Polymorphisms in the Plasmodium falciparum pfcrt and pfmdr-1 genes and clinical response to chloroquine in Kampala, Uganda

Journal of Infectious Diseases

Volumn 183, Issue 9, 2001, Pages 1417-1420

  Dorsey, Grant ^a   Kamya, Moses R ^b   Singh, Ajay ^a   Rosenthal, Philip J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MAKERERE UNIVERSITY   (Uganda)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE;

ADULT; AMINO ACID SEQUENCE; ARTICLE; CHILD; CONTROLLED STUDY; GENETIC POLYMORPHISM; HUMAN; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; NUCLEOTIDE SEQUENCE; PLASMODIUM FALCIPARUM; POINT MUTATION; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; UGANDA;

ANIMALS; ANTIMALARIALS; ATP-BINDING CASSETTE TRANSPORTERS; CASE-CONTROL STUDIES; CHILD, PRESCHOOL; CHLOROQUINE; DRUG RESISTANCE; FEMALE; GENES, PROTOZOAN; HUMANS; INFANT; MALARIA, FALCIPARUM; MALE; MEMBRANE PROTEINS; PLASMODIUM FALCIPARUM; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PROTOZOAN PROTEINS; TREATMENT OUTCOME; UGANDA;

EID: 0035341936     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/319865     Document Type: Article

References (13)

1. Making malaria-treatment policy in the face of drug resistance
2. Mechanisms of quinoline resistance
3. Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum
4. Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum
5. Complex polymorphisms in an approximately kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa
6. Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7
7. Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance
8. A molecular marker for chloroquine-resistant falciparum malaria
9. Predictors of chloroquine treatment failure in children and adults with falciparum malaria in Kampala, Uganda
10. Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: Polymerase chain reaction methods for surveillance in Africa
11. Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum
12. The comparative efficacy of chloroquine and sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in Kampala, Uganda
13. 4-Aminoquinolines: Past, present, and future: A chemical perspective