The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFβ1 responses in human proximal-tubule epithelial cells

Biochemical Journal

Volumn 393, Issue 2, 2006, Pages 601-607

  Phanish, Mysore K ^a   Wahab, Nadia A ^b   Colville Nash, Paul ^a   Hendry, Bruce M ^c   Dockrell, Mark E C ^a  

^a ST HELIER HOSPITAL   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Connective tissue growth factor; CTGF; Epithelial mesenchymal transdifferentiation (EMT); Sma and Mad protein 2 (Smad2); Smad3; Transforming growth factor 1 (TGF 1); Tubulo interstitial fibrosis

Indexed keywords

BIOLOGICAL ORGANS; CELLS; DISEASES; FIBROUS MEMBRANES; IMMUNOLOGY; MUSCLE;

CONNECTIVE-TISSUE GROWTH FACTOR; EPITHELIAL-MESENCHYMAL TRANSDIFFERENTIATION (EMT); SMA AND MAD PROTEIN 2 (SMAD2); SMAD3; TUBULO-INTERSTITIAL FIBROSIS;

EPITAXIAL GROWTH;

ALPHA SMOOTH MUSCLE ACTIN; CONNECTIVE TISSUE GROWTH FACTOR; GELATINASE A; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UVOMORULIN;

ARTICLE; CELL DIFFERENTIATION; CHRONIC KIDNEY DISEASE; EPITHELIUM CELL; HUMAN; HUMAN CELL; INTERSTITIAL NEPHRITIS; KIDNEY FUNCTION; KIDNEY PROXIMAL TUBULE; MESENCHYME CELL; MYOFIBROBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; RNA INTERFERENCE;

BIOLOGICAL MARKERS; CELL LINE; DOWN-REGULATION; EPITHELIAL CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY TUBULES, PROXIMAL; RNA INTERFERENCE; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 30744478450     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20051106     Document Type: Article

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