The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats

European Journal of Pharmacology

Volumn 568, Issue 1-3, 2007, Pages 242-247

  Gojo, Atsushi ^a   Utsunomiya, Kazunori ^a   Taniguchi, Kanta ^a   Yokota, Tamotsu ^a   Ishizawa, Shoh ^a   Kanazawa, Yasushi ^a   Kurata, Hideaki ^a   Tajima, Naoko ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Diabetes; Fasudil; NAD(P)H oxidase; Nephropathy; Rho; Rho kinase; Statin; TGF

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ALBUMIN; CONNECTIVE TISSUE GROWTH FACTOR; FASUDIL; FLUINDOSTATIN; GENE PRODUCT; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MESSENGER RNA; PROTEIN NOX4; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RHO FACTOR; RHO KINASE; RHO KINASE INHIBITOR; STATINE DERIVATIVE; STREPTOZOCIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ENZYME ACTIVITY; ENZYME REPRESSION; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; KIDNEY CORTEX; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STREPTOZOCIN DIABETES; TREATMENT OUTCOME; UPREGULATION; URINARY EXCRETION;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ALBUMINURIA; ANIMALS; BLOOD GLUCOSE; BLOOD PRESSURE; CHOLESTEROL; DEOXYGUANOSINE; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; FATTY ACIDS, MONOUNSATURATED; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMMEDIATE-EARLY PROTEINS; INDOLES; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY CORTEX; MALE; NADPH OXIDASE; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; STREPTOZOCIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 34250797380     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.04.011     Document Type: Article

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