Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition

Nature Cell Biology

Volumn 4, Issue 2, 2002, Pages 111-116

  Okumura, Eiichi ^a   Fukuhara, Takeshi ^a   Yoshida, Hitoshi ^a   Hanada, Shin Ichiro ^a   Kozutsumi, Rie ^a   Mori, Masashi ^a   Tachibana, Kazunori ^a   Kishimoto, Takeo ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN B; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE;

ANIMAL CELL; ARTICLE; ASTERIAS; CELL CYCLE; CELL CYCLE G2 PHASE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EUKARYOTE; FEMALE; MEIOSIS; MITOSIS; NONHUMAN; OOCYTE; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CDC2 PROTEIN KINASE; CYCLIN B; ENZYME ACTIVATION; MEIOSIS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; OOCYTES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; STARFISH;

ANIMALIA; ASTERIAS; ASTERINA; ASTERINA PECTINIFERA; ASTEROIDEA; EUKARYOTA;

EID: 0036174009     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb741     Document Type: Article

References (36)

1. Universal control mechanism regulating onset of M-phase
2. Mitotic kinases as regulators of cell division and its checkpoints
3. Cdc2 regulatory factors
4. Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control
5. Meiotic metaphase arrest in animal oocytes: Its mechanism and biological significance
6. Oocyte maturation in starfish is mediated by the βγ-subunit complex of a G-protein
7. Components of the signaling pathway linking the 1-methyladenine receptor to MPF activation and maturation in starfish oocytes
8. Cell cycle arrest and release in starfish oocytes and eggs
9. Activation of MPF at meiosis reinitiation in starfish oocytes
10. Cellular survival: A play in three Akts
11. The P13K-PDK1 connection: More than just a road to PKB
12. PKB/AKT: Functional insights from genetic models
13. Myt1: A membrane-associated inhibitory kinase that phosphorylates cdc2 on both threonine-14 and tyrosine-15
14. In vivo regulation of cyclin A/Cdc2 and cyclin B/Cdc2 through meiotic and early cleavage cycles in starfish
15. Isolation and identification of meiosis inducing substance in starfish
16. Okadaic acid mimics a nuclear component required for cyclin B-cdc2 kinase microinjection to drive starfish oocytes into M phase
17. Initial triggering of M-phase in starfish oocytes: A possible novel component of maturation-promoting factor besides cdc2 kinase
18. Absence of Weel ensures the meiotic cell cycle in Xenopus oocytes
19. Purification and molecular cloning of plx1, a cdc25-regulatory kinase from Xenopus egg extracts
20. Activated polo-like kinase Plx1 is required at multiple points during mitosis in Xenopus laevis
21. Polo-like kinases: A team that plays throughout mitosis
22. Polo-like kinases: Positive regulators of cell division from start to finish
23. The polo-like kinase Plx1 is required for activation of the phosphatase Cdc25C and cyclin B-Cdc2 in Xenopus oocytes
24. cdc2 inhibitory kinase myt1
25. Cell survival demands some Rsk
26. MAP kinase links the fertilization signal transduction pathway to the G1/S-phase transition in starfish eggs
27. c-Mos forces the mitotic cell cycle to undergo meiosis II to produce haploid gametes
28. Protein kinase B/Akt induces resumption of meiosis in Xenopus oocytes
29. Cip1/WAF1 by Akt-induced phosphorylation in HER2/neu-overexpressing cells
30. Comparison of the specificities of p70 S6 kinase and MAPKAP kinase-1 identifies a relatively specific substrate for p70 S6 kinase: The N-terminal kinase domain of MAPKAP kinase-1 is essential for peptide phosphorylation
31. Dissociation of MAP kinase activation and MPF activation in hormone-stimulated maturation of Xenopus oocytes
32. Rsk
33. Peroxovanadium compounds: A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics
34. Expression cloning of Siamois, a Xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis
35. Microinjection and cytoplasmic transfer in starfish oocytes
36. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates