L.V.8
-
66
-
-
0035979179
-
DNA microarray reveals changes in gene expression of shear stressed human umbilical vein endothelial cells
-
McCormick, S. M., Eskin, S. G., McIntire, L. V., Teng, C. L., Lu, C. M., Russell, C. G., and Chittur, K. K. (2001) DNA microarray reveals changes in gene expression of shear stressed human umbilical vein endothelial cells. Proc. Natl. Acad. Sci. USA 98, 8955-8960.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 8955-8960
-
-
McCormick, S.M.1
Eskin, S.G.2
McIntire, L.V.3
Teng, C.L.4
Lu, C.M.5
Russell, C.G.6
Chittur, K.K.7
-
67
-
-
1842535528
-
Endothelial cell cytochrome P450 1A1 and 1B1: Up-regulation by shear stress
-
Eskin, S. G., Turner, N. A., and McIntire, L. V. (2004) Endothelial cell cytochrome P450 1A1 and 1B1: up-regulation by shear stress. Endothelium 11, 1-10.
-
(2004)
Endothelium
, vol.11
, pp. 1-10
-
-
Eskin, S.G.1
Turner, N.A.2
McIntire, L.V.3
-
68
-
-
0035836653
-
Biomechanical activation of vascular endothelium as a determinant of its functional phenotype
-
Garcia-Cardena, G., Comander, J., Anderson, K. R., Blackman, B. R., Gimbrone, M. A., Jr. (2001) Biomechanical activation of vascular endothelium as a determinant of its functional phenotype. Proc. Natl. Acad. Sci. USA 98, 4478-4485.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 4478-4485
-
-
Garcia-Cardena, G.1
Comander, J.2
Anderson, K.R.3
Blackman, B.R.4
Gimbrone Jr., M.A.5
-
69
-
-
38049027778
-
Pharmacological inhibition of RhoA signaling prevents connective tissue growth factor induction in endothelial cells exposed to non-uniform shear stress
-
Cicha, I., Goppelt-Struebe, M., Muehlich, S., Yilmaz, A., Raaz, D., Daniel, W. G., and Garlichs, C. D. (2008) Pharmacological inhibition of RhoA signaling prevents connective tissue growth factor induction in endothelial cells exposed to non-uniform shear stress. Atherosclerosis 196, 136-145.
-
(2008)
Atherosclerosis
, vol.196
, pp. 136-145
-
-
Cicha, I.1
Goppelt-Struebe, M.2
Muehlich, S.3
Yilmaz, A.4
Raaz, D.5
Daniel, W.G.6
Garlichs, C.D.7
-
70
-
-
12344306644
-
The role of shear stress in the pathogenesis of atherosclerosis
-
Cunningham, K. S., and Gotlieb, A. I. (2005) The role of shear stress in the pathogenesis of atherosclerosis. Lab. Invest. 85, 9-23.
-
(2005)
Lab. Invest.
, vol.85
, pp. 9-23
-
-
Cunningham, K.S.1
Gotlieb, A.I.2
-
71
-
-
18244391728
-
Connective tissue growth factor is overexpressed in complicated atherosclerotic plaques and induces mononuclear cell chemotaxis in vitro
-
Cicha, I., Yilmaz, A., Klein, M., Raithel, D., Brigstock, D. R., Daniel, W. G., Goppelt-Struebe, M., and Garlichs, C. D. (2005) Connective tissue growth factor is overexpressed in complicated atherosclerotic plaques and induces mononuclear cell chemotaxis in vitro. Arterioscler. Thromb. Vasc. Biol. 25, 1008-1013.
-
(2005)
Arterioscler. Thromb. Vasc. Biol.
, vol.25
, pp. 1008-1013
-
-
Cicha, I.1
Yilmaz, A.2
Klein, M.3
Raithel, D.4
Brigstock, D.R.5
Daniel, W.G.6
Goppelt-Struebe, M.7
Garlichs, C.D.8
-
72
-
-
33646112154
-
Mechanisms of low-density lipoprotein-induced expression of connective tissue growth factor in human aortic endothelial cells
-
Sohn, M., Tan, Y., Wang, B., Klein, R. L., Trojanowska, M., and Jaffa, A. A. (2006) Mechanisms of low-density lipoprotein-induced expression of connective tissue growth factor in human aortic endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 290, H1624-1634.
-
(2006)
Am. J. Physiol. Heart Circ. Physiol.
, vol.290
-
-
Sohn, M.1
Tan, Y.2
Wang, B.3
Klein, R.L.4
Trojanowska, M.5
Jaffa, A.A.6
-
73
-
-
33747203246
-
Increased collagen deposition and elevated expression of connective tissue growth factor in human thoracic aortic dissection
-
Wang, X., LeMaire, S. A., Chen, L., Shen, Y. H., Gan, Y., Bartsch, H., Carter, S. A., Utama, B., Ou, H., Coselli, J. S., and Wang, X. L. (2006) Increased collagen deposition and elevated expression of connective tissue growth factor in human thoracic aortic dissection. Circulation 114, I200-205.
-
(2006)
Circulation
, vol.114
-
-
Wang, X.1
Lemaire, S.A.2
Chen, L.3
Shen, Y.H.4
Gan, Y.5
Bartsch, H.6
Carter, S.A.7
Utama, B.8
Ou, H.9
Coselli, J.S.10
Wang, X.L.11
-
74
-
-
0034535271
-
Connective tissue growth factor (CTGF) stimulates vascular smooth muscle cell growth and migration in vitro. [In Process Citation]
-
Fan, W. H., Pech, M., and Karnovsky, M. J. (2000) Connective tissue growth factor (CTGF) stimulates vascular smooth muscle cell growth and migration in vitro. [In Process Citation].Eur. J. Cell Biol. 79, 915-923.
-
(2000)
Eur. J. Cell Biol.
, vol.79
, pp. 915-923
-
-
Fan, W.H.1
Pech, M.2
Karnovsky, M.J.3
-
75
-
-
3242696973
-
Induction of connective tissue growth factor (CTGF) in human endothelial cells by lysophosphatidic acid, sphingosine-1-phosphate, and platelets
-
Muehlich, S., Schneider, N., Hinkmann, F., Garlichs, C. D., Goppelt- Struebe, M. (2004) Induction of connective tissue growth factor (CTGF) in human endothelial cells by lysophosphatidic acid, sphingosine- 1-phosphate, and platelets. Atherosclerosis 175, 261-268.
-
(2004)
Atherosclerosis
, vol.175
, pp. 261-268
-
-
Muehlich, S.1
Schneider, N.2
Hinkmann, F.3
Garlichs, C.D.4
Goppelt- Struebe, M.5
-
76
-
-
34547631574
-
HMG-CoA reductase inhibitors decrease angiotensin II-induced vascular fibrosis: Role of RhoA/ROCK and MAPK pathways
-
Ruperez, M., Rodrigues-Diez, R., Blanco-Colio, L. M., Sanchez-Lopez, E., Rodriguez-Vita, J., Esteban, V., Carvajal, G., Plaza, J. J., Egido, J., Ruiz-Ortega, M. (2007) HMG-CoA reductase inhibitors decrease angiotensin II-induced vascular fibrosis: role of RhoA/ROCK and MAPK pathways. Hypertension 50, 377-383.
-
(2007)
Hypertension
, vol.50
, pp. 377-383
-
-
Ruperez, M.1
Rodrigues-Diez, R.2
Blanco-Colio, L.M.3
Sanchez-Lopez, E.4
Rodriguez-Vita, J.5
Esteban, V.6
Carvajal, G.7
Plaza, J.J.8
Egido, J.9
Ruiz-Ortega, M.10
-
77
-
-
29144485387
-
Differential involvement of the integrin-linked kinase (ILK) RhoA-dependent rearrangement of F-actin fibers and induction of connective tissue growth factor (CTGF)
-
Graness, A., Giehl, K., Goppelt-Struebe, M. (2006) Differential involvement of the integrin-linked kinase (ILK) in RhoA-dependent rearrangement of F-actin fibers and induction of connective tissue growth factor (CTGF). Cell Signal 18, 433-440.
-
(2006)
Cell Signal
, vol.18
, pp. 433-440
-
-
Graness, A.1
Giehl, K.2
Goppelt-Struebe, M.3
-
78
-
-
0242582448
-
Modulation of the Expression of Connective Tissue Growth Factor by Alterations of the Cytoskeleton
-
DOI 10.1074/jbc.M309140200
-
Ott, C., Iwanciw, D., Graness, A., Giehl, K., Goppelt-Struebe, M. (2003) Modulation of the expression of connective tissue growth factor by alterations of the cytoskeleton. J. Biol. Chem. 278, 44305-44311. (Pubitemid 37377176)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.45
, pp. 44305-44311
-
-
Ott, C.1
Iwanciw, D.2
Graness, A.3
Giehl, K.4
Goppelt-Struebe, M.5
-
79
-
-
24944434740
-
Nuclear actin-binding proteins as modulators of gene transcription
-
Gettemans, J., Van Impe, K., Delanote, V., Hubert, T., Vandekerckhove, J., and De, C. V. (2005) Nuclear actin-binding proteins as modulators of gene transcription. Traffic 6, 847-857.
-
(2005)
Traffic
, vol.6
, pp. 847-857
-
-
Gettemans, J.1
Van Impe, K.2
Delanote, V.3
Hubert, T.4
Vandekerckhove, J.5
De, C.V.6
-
80
-
-
0032450986
-
Regulation of SRF activity by Rho family GTPases
-
Treisman, R., Alberts, A. S., and Sahai, E. (1998) Regulation of SRF activity by Rho family GTPases. Cold Spring Harb. Symp. Quant. Biol. 63, 643-651.
-
(1998)
Cold Spring Harb. Symp. Quant. Biol.
, vol.63
, pp. 643-651
-
-
Treisman, R.1
Alberts, A.S.2
Sahai, E.3
-
81
-
-
34250667546
-
Actin-dependent regulation of connective tissue growth factor (CTGF)
-
Muehlich, S., Cicha, I., Garlichs, C. D., Krueger, B., Posern, G., Goppelt- Struebe, M. (2007) Actin-dependent regulation of connective tissue growth factor (CTGF). Am. J. Physiol. Cell Physiol. 292, 1732-1738.
-
(2007)
Am. J. Physiol. Cell Physiol.
, Issue.292
, pp. 1732-1738
-
-
Muehlich, S.1
Cicha, I.2
Garlichs, C.D.3
Krueger, B.4
Posern, G.5
Goppelt- Struebe, M.6
-
82
-
-
44449142302
-
Nuclear actin dynamics--from form to function
-
Vartiainen, M. K. (2008) Nuclear actin dynamics--from form to function. FEBS Lett. 582, 2033-2040.
-
(2008)
FEBS Lett.
, vol.582
, pp. 2033-2040
-
-
Vartiainen, M.K.1
-
83
-
-
41749091574
-
Applications for ROCK kinase inhibition
-
Olson, M. F. (2008) Applications for ROCK kinase inhibition. Curr. Opin. Cell. Biol. 20, 242-248.
-
(2008)
Curr. Opin. Cell. Biol.
, vol.20
, pp. 242-248
-
-
Olson, M.F.1
-
84
-
-
33749538874
-
The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models
-
Ying, H., Biroc, S. L., Li, W. W., Alicke, B., Xuan, J. A., Pagila, R., Ohashi, Y., Okada, T., Kamata, Y., and Dinter, H. (2006) The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models. Mol. Cancer Ther. 5, 2158-2164.
-
(2006)
Mol. Cancer Ther.
, vol.5
, pp. 2158-2164
-
-
Ying, H.1
Biroc, S.L.2
Li, W.W.3
Alicke, B.4
Xuan, J.A.5
Pagila, R.6
Ohashi, Y.7
Okada, T.8
Kamata, Y.9
Dinter, H.10
-
85
-
-
53849089211
-
Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension
-
Oka, M., Fagan, K. A., Jones, P. L., and McMurtry, I. F. (2008) Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension. Br. J. Pharmacol. 155, 444-454.
-
(2008)
Br. J. Pharmacol.
, vol.155
, pp. 444-454
-
-
Oka, M.1
Fagan, K.A.2
Jones, P.L.3
McMurtry, I.F.4
-
86
-
-
12344323503
-
Cardioprotective mechanisms of Rho-kinase inhibition associated with eNOS and oxidative stress-LOX-1 pathway in Dahl salt-sensitive hypertensive rats
-
Mita, S., Kobayashi, N., Yoshida, K., Nakano, S., and Matsuoka, H. (2005) Cardioprotective mechanisms of Rho-kinase inhibition associated with eNOS and oxidative stress-LOX-1 pathway in Dahl salt-sensitive hypertensive rats. J. Hypertens. 23, 87-96.
-
(2005)
J. Hypertens.
, vol.23
, pp. 87-96
-
-
Mita, S.1
Kobayashi, N.2
Yoshida, K.3
Nakano, S.4
Matsuoka, H.5
-
87
-
-
27644449718
-
Efficacy and safety of fasudil in patients with stable angina: A double-blind, placebo-controlled, phase 2 trial
-
Vicari, R. M., Chaitman, B., Keefe, D., Smith, W. B., Chrysant, S. G., Tonkon, M. J., Bittar, N., Weiss, R. J., Morales-Ballejo, H., and Thadani, U. (2005) Efficacy and safety of fasudil in patients with stable angina: a double-blind, placebo-controlled, phase 2 trial. J. Am. Coll. Cardiol. 46, 1803-1811.
-
(2005)
J. Am. Coll. Cardiol.
, vol.46
, pp. 1803-1811
-
-
Vicari, R.M.1
Chaitman, B.2
Keefe, D.3
Smith, W.B.4
Chrysant, S.G.5
Tonkon, M.J.6
Bittar, N.7
Weiss, R.J.8
Morales-Ballejo, H.9
Thadani, U.10
-
88
-
-
73249125357
-
Upregulation of connective tissue growth factor (CTGF/CCN2) in endothelial cells by the microtubule destabilizing agent combretastatin A- 4
-
MCR-08-0292v1
-
Samarin, J., Rehm, M., Krueger, B., Waschke, J., Goppelt-Struebe, M.: Upregulation of connective tissue growth factor (CTGF/CCN2) in endothelial cells by the microtubule destabilizing agent combretastatin A- 4. Mol. Cancer. Res. 1541-7786.MCR-08-0292v1.
-
Mol. Cancer. Res.
, pp. 1541-7786
-
-
Samarin, J.1
Rehm, M.2
Krueger, B.3
Waschke, J.4
Goppelt-Struebe, M.5
-
89
-
-
0034888856
-
Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins)
-
Eberlein, M., Heusinger-Ribeiro, J., Goppelt-Struebe, M. (2001) Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins). Br. J. Pharmacol. 133, 1172-1180. (Pubitemid 32762429)
-
(2001)
British Journal of Pharmacology
, vol.133
, Issue.7
, pp. 1172-1180
-
-
Eberlein, M.1
Heusinger-Ribeiro, J.2
Goppelt-Struebe, M.3
-
90
-
-
0346040260
-
Fluvastatin prevents nephropathy likely through suppression of connective tissue growth factor-mediated extracellular matrix accumulation
-
Song, Y., Li, C., and Cai, L. (2004) Fluvastatin prevents nephropathy likely through suppression of connective tissue growth factor-mediated extracellular matrix accumulation. Exp. Mol. Pathol. 76, 66-75.
-
(2004)
Exp. Mol. Pathol.
, vol.76
, pp. 66-75
-
-
Song, Y.1
Li, C.2
Cai, L.3
-
91
-
-
34250797380
-
The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats
-
Gojo, A., Utsunomiya, K., Taniguchi, K., Yokota, T., Ishizawa, S., Kanazawa, Y., Kurata, H., and Tajima, N. (2007) The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats. Eur. J. Pharmacol. 568, 242-247.
-
(2007)
Eur. J. Pharmacol.
, vol.568
, pp. 242-247
-
-
Gojo, A.1
Utsunomiya, K.2
Taniguchi, K.3
Yokota, T.4
Ishizawa, S.5
Kanazawa, Y.6
Kurata, H.7
Tajima, N.8
-
92
-
-
17444374941
-
Long term Rho-kinase inhibition ameliorates endothelial dysfunction in LDL-Receptor deficient mice
-
Steioff, K., Rutten, H., Busch, A. E., Plettenburg, O., Ivashchenko, Y., and Lohn, M. (2005) Long term Rho-kinase inhibition ameliorates endothelial dysfunction in LDL-Receptor deficient mice. Eur. J. Pharmacol. 512, 247-249.
-
(2005)
Eur. J. Pharmacol.
, vol.512
, pp. 247-249
-
-
Steioff, K.1
Rutten, H.2
Busch, A.E.3
Plettenburg, O.4
Ivashchenko, Y.5
Lohn, M.6
-
93
-
-
44849087809
-
Transforming growth factor- beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independen,t Rac1/Cdc42-dependent mechanism: Statins with forskolin block TGFbeta1-induced CCN2/CTGF expression
-
Black, S. A., Jr., and Trackman, P. C. (2008) Transforming growth factor- beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGFbeta1-induced CCN2/CTGF expression. J. Biol. Chem. 283, 10835-10847.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 10835-10847
-
-
Black Jr., S.A.1
Trackman, P.C.2
-
94
-
-
38849155113
-
The small GTPase Rac-1 is a regulator of mesangial cell morphology and thrombospondin-1 expression
-
Giehl, K., Graness, A., and Goppelt-Struebe, M. (2008) The small GTPase Rac-1 is a regulator of mesangial cell morphology and thrombospondin- 1 expression. Am. J. Physiol. Renal. Physiol. 294, F407-413.
-
(2008)
Am. J. Physiol. Renal. Physiol.
, vol.294
-
-
Giehl, K.1
Graness, A.2
Goppelt-Struebe, M.3
-
95
-
-
56349143203
-
Connective tissue growth factor (CTGF) and cancer progression
-
Chu, C. Y., Chang, C. C., Prakash, E., and Kuo, M. L. Connective tissue growth factor (CTGF) and cancer progression. J. Biomed. Sci. 15, 675-685.
-
J. Biomed. Sci.
, vol.15
, pp. 675-685
-
-
Chu, C.Y.1
Chang, C.C.2
Prakash, E.3
Kuo, M.L.4
-
96
-
-
43049105333
-
Demethylation of (Cytosine-5-C-methyl) DNA and regulation of transcription in the epigenetic pathways of cancer development
-
Patra, S. K., Patra, A., Rizzi, F., Ghosh, T. C., and Bettuzzi, S. (2008) Demethylation of (Cytosine-5-C-methyl) DNA and regulation of transcription in the epigenetic pathways of cancer development. Cancer Metastasis Rev. 27, 315-334.
-
(2008)
Cancer Metastasis Rev.
, vol.27
, pp. 315-334
-
-
Patra, S.K.1
Patra, A.2
Rizzi, F.3
Ghosh, T.C.4
Bettuzzi, S.5
-
97
-
-
34547631272
-
Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer
-
Kikuchi, R., Tsuda, H., Kanai, Y., Kasamatsu, T., Sengoku, K., Hirohashi, S., Inazawa, J., and Imoto, I. (2007) Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer. Cancer Res. 67, 7095-7105.
-
(2007)
Cancer Res.
, vol.67
, pp. 7095-7105
-
-
Kikuchi, R.1
Tsuda, H.2
Kanai, Y.3
Kasamatsu, T.4
Sengoku, K.5
Hirohashi, S.6
Inazawa, J.7
Imoto, I.8
-
98
-
-
21144431660
-
Identification and investigation of methylated genes in hepatoma
-
Chiba, T., Yokosuka, O., Fukai, K., Hirasawa, Y., Tada, M., Mikata, R., Imazeki, F., Taniguchi, H., Iwama, A., Miyazaki, M., Ochiai, T., and Saisho, H. (2005) Identification and investigation of methylated genes in hepatoma. Eur. J. Cancer 41, 1185-1194.
-
(2005)
Eur. J. Cancer
, vol.41
, pp. 1185-1194
-
-
Chiba, T.1
Yokosuka, O.2
Fukai, K.3
Hirasawa, Y.4
Tada, M.5
Mikata, R.6
Imazeki, F.7
Taniguchi, H.8
Iwama, A.9
Miyazaki, M.10
Ochiai, T.11
Saisho, H.12
-
99
-
-
33646894314
-
Sequential gene expression changes in cancer cell lines after treatment with the demethylation agent 5-Aza-20-deoxycytidine
-
Arai, M., Yokosuka, O., Hirasawa, Y., Fukai, K., Chiba, T., Imazeki, F., Kanda, T., Yatomi, M., Takiguchi, Y., Seki, N., Saisho, H., and Ochiai, T. (2006) Sequential gene expression changes in cancer cell lines after treatment with the demethylation agent 5-Aza-20-deoxycytidine. Cancer 106, 2514-2525.
-
(2006)
Cancer
, vol.106
, pp. 2514-2525
-
-
Arai, M.1
Yokosuka, O.2
Hirasawa, Y.3
Fukai, K.4
Chiba, T.5
Imazeki, F.6
Kanda, T.7
Yatomi, M.8
Takiguchi, Y.9
Seki, N.10
Saisho, H.11
Ochiai, T.12
-
100
-
-
38549126847
-
Functional epigenomics approach to identify methylated candidate tumour suppressor genes in renal cell carcinoma
-
Morris, M. R., Gentle, D., Abdulrahman, M., Clarke, N., Brown, M., Kishida, T., Yao, M., Teh, B. T., Latif, F., and Maher, E. R. (2008) Functional epigenomics approach to identify methylated candidate tumour suppressor genes in renal cell carcinoma. Br. J. Cancer 98, 496-501.
-
(2008)
Br. J. Cancer
, vol.98
, pp. 496-501
-
-
Morris, M.R.1
Gentle, D.2
Abdulrahman, M.3
Clarke, N.4
Brown, M.5
Kishida, T.6
Yao, M.7
Teh, B.T.8
Latif, F.9
Maher, E.R.10
-
101
-
-
26844509641
-
Dynamic chromatin: Concerted nucleosome remodelling and acetylation
-
Eberharter, A., Ferreira, R., and Becker, P. (2005) Dynamic chromatin: concerted nucleosome remodelling and acetylation. Biol. Chem. 386, 745-751.
-
(2005)
Biol. Chem.
, vol.386
, pp. 745-751
-
-
Eberharter, A.1
Ferreira, R.2
Becker, P.3
-
102
-
-
13844309711
-
Clinical development of histone deacetylase inhibitors as anticancer agents
-
Drummond, D. C., Noble, C. O., Kirpotin, D. B., Guo, Z., Scott, G. K., and Benz, C. C. (2005) Clinical development of histone deacetylase inhibitors as anticancer agents. Ann. Rev. Pharmacol. Toxicol. 45, 495-528.
-
(2005)
Ann. Rev. Pharmacol. Toxicol.
, vol.45
, pp. 495-528
-
-
Drummond, D.C.1
Noble, C.O.2
Kirpotin, D.B.3
Guo, Z.4
Scott, G.K.5
Benz, C.C.6
-
103
-
-
34547549214
-
Epigenetic therapy in cancer: Molecular background and clinical development of histone deacetylase and DNA methyltransferase inhibitors
-
Schneider-Stock, R., and Ocker, M. (2007) Epigenetic therapy in cancer: molecular background and clinical development of histone deacetylase and DNA methyltransferase inhibitors. IDrugs 10, 557-561.
-
(2007)
IDrugs
, vol.10
, pp. 557-561
-
-
Schneider-Stock, R.1
Ocker, M.2
-
104
-
-
24944496184
-
Role of histone and transcription factor acetylation in diabetes pathogenesis
-
Gray, S. G., De Meyts, P. (2005) Role of histone and transcription factor acetylation in diabetes pathogenesis. Diabetes Metab. Res. Rev. 21, 416-433.
-
(2005)
Diabetes Metab. Res. Rev.
, vol.21
, pp. 416-433
-
-
Gray, S.G.1
De Meyts, P.2
-
105
-
-
33644861578
-
Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding
-
Kee, H. J., Sohn, I. S., Nam, K. I., Park, J. E., Qian, Y. R., Yin, Z., Ahn, Y., Jeong, M. H., Bang, Y. J., Kim, N., Kim, J. K., Kim, K. K., Epstein, J. A., and Kook, H. (2006) Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding. Circulation 113, 51-59.
-
(2006)
Circulation
, vol.113
, pp. 51-59
-
-
Kee, H.J.1
Sohn, I.S.2
Nam, K.I.3
Park, J.E.4
Qian, Y.R.5
Yin, Z.6
Ahn, Y.7
Jeong, M.H.8
Bang, Y.J.9
Kim, N.10
Kim, J.K.11
Kim, K.K.12
Epstein, J.A.13
Kook, H.14
-
106
-
-
34547886153
-
Inhibition of histone deacetylase on ventricular remodeling in infarcted rats
-
Lee, T. M., Lin, M. S., and Chang, N. C. (2007) Inhibition of histone deacetylase on ventricular remodeling in infarcted rats. Am. J. Physiol. Heart. Circ. Physiol. 293, H968-977.
-
(2007)
Am. J. Physiol. Heart. Circ. Physiol.
, vol.293
-
-
Lee, T.M.1
Lin, M.S.2
Chang, N.C.3
-
107
-
-
4344639284
-
Cell Growth Inhibition and gene expression induced by the histone deacetylase inhibitor, Trichostatin, A., on Human Hepatoma Cells
-
Chiba, T., Yokosuka, O., Fukai, K., Kojima, H., Tada, M., Arai, M., Imazeki, F., and Saisho, H. (2004) Cell Growth Inhibition and Gene Expression Induced by the Histone Deacetylase Inhibitor, Trichostatin, A., on Human Hepatoma Cells. Oncology 66, 481-491.
-
(2004)
Oncology
, vol.66
, pp. 481-491
-
-
Chiba, T.1
Yokosuka, O.2
Fukai, K.3
Kojima, H.4
Tada, M.5
Arai, M.6
Imazeki, F.7
Saisho, H.8
-
108
-
-
1842830815
-
Microarray profiling of the effects of histone deacetylase inhibitors on gene expression in cancer cell lines
-
Gray, S. G., Qian, C. N., Furge, K., Guo, X., and Teh, B. T. (2004) Microarray profiling of the effects of histone deacetylase inhibitors on gene expression in cancer cell lines. Int. J. Oncol. 24, 773-795.
-
(2004)
Int. J. Oncol.
, vol.24
, pp. 773-795
-
-
Gray, S.G.1
Qian, C.N.2
Furge, K.3
Guo, X.4
Teh, B.T.5
-
109
-
-
67349235683
-
Differential Regulation of Connective Tissue Growth Factor in Renal Cells by Histone Deacetylase Inhibitors
-
10.1111/j.1582-4934.2008.00674.x
-
Komorowsky, C., Ocker, M., and Goppelt-Struebe, M. Differential Regulation of Connective Tissue Growth Factor in Renal Cells by Histone Deacetylase Inhibitors. J. Cell. Mol. Med. 10.1111/j.1582-4934.2008.00674.x.
-
J. Cell. Mol. Med.
-
-
Komorowsky, C.1
Ocker, M.2
Goppelt-Struebe, M.3
-
110
-
-
0032873465
-
Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: Down-regulation by cAMP
-
Duncan, M. R., Frazier, K. S., Abramson, S., Williams, S., Klapper, H., Huang, X., and Grotendorst, G. R. (1999) Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP. FASEB J. 13, 1774-1786.
-
(1999)
FASEB J.
, vol.13
, pp. 1774-1786
-
-
Duncan, M.R.1
Frazier, K.S.2
Abramson, S.3
Williams, S.4
Klapper, H.5
Huang, X.6
Grotendorst, G.R.7
-
111
-
-
0034953832
-
Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients
-
Stratton, R., Shiwen, X., Martini, G., Holmes, A., Leask, A., Haberberger, T., Martin, G. R., Black, C. M., and Abraham, D. (2001) Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients. J. Clin. Invest. 108, 241-250.
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 241-250
-
-
Stratton, R.1
Shiwen, X.2
Martini, G.3
Holmes, A.4
Leask, A.5
Haberberger, T.6
Martin, G.R.7
Black, C.M.8
Abraham, D.9
-
112
-
-
53249092406
-
Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways
-
Gressner, O. A., Lahme, B., Rehbein, K., Siluschek, M., Weiskirchen, R., and Gressner, A. M. (2008) Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways. J. Hepatol. 49, 758-767.
-
(2008)
J. Hepatol.
, vol.49
, pp. 758-767
-
-
Gressner, O.A.1
Lahme, B.2
Rehbein, K.3
Siluschek, M.4
Weiskirchen, R.5
Gressner, A.M.6
|