Nonmonotonic dose-response relationships: Mechanistic basis, kinetic modeling, and implications for risk assessment

Toxicological Sciences

Volumn 77, Issue 1, 2004, Pages 151-157

  Conolly, Rory B ^a   Lutz, Werner K ^b  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Dose response relationship; Hormesis; Mechanisms; Models

Indexed keywords

ADENOSINE RECEPTOR; ADENYLATE CYCLASE; ANDROGEN RECEPTOR; ANDROSTANOLONE; CARCINOGEN; FORMALDEHYDE; HYDROXYFLUTAMIDE; PHENYLISOPROPYLADENOSINE; RECEPTOR SUBTYPE; XENOBIOTIC AGENT;

ARTICLE; CARCINOGENICITY; CELL CYCLE; CELL DIVISION; CELL HYPERPLASIA; CHEMICAL INTERACTION; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA ADDUCT; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; ENZYME ACTIVITY; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; HORMESIS; HUMAN; HUMAN CELL; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; RISK ASSESSMENT; TOXICITY TESTING;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, BIOLOGICAL; RATS; RISK ASSESSMENT; XENOBIOTICS;

EID: 1642504765     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh007     Document Type: Article

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