pfcrt polymorphism and chloroquine resistance in Plasmodium falciparum strains isolated in Cambodia

Antimicrobial Agents and Chemotherapy

Volumn 47, Issue 1, 2003, Pages 87-94

  Lim, Pharath ^a   Chy, Sophy ^a   Ariey, Frédéric ^e   Incardona, Sandra ^a   Chim, Pektra ^a   Sem, Rithy ^a,d   Denis, Mey Bouth ^b,d   Hewitt, Sean ^b   Hoyer, Stefan ^c   Socheat, Doung ^d   Merecreau Puijalon, Odile ^e   Fandeur, Thierry ^a  

^a INSTITUT PASTEUR DU CAMBODGE   (Cambodia)

^b Eur Comn KHM Malaria Contr Prog   (Cambodia)

^c WHO   (Cambodia)

^d National Malaria Center   (Cambodia)

^e INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; GENE PRODUCT; PROTEIN PFCRT; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CAMBODIA; CODON; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HAPLOTYPE; NONHUMAN; PARASITE ISOLATION; PLASMODIUM FALCIPARUM; POINT MUTATION; PRIORITY JOURNAL;

ANIMALS; BASE SEQUENCE; CAMBODIA; CHLOROQUINE; DRUG RESISTANCE; MEMBRANE PROTEINS; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PROTOZOAN PROTEINS;

EID: 12244269105     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.47.1.87-94.2003     Document Type: Article

References (31)

1. Anderson, T. J. C., B. Haubold, J. T. Williams, J. G. Estrada-Franco, L. Richardson, R. Mollinedo, M. Bockarie, J. Mokili, S. Mharakurwa, N. French, J. Whitworth, I. D. Velez, A. H. Brockman, F. Nosten, M. U. Ferreira, and K. Day. 2000. Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum. Mol. Biol. Evol. 17:1467-1482.
2. Basko, L. K., P. E. de Pécoulas, J. Lebras, and M. W. Wilson. 1996. Plasmodium falciparum: characterization of multidrug-resistant Cambodian isolates. Exp. Parasitol 82:97-103.
3. Basco, L. K., and P. Ringwald. 1997. Pfmdr1 gene mutation and clinical response to chloroquine in Yaoundé, Cameroon. Trans. R. Soc. Trop. Med. Hyg. 91:210-211.
4. Basco, L. K., and P. Ringwald. 2001. Analysis of the key pfcrt point mutation and in vitro and in vivo response to chloroquine in Yaoundé, Cameroon. J. Infect. Dis. 183:1828-1831.
5. Contamin, H., T. Fandeur, S. Bonnefoy, F. Skoury, F. Ntoumi, and O. Mercereau-Puijalon. 1995. PCR typing of field isolates of Plasmodium falciparum. J. Clin. Microbiol. 33:944-951.
6. Denis, M. B. 1986. Etude préliminaire in vitro de la sensibilité de P. falciparum à la chloroquine, la méfloquine et à la quinine en 1985 au Kampuchéa. Bull. Soc. Path. Ex. 79:360-367.
7. Denis, M. B. 1999. Evolution de la Chimiorésistance de Plasmodium falciparum aux traitements antipaludiques au Cambodge (1991-1997). Doctoral thesis 449 in medicine. Université des Sciences de la Santé, Phnom Penh, Cambodia.
8. Desjardins, R. E., C. J. Canfield, J. D. Haynes, and J. D. Chulay. 1979. Quantitative assessment of antimalarial activity in vitro by an automated microdilution technique. Antimicrob. Agents Chemother. 16:710-718.
9. Djimdé, A., O. K. Doumbo, J. F. Cortese, K. Kayento, S. Doumbo, Y. Diourté, A. Dicko, X.-Z. Su, T. Nomura, D. A. Fidock, T. E. Wellems, and C. V. Plowe. 2001. A molecular marker for chloroquine-resistant falciparum malaria. N. Engl. J. Med. 3344:257-263.
10. Durand, R., S. Jafari, J. Vauzelle, J. F. Delabre, Z. Jesic, and J. Le Bras. 2001. Analysis of pfcrt point mutations and chloroquine susceptibility in isolates of Plasmodium falciparum. Mol. Biochem. Parasitol. 114:95-102.
11. Eyles, D. E., C. C. Hoo, M. C. Warren, and A. A. Sandosham. 1963. Plasmodium falciparum resistant to chloroquine in Cambodia. Am. J. Trop. Med. Hyg. 12:840-843.
12. Fandeur, T., S. Bonnefoy, and O. Mercereau-Puijalon. 1991. In vivo and in vitro derived Palo alto lines of Plasmodium falciparum are genetically unrelated. Mol. Biochem. Parasitol. 47:167-178.
13. Fidock, D. A., T. Nomura, A. K. Talley, R. A. Cooper, S. M. Dzekunov, M. T. Ferdig, L. M. Ursos, A. B. Sidhu, B. Naudé, K. W. Deitsch, X.-Z. Su, J. C. Wootton, P. D. Roepe, and T. E. Wellems. 2000. Mutations in the P. falciparum digestive vacuole transmembrane protein pfcrt and evidence of their role in chloroquine resistance. Mol. Cell 6:861-871.
14. Foote, S. J., D. E. Kyle, R. K. Martin, A. M. J. Oduola, K. Forsyth, D. J. Kemp, and A. F. Cowman. 1990. Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum. Nature 345:255-258.
15. Giboda, M., and M. B. Denis. 1988. Response of Kampuchean strains of Plasmodium falciparum to antimalarials: in vivo assessment of quinine and quinine plus tetracycline; multiple drug resistance in vitro. J. Trop. Med. Hyg. 91:205-211.
16. McCutchean, K. R. G., J. A. Freese, J. A. Frean, B. L. Sharp, and M. B. Markus. 1999. Two mutations in the multidrug-resistance gene homologue of Plasmodium falciparum, pfmdr, are not useful predictors of in vivo or in vitro chloroquine resistance in Southern Africa. Trans. R. Soc. Trop. Med. Hyg. 93:300-302.
17. Meek, S. R., E. B. Doberstyn, B. A. Gauzère, C. Thanapanich, E. Nordlander, and S. Phuphaisan. 1986. Treatment of falciparum malaria with quinine and tetracycline or combined mefloquine/sulfadoxine/pyrimethamine on the Thai-Kampuchean Border. Am. J. Trop. Med. Hyg. 35:246-250.
18. Mehlotra, R. K., H. Fujioka, P. D. Roepe, O. Janneh, L. M. Ursos, V. Jacobs-Lorena, D. T. McNamara, M. J. Bockarie, J. W. Kazura, D. E. Kyle, D. A. Fidock, and P. A. Zimmerman. 2001. Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America. Proc. Natl. Acad. Sci. USA 98:12689-12694.
19. Ministry of Health, National Malaria Control Program. 2000. Treatment guideline for malaria in the Kingdom of Cambodia. National Malaria Center, Phnom Penh, Cambodia.
20. Nomura, T., J. M. R. Carlton, J. K. Baird, H. A. Del Portillo, D. J. Fryauff, D. Rathore, D. A. Fidock, X.-Z. Su, W. Collins, T. F. McCutchan, J. C. Wootton, and T. E. Wellems. 2000. Evidence for different mechanisms of chloroquine resistance in two Plasmodium species that cause malaria. J. Infect. Dis. 183:1653-1661.
21. Pillai, D. R., A.-C. Labbé, V. Yanaviseth, B. Hongvangthong, S. Phomphida, S. Inkathone, K. Zhong, and K. C. Kain. 2001. Plasmodium falciparum malaria in Laos: chloroquine treatment outcome and predictive value of molecular markers. J. Infect. Dis. 183:789-795.
22. Plasai, V., and A. Spelman. 1996. Mefloquine insusceptibility of malaria in Thailand not promoted by nonregulated drug-use. Acta Trop. 60:281-289.
23. Rozendaal, J. 2001. Fake antimalaria drug in Cambodia. Lancet 357:890.
24. Sambrook, J., and D. W. Russel. 2001. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
25. a.Singhasivahon, P. 1999. Mekong malaria. Malaria, multi-drug resistance and economic development in the greater Mekong subregion of Southeast Asia. Southeast Asian J. Trop. Med. Public Health 30(Suppl. 4):1-101.
26. Su, X.-Z., L. S. Kirkman, and T. E. Wellems. 1997. Complex polymorphisms in a ∼330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa. Cell 91:593-603.
27. Viera, P. P., M. Das Craças Alecrim, L. H. P. Da Silva, I. Gonzalez-Jilmenez, and M. G. Zalis. 2001. Analysis of the Pfcrt K76T mutation in Plasmodium falciparum isolates from the Amazon region of Brazil. J. Infect. Dis. 183:1832-1833.
28. Wellems, T., and C. Plowe. 2001. Chloroquine-resistant malaria. J. Infect. Dis. 184:770-776.
29. Wellems, T. E., L. J. Panton, I. Y. Gluzman, and D. E. do Rosario. 1990. Chloroquine resistance is not linked to mdr-like genes in Plasmodium falciparum cross. Nature 345:253-255.
30. World Health Organization. 2000. Report on the informal consultation on monitoring resistance to antimalarial drugs in the Mekong region. World Health Organization, Geneva, Switzerland.
31. Wootton, J. C., X. Feng, M. T. Ferdig, R. A. Cooper, J. Mu, D. I. Baruch, A. J. Magill, and X.-Z. Su. 2002. Widespread use of antimalarial agents can profoundly influence the evolution of the human malaria parasite Plasmodium falciparum. Nature 418:320-323.