The effects of chloroquine and verapamil on digestive vacuolar pH of P. falciparum either sensitive or resistant to chloroquine

Molecular and Biochemical Parasitology

Volumn 110, Issue 1, 2000, Pages 125-134

  Ursos, Lyann May B ^a   Dzekunov, Sergey M ^a   Roepe, Paul D ^a  

^a GEORGETOWN UNIVERSITY   (United States)

Author keywords

Antimalarial drug resistance; Chemoreversal; Single cell photometry; Vacuolar pH

Indexed keywords

BUFFER; CHLOROQUINE; VERAPAMIL;

ANTIBIOTIC RESISTANCE; ARTICLE; CELL PH; CELL VACUOLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EXPOSURE; ERYTHROCYTE; FLUORESCENCE; HUMAN; HUMAN CELL; NONHUMAN; PHOTOMETRY; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; STRAIN DIFFERENCE;

ACRIDINE ORANGE; ANIMALS; ANTIMALARIALS; CALCIUM CHANNEL BLOCKERS; CHLOROQUINE; HUMANS; HYDROGEN-ION CONCENTRATION; MICROSCOPY, FLUORESCENCE; PARASITIC SENSITIVITY TESTS; PHOTOMETRY; PLASMODIUM FALCIPARUM; VACUOLES; VERAPAMIL;

PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0033824184     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(00)00262-0     Document Type: Article

References (20)

1. Robinson L.J., Roberts W.K., Ling T.T., Lamming D., Sternberg S.S., Roepe P.D. Human MDR 1 protein delays the apoptotic cascade in Chinese hamster ovary fibroblasts. Biochemistry. 36:1997;11169-11178.
2. Dzekunov SM, Ursos LMB, Roepe PD. Digestive vacuolar pH of intact intraerythrocytic P. falciparum either sensitive or resistant to chloroquine. Mol. Biochem. Parasitol. 2000; previous paper, this issue.
3. Krogstad D.J., Schlesinger P.H., Gluzman L.Y. Antimalarials increase vesicle pH in Plasmodium falciparum. J. Cell Biol. 101:1985;2302-2309.
4. Krogstad D.J., Schlesinger P.H. The basis of antimalarial action: non-weak base effects of chloroquine on acid vesicle pH. Am. J. Trop. Med. Hyg. 36:1987;213-230.
5. Ginsburg H., Nissani E., Krugliak M. Alkalinization of the food vacuole of malaria parasites by quinoline drugs and alkylamines is not correlated with their antimalarial activity. Biochem. Pharmacol. 38:1989;2645-2654.
6. Krogstad D.J., Gluzman L.Y., Kyle D.E., Oduola A.M.J., Martin S.K., Milhous W.K., et al. Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance. Science. 238:1987;1283-1285.
7. Martiney J.A., Cerami A., Slater A.F.G. Verapamil reversal of chloroquine resistance in the malaria parasite Plasmodium falciparum is specific for resistant parasites and independent of the weak base effect. J. Biol. Chem. 270:1995;22393-22398.
8. Hoffman M.M., Wei L.Y., Roepe P.D. Are altered pHi and membrane potential in hu MDR 1 transfectants sufficient to cause MDR protein-mediated multidrug resistance? J. Gen. Physiol. 108:1996;295-313.
9. - exchange in Chinese hamster ovary cells. Biochemistry. 33:1994;7239-7249.
10. Diribe C.O., Warhurst D.C. A study of the uptake of chloroquine in malaria infected erythrocytes. Biochem. Pharmacol. 34:1985;3019-3027.
11. Bray P.G., Hawley S.R., Ward S.A. 4-Aminoquinoline resistance of Plasmodium falciparum: insights from the study of amodiaquine uptake. Mol. Pharmacol. 50:1996;1551-1558.
12. Sullivan D.J., Gluzman L.Y., Russell D.G., Goldberg D.E. On the molecular mechanism of chloroquine’s antimalarial action. Proc. Natl. Acad. Sci. 93:1996;11865-11870.
13. Dorn A., Vippagunta S.K., Matile H., Jaquet C., Vennerstrom L.L., Ridley R.G. An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials. Biochem. Pharmacol. 55:1998;727-736.
14. Gottesman M.M., Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Am. Rev. Biochem. 62:1993;385-427.
15. Bray P.G., Ward S.A. A comparison of the phenomenology and genetics of multidrug resistance in cancer cells and quinoline resistance in Plasmodium falciparum. Pharmacol. Ther. 77:1998;1-28.
16. Wadkins R.M., Roepe P.D. The biophysics of multidrug resistance. Int. Rev. Cytol. 171:1997;121-165.
17. Bray P.G., Mungthin M., Ridley R.G., Ward S.A. Access to hematin: the basis of chloroquine resistance. Mol. Pharmacol. 54:1998;170-179.
18. Bornmann W.G., Roepe P.D. Analysis of drug transport kinetics in multidrug-resistant cells using a novel coumarin-vinblastine compound. Biochemistry. 33:1994;12665-12675.
19. Martiney J.A., Roepe P.D. Are ion exchange processes central to understanding drug-resistance phenomena? Trends Pharmacol. Sci. 20:1999;62-65.
20. Roepe P.D. Analysis of the steady state and initial rate of doxorubicin efflux from a series of MDR cells expressing different levels of P-glycoprotein. Biochemistry. 31:1992;12555-12564.