High incidence of Notch-1 mutations in adult patients with T-cell acute lymphoblastic leukemia [12]

Leukemia

Volumn 20, Issue 3, 2006, Pages 537-539

  Mansour, M R ^a   Linch, D C ^a   Foroni, L ^a   Goldstone, A H ^a   Gale, R E ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; NOTCH1 RECEPTOR;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AMINO ACID SUBSTITUTION; CANCER REGRESSION; CANCER RELAPSE; CARBOXY TERMINAL SEQUENCE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DENATURING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; DNA SCREENING; DNA SEQUENCE; FEMALE; GENE DELETION; GENE INSERTION; GENE MUTATION; GENE TARGETING; GENETIC HETEROGENEITY; GENETIC VARIABILITY; HUMAN; INCIDENCE; LETTER; MALE; MOLECULAR CLONING; MUTATIONAL ANALYSIS; PATHOGENESIS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; SEQUENCE ANALYSIS; STOP CODON; T CELL LEUKEMIA; TRANSACTIVATION;

EID: 33644523406     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404101     Document Type: Letter

References (7)

1. Pear WS, Aster JC, Scott ML, Hasserjian RP, Soffer B, Sklar J et al. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med 1996; 183: 2283-2291.
2. Ellisen LW, Bird J, West DC, Soreng AL, Reynolds TC, Smith SD et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 1991; 66: 649-661.
3. Weng AP, Ferrando AA, Lee W, Morris JPt, Silverman LB, Sanchez-Irizarry C et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004; 306: 269-271.
4. Pui CH, Evans WE. Acute lymphoblastic leukemia. N Engl J Med 1998; 339: 605-615.
5. Lee SY, Kumano K, Masuda S, Hangaishi A, Takita J, Nakazaki K et al. Mutations of the Notch1 gene in T-cell acute lymphoblastic leukemia: analysis in adults and children. Leukemia 2005; 19: 1841-1843.
6. Sanchez-Irizarry C, Carpenter AC, Weng AP, Pear WS, Aster JC, Blacklow SC. Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats. Mol Cell Biol 2004; 24: 9265-9273.
7. Marshall GM, Kwan E, Haber M, Brisco MJ, Sykes PJ, Morley AA et al. Characterization of clonal immunoglobulin heavy chain and I cell receptor gamma gene rearrangements during progression of childhood acute lymphoblastic leukemia. Leukemia 1995; 9: 1847-1850.