Identification and investigation of methylated genes in hepatoma

European Journal of Cancer

Volumn 41, Issue 8, 2005, Pages 1185-1194

  Chiba, Tetsuhiro ^a   Yokosuka, Osamu ^a   Fukai, Kenichi ^a   Hirasawa, Yuichi ^a   Tada, Motohisa ^a   Mikata, Rintaro ^a   Imazeki, Fumio ^a   Taniguchi, Hideki ^b   Iwama, Atsushi ^a   Miyazaki, Masaru ^a   Ochiai, Takenori ^a   Saisho, Hiromitsu ^a  

^a CHIBA UNIVERSITY   (Japan)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

5 aza 2 deoxycytidine; cDNA microarray; DNA methylation; Epigenetics; Hepatoma; Histone acetylation

Indexed keywords

BISULFITE; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; SOMATOMEDIN BINDING PROTEIN; UVOMORULIN;

ACETYLATION; ADULT; AGED; ARTICLE; CANCER PATIENT; CELL LINE; CHROMATIN; CLINICAL ARTICLE; DEACETYLATION; DISEASE COURSE; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE SEQUENCE; HUMAN; HUMAN TISSUE; IMMUNOPRECIPITATION; LIVER CELL CARCINOMA; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; COLLAGEN TYPE I; CPG ISLANDS; DNA METHYLATION; DNA, COMPLEMENTARY; FEMALE; FIBRONECTINS; HISTONES; HUMANS; IMMEDIATE-EARLY PROTEINS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 2; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER NEOPLASMS; MALE; MICROARRAY ANALYSIS; MIDDLE AGED; ONCOGENES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 21144431660     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2005.02.014     Document Type: Article

References (34)

1. P.A. Jones, and D. Takai The role of DNA methylation in mammalian epigenetics Science 293 2001 1068 1070
2. M. Grunstein Histone acetylation in chromatin structure and transcription Nature 389 1997 349 352
3. F. Larsen, G. Gundersen, and R. Lopez CpG islands as gene markers in the human genome Genomics 13 1992 1095 1107
4. A.D. Riggs, and G.P. Pfeifer X-chromosome inactivation and cell memory Trends Genet 8 1992 169 174
5. A. Razin, and H. Cedar DNA methylation and genomic imprinting Cell 77 1994 473 476
6. A. Merlo, J.G. Herman, and L. Mao 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers Nat Med 1 1995 686 692
7. M. Esteller CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future Oncogene 21 2002 5427 5440
8. C. Liao, M. Zhao, and H. Song Identification of the gene for a novel liver-related putative tumor suppressor at a high-frequency loss of heterozygosity region of chromosome 8p23 in human hepatocellular carcinoma Hepatology 32 2000 721 727
9. Y. Murakami, K. Hayashi, and T. Sekiya Aberration of the tumor suppressor p53 and retinoblastome in human hepatocellular carcinomas Cancer Res 51 1991 5520 5525
10. Y. Kondo, Y. Kanai, and M. Sakamoto Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis - A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma Hepatology 32 2000 970 978
11. Y. Kanai, S. Ushijima, and H. Tsuda Aberrant DNA methylation precedes loss of heterozygosity on chromosome 16 in chronic hepatitis and liver cirrhosis Cancer Lett 148 2000 73 80
12. M. Roncalli, P. Bianchi, and B. Bruni Methylation framework of cell cycle gene inhibitors in cirrhosis and associated hepatocellular carcinoma Hepatology 36 2002 427 432
13. B. Yang, M. Guo, and J.G. Herman Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma Am J Pathol 163 2003 1101 1107
14. N. Iwata, H. Yamamoto, and S. Sasaki Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3 sigma gene in human hepatocellular carcinoma Oncogene 19 2000 5298 5302
15. K. Fukai, O. Yokosuka, and T. Chiba Hepatocyte growth factor activator inhibitor 2/placental bikunin (HAI-2/PB) gene is frequently hypermethylated in human hepatocellular carcinoma Cancer Res 63 2003 8674 8679
16. M. Gardiner-Garden, and M. Frommer CpG islands in vertebrate genomes J Mol Biol 196 1987 261 282
17. T. Chiba, O. Yokosuka, and K. Fukai Cell growth inhibition and gene expression induced by the histone deacetylase inhibitor, trichostatin A, on human hepatoma cells Oncology 66 2004 481 491
18. T. Chiba, O. Yokosuka, and M. Arai Identification of genes up-regulated by histone deacetylase inhibition with cDNA microarray and exploration of epigenetic alterations on hepatoma cells J Hepatol 41 2004 436 445
19. J.G. Herman, J.R. Graff, and S. Myohanen Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands Proc Natl Acad Sci USA 93 1996 9821 9826
20. G.C. Prendergast, and E.B. Ziff Methylation-sensitive sequence-specific DNA binding by the c-Myc basic region Science 251 1991 186 189
21. S.J. Clark, J. Harrison, and P.L. Molloy Sp1 binding is inhibited by (m)Cp (m)CpG methylation Gene 195 1997 67 71
22. P.A. Wade Methyl CpG-binding proteins and transcriptional repression Bioessays 23 2001 1131 1137
23. E. Ballestar, and M. Esteller The impact of chromatin in human cancer: linking DNA methylation to gene silencing Carcinogenesis 23 2002 1103 1109
24. C.J. Van Groeningen, A. Leyva, and A.M. O'Brien Phase I and pharmacokinetic study of 5-aza-2′-deoxycytidine (NSC 127716) in cancer patients Cancer Res 46 1986 4831 4836
25. R. Juttermann, E. Li, and R. Jaenisch Toxicity of 5-aza-2′- deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation Proc Natl Acad Sci USA 91 1994 11797 11801
26. H. Suzuki, E. Gabrielson, and W. Chen A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer Nat Genet 31 2002 141 149
27. T. Niki, K. Rombouts, and P. De Bleser A histone deacetylase inhibitor, trichostatin A, suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture Hepatology 29 1999 858 867
28. P.K. Sengupta, E.M. Smith, and K. Kim DNA hypermethylation near the transcription start site of collagen alpha2 (I) gene occurs in both cancer cell lines and primary colorectal cancers Cancer Res 63 2003 1789 1797
29. A. Grimberg, and P. Cohen Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis J Cell Physiol 183 2000 1 9
30. Z.J. Zeng, L.Y. Yang, and X. Ding Expressions of cysteine-rich61, connective tissue growth factor and Nov genes in hepatocellular carcinoma and their clinical significance World J Gastroenterol 10 2004 3414 3418
31. M. Bittner, P. Meltzer, and Y. Chen Molecular classification of cutaneous malignant melanoma by gene expression profiling Nature 406 2000 536 540
32. E.E. Cameron, K.E. Bachman, and S. Myohanen Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer Nat Genet 21 1991 103 107
33. K.M. Stimson, and P.M. Vertino Methylation-mediated silencing of TMS1/ASC is accompanied by histone hypoacetylation and CpG island-localized changes in chromatin architecture J Biol Chem 277 2002 4951 4958
34. A. Miyoshi, Y. Kitajima, and K. Sumi Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells Br J Cancer 90 2004 1265 1273