Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression

Carcinogenesis

Volumn 24, Issue 8, 2003, Pages 1389-1399

  Kinoshita, Anna ^a   Wanibuchi, Hideki ^a   Morimura, Keiichirou ^a   Wei, Min ^a   Shen, Jun ^a   Imaoka, Susumu ^a,b   Funae, Yoshihiko ^a   Fukushima, Shoji ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KWANSEI GAKUIN UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 8 HYDROXYDEOXYGUANOSINE; BIOLOGICAL MARKER; COMPLEMENTARY DNA; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; CYTOCHROME P450 3A2; CYTOCHROME P450 REDUCTASE; DIETHYLNITROSAMINE; DNA; DNA GLYCOSYLTRANSFERASE; GLUTAMATE DECARBOXYLASE; GLUTATHIONE TRANSFERASE; GUANINE DERIVATIVE; GUANINE NUCLEOTIDE BINDING PROTEIN; HYDROXYL RADICAL; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHENOBARBITAL; PHOSPHATASE; PROTEIN KINASE; PROTEIN SUBUNIT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SYNAPTOPHYSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; CANCER INHIBITION; CELL NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; DIETARY INTAKE; DNA DAMAGE; DNA MICROARRAY; DOSE RESPONSE; DRUG MECHANISM; DRUG MEGADOSE; ENZYME ACTIVITY; GENE EXPRESSION; GENE LOCUS; HORMESIS; LIVER CARCINOGENESIS; LIVER PARENCHYMA; LIVER TUMOR; LOW DRUG DOSE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RAT STRAIN; REVIEW; SYNTHESIS;

ALKYLATING AGENTS; ANIMALS; APOPTOSIS; CELL DIVISION; CYTOCHROME P-450 ENZYME SYSTEM; DEOXYGUANOSINE; DIETHYLNITROSAMINE; DNA DAMAGE; DNA, NEOPLASM; DNA-FORMAMIDOPYRIMIDINE GLYCOSYLASE; ELECTRON SPIN RESONANCE SPECTROSCOPY; EXCITATORY AMINO ACID ANTAGONISTS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTAMATE DECARBOXYLASE; GLUTATHIONE TRANSFERASE; LIVER NEOPLASMS, EXPERIMENTAL; MALE; N-GLYCOSYL HYDROLASES; OXIDATIVE STRESS; PHENOBARBITAL; RATS; RATS, INBRED F344; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0042889217     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/bgg079     Document Type: Review

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