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The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double TSP1/TSP2-null mice
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Bradshaw A.D., Sage E.H. SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury. J Clin Invest. 107:2001;1049-1054. This review is current and emphasizes findings with SPARC-null mice.
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28
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Rempel S.A., Golembieski W.A., Fisher J.L., Maile M., Nakeff A. SPARC modulates cell growth, attachment and migration of U87 glioma cells on brain extracellular matrix proteins. J Neurooncol. 53:2001;149-160. This paper utilizes inducible expression of SPARC in glioma cell lines to show that SPARC affects tumor-cell adhesion and proliferation in a substrate-specific manner.
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An excellent review of current literature, with novel ideas on integrins and growth factor co-signaling.
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Danen E.J., Yamada K.M. Fibronectin, integrins, and growth control. J Cell Physiol. 189:2001;1-13. An excellent review of current literature, with novel ideas on integrins and growth factor co-signaling.
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The authors identify a mechanism for cataract formation in SPARC-null mice: a basement membrane (lens capsule) that is more permeable to water and small molecules.
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A well written update on pathways and signaling networks involving integrins.
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Schwartz M.A. Integrin signaling revisited. Trends Cell Biol. 11:2001;466-470. A well written update on pathways and signaling networks involving integrins.
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Yiu G.K., Chan W.Y., Ng S.W., Chan P.S., Cheung K.K., Berkowitz R.S., Mok S.C. SPARC (secreted protein acidic and rich in cysteine) induces apoptosis in ovarian cancer cells. Am J Pathol. 159:2001;609-622. This paper is the first indication that SPARC could influence tumor growth by its induction of apoptosis.
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Am J Pathol
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A current review on the biology of osteopontin, with emphasis on inflammation and apoptosis.
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