Oltipraz is a bifunctional inducer activating both phase I and phase II drug-metabolizing enzymes via the xenobiotic responsive element

Molecular Pharmacology

Volumn 64, Issue 2, 2003, Pages 346-354

  Miao, Weimin ^a   Hu, Lianggao ^a   Kandouz, Mustapha ^a   Batist, Gerald ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; AROMATIC HYDROCARBON RECEPTOR; CARCINOGEN; CIS ACTING ELEMENT; CYTOCHROME P450 1A1; DRUG METABOLIZING ENZYME; GLUTATHIONE TRANSFERASE; OLIGONUCLEOTIDE; OLTIPRAZ; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (QUINONE); XENOBIOTIC AGENT;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL STRAIN HEPG2; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DRUG DETOXIFICATION; ENHANCER REGION; ENZYME INDUCTION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE STRUCTURE; HEPATOMA CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION SITE; XENOBIOTIC METABOLISM; XENOBIOTIC RESPONSIVE ELEMENT;

ANIMALS; ANTICARCINOGENIC AGENTS; BASE SEQUENCE; DNA; ENZYME ACTIVATION; GLUTATHIONE TRANSFERASE; METABOLIC DETOXICATION, DRUG; MOLECULAR SEQUENCE DATA; PYRAZINES; RATS; XENOBIOTICS;

EID: 0041341933     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.64.2.346     Document Type: Article

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